International Journal of Psychiatry in Medicine最新文献

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Between Trust and Tension: Psychosocial Impact of AI Integration on Health Professionals' Wellbeing. 信任与紧张之间:人工智能整合对卫生专业人员幸福感的社会心理影响
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-10-07 DOI: 10.1177/00912174251387812
Zill E Huma, Adeeba Sania, Benjamin Doolittle, Malik Muhammad Sohail
{"title":"Between Trust and Tension: Psychosocial Impact of AI Integration on Health Professionals' Wellbeing.","authors":"Zill E Huma, Adeeba Sania, Benjamin Doolittle, Malik Muhammad Sohail","doi":"10.1177/00912174251387812","DOIUrl":"10.1177/00912174251387812","url":null,"abstract":"<p><p>ObjectiveThis study explored health professionals' experiences of using Artificial Intelligence (AI) in healthcare with a particular focus on the potential benefits and challenges of using AI in clinical practice.MethodUsing a qualitative research design, data were collected through in-depth interviews with a convenience sample of twenty-two health professionals from various medical specialties in northern Punjab, Pakistan. Thematic analysis identified recurring themes on AI adoption.ResultsHealth professionals recognized AI as a psychosocial modifier which increased efficiency and overall professional well-being. Participants expressed that AI should function as a supportive tool rather than a replacement for human judgment, empathy, and patient interaction. They also acknowledged a hesitation to incorporate AI due to a distrust of its accuracy, and also indicated that institutions have been slow to adopt AI due to ethical, technical, and institutional challenges.ConclusionAI adoption is increasingly reshaping clinical practice, but sustainable integration in Pakistan requires balancing innovation with ethical safeguards, trust, and empathy.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"467-485"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADHD Comorbidity in Women with Depression and Anxiety: Prevalence, Clinical Features and Hyperfocus Dynamics. 患有抑郁和焦虑的女性ADHD合并症:患病率、临床特征和过度聚焦动力学。
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-09-11 DOI: 10.1177/00912174251376111
Hazal Yavuzlar Civan, Tonguc Demir Berkol
{"title":"ADHD Comorbidity in Women with Depression and Anxiety: Prevalence, Clinical Features and Hyperfocus Dynamics.","authors":"Hazal Yavuzlar Civan, Tonguc Demir Berkol","doi":"10.1177/00912174251376111","DOIUrl":"10.1177/00912174251376111","url":null,"abstract":"<p><p>ObjectiveThe present study investigated ADHD comorbidity and clinical features, including hyperfocus, in women with depressive or anxiety disorders, addressing the diagnostic complexities arising from symptom overlap and the underdiagnosis of ADHD in this population.MethodsFemale patients from outpatient psychiatric clinics (n = 170) were assessed using the Beck Depression Inventory and Beck Anxiety Inventory. Participants meeting threshold scores underwent further evaluation with the Wender-Utah Rating Scale, Hyperfocus Scale and Adult ADHD DSM-IV-Based Diagnostic Screening Scale, complemented by structured clinical interviews.ResultsADHD was identified in 19.6% (n = 33) of patients, 45.5% (n = 15) of whom were previously undiagnosed. ADHD was most prevalent in patients with social anxiety disorder (46.4%) and double depression (40.6%). In non-ADHD participants, (a) attention deficit scores correlated positively with depression (r = 0.236, <i>p</i> = 0.005), (b) hyperactivity with anxiety (r = 0.187, <i>p</i> = 0.029), and (c) hyperfocus with ADHD scores (r = 0.434, <i>p</i> < 0.001; r = 0.292, <i>p</i> = 0.001); no such correlations were seen in the ADHD group.ConclusionADHD is common and frequently overlooked in women presenting with depression or anxiety. While hyperfocus is a relevant clinical feature, it is not diagnostic alone and correlates with ADHD symptoms in the absence of ADHD. Clinicians should conduct thorough screenings for ADHD and carefully interpret hyperfocus within the broader clinical context to ensure accurate diagnosis and timely, appropriate treatment.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"428-444"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized Controlled Trial of a Remotely Delivered Self-Management Program (TEAM-Red) for Depressed Young Black Women at Risk for Hypertension. 一项针对有高血压风险的年轻抑郁黑人女性的远程自我管理项目(TEAM-Red)的前瞻性先导随机对照试验结果
IF 1.9 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-08-19 DOI: 10.1177/00912174251365432
Jennifer B Levin, Erika Kelley, Farren Briggs, Mahboob Rahman, Taylor Maniglia, Emma Church, Nicole Fiorelli, Carla Conroy, Jessica Surdam, Kathy-Diane Reich, Gracie Howard Griggs, Danette Conklin, Carla Harwell, Vicki Haywood Doe, Martha Sajatovic
