International Journal of Psychiatry in Medicine最新文献

{"title":"Glucagon-like peptide-1 receptor agonists in individuals with severe mental illness: A systematic review and meta-analysis of randomized controlled trials.","authors":"Manit Srisurapanont, Sirijit Suttajit, Surinporn Likhitsathian, Chawisa Suradom, Benchalak Maneeton","doi":"10.1177/00912174261422822","DOIUrl":"10.1177/00912174261422822","url":null,"abstract":"<p><p>ObjectiveThis systematic review and meta-analysis evaluated the efficacy, acceptability, and tolerability of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in individuals with severe mental illness (SMI).MethodsPubMed, Embase, the Cochrane Library, Google Scholar, and Clinical- Trials.gov were searched on December 1, 2025, for randomized controlled trials (RCTs) of GLP-1RAs in participants with SMI. Primary outcomes were weight reduction, glycated hemoglobin (HbA1c) reduction, all-cause dropouts, and adverse effect dropouts. Mean differences (MDs) and risk ratios (RRs) were estimated using a frequentist random-effects model.ResultsIncluded were 10 RCTs (N = 665) of exenatide, liraglutide, and semaglutide. Participants were those with schizophrenia, schizophrenia-spectrum disorders, or bipolar disorder with cardiometabolic risk. Compared with placebo/usual care, GLP- 1RAs significantly reduced weight (MD = 6.17 kg, 95% CI=9.10 to_3.25, <i>I²</i> = 91.8%, 9 trials) and HbA1c (MD = 0.31%, 95% CI: 0.40 to 0.22, <i>I²</i> = 51.3%, 8 trials). All-cause dropouts did not differ significantly between groups (RR = 0.98, 95% CI: 0.71 to 1.35, <i>I²</i> = 28.5%, 10 trials), nor did adverse effect dropouts (RR = 0.99, 95% CI: 0.35 to 2.77, <i>I²</i> = 31.6%, 5 trials). Low certainty evidence supports the tolerability and efficacy of GLP-1RAs for weight and HbA1c reduction. Moderate certainty evidence also supports their acceptability.ConclusionThe available evidence suggests that GLP-1RAs may reduce body weight and slightly reduce HbA1c in individuals with SMI who have prediabetes or are overweight/obese. GLP-1RAs are generally acceptable and tolerated in this population.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"312-328"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotropic medications and their role in physical, mental, and behavioral health.","authors":"Harold G Koenig","doi":"10.1177/00912174261431395","DOIUrl":"10.1177/00912174261431395","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"259-261"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of metabolic syndrome in patients with bipolar disorder in Türkiye: A one-year follow-up study.","authors":"Rukiye Tekdemir, Fatih Ekici, Hasan Ali Güler, Muhammet Tuğrul Ergün, Yavuz Selvi","doi":"10.1177/00912174251350817","DOIUrl":"10.1177/00912174251350817","url":null,"abstract":"<p><p>ObjectiveThis study examined the incidence of metabolic syndrome (MetS) in individuals with bipolar disorder (BD) and identified clinical and biological predictors of incident MetS during a 1-year follow-up.MethodsThe study included 100 euthymic BD type-1 patients consecutively recruited from outpatient clinics between July 2023 and July 2024. MetS was defined according to International Diabetes Federation criteria. Patients without MetS at baseline but with MetS during follow-up were classified as having incident MetS. A logistic regression model was utilized to estimate the adjusted odds ratios (OR) and corresponding 95% confidence intervals (CIs) for associations between predictors and incident MetS.ResultsOf the participants enrolled in the study (n = 100, 92% response rate), 29% met MetS criteria at baseline. Of the 71 without baseline MetS, 29 (40.8%) developed MetS over a 1-year period. Significant predictors of MetS onset included a higher number of manic/hypomanic episodes (OR = 1.459, 95% CI = 1.005-2.118, <i>P</i> = .047), increased chlorpromazine-equivalent antipsychotic dosages (OR = 1.007, 95% CI = 1.001-1.013, <i>P</i> = .024), high waist circumference (OR = 1.247, 95% CI = 1.052-1.479, <i>P</i> = .011), and hypertriglyceridemia (OR = 1.041, 95% CI = 1.007-1.077, <i>P</i> = .020). Conversely, lamotrigine use was inversely associated with MetS development (OR = 0.030, 95% CI = 0.001-0.659, <i>P</i> = .026).ConclusionA high incidence of MetS (41%) was observed during a 1-year follow-up of patients with BD in Turkey. Identified risk factors highlight opportunities for intervention through mood recurrence prevention, careful pharmacotherapy management, and treatment of pre-existing components of MetS.