International Journal of Psychiatry in Medicine最新文献

{"title":"Clinical efficacy of electroconvulsive therapy combined with antidepressant medication in patients with treatment-resistant depression: A meta-analysis.","authors":"Xiaoli Sun, Junyun Liu, Wanwen Li","doi":"10.1177/00912174251338962","DOIUrl":"10.1177/00912174251338962","url":null,"abstract":"<p><p>ObjectiveTo systematically evaluate the efficacy of electroconvulsive therapy (ECT) combined with antidepressant medication in patients with treatment-resistant depression.MethodsA search of the CNKI, Wanfang, Vip, China Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science databases was conducted from their inception to January 1, 2025. Randomized controlled trials evaluating the efficacy of ECT combined with antidepressant medication in patients with treatment resistant depression were included. The experimental group received ECT combined with antidepressant drugs, while the control group received either ECT alone or ECT combined with a placebo. Data were analyzed using RevMan 5.2 software.ResultsA total of 11 randomized controlled trials involving 1254 patients were included in the analysis. Patients treated with ECT combined with antidepressants showed significantly greater improvement in depressive symptoms (<i>SMD</i> = 0.29, 95% <i>CI</i> = 0.47 to 0.12, <i>P</i> = 0.001) and higher remission rates (<i>OR</i> = 1.73, 95% <i>CI</i> = 1.24 to 2.40, <i>P</i> = 0. 001) compared to patients treated with ECT alone. There was no significant difference between the two groups in seizure duration (<i>SMD</i> = 0.17, 95% <i>CI</i> = 0.14 to 0.49, <i>P</i> = 0.28) or the incidence of adverse effects (<i>OR</i> = 1.15, 95% <i>CI</i> = 0.73 to 21.82, <i>P</i> = 0.54).ConclusionThe combination of ECT and antidepressant medication modestly improves depressive symptoms and increases remission rates in patients with treatment resistant depression. Additionally, there is no significant difference in seizure duration or the incidence of adverse reactions compared to ECT alone, suggesting a comparable safety profile.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"50-63"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of comprehensive specialized case management and intravenous therapy on negative emotions in patients with postoperative radiotherapy for breast cancer.","authors":"Litao Zhang, Qiufeng Li, Xiaoxia Guo","doi":"10.1177/00912174251340754","DOIUrl":"10.1177/00912174251340754","url":null,"abstract":"<p><p>ObjectiveTo explore the impact of comprehensive professional case management on the negative emotions of breast cancer patients undergoing postoperative radiotherapy.MethodsA total of 102 breast cancer patients who underwent their first radiation treatment between July 2021 and June 2022 at a hospital in Guangzhou, China, were randomly assigned to two groups: a control group of 51 patients who received routine nursing care, and an intervention group of 51 patients who received comprehensive professional case management in addition to routine nursing care, including personalized interventions such as extended care for breast cancer patients with indwelling infusion ports. The effects of the intervention were evaluated using the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and Self-Efficacy Scale (positive attitude, self-relaxation, and self-decision making) before and after the intervention.ResultsThere were no significant differences in anxiety, depression, or self-efficacy scores between the two groups before radiation therapy (<i>P</i> > .05). However, the SAS and SDS scores of the intervention group after radiation therapy (43.32 ± 3.87 and 40.7 ± 2.89, respectively) were significantly lower than those of the control group (49.66 ± 3.49 and 49.2 ± 3.19, respectively; t = 8.672 and 14.130, <i>P</i> < .01). The self-efficacy scores of the intervention group after radiation therapy (positive attitude: 49.3 ± 1.31, self-relaxation: 9.04 ± .68, and self-decision making: 37.03 ± .98) were also significantly higher than those of the control group (positive attitude: 44.6 ± .95, self-relaxation: 7.32 ± .53, and self-decision making: 31.42 ± .89; t = 20.48, 17.15, and 30.330, respectively; <i>P</i> < .01).ConclusionComprehensive professional case management, in conjunction with specialized intravenous therapy, compared to usual standard care, significantly improved negative emotions and self-efficacy in breast cancer patients undergoing radiotherapy.