革新癌症治疗:利用细胞膜涂层纳米粒子实现精确靶向和治疗

Pranali Waghode, S. N. K. Rao G, Sanika Deshpande, Roja Rani Budha, R. R. Alavala, Surya Kovvasu
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引用次数: 0

摘要

癌症仍然是一个重大的世界性健康问题,需要新的诊断和治疗技术。本文探讨了与癌症相关的并发症,并介绍了生物仿生纳米粒子的新概念,认为它是抗击癌症的潜在突破口。导言对癌症进行了总体回顾,解释了癌症的复杂性和致癌的根本机制。流行病学研究结果强调了癌症对整个世界的影响,以及最广泛发现的癌症对创新治疗方法的需求。随后对各种癌症类型进行了全面回顾,重点介绍了癌症的独特特征、诊断方法和治疗方式,并强调了各种困难。在介绍了纳米粒子的多种类型和应用之后,对其进行了详尽的综述。纳米粒子的创造性源于生物系统的启发,并通过对其合成方法的解释得到了强调。重点是基于癌细胞膜的仿生物纳米粒子,这是一种新型的给药和靶向治疗手段。目前正在研究它们在癌症治疗中的应用,重点是它们在提高疗效和减轻副作用方面的潜力。特别值得一提的是,文章深入讨论了治疗肺癌、乳腺癌、前列腺癌、结肠癌、结直肠癌、卵巢癌、白血病、淋巴瘤、黑色素瘤、胰腺癌、膀胱癌、口腔癌、胃癌、肝癌、肝周胆管癌和宫颈癌时遇到的独特困难。文章还提到了整个过程中可能出现的各种挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Revolutionizing Cancer Treatment: Harnessing Cell-membrane Coated Nanoparticles for Precise Targeting and Therapy
Cancer is still a significant worldwide health issue that requires novel techniques for diagnosis and treatment. The complications associated with cancer are explored in this article, which also introduces the novel concept of biomimetic nanoparticles as potential breakthrough in the fight against the disease. The introduction gives a general review of cancer, explaining its complexity and the underlying mechanisms that give rise to it. Epidemiological findings highlight the impact of cancer on the entire world and the most extensively found cancer driving the demand for innovative therapeutic approaches. A comprehensive review of the various cancer types follows with emphasis on unique traits, diagnostic methods, and treatment modalities, highlighting the variety of difficulties. An achievable path forward for targeted cancer therapy is the emerging science of biomimetic nanoparticles. A thorough review of their many varieties and applications follows their introduction. These nanoparticles’ inventive nature, which was inspired by biological systems, is highlighted by the explanation of how they were synthesized. The focus is on biomimetic nanoparticles based on cancer cell membranes as a novel means of medication administration and targeted therapy. Their use in the treatment of cancer is being investigated, with an emphasis on their potential to improve therapeutic efficacy and lessen side effects. Particularly noteworthy are the in-depth discussions of the unique difficulties encountered in treating lung, breast, prostate, colon, colorectal, ovarian, leukemia, lymphoma, melanoma, pancreatic, bladder, oral, gastric, hepatic, perihilar cholangiocarcinoma, and cervical cancers. The article also mentions the various challenges which may occur during this entire process.
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