International Journal of Psychiatry in Medicine最新文献

{"title":"Relationship Between White Matter Integrity and Childhood Trauma in Patients with Major Depressive Disorder in Türkiye.","authors":"Kısmet Çiftci, Muhammed Şamil Aydın, Ertuğrul Eşel, Akif Asdemir, İzzet Ökçesiz, Özlem Olguner Eker","doi":"10.1177/00912174261425400","DOIUrl":"https://doi.org/10.1177/00912174261425400","url":null,"abstract":"<p><p>ObjectiveChildhood trauma can lead to major depressive disorder (MDD) in adulthood. Based on the hypothesis that childhood trauma disrupts white matter integrity and predisposes individuals to MDD, this study investigated the relationship between childhood trauma, white matter integrity disruption, and the presence of MDD.MethodsThis study included 30 patients with MDD in a depressive episode and 30 control subjects aged 18-65. All subjects underwent magnetic resonance diffusion tensor imaging (MR-DTI) and completed the Hamilton Depression Rating Scale (HAM-D) and the Childhood Trauma Questionnaire (CTQ).ResultsControlling for age and education, no difference was found between the patient and control groups for the mean fractional anisotropy (FA) values of the forceps major, forceps minor, and the right and left corticospinal tracts. However, the apparent diffusion coefficient (ADC) value of the forceps minor (a white matter fiber tract in the brain, located in the anterior part of the corpus callosum that connects the two frontal lobes) was significantly higher in the patient group than in the control group. There was also a positive correlation between the ADC value of the left corticospinal tract and physical neglect in the patient group.ConclusionThe significantly higher ADC values observed in the forceps minor group compared to the control group suggests impaired white matter integrity in depressed patients. The positive correlation between the ADC value of the left corticospinal tract and physical neglect in the patient group supports the possibility that childhood trauma affects the integrity of brain white matter, thereby predisposing individuals to psychopathology. Prospective studies involving larger samples are needed to replicate the initial findings from this case-control study.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261425400"},"PeriodicalIF":1.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmological Findings and Their Clinical Correlations in Children With Autism Spectrum Disorder: A Comparative Study.","authors":"Öykü Akkaş, Sezen Köse, Zeynep Akgün, Elif Demirkilinç Biler","doi":"10.1177/00912174261425404","DOIUrl":"https://doi.org/10.1177/00912174261425404","url":null,"abstract":"<p><p>ObjectiveAutism spectrum disorder (ASD) can affect vision both directly through central nervous system involvement and indirectly by complicating ophthalmological examinations due to limited eye contact and poor cooperation. Visual impairments may exacerbate social interaction difficulties and affect motor development in individuals with ASD. Previous studies reported ophthalmological involvement in 27-71% of children with ASD, including refractive errors, strabismus, and amblyopia. The purpose of this study was to investigate visual impairments in children with ASD and examine their relationship with ASD severity, anxiety levels, and attention disorders, while highlighting the importance of routine ophthalmological examinations.MethodParticipants were 57 children aged 7-18 years diagnosed with ASD. All except for 2 participants underwent comprehensive ophthalmological examinations and were assessed using the Childhood Autism Rating Scale (CARS), Turgay DSM-IV-based Child and Adolescent Behavior Disorders Screening Scale (T-DSM-IV-S), Strengths and Difficulties Questionnaire (SDQ), Screen for Child Anxiety Related Emotional Disorders (SCARED), and Repetitive Behaviors Scale-Revised (RBS-R).ResultsVisual impairment was detected in 24 (42.1%) participants, with exotropia (21%), stereopsis deficits (15.8%), and convergence insufficiency (5.3%) being the most common findings. The visually impaired group showed significantly higher scores in attention deficit (<i>P</i> < .001), peer relationship problems (<i>P</i> = .003), social phobia (<i>P</i> < .001), stereotypic behaviors (<i>P</i> < .001), and self-injurious behaviors (<i>P</i> < .001) compared to those without visual impairment.ConclusionsVisual impairments significantly impact attention, peer relationships, social anxiety, and repetitive behaviors in children with ASD. Early identification and treatment of visual disorders through routine ophthalmological screening may improve overall outcomes in this population.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261425404"},"PeriodicalIF":1.