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"7-18"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive preservation and antidepressant efficacy of magnetic seizure therapy in adolescents with treatment resistant major depressive disorder in China: A randomized controlled trial.","authors":"Wei Wang, Yi Lu, Guo-Lin Mi, Su-Fang Qi","doi":"10.1177/00912174251364987","DOIUrl":"10.1177/00912174251364987","url":null,"abstract":"<p><p>ObjectiveTo compare the antidepressant efficacy, cognitive impact, and safety profile of magnetic seizure therapy (MST) vs. modified electroconvulsive therapy (MECT) in Chinese adolescents with treatment-resistant major depressive disorder (MDD).MethodsThis single-center, evaluator-blinded, prospective randomized controlled trial enrolled 120 adolescents aged 13-18 years diagnosed with treatment-resistant MDD. Participants were randomly assigned to either the MST group or the MECT group (n = 60 per group). The primary outcome was improvement in depressive symptoms measured by the Beck Depression Inventory-II (BDI-II) score. Secondary outcomes included changes in cognitive function assessed by the Montreal Cognitive Assessment (MoCA), time to reorientation, and adverse event incidence per CTCAE 5.0 criteria.ResultsThe reduction of depressive symptoms on the BDI-II was significantly greater in the MECT group (51.8%) compared to the MST group (46.5%) (<i>P</i> < 0.001), although clinical response rates were similar (90.0% vs 91.1%). The MST group showed significant improvement in MoCA total score, whereas the MECT group demonstrated a slight decline (<i>P</i> < 0.001). MST was associated with greater cognitive preservation (+0.96 vs 0.36 MoCA score), fewer adverse events (28.9% vs 64.0%, <i>P</i> < 0.001), and faster reorientation (6.9 ± 1.8 min vs 18.7 ± 6.8 min, <i>P</i> < 0.001) compared to MECT.ConclusionMST exhibited comparable antidepressant efficacy to MECT while offering superior cognitive protection and safety in adolescents with treatment-resistant MDD. These findings suggest MST may be a preferred treatment option balancing symptom relief with neurodevelopmental preservation.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"64-75"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Image Disturbance as a Moderator Between Childhood Sexual Abuse and Self-Injury in Borderline Personality Disorder in Turkey.","authors":"Bahruz Shukurov, İrem Yıldırım, Ersel Bulu, Fatma Yağmur Evcil, Cana Aksoy Poyraz","doi":"10.1177/00912174251408624","DOIUrl":"https://doi.org/10.1177/00912174251408624","url":null,"abstract":"<p><p>ObjectiveBody image disturbance may moderate childhood sexual abuse and self-injury in borderline personality disorder (BPD).MethodsThe study involved 60 female patients diagnosed with BPD and 60 healthy participants. The diagnosis of BPD (and identification of healthy participants) was conducted through standardized psychiatric interviews. Participants were assessed with the Multidimensional Body Self Relations Questionnaire (MBSRQ), Inventory of Statements About Self-injury (ISAS), and Childhood Trauma Questionnaire-Short Form (CTQ-SF).ResultsThe findings indicated significantly higher negative scores on both the CTQ-SF and MBSRQ among patients diagnosed with BPD. Appearance orientation moderated the relationship between sexual abuse experiences and self-harm behaviors in a non-linear way. Specifically, low appearance orientation amplified the effect of sexual abuse on self-injury risk, whereas high appearance orientation acted as a protective factor, buffering the impact of sexual abuse on self-harm.ConclusionsThe relationship between childhood sexual abuse and self-injury in BPD patients is non-linear, and appearance orientation conditionally moderates this link. Low appearance orientation amplifies the impact of sexual abuse whereas high appearance orientation attenuates it. Therefore, appearance orientation is a clinically meaningful individual-difference indicator in trauma-informed self injury risk assessment and case formulation in BPD.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251408624"},"PeriodicalIF":1.3,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Obstructive Sleep Apnea Risk and Predictors in Chronic Schizophrenia: A Cross-Sectional Study.","authors":"Yu-Chin Ma, Shiou-Rung Lin, Jiin-Ling Jiang, Jen-Hung Wang","doi":"10.1177/00912174251406085","DOIUrl":"https://doi.org/10.1177/00912174251406085","url":null,"abstract":"<p><p>ObjectiveThis study examined the prevalence and predictors of obstructive sleep apnea (OSA) risk in patients with chronic schizophrenia.MethodsA cross-sectional survey was conducted with 441 institutionalized patients with schizophrenia at hospital. Participants completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and STOP-Bang