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"368-385"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing severe alcohol withdrawal with bromocriptine: A case series.","authors":"Sayantan Chattopadhyay, Ayan Basak, Sukriti Mukherjee","doi":"10.1177/00912174251321962","DOIUrl":"10.1177/00912174251321962","url":null,"abstract":"<p><p>ObjectiveAlcohol withdrawal syndrome poses a significant health burden worldwide, with its prevalence steadily rising in countries like India due to high rates of alcohol use disorders. The treatment landscape for alcohol withdrawal syndrome is evolving with the introduction of bromocriptine offering a promising adjunctive treatment for patients resistant to standard benzodiazepine therapy.MethodsWe report two cases from India of severe alcohol withdrawal syndrome successfully treated with bromocriptine.ResultsClinically significant improvements were present in both patients with regard to alcohol withdrawal symptoms in a relatively short time span.ConclusionsBromocriptine may represent an addition to the therapeutic options for alcohol withdrawal syndrome management, offering symptom relief, improving clinical outcomes, and addressing neuropsychiatric symptom burden.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"329-337"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional intake and adequacy of intake among Vietnamese outpatients with major depressive disorder: A 24-hour recall study.","authors":"Manh Xuan Bui, Linh Tich Ngo, Phuc Truong Vinh Le, Phong Duy Nguyen","doi":"10.1177/00912174251352405","DOIUrl":"10.1177/00912174251352405","url":null,"abstract":"<p><p>ObjectiveThis study assessed the 24-hour nutrient intake, adequacy of intake, and associated factors among outpatients diagnosed with major depressive disorder (MDD).MethodA cross-sectional study was conducted among 290 adult outpatients diagnosed with MDD at University Medical Center, Ho Chi Minh City, Vietnam. Participants completed a 24-hour dietary recall and the Quick Inventory of Depressive Symptomatology (QIDS-SR). Nutrient intake was analyzed using Vietnamese food composition tables and categorized based on national dietary recommendations. Mean daily nutrient intakes were calculated for energy, macronutrients, and micronutrients. Multivariate analyses assessed associations between demographic, clinical, and psychosocial factors and nutrient intake.ResultsParticipants demonstrated low average intake of energy, macronutrients, and essential micronutrients. A majority had inadequate intake of total energy, carbohydrates, fats, and key vitamins and minerals such as calcium, potassium, and vitamins A and C. Nutritional deficiencies were more pronounced among individuals with greater depression severity, limited time for self-care, underweight status, and fewer economic resources. Principal component analysis revealed two main dietary patterns: one nutrient-rich and another characterized by high fat and sodium with low vitamin content.ConclusionsIndividuals with MDD in Vietnam demonstrate widespread inadequacy of nutrient intake, which is associated with both depression severity and several sociodemographic factors. These findings underscore the importance of integrating nutrition assessment and intervention into mental health care in Vietnam and likely other countries in southeast Asia.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"338-367"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes of Death During Psychiatric Hospitalization: An 11-Year Matched Case-Case Study in Northeast Brazil.","authors":"Maximiliano Loiola Ponte de Souza, Márcio Flávio Moura de Araújo","doi":"10.1177/00912174261445498","DOIUrl":"https://doi.org/10.1177/00912174261445498","url":null,"abstract":"<p><p>ObjectiveTo compare the distribution of specific causes of death occurring during psychiatric and non-psychiatric hospitalizations in the state of Ceará, Brazil, over an 11-year period.MethodA retrospective matched case-case study was conducted using data from the Brazilian Mortality Information System from 2012 to 2022. A total of 115 deaths occurring in psychiatric hospitals were identified. For each psychiatric hospital death, 5 comparison deaths from non-psychiatric hospitals were randomly selected and matched by year of death, sex, and exact age.ResultsCardiovascular diseases were the most frequent cause of death in psychiatric hospitals (39.1%) and were more frequent than in non-psychiatric hospitals (18.3%) (OR = 2.87, 95% CI = 1.87-4.42). Deaths attributed to mental and behavioral disorders (OR = 7.72, 95% CI = 2.87-20.75), ill-defined natural causes (OR = 3.12, 95% CI = 1.39-7.01), and events of undetermined intent (OR = 28.60, 95% CI = 8.13-100.59) were also comparatively more frequent in psychiatric settings, whereas neoplasms were markedly less frequent (OR = 0.03, 95% CI = 0.00-0.26).ConclusionsCardiovascular diseases were the most common specific cause of death during psychiatric hospitalization. The comparatively higher frequency of diagnostically broad categories suggests challenges in clinical monitoring, diagnostic capacity, cause-of-death certification, as well as potential stigma-related influences on the classification of deaths of undetermined intent, including possible suicides, in psychiatric inpatient settings. These findings underscore the need for closer integration between psychiatric and general medical care.