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Psychiatric Disorders Among Transgender Individuals With Gender Dysphoria in India and Unmet Needs of Those With Psychiatric Disorders.","authors":"Sri Sai Priya Sudarisan, Suriyaranjani Kumar, Priyanga Selvaraju","doi":"10.1177/00912174261416623","DOIUrl":"https://doi.org/10.1177/00912174261416623","url":null,"abstract":"<p><p>ObjectiveTransgender individuals (TGs) experience discrimination, socio-cultural, and financial challenges, along with disparities in access to health care as well as gender affirming care, all of which are compounded by the presence of psychiatric morbidity. The objective of this study was to estimate the prevalence of psychiatric morbidity among TGs and assess the unmet needs of those with psychiatric morbidity.MethodsThis cross-sectional study was conducted from October 2023 to May 2024 in India. A convenience sample of 128 transgender women assigned male at birth, with gender dysphoria attending awareness camps about mental health issues were assessed using DSM-5-TR. They were administered a semi-structured interview, and the Camberwell Assessment of Needs Short Appraisal Schedule (CANSAS).ResultsThe prevalence of any DSM-5-TR mental disorder was 72% (n = 92). Major depressive disorder (n = 51, 40%) was the most common diagnosis. The mean number of needs on CANSAS was 6.1. Only 8.5% of these needs were met. The most commonly reported unmet needs among those with psychiatric disorder were money (79.3%), welfare benefits (69.5%), basic education (40.1%), psychological distress (44.5%), intimate relationships (37%), accommodation (34%), transportation (32%), and information on condition and treatment (29.3%).ConclusionThe prevalence of any DSM-5-TR mental disorder was high, with depression being the most common. Most of the needs expressed by the transgender individuals with psychiatric disorders were unmet, with the most reported needs being access to basic amenities, financial difficulties, and unaddressed psychological distress.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261416623"},"PeriodicalIF":1.3,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Frequency Left-Sided Repetitive Transcranial Magnetic Stimulation (rTMS) for Post Traumatic Stress Disorder With Comorbid Major Depressive Disorder.","authors":"Natalie Seiler, Thomas P Nguyen, Amy Coelen, Benjamin Newham, Timothy Rolfe","doi":"10.1177/00912174261420110","DOIUrl":"https://doi.org/10.1177/00912174261420110","url":null,"abstract":"<p><p>ObjectiveRepetitive transcranial magnetic stimulation (rTMS) is an established treatment for comorbid post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). However, there are no universal protocols regarding the type of rTMS recommended, including among military and first responders. This study aimed to describe high frequency rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) administered to inpatients with comorbid PTSD and MDD at Ward 17, Austin Health in Melbourne, Australia.MethodRetrospective review of patient files was undertaken for adult inpatients admitted between 01/01/2017 and 01/12/2024 with PTSD and MDD who received ten or more rTMS treatments during admission. Paired t-tests were used for statistical analysis.ResultsAmong 65 patients and 118 admissions, the majority received high frequency rTMS to the left DLPFC (n = 106, 89.8%), followed by rTMS applied to the right DLPFC (n = 8, 6.8%). The group who received left-sided rTMS had an average of 6 fewer treatments and admission length that was 10 days shorter, but almost half required readmission for further rTMS treatments. The most common side effects reported were pain, fatigue, light-headedness or dizziness, and increased anxiety. Left-sided rTMS was associated with significant improvements in MADRS (Cohen's D = 1.36, 95% CI = 1.06-1.65, <i>P</i> < .001), PCL-5 (D = 1.18, 95% CI = 0.72-1.63, <i>P</i> < .001), HoNOS (D = 1.20, 95% CI = 0.94-1.46, <i>P</i> < .001), and MoCA scores (D = -0.56, 95% CI = -0.81 to -0.31, <i>P</i> < .001).ConclusionsHigh frequency left-sided rTMS is generally well tolerated and may reduce both depressive and PTSD symptoms. Further research to assess rTMS subtypes and target specific symptomatology would support standardization of care and inform future protocol guidelines.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261420110"},"PeriodicalIF":1.3,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERMA-based psychological intervention in glioma rehabilitation: An RCT examining affective distress, treatment adherence, and neuro-oncological outcomes.","authors":"Yang Huang, Zijuan Jiang, Yujuan Qi, Juan Deng, Dan Wang, Qian Zhang, Haiyan Qiu","doi":"10.1177/00912174251341978","DOIUrl":"10.1177/00912174251341978","url":null,"abstract":"<p><p>ObjectivePostoperative glioma patients often experience negative emotions, which affect their treatment adherence and prognosis. The PERMA intervention (focusing on Positive emotions, Engagement, Relationship, Meaning, and Accomplishment) seeks to enhance psychological well-being and quality of life (QoL). This study examines the effects of the PERMA intervention on negative