International Journal of Psychiatry in Medicine最新文献

{"title":"Peripheral immune cell markers and cognitive function in patients with schizophrenia.","authors":"Aykut Karahan, Işılay Manzak Saka, Demet Sağlam Aykut, Filiz Civil Arslan, Ezgi Selçuk Özmen, Evrim Özkorumak Karagüzel","doi":"10.1177/00912174241266059","DOIUrl":"10.1177/00912174241266059","url":null,"abstract":"<p><p>ObjectivesThe purpose of this study was to investigate the relationship between peripheral immune cell markers and cognitive function in patients with schizophrenia and healthy controls.MethodsThirty-five patients diagnosed with schizophrenia with a stable course and a control group of 35 individuals matched by sex, education, and age were included in this cross-sectional study. The Wisconsin Card Sorting Test (WCST), the Rey Auditory Verbal Learning Test (RAVLT), and the Stroop Test were used for neuropsychological evaluation. Blood neutrophil and lymphocyte percentages, neutrophil-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) values were calculated.ResultsThe female patients exhibited significantly higher NLR and neutrophil percentages than the female controls. They also demonstrated higher NLR, neutrophil percentage, and SII when compared to male patients. The increased neutrophil percentages and NLR and decreased lymphocyte percentages in the female patients were significantly correlated with worsening Stroop interference and RAVLT 1 scores. Additionally, a longer duration of illness was significantly correlated with elevated NLR, SII, and neutrophil percentage, and decreased lymphocyte percentage. A higher number of previous hospitalizations was correlated with elevated SII and decreased lymphocyte percentage. Regression analysis showed a significant association between neutrophil percentage and Stroop interference scores used to evaluate attentional functions in patients with schizophrenia.ConclusionsThese results suggest that gender and course of illness may affect NLR and SII values. An elevated neutrophil percentage may be one of the factors affecting attentional dysfunction in patients with schizophrenia. Prospective studies are now needed to verify these findings.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"405-419"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms, all-cause mortality, and cardiovascular-specific mortality among adults with different diabetic status in the United States.","authors":"Hua-Zhao Xu, Xiang-Da Meng, Qian Liu, Yu-Jun Xiong","doi":"10.1177/00912174241303099","DOIUrl":"10.1177/00912174241303099","url":null,"abstract":"<p><p>ObjectiveThe relationship between diabetes, depressive symptoms, and mortality is well established. However, the effect of depressive symptoms on mortality among people with prediabetes remains unclear. This study examined the effects of depressive symptoms on mortality across different diabetic statuses.MethodsData were analyzed from cross-sectional samples collected as part of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, with a final sample size of 36,246 participants. Mortality status and cause of death were prospectively determined by cross-referencing records with the publicly accessible National Death Index through 2019. Kaplan-Meier survival curves and Cox regression analysis were utilized to assess the relationship between depressive symptoms and mortality across different diabetic statuses from nondiabetic to prediabetic to diabetic.ResultsIn the non-diabetic group, no effect of depression severity on all-cause mortality or cardiovascular mortality was found in the final models. In the prediabetic group, however, the hazard ratios were increased for both mild depressive symptoms (HR = 1.35, 95% CI = 1.14-1.60) and moderate-to-severe depressive symptoms (HR = 1.65, 95% CI = 1.31-2.08). In the diabetic group, surprisingly, the all-cause mortality risk was somewhat lower than in the pre-diabetic group (HR = 1.28, 95% CI = 1.08-1.51 for mild and HR = 1.29, 95% CI = 1.06-1.56 for moderate-to-severe depressive symptoms). Similar patterns were noted for cardiovascular mortality, where risk of moderate-severe depressive symptoms was even greater in the prediabetic group (HR = 1.83, 95% CI = 1.18-2.85) than in the diabetic group.ConclusionIn this prospective cohort study of a nationally representative sample of U.S. adults, a positive association was found between depressive symptoms and mortality across different diabetic statuses. These findings highlight the importance of evaluating depressive symptoms across the glycemic spectrum, especially among individuals with prediabetes.