Arya Moftakhar, S. Khoshnam, D. Dayer, Maryam Farzaneh
{"title":"探索lncRNA-HOTAIR在胶质瘤中的功能作用:揭示其对肿瘤进展的影响","authors":"Arya Moftakhar, S. Khoshnam, D. Dayer, Maryam Farzaneh","doi":"10.2174/0115733947296461240312051407","DOIUrl":null,"url":null,"abstract":"\n\nGliomas, a heterogeneous class of brain cancers, pose significant challenges as they are\nconsidered incurable. They represent the most recurrent primary intracranial cancer and exhibit distinct\nclinical and biological characteristics. Traditional treatment options for glioma include radiotherapy,\nchemotherapy, and surgery; however, the emergence of molecular-targeted therapy has provided\na new avenue for improved therapeutic responses. One intriguing oncogene type of long noncoding\nRNAs (lncRNAs) in glioma is the HOX Transcript Antisense RNA, commonly referred to as\nHOTAIR. HOTAIR is characterized by its overexpression in various cancers and is situated in the\nintergenic region between HOXC12 and HOXC11 of the HOXC cluster on chromosome 12. Its upregulation\nin glioma has been found to be associated with tumor grade and plays a significant role in\ndisease progression. HOTAIR exerts vital functions in glioma, including promoting angiogenesis,\nmodulating glutamine catabolism, and influencing sensitivity to temozolomide (TMZ), a commonly\nused chemotherapy drug. Knockdown of HOTAIR has been shown to suppress cell invasion, migration,\nand proliferation, while inducing apoptosis, ultimately leading to tumor repression. HOTAIR\nachieves its biological effects, by targeting specific microRNAs (miRNAs). In this review study, we\nhave summarized several signaling pathways that are intricately linked to HOTAIR in the context of\nglioma. Understanding the mechanisms and interactions involving HOTAIR and these signaling\npathways may provide valuable insights for the development of targeted therapies and improved\nmanagement strategies for glioma. This review provides a summary of the potential roles of HOTAIR\nin glioma, encompassing its effects in commercial cell lines, patient-derived cell lines, animal studies,\nand clinical trials.\n","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":" 30","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Functional Roles of lncRNA-HOTAIR in Glioma: Unraveling its Impact on Tumor Progression\",\"authors\":\"Arya Moftakhar, S. Khoshnam, D. Dayer, Maryam Farzaneh\",\"doi\":\"10.2174/0115733947296461240312051407\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nGliomas, a heterogeneous class of brain cancers, pose significant challenges as they are\\nconsidered incurable. They represent the most recurrent primary intracranial cancer and exhibit distinct\\nclinical and biological characteristics. Traditional treatment options for glioma include radiotherapy,\\nchemotherapy, and surgery; however, the emergence of molecular-targeted therapy has provided\\na new avenue for improved therapeutic responses. One intriguing oncogene type of long noncoding\\nRNAs (lncRNAs) in glioma is the HOX Transcript Antisense RNA, commonly referred to as\\nHOTAIR. HOTAIR is characterized by its overexpression in various cancers and is situated in the\\nintergenic region between HOXC12 and HOXC11 of the HOXC cluster on chromosome 12. Its upregulation\\nin glioma has been found to be associated with tumor grade and plays a significant role in\\ndisease progression. HOTAIR exerts vital functions in glioma, including promoting angiogenesis,\\nmodulating glutamine catabolism, and influencing sensitivity to temozolomide (TMZ), a commonly\\nused chemotherapy drug. Knockdown of HOTAIR has been shown to suppress cell invasion, migration,\\nand proliferation, while inducing apoptosis, ultimately leading to tumor repression. HOTAIR\\nachieves its biological effects, by targeting specific microRNAs (miRNAs). In this review study, we\\nhave summarized several signaling pathways that are intricately linked to HOTAIR in the context of\\nglioma. Understanding the mechanisms and interactions involving HOTAIR and these signaling\\npathways may provide valuable insights for the development of targeted therapies and improved\\nmanagement strategies for glioma. This review provides a summary of the potential roles of HOTAIR\\nin glioma, encompassing its effects in commercial cell lines, patient-derived cell lines, animal studies,\\nand clinical trials.\\n\",\"PeriodicalId\":503819,\"journal\":{\"name\":\"Current Cancer Therapy Reviews\",\"volume\":\" 30\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Cancer Therapy Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0115733947296461240312051407\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cancer Therapy Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115733947296461240312051407","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Exploring the Functional Roles of lncRNA-HOTAIR in Glioma: Unraveling its Impact on Tumor Progression
Gliomas, a heterogeneous class of brain cancers, pose significant challenges as they are
considered incurable. They represent the most recurrent primary intracranial cancer and exhibit distinct
clinical and biological characteristics. Traditional treatment options for glioma include radiotherapy,
chemotherapy, and surgery; however, the emergence of molecular-targeted therapy has provided
a new avenue for improved therapeutic responses. One intriguing oncogene type of long noncoding
RNAs (lncRNAs) in glioma is the HOX Transcript Antisense RNA, commonly referred to as
HOTAIR. HOTAIR is characterized by its overexpression in various cancers and is situated in the
intergenic region between HOXC12 and HOXC11 of the HOXC cluster on chromosome 12. Its upregulation
in glioma has been found to be associated with tumor grade and plays a significant role in
disease progression. HOTAIR exerts vital functions in glioma, including promoting angiogenesis,
modulating glutamine catabolism, and influencing sensitivity to temozolomide (TMZ), a commonly
used chemotherapy drug. Knockdown of HOTAIR has been shown to suppress cell invasion, migration,
and proliferation, while inducing apoptosis, ultimately leading to tumor repression. HOTAIR
achieves its biological effects, by targeting specific microRNAs (miRNAs). In this review study, we
have summarized several signaling pathways that are intricately linked to HOTAIR in the context of
glioma. Understanding the mechanisms and interactions involving HOTAIR and these signaling
pathways may provide valuable insights for the development of targeted therapies and improved
management strategies for glioma. This review provides a summary of the potential roles of HOTAIR
in glioma, encompassing its effects in commercial cell lines, patient-derived cell lines, animal studies,
and clinical trials.