{"title":"Randomized Controlled Trial of a Remotely Delivered Self-Management Program (TEAM-Red) for Depressed Young Black Women at Risk for Hypertension.","authors":"Jennifer B Levin, Erika Kelley, Farren Briggs, Mahboob Rahman, Taylor Maniglia, Emma Church, Nicole Fiorelli, Carla Conroy, Jessica Surdam, Kathy-Diane Reich, Gracie Howard Griggs, Danette Conklin, Carla Harwell, Vicki Haywood Doe, Martha Sajatovic","doi":"10.1177/00912174251365432","DOIUrl":"10.1177/00912174251365432","url":null,"abstract":"<p><p>ObjectiveFew studies have simultaneously addressed self-management of cardiovascular disease and mental health in Black women at cardiovascular risk. This 24-week pilot prospective crossover randomized-controlled trial tested TEAM-Red, a 5-session, biweekly, nurse and peer-educator remotely delivered group self-management intervention for young Black women, compared to an enhanced waitlist control (eWL) group.MethodsThe TEAM-Red intervention, adapted from an evidence-based program and culturally tailored based on stakeholder input, enrolled 50 depressed Black women ages 18-49 with at least one risk factor for hypertension. Participants were randomized to TEAM-Red (n = 25) or eWL (n = 24) and assessed at screening, baseline, 12 weeks, and 24 weeks. Those in eWL crossed over to receive TEAM-Red at 12 weeks and all participants were followed to 24 weeks. The primary goal was acceptability and feasibility. The primary outcome was change in depression severity from baseline to 12 weeks assessed by the 9-item Patient Health Questionnaire (PHQ-9). Secondary outcomes were perceived stress, mental health quality of life, diet quality, energy expended, social support, hypertension knowledge, and alcohol use.ResultsAmong women depressed at baseline (N = 31), TEAM-Red participants had 17.1 times higher odds of depression remission at week 12 (OR = 17.14, 95% CI: 1.78, 164.97; <i>P</i> = .014). At 12 weeks, TEAM-Red participants also showed significantly lower PHQ-9 scores (<i>P</i> = .042), improved diet quality (<i>P</i> = .025), higher mental health quality of life (<i>P</i> = .032), and reduced perceived stress (<i>P</i> = .038) compared to those in the eWL. Treatment satisfaction and engagement in the intervention group was high (89% found it useful), with 22% attrition.ConclusionsThe TEAM-Red intervention demonstrated significant clinical benefits with a 17-fold higher odds of depression remission and meaningful improvements in mental health quality of life, diet quality, and perceived stress compared to controls. Despite limitations including small sample size and short follow-up period, this culturally tailored intervention showed promise for reducing cardiovascular risk and improving mental health outcomes in young Black women at risk for hypertension. These results need replication in a larger sample as part of a fully powered trial.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"405-427"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of AI and Neuroscience: New Methods in Studying the Causes of Mental Disorders. 人工智能与神经科学的结合:精神障碍病因研究的新方法。
IF 1.9 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2026-02-28 DOI: 10.1177/00912174261428872
Andrei Efremov
{"title":"Integration of AI and Neuroscience: New Methods in Studying the Causes of Mental Disorders.","authors":"Andrei Efremov","doi":"10.1177/00912174261428872","DOIUrl":"10.1177/00912174261428872","url":null,"abstract":"<p><p>ObjectiveThis review systematizes knowledge about the use of artificial intelligence (AI) in neurobiological research of mental disorders and assesses its potential in identifying their causes.MethodsA qualitative synthesis of scientific literature from the Scopus and Web of Science databases for 2020-2024 was conducted. A total of 50 sources were identified, including papers describing the use of AI in the analysis of neuroimaging, biomarkers, cognitive impairment, and genetics data. A thematic encoding was used to analyze methods, accuracy, and limitations.ResultsMachine learning algorithms have accelerated the processing of large amounts of data, including magnetic resonance imaging, electroencephalogram, and genomic profiles, which has revealed new biomarkers and neural patterns associated with depression and schizophrenia. However, AI technologies face several limitations: low specificity, high computational complexity, and problems with reproducibility of results.ConclusionsThe integration of AI with neuroscience has significantly advanced the understanding of the etiology of mental disorders, revealing the complex relationships between genetic, neural, and behavioral factors. The practical significance of the research lies in the potential of AI to create personalized approaches to the diagnosis and treatment of mental disorders. This can improve the quality of life of patients and reduce the burden on healthcare systems.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"498-514"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: Regarding the Effects of Electroconvulsive Therapy on Optic Nerve Sheath Diameter as a Proxy for Intracranial Pressure. 给编辑的信;关于电休克治疗对视神经鞘直径作为颅内压指标的影响。
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-08-01 DOI: 10.1177/00912174251365490
Rutger V A Hollestelle, Jochem K H Spoor, Iscander M Maissan, Maxine Dibué
{"title":"Letter to the Editor: Regarding the Effects of Electroconvulsive Therapy on Optic Nerve Sheath Diameter as a Proxy for Intracranial Pressure.","authors":"Rutger V A Hollestelle, Jochem K H Spoor, Iscander M Maissan, Maxine Dibué","doi":"10.1177/00912174251365490","DOIUrl":"10.1177/00912174251365490","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"529-530"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI as a Novel Digital Stressor in Adolescent Psychosis: Clinical and Ethical Implications. 人工智能在青少年精神病中作为一种新的数字压力源:临床和伦理意义。
