Retinal changes in generalized anxiety disorder patients.

IF 1.1 4区 医学 Q4 PSYCHIATRY
Sema Baykara, Aslı Kazğan, Hakan Yıldırım, Muhammed Fatih Tabara, Halim Ömer Kaşıkcı, Denizhan Danacı Keleş
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引用次数: 0

Abstract

Objective: Optical coherence tomography (OCT) is a method that allows high-resolution cross-sectional imaging of biological tissues. It was suggested that changes in the cranial structure or functions would be reflected in the retina. OCT has been an important method in the diagnosis and follow-up of diseases via morphometric or quantitative retinal measurements. Free radicals, inflammatory processes, and neurotransmission disorders play a role in the etiology of generalized anxiety disorder (GAD). The study aimed to demonstrate the retinal changes in GAD patients due to neurodegeneration based on the comparison of the OCT data of the GAD patients and controls, and the differences between OCT findings of GAD patients and those of controls.

Methods: The study group included 21 GAD patients. The control group included 21 individuals without any known psychiatric or organic disease, including eye diseases.

Results: There was a statistically significant difference between the macular volumes (MV) of the GAD and control groups, the macular volume was lower in the GAD group. There were positive correlations between BDI scores and MV, GCLT, RNFLT-i, RNFLT-n, between BAE scores and (RNFLT-n), and between the CGI severity scale scores and MV, RNFLT-n, and RNFLT-t.

Conclusion: OCT analysis of the GAD patients demonstrated that MV values were lower when compared to the control group. Patients with GAD should be screened for these retinal changes. OCT, a simple, non-invasive, and relatively inexpensive method could be employed as a supplementary method in the follow-up of GAD patients.

广泛性焦虑症患者的视网膜变化。
目的:光学相干断层扫描(OCT)是一种可以对生物组织进行高分辨率横截面成像的方法。有人认为,大脑结构或功能的变化将反映在视网膜上。OCT是通过形态计量学或定量视网膜测量来诊断和随访疾病的一种重要方法。自由基、炎症过程和神经传递障碍在广泛性焦虑症(GAD)的病因中发挥作用。本研究旨在通过对GAD患者和对照组的OCT数据的比较,以及GAD患者与对照组OCT结果之间的差异,证明GAD患者因神经退行性变引起的视网膜变化。方法:研究组包括21例GAD患者。对照组包括21名没有任何已知的精神或器质性疾病(包括眼部疾病)的患者。结果:GAD组的黄斑体积(MV)与对照组相比有统计学意义,GAD组黄斑体积较低。BDI评分与MV、GCLT、RNFLT-i、RNFLT-n呈正相关,BAE评分与(RNFLT-n)呈正相关,CGI严重程度量表评分与MV,RNFLT-n和RNFLT-t呈正相关。结论:GAD患者的OCT分析表明,与对照组相比,MV值较低。GAD患者应筛查这些视网膜变化。OCT是一种简单、无创且相对便宜的方法,可作为GAD患者随访的补充方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
5.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...
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