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"468-488"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of six antipsychotic drug treatment regimens on short-term heart rate variability in patients with schizophrenia.","authors":"Lifen Huang, Chaoyang Wei, Qinghua Qin","doi":"10.1177/00912174241293650","DOIUrl":"10.1177/00912174241293650","url":null,"abstract":"<p><p>ObjectiveMany antipsychotic drugs have cardiac side effects. Heart rate variability (HRV) analysis can be used as a indicator of cardiotoxicity in cases where a decrease in HRV occurs after the administration of antipsychotics such as clozapine. The purpose of this study was to explore the effects of 6 antipsychotic drug regimens on short-term HRV in patients with schizophrenia.MethodsData from 164 patients with schizophrenia between January 2018 and June 2023 were retrospectively analyzed. Based on the drug used for treatment, patients were categorized into clozapine combination (clozapine combined with aripiprazole, risperidone or ziprasidone), clozapine alone, olanzapine, aripiprazole, ziprasidone, and risperidone groups. Heart rate variability indices were calculated using time domain analysis, including the standard deviation of the RR intervals (SDNN), the root mean square of successive RR interval differences (RMSSD), and the percentage of successive RR intervals over 50 ms (PNN50).ResultsCompared with the pretreatment period, the SDNN, RMSSD, and PNN50 were significantly lower in the clozapine combination, clozapine, olanzapine and aripiprazole groups at the end of weeks 2 and 4 of treatment (<i>P</i> < 0.05). However, those indicators in ziprasidone and risperidone groups did not show this decrease (<i>P</i> > 0.05).ConclusionThe effects of clozapine combination and clozapine on HRV were greater than for olanzapine, aripiprazole, ziprasidone, or risperidone. Attention should be paid to controlling the dose of clozapine combination and clozapine alone and monitoring the patient's electrocardiogram during administration.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"363-377"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of uremic toxins and systemic inflammation with depression and anxiety among hemodialysis patients in Montenegro.","authors":"Batric Babovic, Natasa Belada Babovic, Filip Tomovic, Snezana Radovanovic, Mladen Debeljevic, Jelena Djordjevic, Olgica Mihaljevic","doi":"10.1177/00912174241298837","DOIUrl":"10.1177/00912174241298837","url":null,"abstract":"<p><p>ObjectiveThe purpose of this study was to examine the association between uremic toxins, inflammation, depression and anxiety among hemodialysis patients in Montenegro.MethodThe cross-sectional study included 88 patients undergoing hemodialysis. Depression symptoms were assessed by Patient Health Questionnaire (PHQ-9), and anxiety symptoms were measured by the Beck Anxiety Inventory (BAI). Standard laboratory methods were used to measure uremic toxins and systemic inflammation (C-reactive protein, Neutrophil-to-Lymphocyte Ratio [NLR] and Platelet-to-Lymphocyte Ratio [PLR]).ResultsClinically significant depression (PHQ-9 ≥ 10) and anxiety (BAI ≥16) were found in 55.7% and 27.2%, respectively. Logistic regression analyses revealed that serum urea, beta 2-microglobulin (B2M), and systemic inflammation (CRP, NLR, PLR) were significantly and independently associated with depressive symptoms, whereas serum urea, creatinine, uric acid, B2M, and systemic inflammation (CRP nad NLR) were associated with anxiety symptoms.ConclusionsDepressive symptoms and anxiety are common among hemodialysis patients in Montenegro, and are associated with increased levels of systematic inflammation, serum urea, and beta 2-microglobulin.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"443-455"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of cognitive behavioral therapy in relieving tinnitus.","authors":"Fatih Bal","doi":"10.1177/00912174241272674","DOIUrl":"10.1177/00912174241272674","url":null,"abstract":"<p><p>ObjectiveThis study examined the effects of Cognitive Behavioral Therapy (CBT) on tinnitus in individuals aged 18-60 years.MethodsThirty participants with subjective tinnitus for at least six months were included in a randomized controlled trial. Randomized were 15 participants in the experimental group and 15 in the control group, with pre-test and post-test measurements. The experimental group received eight CBT sessions over eight weeks. Data were collected using Tinnitus Handicap Inventory (THI) and Visual Analog Scale (VAS). The Mann-Whitney and Wilcoxon Signed Rank Test were used to compare scores between experimental and control groups at baseline and after the intervention.ResultsA within-group difference was found between total scores on THI and VAS before and after CBT in the experimental (z = -3.241, <i>P</i> = 0.001), but not in the control group (z = -1.764, <i>P</i> = 0.078). Following the intervention, there was a significant between-group difference on the THI Emotional, Catastrophic, and Functional tinnitus subscale scores, favoring the experimental group.ConclusionsCBT significantly reduced tinnitus level, severity, duration, frequency, discomfort, tinnitus-related attention deficit, and sleep problems. Further studies are needed to replicate these findings in larger samples and other populations.