emotions, treatment adherence, and prognosis in postoperative glioma patients.MethodsA total of 124 postoperative glioma patients recruited from January 2022 to February 2024 were randomly assigned to an intervention group (n = 62) or a control group (n = 62). The control group received routine postoperative care, while the intervention group received an additional PERMA psychological intervention for 1 month. Outcome assessments included anxiety symptoms (SAS), depressive symptoms (SDS), treatment adherence, complications, and QoL. Outcomes were analyzed using Kaplan-Meier (KM) survival curves.ResultsBaseline characteristics were comparable between groups (<i>P</i> > 0.05). After the intervention, both groups showed significant improvements in SAS and SDS scores (<i>P</i> < 0.05); furthermore, post-intervention SAS and SDS scores in the intervention group were significantly lower than those in the control group (<i>P</i> < 0.0001). Treatment adherence was significantly higher and complication rates significantly lower in the intervention group compared to control group (<i>P</i> < 0.05). QoL was improved in both groups (<i>P</i> < 0.05); however, the intervention group scored significantly higher than the control group across all QoL domains (<i>P</i> < 0.0001). KM analysis revealed a significant association between the PERMA-based intervention and better outcomes overall (<i>P</i> < 0.05).ConclusionA PERMA-based psychological intervention effectively reduced anxiety and depression, enhanced treatment adherence, lowered complication risks, and improved QoL compared to routine post-operative care in postoperative glioma patients.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"19-38"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with antidepressant use following hospitalization for acute stroke.","authors":"Hely D Nanavati, Nicole C Wright, Melissa J Smith, Shakia T Hardy, Virginia J Howard, Chen Lin","doi":"10.1177/00912174251348329","DOIUrl":"10.1177/00912174251348329","url":null,"abstract":"<p><p>ObjectiveDepression is the most common mental health complication after stroke, leading to poor post-stroke outcomes. Few observational studies have reported factors associated with antidepressant use in these patients. Therefore, this study assessed patient and clinical characteristics associated with receiving antidepressant prescriptions at discharge following hospital admission for acute stroke.MethodsIdentified were patients admitted with acute stroke or transient ischemic attack from an institutional stroke registry (October 1, 2019, through October 31, 2020). Electronic health record review was used to assess antidepressant prescription at discharge and predictors such as demographics, health behaviors, clinical comorbidities, and stroke prognostic characteristics.ResultsOut of 803 patients with stroke, 220 (27.4%) received an antidepressant prescription at discharge, including 82 (12.8%) patients who were started on antidepressants at discharge. A multivariable model indicated that sex (female vs. male OR = 1.53; 95% CI = 1.09-2.16), race (Black vs. White: OR = 0.67; 95% CI = 0.47-0.96), number of clinical comorbidities (OR = 1.16; 95% CI = 1.03-1.32), history of depression (OR = 4.91; 95% CI = 2.59-9.31), and discharge disposition (to inpatient rehabilitation facility vs. home: OR = 1.52; 95% CI = 1.01-2.30) were significantly associated with receipt of antidepressant prescriptions among all users. Discharge disposition (to an inpatient rehabilitation facility) was the only variable associated with initiating an antidepressant prescription at discharge (OR = 2.92; 95% CI = 1.62-5.28).ConclusionAntidepressant prescriptions for poststroke patients were more frequent among females, White adults, and those discharged to an inpatient rehabilitation facility. These findings describing antidepressant prescription patterns underscore the need for specific guidelines aiding antidepressant use after stroke.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"92-106"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of electroconvulsive therapy on intracranial pressure: A study of optic nerve sheath diameter measurements.","authors":"Iram Fatima, Aung Khine Phyoe, Abhimanyu Sharma, Shubh Mehta, Sara Tabassum, Manjeet Singh, Rama Siddiqui, Shivendra Shah, Kirpa Kaur, Hend Makky, Aadil Mahmood Khan","doi":"10.1177/00912174251345007","DOIUrl":"10.1177/00912174251345007","url":null,"abstract":"<p><p>ObjectiveThis study investigated the effects of Electroconvulsive Therapy (ECT) on intracranial pressure (ICP) by measuring the optic nerve sheath diameter (ONSD) using ultrasonography. While ECT is a common and effective treatment for various psychiatric disorders, its impact on cerebral hemodynamics, particularly ICP, remains unclear. Previous research suggests that ECT may increase cerebral blood flow and oxygen consumption, potentially elevating ICP. However, there is limited direct evidence linking ECT to measurable ICP changes.MethodsIn this study, ONSD was measured at 4 time points during ECT in 24 patients, including pre-ECT, post-induction, post-ictal, and in the post-anesthesia care unit (PACU).ResultsThe results showed no statistically significant changes in ONSD, indicating that ECT does not significantly alter ICP based on this non-invasive measurement.ConclusionThese findings suggest that, at least in the context of this study, ECT does not lead to clinically relevant changes in ICP.