International Journal of Psychiatry in Medicine最新文献

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Addressing severe alcohol withdrawal with bromocriptine: A case series. 溴隐亭治疗严重酒精戒断:一个病例系列
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-02-16 DOI: 10.1177/00912174251321962
Sayantan Chattopadhyay, Ayan Basak, Sukriti Mukherjee
{"title":"Addressing severe alcohol withdrawal with bromocriptine: A case series.","authors":"Sayantan Chattopadhyay, Ayan Basak, Sukriti Mukherjee","doi":"10.1177/00912174251321962","DOIUrl":"https://doi.org/10.1177/00912174251321962","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol withdrawal syndrome poses a significant health burden worldwide, with its prevalence steadily rising in countries like India due to high rates of alcohol use disorders. The treatment landscape for alcohol withdrawal syndrome is evolving with the introduction of bromocriptine offering a promising adjunctive treatment for patients resistant to standard benzodiazepine therapy.</p><p><strong>Methods: </strong>We report two cases from India of severe alcohol withdrawal syndrome successfully treated with bromocriptine.</p><p><strong>Results: </strong>There were clinically significant improvements in both patients with regard to Alcohol Withdrawal Symptoms in a relatively short time span.</p><p><strong>Conclusions: </strong>Bromocriptine represents an addition to the therapeutic options for alcohol withdrawal syndrome management, offering symptom relief, improving clinical outcomes, and addressing the neuropsychiatric burden associated with the condition.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251321962"},"PeriodicalIF":1.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications. 心血管疾病和双相情感障碍:病理生理学和治疗意义的综述。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-23 DOI: 10.1177/00912174251316947
Mayuresh Chaudhari, Luis Mendez, Rene L Olvera, Sudha Seshadri, Antonio L Teixeira
{"title":"Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications.","authors":"Mayuresh Chaudhari, Luis Mendez, Rene L Olvera, Sudha Seshadri, Antonio L Teixeira","doi":"10.1177/00912174251316947","DOIUrl":"https://doi.org/10.1177/00912174251316947","url":null,"abstract":"<p><strong>Objective: </strong>Despite the well-established increased risk of cardiovascular mortality in individuals with bipolar disorder (BD), prevention and treatment of cardiovascular risk factors and diseases have been largely overlooked in this population. This manuscript reviews the pathophysiological basis of the connection between BD and cardiovascular diseases, highlighting their shared mechanisms, reciprocal interactions, and relevant prevention and treatment strategies.</p><p><strong>Methods: </strong>For this narrative review, a search was carried out on PubMed using the keywords bipolar disorder, cardiovascular diseases, and cardiovascular risk factors.</p><p><strong>Results: </strong>The increased frequency of cardiovascular morbidity in BD can be attributed to overlapping biological and psychosocial mechanisms. These mechanisms are complex and involve both direct effects of BD and indirect effects mediated by lifestyle and pharmacological factors. Cardiovascular diseases also significantly exacerbate the clinical course of BD and increase morbidity and healthcare costs; thus, their effective management can improve psychiatric outcomes and vice versa. However, patients with BD frequently encounter healthcare barriers.</p><p><strong>Conclusion: </strong>Awareness initiatives and research on integrated care are needed to determine the best strategies for improving cardiovascular and psychiatric outcomes in individuals with BD.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251316947"},"PeriodicalIF":1.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric problems in medical patients relevant to primary care physicians and mental health providers. 与初级保健医生和心理保健提供者相关的内科病人的精神问题。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.1177/00912174241297503
Harold G Koenig
{"title":"Psychiatric problems in medical patients relevant to primary care physicians and mental health providers.","authors":"Harold G Koenig","doi":"10.1177/00912174241297503","DOIUrl":"10.1177/00912174241297503","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"3-6"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and correlates of post-traumatic stress disorder among internal displaced people in Qoloji Camps, Somali regional state, Eastern Ethiopia. 埃塞俄比亚东部索马里州 Qoloji 营地境内流离失所者中创伤后应激障碍的患病率及相关因素。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-02-14 DOI: 10.1177/00912174241232001