Questionnaire (SBQ) assessing risk of OSA. Logistic regression analysis was used to identify factors associated with OSA risk (SBQ score ≥3).ResultsOSA risk was identified in 236 participants (53.5%). Each 1-cm increase in waistline was associated with an 8% increased risk of OSA (OR = 1.08), and each 1-point increase in insomnia severity score was associated with a 9% increased risk (OR = 1.09).ConclusionsOver half of patients with chronic schizophrenia were at elevated risk for OSA, with insomnia severity and central obesity as the main correlates. Early screening, ongoing monitoring, and collaboration with mental health professional staff are essential for timely intervention, tailored care, and health promotion.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251406085"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Appendicular Skeletal Muscle Mass and Depression Among Adults With Prior Head Injury and Loss of Consciousness: Results From the NHANES 2011-2014.","authors":"Zhipeng Yan, Xiang Qiu, Kunhui Li, Jiemin Lin, Bilian Guo","doi":"10.1177/00912174251395851","DOIUrl":"https://doi.org/10.1177/00912174251395851","url":null,"abstract":"<p><p>ObjectiveHead injury often causes depression, yet risk factors remain poorly understood. Muscle mass, linked to metabolic and neuroendocrine functions, may influence depression among adults with prior head injury and loss of consciousness (DPHI-LOC), but evidence is lacking.MethodsA cross-sectional analysis was conducted using data from the 2011-2014 National Health and Nutrition Examination Survey. The Appendicular Skeletal Muscle Mass Index (ASMI) was used to quantify muscle mass, and depressive symptoms were measured by the 9-item Patient Health Questionnaire (PHQ-9). Weighted multivariate logistic regression and propensity score matching (PSM) were used to evaluate associations between low muscle mass and DPHI-LOC, adjusting for demographic, socioeconomic, and clinical confounders. Subgroup analyses and interaction tests examined effect modifications across strata.ResultsAmong 2361 adults with head injuries, 232 (8.8%) were reported with DPHI-LOC. Low ASMI was independently associated with an elevated DPHI-LOC risk (adjusted OR = 2.35, 95% CI = 1.24∼4.46, <i>P</i> = 0.020). PSM analysis confirmed a 2.82-fold increased likelihood of depression in participants with low muscle mass (95% CI: 1.54∼4.09, <i>P</i> = 0.007). Subgroup analyses demonstrated that there were no significant effect modifications.ConclusionReduced muscle mass is a significant correlate of DPHI-LOC. These findings suggest that preservation of muscle mass may help to mitigate risk of depression after head injury.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251395851"},"PeriodicalIF":1.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quetiapine combined with escitalopram in the treatment of bipolar depression.","authors":"Pingping Zhang, Jinchang Huang, Zheng Xiong, Xueqin Liu, Haiying Peng","doi":"10.1177/00912174251316653","DOIUrl":"10.1177/00912174251316653","url":null,"abstract":"<p><p>ObjectivesTo assess the efficacy of escitalopram combined with quetiapine vs quetiapine alone in the treatment of depressive episodes of bipolar disorder (BPD).MethodsEighty-eight hospitalized patients with a BPD depressive episode were recruited into the study. All patients were randomized to a control group (n = 44) or the intervention group (n = 44). Members of the control group received quetiapine fumarate alone, with an initial dose 50 mg twice/day; the dose was increased by 50-100 mg daily until 300-600 mg/d was reached. The treatment group received quetiapine at the same doses plus escitalopram, with the initial dose of escitalopram 10 mg/d, adjusting the dose to 20 mg/d after 1 week. Both groups were treated for 8 weeks. Scores on the Hamilton Depression Scale (HAMD) and Young Mania Rating Scale (YMRS), along with levels of IL-6, IL-1β, MIF, SOD, CAT, MDA and GSH-Px, were compared between groups.ResultsAmong those in the intervention group, 88.6% of participants experienced a 50% or greater reduction in HAMD score compared to 70.5% in the control group (<i>P</i> < .05). Participants in the intervention group also experienced a significantly greater reductions in IL-6, IL-1β, MIF and MDA levels (<i>P</i> < .05), and a significant increase in SOD, CAT and GSH-Px levels compared to the control group (<i>P</i> < .05).ConclusionEscitalopram oxalate combined with quetiapine is more effective than quetiapine alone in the treatment of patients with bipolar depressive episodes. This combination can effectively improve the symptoms of depression, inhibit the body's inflammatory response, regulate the state of oxidative stress, and does not increase the risk of mania.