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"39-49"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B intake and post-stroke depression: Results from the US national health and nutrition examination surveys (NHANES) 2007-2018.","authors":"Mei Liu, Yanyu Sun, Jin Wu","doi":"10.1177/00912174251376110","DOIUrl":"10.1177/00912174251376110","url":null,"abstract":"<p><p>ObjectivePost-stroke depression (PSD) is the most frequent psychiatric disorder after stroke, occurring in about 30% of stroke survivors. Little is known about the influence of dietary B-vitamin intake on PSD risk. This analysis examined the relationship between dietary B-vitamin intake and depression among post-stroke patients.MethodsA total of 1080 patients aged ≥20 years who had suffered a stroke participating in the 2007-2018 National Health and Nutritional Examination Surveys (NHANES) were included in this cross-sectional study. Depressive symptoms were evaluated using the 9-item Patient Health Questionnaire (PHQ-9). The association between dietary B vitamins intake and PSD was examined using logistic regression analysis.ResultsAfter controlling for potential confounders (sex, age, race, BMI, family PIR, education level, marital status, history of disease, hypertension, hypercholesterolemia, diabetes, smoking, alcohol use and energy), significant inverse associations were found between dietary vitamin B1 (<i>P</i> = 0.002) and B6 (<i>P</i> = 0.002) intake and PHQ-9 scores. These association were significantly modified by unhealthy lifestyle factors and inflammation-related markers.ConclusionsDietary vitamin B1 and B6 intake were inversely associated with PSD risk. The association between vitamin B1 or B6 and PSD was modified by unhealthy lifestyle factors and inflammation-related indicators. Future prospective studies are needed to determine the causal relationship between higher dietary vitamin B1 and B6 intake and lower risk of PSD.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"107-122"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New psychosocial treatments for patients with breast and brain cancers, impact of ECT on intracranial pressure, approaches to treatment resistant depression, and predictors of and treatments for post-stroke depression.","authors":"Harold G Koenig","doi":"10.1177/00912174251393095","DOIUrl":"10.1177/00912174251393095","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"3-6"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-derived neurotrophic factor as predictor of early-onset poststroke depression.","authors":"Emine Yıldırım Uslu, Sevler Yildiz, Sevda Korkmaz","doi":"10.1177/00912174251347410","DOIUrl":"10.1177/00912174251347410","url":null,"abstract":"<p><p>BackgroundPoststroke depression (PSD), with an approximately one third prevalence in stroke patients, is associated with increased morbidity and mortality. This study investigated the relationship between serum brain-derived neurotrophic factor (BDNF) levels and early-onset PSD, along with other clinical variables.MethodsClinical data and radiological images of 88 patients diagnosed with acute ischemic stroke were examined. Serum BDNF levels were measured within the first 72 hours following stroke diagnosis. On the 14th day following stroke diagnosis, Montreal Cognitive Assessment (MoCA), Hamilton Depression Rating Scale (HAMD17), and National Institutes of Health Stroke Scale (NIHSS) were administered to the patients.ResultsSerum BDNF levels (<i>P</i> = 0.022) and MoCA values (<i>P</i> = 0.004) of patients with early-onset PSD were significantly lower, and NIHSS values (<i>P</i> = 0.027) were significantly higher compared to patients without early-onset PSD. There was a significantly negative correlation between BDNF value and HAMD-17 score. Receiver operating characteristic (ROC) analysis was used to investigate the extent that BDNF level could predict early-onset PSD, and cut-off values were determined. For a BDNF cut-off value of 361.5, sensitivity and specificity values were 75% and 56%, respectively, indicating that serum BDNF levels could serve as a useful predictor of early-onset PSD.ConclusionLower serum BDNF levels are associated with early-onset PSD and may serve as a potential biomarker, although causal conclusions are limited due to the study's cross-sectional design.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"76-91"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}