Abdi Mahamed Muhummed, Meka Kedir Jibril, Ahmed Adem Yimam, Seid Yimam Ali
{"title":"Prevalence and correlates of post-traumatic stress disorder among internal displaced people in Qoloji Camps, Somali regional state, Eastern Ethiopia.","authors":"Abdi Mahamed Muhummed, Meka Kedir Jibril, Ahmed Adem Yimam, Seid Yimam Ali","doi":"10.1177/00912174241232001","DOIUrl":"10.1177/00912174241232001","url":null,"abstract":"<p><strong>Objectives: </strong>This study assessed the prevalence and correlates of post-traumatic stress disorder (PTSD) among internally displaced people (IDP) in the Qoloji Camp, Somali Regional State, Eastern Ethiopia.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted from October 20 to November 5, 2021. The study utilized systematic random sampling to identify 410 IDP participants from the Qoloji Camp. PTSD was measured using the PTSD Check-list for DSM-5 (PCL-5). Bivariate analysis was performed to determine the crude odds ratio, and multivariate analysis was used to calculate adjusted odds ratios for associations between PTSD and independent variables.</p><p><strong>Results: </strong>A total of 404 participants were interviewed (98.5% response rate). The estimated prevalence of PTSD symptoms was 41.1%. In the multivariate logistic regression analysis, several factors were significantly associated with PTSD: being female (AOR = 2.5, 95% CI = 1.39-4.44), lack of food and water (AOR = 2.2, 95% CI = 1.17, 4.23), destruction of personal property (AOR = 3.1, 95% CI = 1.62-6.09), and experiencing torture or beatings (AOR = 1.8, 95% CI = 1.01-3.28).</p><p><strong>Conclusion: </strong>This study found a high prevalence of PTSD symptoms among IDPs, with factors such as female sex, property destruction, deprivation of essential goods and services, and experiences of torture or beatings significantly associated with those symptoms. To address these findings, prioritizing the well-being of IDPs with a specific focus on women, on-site screening, and the establishment of a referral system to facilitate access to specialized care are essential to enhance the overall mental health of such persons.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"17-32"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PTSD symptoms among patients with multiple sclerosis in Jordan during October 7th Gaza war outbreak. "10月7日加沙战争爆发期间约旦多发性硬化症患者的创伤后应激障碍症状"。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-08-06 DOI: 10.1177/00912174241272680
Omar Gammoh, Esam Qnais, Hanan Abu Alshaikh, Mohammad Mansour, Suha Al-Habahbeh, Feras Weshah, Wail Ennab, Badriyah S Alotaibi, Abdelrahim Alqudah
{"title":"PTSD symptoms among patients with multiple sclerosis in Jordan during October 7th Gaza war outbreak.","authors":"Omar Gammoh, Esam Qnais, Hanan Abu Alshaikh, Mohammad Mansour, Suha Al-Habahbeh, Feras Weshah, Wail Ennab, Badriyah S Alotaibi, Abdelrahim Alqudah","doi":"10.1177/00912174241272680","DOIUrl":"10.1177/00912174241272680","url":null,"abstract":"<p><strong>Objective: </strong>Clinicians have noted that the ongoing war on Gaza has had a psychological impact on people with multiple sclerosis (PwMS) whose mental health is particularly vulnerable during stressful times such as these. The present study sought to examine the prevalence and correlates of posttraumatic stress disorder (PTSD) symptoms among PwMS in Jordan during the Gaza war outbreak.</p><p><strong>Methods: </strong>This was a cross-sectional study involving 171 patients (PwMS) out of 372 patients approached (46% response rate) who were being seen in the MS unit at Al Bashir Hospital, Ammann, Jordan. Inclusion criteria required that participants had been following daily news updates of the October 7 war in Gaza during a period of 4 months.</p><p><strong>Results: </strong>Of participants, 125 (73.1%) were female, 98 (57.3%) were on therapy for less than five years, and 30 (17.5%) reported having a relapse during the past 6 months. Significant PTSD symptoms were identified in 58.5% (100 of 171 participants). Those at higher risk were the unemployed (OR = 2.14, 95% CI = 1.13-4.07, <i>P</i> = 0.02), whereas patients receiving dimethyl fumarate (19.9%) were at lower risk (OR = 0.43, 95% CI = 0.19-0.94, <i>P</i> = 0.02).</p><p><strong>Conclusion: </strong>The high rate of significant PTSD symptoms among people with MS in this study underscores the need for attention by primary care providers and the implementation of a comprehensive multidisciplinary approach to optimize the mental well-being of this fragile population.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"7-16"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychosexual dysfunction in male patients with cannabis dependence and synthetic cannabinoid dependence. 大麻依赖和合成大麻素依赖男性患者的性心理功能障碍。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-01-28 DOI: 10.1177/00912174241230886