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261445498"},"PeriodicalIF":1.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Bidirectional Relationship Between Pain Burden and Depressive Symptoms Among Middle-Aged and Elderly Individuals: A Cross-Lagged Panel Model.","authors":"Yiting Kang","doi":"10.1177/00912174261436560","DOIUrl":"https://doi.org/10.1177/00912174261436560","url":null,"abstract":"<p><p>ObjectivePain and depressive symptoms are highly prevalent among middle-aged and older adults and frequently co-occur, yet the temporal ordering and directionality of the relationship between pain and depressive symptoms are inconsistent. This study aimed to examine the longitudinal bidirectional relationship between pain burden and depressive symptoms among middle-aged and older adults in China.MethodsData were derived from five waves (2011-2020) of the China Health and Retirement Longitudinal Study (CHARLS). Pain burden was assessed as the number of body sites with pain (range: 0-15), and depressive symptoms were measured using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10; range: 0-30). Cross-lagged panel models (CLPM) were applied to evaluate the temporal associations between pain burden and depressive symptoms across five waves, while adjusting for baseline sociodemographic characteristics, health behaviors, self-rated health, function limitation, and number of chronic diseases.ResultsA total of 7288 participants were included in the study. Pain burden demonstrated significant autoregressive stability over time and consistently predicted higher levels of depressive symptoms at subsequent waves. These prospective associations remained robust after adjustment for covariates. In contrast, depressive symptoms did not show a significant or consistent longitudinal effect on subsequent pain burden. Overall, the findings indicated a predominantly unidirectional temporal relationship, with pain burden preceding and contributing to later depressive symptoms.ConclusionsThese findings highlight the importance of considering cumulative pain as an early risk signal for depression and underscore the need to integrate pain assessment into mental health screening and chronic disease management strategies for aging populations.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261436560"},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Testosterone Deficiency and Depressive Symptoms in Obese Males: Role of Inflammatory Mediators.","authors":"Huadong Xie, Chengjie Ban, Yi Zhan, Yongyan Meng, Ke Zhang, Yanxiang Xiong, Siping Zeng","doi":"10.1177/00912174261435803","DOIUrl":"https://doi.org/10.1177/00912174261435803","url":null,"abstract":"<p><p>BackgroundThe relationship between testosterone deficiency (TD) and depressive symptoms among obese individuals has not been fully clarified. This study explores the relationship between TD and depressive symptoms in obese males and possible mediating factors.MethodsThese cross-sectional analyses included 6177 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2016. Logistic regression models were employed to assess the association of TD with depressive symptoms in different subgroups. Sensitivity analyses were performed using restricted cubic splines (RCS), subgroup analysis, and mediation analysis.ResultsThere was a significant positive correlation between TD and depressive symptoms in obese males (OR = 1.33, 95% CI = 1.04-1.69, <i>P</i> = 0.023). The analysis further demonstrated a significant L-shaped nonlinear relationship between testosterone levels and depressive symptoms in obese males. The analysis of the threshold effects showed that the risk of depressive symptoms increased below testosterone levels of 273 ng/dL. Furthermore, the study also found that inflammatory markers demonstrated a statistically significant partial mediating effect in the observed association between TD and depressive symptoms.ConclusionIn obese males, testosterone levels exhibit an L-shaped correlation with depressive symptoms, with inflammation acting as a statistical mediating factor. These findings offer new hypotheses for future clinical interventional studies.