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"420-442"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic awareness, psychosocial symptoms, and survival time in patients with advanced lung cancer.","authors":"Hulya Abali, Seda Tural Onur, Yusuf Baser, Dilara Demir, Asli Bicen","doi":"10.1177/00912174241291714","DOIUrl":"10.1177/00912174241291714","url":null,"abstract":"<p><p>ObjectiveDisclosing to patients the diagnosis of lung cancer is an issue, especially in the Middle East where cultural factors may prohibit disclosure from being done. The psychosocial consequences of diagnostic awareness and its impact on life expectancy is an important issue that may influence the disclosure decision. The present study evaluated the effects of diagnostic awareness on psychosocial symptomatology and survival time in patients with advanced lung cancer in Turkey.MethodsThis prospective cohort study included 126 advanced lung cancer patients admitted to the oncology department between February 2021 and August 2021. A face-to-face survey included questions on age, gender, marital/employment statuses, comorbidities, and psychological symptoms (SCL-90-R). Diagnostic awareness was assessed by asking patients whether they knew their diagnosis. The correlation of diagnostic awareness with 2-year survival time was analyzed using Cox regression analysis.ResultsOf the 126 patients, had 86 died at the time of follow-up. Survival time and scores on SCL-90-R symptom subscales were compared between diagnosis-aware (79.4%) and diagnosis-unaware groups (20.6%). Somatization (<i>P</i> = 0.04), depression (<i>P</i> = 0.01), hostility (<i>P</i> = 0.03), scores on additional symptom scales (<i>P</i> = 0.01), and symptom total scores (<i>P</i> = 0.01) were significantly higher in the diagnosis-unaware group. No significant difference was found between diagnostic awareness and survival time (<i>P</i> = 0.24).ConclusionsAdvanced lung cancer patients aware of their diagnosis experienced less psychosocial burden. However, no significant difference was found in survival time between diagnosis-aware and diagnosis-unaware patients. These findings suggest that the diagnosis should be disclosed to lung cancer patients after confirmation.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"456-467"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotropic medication and hepatobiliary health: Ultrasound observations on patients with schizophrenia.","authors":"Linlin Yue, Linlin Sun, Nan Li","doi":"10.1177/00912174241280510","DOIUrl":"10.1177/00912174241280510","url":null,"abstract":"<p><p>ObjectiveThis study sought to examine the association between antipsychotic drug use and hepatobiliary health based on serum markers and ultrasound observations on a sample of patients with schizophrenia compared to age and gender matched healthy controls.MethodsThe 120 patients with schizophrenia and 60 control subjects had their blood drawn to measure liver function tests and underwent hepatobiliary ultrasonography to determine hepatobiliary lesions. Liver function tests included total cholesterol (TC), triglycerides (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Standardized cross-sectional images of the liver and kidneys were obtained from patients and controls, and analyses were stratified by length of taking psychotropic medication among those with schizophrenia. Liver echo attenuation coefficients, liver-kidney ratios, and liver fat content were determined.ResultsPsychotropic drug use was associated with greater liver burden and liver lesions in patients with schizophrenia compared to controls. The levels of TC, TG, ALT and AST in patients with schizophrenia were all significantly higher among patients with schizophrenia. Long-term psychotropic medication was associated with increased levels of fatty liver in patients compared with controls. Levels of TC, TG, ALT and AST were significantly higher in the long-term psychotropic medication use group than in the short-term group. Liver echo attenuation coefficient, liver-kidney ratio, and liver fat content were also higher in the long-term medication use group compared to the short-term group.ConclusionAntipsychotic drug use, particularly long-term use, is associated with increased liver burden in patients with schizophrenia, impaired lipid metabolism, increased liver lesions and fat content.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"395-404"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional intake and adequacy of intake among Vietnamese outpatients with major depressive disorder: A 24-hour recall study.","authors":"Manh Xuan Bui, Linh Tich Ngo, Phuc Truong Vinh Le, Phong Duy Nguyen","doi":"10.1177/00912174251352405","DOIUrl":"https://doi.org/10.1177/00912174251352405","url":null,"abstract":"<p><p>ObjectiveThis study assessed the 24-h nutrient intake, adequacy of intake, and associated factors among outpatients diagnosed with major depressive disorder (MDD) in Ho Chi Minh City, Vietnam.MethodA cross-sectional study was conducted among 290 adult outpatients diagnosed with MDD at University Medical Center, Ho Chi Minh City, Vietnam. Participants completed a 24-h dietary recall and the Quick Inventory of Depressive Symptomatology (QIDS-SR). Nutrient intake was analyzed using Vietnamese food composition tables and categorized based on national dietary recommendations. Mean daily nutrient intakes were calculated for energy, macronutrients, and micronutrients. Multivariate analyses assessed associations between demographic, clinical, and psychosocial factors and nutrient intake.ResultsParticipants demonstrated low average intake of energy, macronutrients, and essential micronutrients. A majority had inadequate intake of total energy, carbohydrates, fats, and key vitamins and minerals such as calcium, potassium, and vitamins A and C. Nutritional deficiencies were more pronounced among individuals with greater depression severity, limited time for self-care, underweight status, and fewer economic resources. Principal component analysis revealed two main dietary patterns: one nutrient-rich and another characterized by high fat and sodium with low vitamin content.ConclusionsIndividuals with MDD in Vietnam demonstrate widespread inadequacy of nutrient intake, which was associated with both depression severity and several sociodemographic factors. These findings underscore the importance of integrating nutrition assessment and intervention into mental health care in the country of Vietnam and likely elsewhere.