Abdelrahman A Asal, Doaa R Ayoub, Mohamed E Mazen, Shirin M El Makawi
{"title":"Psychosexual dysfunction in male patients with cannabis dependence and synthetic cannabinoid dependence.","authors":"Abdelrahman A Asal, Doaa R Ayoub, Mohamed E Mazen, Shirin M El Makawi","doi":"10.1177/00912174241230886","DOIUrl":"10.1177/00912174241230886","url":null,"abstract":"<p><strong>Objective: </strong>There are inconsistent reports regarding the relationship between cannabis use and male sexual function with almost no data about synthetic cannabinoids (SC) and their effect on male sexual functions. This study investigated psychological concerns related to male sexual functions among cannabis and SC users. The research assessed different sexual functions and aspects of sexual psychopathology in cannabis and SCs dependent men compared to controls.</p><p><strong>Method: </strong>Thirty male patients with cannabis dependence, thirty male patients with SCs dependence, and thirty matched controls from the outpatient clinic at Kasr Al Ainy hospital, Egypt, were assessed using the Structured Clinical Interview for DSM-IV TR Axis I Disorders (SCID-I), International Index of Erectile Function (IIEF), and Sexuality scale.</p><p><strong>Results: </strong>The means of IIEF questionnaire in the cannabis and SC group were significant lower (worse) than the means of the control group (<i>P</i> < .001) except the orgasmic function in cannabis group (<i>P</i> = .052). In the SCs group, sexual depression was higher and preoccupation lower than in the cannabis group (<i>P</i> < .020; <i>P</i> < .003, respectively) and control groups (<i>P</i> < .001; <i>P</i> < .001, respectively). The duration and dose of cannabis and SCs correlated significantly with sexual esteem, sexual preoccupation and all domains of IIEF.</p><p><strong>Conclusion: </strong>Cannabis and SC dependence were associated with lower erectile function, sexual desire, intercourse satisfaction and overall satisfaction, and lower orgasmic functions in the SC group than controls. Both groups showed higher sexual depression, lower sexual esteem and sexual preoccupation than controls. SC has a higher negative impact on male sexual functions and psychopathology than does cannabis.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"44-56"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spirituality and people with psychosis: A content analysis of influential primetime television programs. 精神与精神病患者:对有影响力的黄金时段电视节目的内容分析。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-03-27 DOI: 10.1177/00912174241240305
David R Hodge, Patricia R Turner
{"title":"Spirituality and people with psychosis: A content analysis of influential primetime television programs.","authors":"David R Hodge, Patricia R Turner","doi":"10.1177/00912174241240305","DOIUrl":"10.1177/00912174241240305","url":null,"abstract":"<p><strong>Objective: </strong>This mixed methods study examined depictions of spirituality among people with psychosis in influential television programming. Spirituality is a central strength for many people with psychosis. Yet, despite the important role media plays in shaping perceptions, little research has examined the intersection between spirituality and psychosis in the popular media.</p><p><strong>Methods: </strong>To address this gap, we conducted a content analysis of the 50 most viewed primetime fictional television shows over a 10-year period as determined by the Nielsen rating organization. Characters with psychosis were identified via keyword searches of online sources (Wikis, IMDb, etc.) and subsequently independently coded by two individuals. Characters were rated on 18 items in three domains related to demographics, life status, and character framing. Inter-rater reliability ranged from good to excellent across variables.