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"624-636"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psilocybin-assisted psychotherapy as a rapid-acting treatment for cancer-related depression and anxiety: Evidence from a network meta-analysis.","authors":"Damian Swieczkowski, Aleksander Kwaśny, Michal Pruc, Zuzanna Gaca, Lukasz Szarpak, Wiesław J Cubała","doi":"10.1177/00912174251337572","DOIUrl":"10.1177/00912174251337572","url":null,"abstract":"<p><p>ObjectiveTo evaluate psilocybin's efficacy in reducing depressive and anxiety symptoms in cancer patients based on randomized controlled trials (RCTs).MethodsThis systematic review and network meta-analysis (NMA) followed PRISMA and Cochrane Handbook guidelines. PubMed, Embase and Cochrane Library data up to July 2024 were analyzed. Two RCTs met the inclusion criteria. Changes in Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores were assessed on day 1 and on 2-week follow-up. The risk of bias was evaluated with the Cochrane Risk of Bias Tool 2.0.ResultsPsilocybin significantly reduced BDI scores at day 1 post-administration (MD = 2.26; <i>P</i> = 0.01), though effects were not sustained at 2 weeks. STAI state scores showed substantial reductions at both day 1 (MD = 11.52; <i>P</i> < 0.001) and 2 weeks (MD = 12.66; <i>P</i> < 0.001). STAI trait scores also improved on both day 1 and day 14. The highest psilocybin dose (0.3 mg/kg) was the most effective, with SUCRA values of 87.81% (BDI), 91.58% (STAI state), and 94.2% (STAI trait).ConclusionsFindings suggest psilocybin may rapidly reduce depressive and anxiety symptoms in cancer patients, but methodological limitations, including the small number of trials, necessitate cautious interpretation. Larger, high-quality RCTs are needed to verify its clinical potential.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"603-623"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and correlates of problematic pornography use among undergraduate medical students in Egypt.","authors":"Eman Fouad Mohamed, Amany Elshabrawy Mohamed, Amira Mohamed Youssef, Mohammad Gamal Sehlo, Eman Seif Alnasr Soliman, Abdallah Saad Ibrahim","doi":"10.1177/00912174251329440","DOIUrl":"10.1177/00912174251329440","url":null,"abstract":"<p><p>ObjectivePornography use can become addictive when a person loses control of watching sexual materials, such as sex graphic images and movies, and is unable to stop doing so despite negative consequences. Pornography addiction is a disorder that can impair mental health, behavior, and performance. The purpose of this study was to determine the prevalence and correlates of problematic pornography use among medical students in Egypt.MethodsThis cross-sectional study included 614 undergraduate medical students selected from each of the 6 academic years at a faculty of medicine in Egypt. The short version of the problematic pornography consumption scale (PPCS-6) was used to determine problem pornography use. Sociodemographic information and academic performance data were collected, and the Depression Anxiety Stress Scale-21 (DASS-21) was administered to assess depression, anxiety, and stress symptoms.ResultsNearly one-quarter (23.3%) of students had problematic pornography use. Problematic pornography use was associated with older age and male sex. Students with problematic pornography use reported fewer hours studying and had lower test scores in the previous year than those without problematic pornography use. Medical students with problematic pornography had significantly higher levels of depression, anxiety and stress symptoms compared to those without.ConclusionsProblematic pornography use is a common problem among medical students at a university in Egypt, is present in nearly one-quarter of students, and is significantly associated with older age, male sex, and depression, anxiety, and stress symptoms, as well as poorer academic performance.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"714-731"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psilocybin-assisted psychotherapy, combined antipsychotic and antidepressant treatment for bipolar depression, duration of birth control pill use and risk of depression, handgrip strength and cognitive function, mood disorders in epilepsy, and mental health issues among physicians.","authors":"Harold G Koenig","doi":"10.1177/00912174251369880","DOIUrl":"10.1177/00912174251369880","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"599-602"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}