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261435803"},"PeriodicalIF":1.3,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship Between Surgical Outcomes and Psychiatric Disorders: A Database Mining Study on Postoperative Depression and Anxiety.","authors":"Meiping Shi, Jieying Wang, Lulu Wang, Xin Cheng, Peng Li, Ziqing Dai, Yu Chen","doi":"10.1177/00912174261435021","DOIUrl":"https://doi.org/10.1177/00912174261435021","url":null,"abstract":"<p><p>ObjectiveThis study used population-scale administrative data to quantify the frequency, risk factors, and healthcare utilization implications of postoperative depression and anxiety.MethodsA retrospective cohort analysis was conducted using the U.S. Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS) database from 2016 to 2022, encompassing 4.2 million surgical procedures across 47 states. Newly coded postoperative psychiatric disorders were identified using ICD-10 diagnostic codes (F32. x for depression and F41.x for anxiety) within 30 days post-surgery. Multivariable logistic regression and propensity score matching (1:1 nearest neighbor, caliper width 0.2σ) were employed to evaluate associations between surgical characteristics and psychiatric outcomes, adjusting for demographics, comorbidities, and institutional factors.ResultsThe overall frequency of newly coded postoperative psychiatric disorders was 14.3%, including depression (9.1%), anxiety (8.7%), and mixed presentations (3.5%). Hip fracture surgery demonstrated the highest adjusted odds ratio (aOR 2.34, 95% CI = 2.18-2.51), followed by thoracotomy (aOR 1.89, 95% CI = 1.76-2.03) and cardiac procedures (aOR 1.67, 95% CI = 1.58-1.76). Significant associated factors included female sex (aOR 1.43, 95% CI = 1.39-1.47), age >65 years (aOR 1.28, 95% CI = 1.23-1.33), and operative duration exceeding 5 hours (aOR 1.52, 95% CI = 1.47-1.57). Propensity-matched analysis revealed substantial healthcare utilization disparities, including prolonged hospitalization (13.2 vs 8.4 days, <i>P</i> < 0.001), higher 30-day readmission rates (28.9% vs 19.6%, <i>P</i> < 0.001), and increased total costs ($47,680 vs $31,250, <i>P</i> < 0.001).ConclusionsThis comprehensive population-based analysis demonstrated substantial heterogeneity in the risk of postoperative psychiatric disorders across surgical specialties, with profound implications for healthcare utilization. These findings support the implementation of systematic psychiatric screening protocols and targeted perioperative interventions for high-risk surgical populations.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261435021"},"PeriodicalIF":1.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Brain Stimulation for Refractory OCD and Depression: From Neurocircuitry to Personalised Neuromodulation.","authors":"Joel Zen-Yew Chiu, Yeannie Hui-Yeng Yap, Soon-Hao Tan","doi":"10.1177/00912174261435019","DOIUrl":"https://doi.org/10.1177/00912174261435019","url":null,"abstract":"<p><p>ObjectiveDeep brain stimulation (DBS) has emerged as a promising intervention for severe, treatment-resistant psychiatric disorders such as obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD), where conventional therapies often fail. Despite overlapping neurocircuitry, the clinical trajectories and translational challenges of these conditions differ substantially. This review examines the current evidence and advancements in DBS for severe, treatment-resistant psychiatric disorders.MethodsA literature search was conducted to identify relevant studies on DBS for OCD and TRD. The search was performed in PubMed and Google Scholar, covering publications from 2020 to 2025. Older studies were included if deemed essential references. Keywords and Boolean combinations such as \"DBS,\" \"deep brain stimulation,\" \"OCD,\" \"TRD,\" \"treatment-resistant depression,\" and \"psychiatric neuromodulation\" were used to refine the search and enhance specificity.ResultsClinical findings demonstrate sustained long-term benefits of DBS in OCD, although recent sham-controlled trials report smaller effect sizes than earlier open-label studies. In TRD, outcomes remain inconsistent, with open-label trials showing high response rates but larger randomised trials failing to significantly outperform sham stimulation. Emerging innovations include connectomic-guided targeting, AI-assisted predictive models, and closed-loop DBS systems driven by neural biomarkers.ConclusionDBS remains a promising therapy for refractory OCD and TRD. Future progress depends on addressing methodological, ethical, and translational challenges while advancing personalised, data-driven neuromodulation strategies.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261435019"},"PeriodicalIF":1.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}