</p><p><strong>Results: </strong>Of 120 identified characters with psychosis, just 16% (n = 19) had a spiritual identity. Analysis revealed few differences between spiritual and secular characters on demographic and life status variables. Conversely, an examination of framing variables revealed spiritual characters were comparatively less attractive, exhibited a greater negative impact on society, and were more likely to be referred to pejoratively (as a psychopath) and engage in criminal activity. Trend analysis indicated portrayals of spiritual characters decreased over time.</p><p><strong>Conclusions: </strong>The results suggest media depictions of spirituality contribute to the stigmatization of spirituality among people with psychosis, potentially preventing access to important coping resources and discouraging professional help-seeking. Primary care physicians should consider incorporating a spiritual assessment into care to determine spiritual coping assets and then support these.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"71-86"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 and mental health treatment in primary care: Impact of a global pandemic on a psychopharmacological collaborative care management program. COVID-19 与初级保健中的心理健康治疗:全球大流行对精神药物合作护理管理计划的影响。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-06-22 DOI: 10.1177/00912174241264592
Zachary D Zuschlag, Benjamin Lord, Teagan Smith, Alexander Lengerich, Kaitlin Leonard, Yvette Guereca, Ambuj Kumar, Vanessa A Milsom
{"title":"COVID-19 and mental health treatment in primary care: Impact of a global pandemic on a psychopharmacological collaborative care management program.","authors":"Zachary D Zuschlag, Benjamin Lord, Teagan Smith, Alexander Lengerich, Kaitlin Leonard, Yvette Guereca, Ambuj Kumar, Vanessa A Milsom","doi":"10.1177/00912174241264592","DOIUrl":"10.1177/00912174241264592","url":null,"abstract":"<p><strong>Objective: </strong>The COVID-19 pandemic has had a profound impact on individuals with mental health (MH) disorders and on the delivery of MH services. Few studies have examined treatment models not requiring substantial changes to the delivery of services during pandemic restrictions, such as collaborative care management (CoCM) programs. Therefore, a longitudinal retrospective cohort analysis was conducted to examine the impact of the COVID-19 pandemic on a psychopharmacological CoCM program.</p><p><strong>Method: </strong>Data were collected on all U.S. Veterans enrolled in a CoCM program at a large VA during the first 10 months of the COVID-19 pandemic and compared to a matched control group one-year prior to that date. Treatment in the program pre-COVID vs. treatment during the pandemic was compared in relation to baseline symptomatology, improvements in MH symptoms, and program adherence.</p><p><strong>Results: </strong>A total of 462 Veterans were referred during the control period, compared to 351 during the same time period during the pandemic. Veterans enrolled during the first four months of each study arm, to allow for a minimum of 6 months of follow up data, had no differences in baseline symptoms of depression or anxiety between groups. Veterans receiving care during the pandemic had higher rates of program completion than pre-pandemic controls. COVID-era Veterans also had higher rates of depression response compared to controls, but no differences were observed between groups on depression remission, anxiety response, or anxiety remission.</p><p><strong>Conclusions: </strong>Psychopharmacological CoCM treatment models can successfully manage depression and anxiety with no observed decrease in the effectiveness of this intervention even during periods of unprecedented disruptions to MH services.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"33-43"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and risk factors for chronic kidney disease among older adult patients with schizophrenia in Taiwan. 台湾老年精神分裂症患者中慢性肾病的患病率和风险因素。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2025-01-01 Epub Date: 2024-05-19 DOI: 10.1177/00912174241256164
Shu-Ting Chang, Jiunn-Ying Liou, Bo-Jian Wu, Hsing-Kang Chen
