S. Mehrabadi, Azam Alinaghipour, Ghazaleh Khalili-tanha, Amir Avan
{"title":"作为结直肠癌潜在诊断和治疗靶点的生长激素释放激素","authors":"S. Mehrabadi, Azam Alinaghipour, Ghazaleh Khalili-tanha, Amir Avan","doi":"10.2174/0115733947278625240304050815","DOIUrl":null,"url":null,"abstract":"\n\nAs the third most prevalent cancer, there is no convincing treatment for colorectal cancer.\nGrowth Hormone-releasing Hormone (GHRH) is an important hormone for the growth and maturity\nof humans and other animals. Also, recent studies show both GHRH and GHRH receptor to be expressed\nin many types of cancers, such as lung, breast, colon, ovarian, gastric, and pancreatic cancer.\nGHRH has been shown to augment the growth and proliferation of cancer cells in in vivo and in vitro\nstudies, but studies have shown that its antagonist can inhibit the growth or even metastasis of cancer\ncells. The development of many classes of GHRH-R antagonists over the past three decades has\nshown strong in vivo and in vitro growth inhibitory effects on cancer. The present study is an attempt\nto review the studies on the association between GHRH and colorectal cancer and examine if the\nhormone can be targeted for therapy or used as a prognostic marker for colorectal cancer or not.\n","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"41 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Growth Hormone-Releasing Hormone as Potential Diagnostic and\\nTherapeutic Target in Colorectal Cancer\",\"authors\":\"S. Mehrabadi, Azam Alinaghipour, Ghazaleh Khalili-tanha, Amir Avan\",\"doi\":\"10.2174/0115733947278625240304050815\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nAs the third most prevalent cancer, there is no convincing treatment for colorectal cancer.\\nGrowth Hormone-releasing Hormone (GHRH) is an important hormone for the growth and maturity\\nof humans and other animals. Also, recent studies show both GHRH and GHRH receptor to be expressed\\nin many types of cancers, such as lung, breast, colon, ovarian, gastric, and pancreatic cancer.\\nGHRH has been shown to augment the growth and proliferation of cancer cells in in vivo and in vitro\\nstudies, but studies have shown that its antagonist can inhibit the growth or even metastasis of cancer\\ncells. The development of many classes of GHRH-R antagonists over the past three decades has\\nshown strong in vivo and in vitro growth inhibitory effects on cancer. The present study is an attempt\\nto review the studies on the association between GHRH and colorectal cancer and examine if the\\nhormone can be targeted for therapy or used as a prognostic marker for colorectal cancer or not.\\n\",\"PeriodicalId\":503819,\"journal\":{\"name\":\"Current Cancer Therapy Reviews\",\"volume\":\"41 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Cancer Therapy Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0115733947278625240304050815\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cancer Therapy Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115733947278625240304050815","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Growth Hormone-Releasing Hormone as Potential Diagnostic and
Therapeutic Target in Colorectal Cancer
As the third most prevalent cancer, there is no convincing treatment for colorectal cancer.
Growth Hormone-releasing Hormone (GHRH) is an important hormone for the growth and maturity
of humans and other animals. Also, recent studies show both GHRH and GHRH receptor to be expressed
in many types of cancers, such as lung, breast, colon, ovarian, gastric, and pancreatic cancer.
GHRH has been shown to augment the growth and proliferation of cancer cells in in vivo and in vitro
studies, but studies have shown that its antagonist can inhibit the growth or even metastasis of cancer
cells. The development of many classes of GHRH-R antagonists over the past three decades has
shown strong in vivo and in vitro growth inhibitory effects on cancer. The present study is an attempt
to review the studies on the association between GHRH and colorectal cancer and examine if the
hormone can be targeted for therapy or used as a prognostic marker for colorectal cancer or not.