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251352405"},"PeriodicalIF":1.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence rates of depression, anxiety, and suicidal ideation in patients with ovarian cancer: A systematic review from 1977 to 2024.","authors":"Tong Qiu, Tian Zhang, YiHan Zhang, XingKe Qiu","doi":"10.1177/00912174251350465","DOIUrl":"https://doi.org/10.1177/00912174251350465","url":null,"abstract":"<p><p>ObjectiveOvarian cancer patients are more likely to have mental disorders than other patients. However, to our knowledge, there has been no systematic analysis of its global epidemiology. Therefore, a systematic review was conducted to identify the prevalence of depression, anxiety, and suicidal ideation in ovarian cancer patients in different countries.MethodWe searched PubMed, Embase, Elsevier ScienceDirect, China National Knowledge Infrastructure, WanFang Data Knowledge Service Platform, and Duxiu Academic Search Platform to identify observational studies on depression, anxiety, and suicidal ideation in patients with ovarian cancer published up to 30 June 2024. We estimated the prevalence of depression, anxiety, and suicidal ideation in ovarian cancer patients worldwide and by region, country, research period, and assessment scales.ResultsA total of 31 studies were identified involving 8315 ovarian cancer patients. The prevalence rates of depression and anxiety were 35% and 37%, respectively. In China, the prevalence of suicidal ideation of ovarian cancer patients was 32%. Ovarian cancer patients in Asia had the highest prevalence of depression, while those in Oceania (Australia, New Zealand, etc.) had the lowest. Additionally, the prevalence rates of depression and anxiety increased considerably worldwide after 2000 and have gradually stabilized since then.ConclusionThis study found that the prevalence of depression and anxiety was high (more than one-third) among ovarian cancer patients. These findings underscore the need for a comprehensive study to address mental health problems in these patients, including the determination of incidence rates, investigation of regional differences, and assessment of comorbidities and treatment strategies.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251350465"},"PeriodicalIF":1.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-disciplinary cardiovascular and psychiatric recommendations: A systematic review of clinical guidelines.","authors":"Marina Delli Colli, Kyle T Greenway, Michael Goldfarb","doi":"10.1177/00912174251348996","DOIUrl":"https://doi.org/10.1177/00912174251348996","url":null,"abstract":"<p><p>IntroductionIndividuals with serious mental illness (SMI), including major depression, schizophrenia, and bipolar disorder, experience disproportionately high rates of cardiovascular (CV) risk and disease. Despite this well-established connection, it remains unclear how professional society guidelines across cardiology and psychiatry address this relationship.MethodsMajor American and European CV and psychiatric society guidelines published from 2013-2023 were reviewed. Included were guidelines on primary and secondary CV disease prevention, and disease-specific guidelines for schizophrenia, bipolar disorder, and major depressive disorder. Relevant text was extracted and classified as recommendations or supporting text.ResultsTwenty-six guidelines were included (13 CV; 13 psychiatric). Psychiatric considerations appeared in 5 CV guidelines (38%), most commonly addressing mental illness treatment to improve CV outcomes (n = 5), pharmacological considerations (n = 2), and recognition of mental illness as a CV risk factor (n = 2). Only 13% of American CV guidelines included psychiatric content, compared to 80% of European CV guidelines. In contrast, 10 psychiatric guidelines (77%) included CV-related recommendations, including CV screening (n = 16), pharmacological considerations (n = 8), and risk factor control (n = 7). Among psychiatric guidelines, 40% of U.S. and 100% of European documents included CV content.ConclusionsCV considerations are more frequently addressed in psychiatric than psychiatric considerations in CV guidelines. European guidelines showed greater cross-disciplinary integration. These findings highlight the need for more unified, interdisciplinary guidance to reduce CV risk in individuals with SMI.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251348996"},"PeriodicalIF":1.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}