{"title":"Prevalence and risk factors for chronic kidney disease among older adult patients with schizophrenia in Taiwan.","authors":"Shu-Ting Chang, Jiunn-Ying Liou, Bo-Jian Wu, Hsing-Kang Chen","doi":"10.1177/00912174241256164","DOIUrl":"10.1177/00912174241256164","url":null,"abstract":"<p><strong>Objectives: </strong>There is an increasing incidence and prevalence of patients with chronic kidney disease (CKD) worldwide. Little is known the prevalence of CKD among older patients with schizophrenia. The purpose of this study was to investigate the prevalence of CKD and its risk factors in older adults with schizophrenia.</p><p><strong>Methods: </strong>In this cross-sectional study, a convenience sample of 240 patients with schizophrenia age 50 or older was recruited. In addition to demographic and clinical data, participants' estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease equation based on age, sex, ethnicity, and serum creatinine level determined from a blood sample taken from participants.</p><p><strong>Results: </strong>The overall prevalence of CKD was 11.3%. Those with CKD were older, had a longer duration of psychiatric illness, a higher body mass index (BMI), and diagnoses of hypertension compared to those in the non-CKD group. Independent of other risk factors, older age and BMI were significantly associated with CKD.</p><p><strong>Conclusions: </strong>This study found that the overall prevalence of CKD in older patients with schizophrenia was 11.3%. Independent risk factors for CKD in this population were older age and higher BMI. In addition to early identification and early treatment of CKD in older patients with schizophrenia, clinicians should actively manage the risk factors identified in this study.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"87-96"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review of long-acting injectable antipsychotic medications approved from 2008 to october 2024 and agents in phase 3. 2008年至2024年10月批准的长效注射抗精神病药物和iii期药物的系统回顾。
IF 1.1 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2024-12-19 DOI: 10.1177/00912174241310091
Ashley Meyer, Kyla Truman, Jayant Totlani, Catherine William, Haze Brown, Shaishav Shah, Drew Hirsch, Mohamed Salem, Tiffany Chang, Rasha Abdelsalam, Sabrina Renteria, Nathalie Murphy, Rebecca Hedrick, Itai Danovitch, Robert N Pechnick, Waguih William IsHak
{"title":"Systematic review of long-acting injectable antipsychotic medications approved from 2008 to october 2024 and agents in phase 3.","authors":"Ashley Meyer, Kyla Truman, Jayant Totlani, Catherine William, Haze Brown, Shaishav Shah, Drew Hirsch, Mohamed Salem, Tiffany Chang, Rasha Abdelsalam, Sabrina Renteria, Nathalie Murphy, Rebecca Hedrick, Itai Danovitch, Robert N Pechnick, Waguih William IsHak","doi":"10.1177/00912174241310091","DOIUrl":"https://doi.org/10.1177/00912174241310091","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this systematic review is to provide a detailed summary of the long-acting injectable antipsychotic medications approved by the Food and Drug Administration (FDA) between 2008 to October 2024. We aim to provide an overview of the mechanism of action, indications for both labeled and off-label uses, evidence for efficacy, dosing, and the adverse effects of each drug.</p><p><strong>Methods: </strong>Studies published from 2008 to October 1, 2024, were identified from the PubMed database, using the keywords: 'long-acting injectables' OR 'LAI*'AND 'psychopharm*\" OR 'schizophrenia' The authors conducted a focused analysis independently and reached a consensus on the recently approved long-acting injectable antipsychotic medications to be included in this systematic review. Key findings were derived from the full text in order to create the tables from selected studies.</p><p><strong>Results: </strong>A total of 13 long-acting injectable antipsychotic medications for the treatment of schizophrenia were FDA-approved between 2008 and October 1, 2024. One long-acting injectable antipsychotic is currently being investigated in a Phase 3 clinical trial. The indications, evidence, practical implementation issues, and adverse effects of each drug are discussed in this review.</p><p><strong>Conclusion: </strong>Improved understanding of newly approved long-acting injectables is critical in the management of patients with schizophrenia. The FDA approval of long-acting injectables in the past 15 years creates hopeful options for clinicians to improve clinical outcomes and quality of life for their patients.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174241310091"},"PeriodicalIF":1.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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