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-10-22 DOI: 10.1177/00912174251392768
Venkata Sushma Chamarthi, Piyush Das, Rahul Kashyap
{"title":"AI as a Novel Digital Stressor in Adolescent Psychosis: Clinical and Ethical Implications.","authors":"Venkata Sushma Chamarthi, Piyush Das, Rahul Kashyap","doi":"10.1177/00912174251392768","DOIUrl":"10.1177/00912174251392768","url":null,"abstract":"<p><p>ObjectiveWith the rapid adoption of artificial intelligence (AI) technologies by adolescents, the impact on their mental health is of critical concern. This article examines the emerging phenomenon of AI-related psychosis, which can be defined as new-onset or exacerbated psychotic experiences associated with generative AI platforms, such as chatbots, avatars, and virtual agents like Siri and Alexa.MethodNarrative review and perspective.ResultsAdolescents are particularly susceptible due to ongoing neurodevelopmental immaturity, including underdeveloped prefrontal regulatory circuits and heightened limbic system reactivity, which may impair emotional regulation and reality testing. Combined with extensive digital engagement, these factors increase vulnerability to psychotic experiences in response to AI interactions. There are behavioral risk factors, online habits, and neurobiological susceptibilities that may predispose adolescents to such experiences. In addition, implications are outlined for healthcare providers, including an emphasis on proactive screening, digital literacy education, and early intervention strategies. Clinical approaches to recognize and manage AI-related mental health risks in adolescents are also proposed.ConclusionsA multidisciplinary response by clinicians, educators, developers, and policymakers is needed to guide ethical AI design and safeguard the well-being of adolescents in today's digital environment.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"486-497"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Influencing the Psychological Health of Pregnant Women of Advanced Maternal Age During the Peripartum Period in China. 中国高龄产妇围生期心理健康的影响因素
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-07-29 DOI: 10.1177/00912174251360100
Jin Song, Zi-Long Ma, Hui-Shi Zhang, Ting Liang, Xiwen Zhang, Autumn Wang
{"title":"Factors Influencing the Psychological Health of Pregnant Women of Advanced Maternal Age During the Peripartum Period in China.","authors":"Jin Song, Zi-Long Ma, Hui-Shi Zhang, Ting Liang, Xiwen Zhang, Autumn Wang","doi":"10.1177/00912174251360100","DOIUrl":"10.1177/00912174251360100","url":null,"abstract":"<p><p><b>Objective:</b> The age of childbirth for women has been significantly delayed in recent times, leading to an increase in the proportion of pregnant women of advanced maternal age (AMA). Due to increased physiological challenges and higher incidence of pregnancy complications, women of advanced maternal age often face greater mental stress, including familial and societal pressures associated with childbirth in advanced age. A cross-sectional study was conducted among women in the later stages of pregnancy and peripartum period in order to identify psychosocial predictors of mental health, we conducted a cross-sectional study on this.<b>Methods:</b> A convenience sample of primiparous women were assessed at three time points (at the 8th month prenatal examination, the day of delivery and 42 days postpartum). A total of 125 eligible pregnant women were assessed at each time point. Sociodemographic characteristics, psychological concerns, and mental health were measured.<b>Results:</b> The incidence of psychological distress among older peripartum women was significantly higher than among younger women. Increased psychological stress was correlated with concerns about maternal and infant health, fear of labor pain, apprehension regarding personal career development, and worries about family support and financial conditions.<b>Conclusions:</b> The mental health status of older peripartum women is concerning, suggesting the need for psychological support by primary care physicians and other healthcare providers.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"395-404"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric Conditions in Women With Health Problems, and the Role of Artificial Intelligence (AI) in the Well-Being of Health Professionals and the Identification of Mental Disorders. 有健康问题的妇女的精神状况,以及人工智能(AI)在卫生专业人员福祉和精神障碍识别中的作用。
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2026-04-14 DOI: 10.1177/00912174261444479
{"title":"Psychiatric Conditions in Women With Health Problems, and the Role of Artificial Intelligence (AI) in the Well-Being of Health Professionals and the Identification of Mental Disorders.","authors":"","doi":"10.1177/00912174261444479","DOIUrl":"10.1177/00912174261444479","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"391-394"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probable Autoimmune Encephalitis Presenting With Catatonia in a Young Woman: A Case Report and Review of the Literature. 可能的自身免疫性脑炎表现为紧张症在一个年轻女性:一个病例报告和文献复习。
IF 1.9 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-09-15 DOI: 10.1177/00912174251380668
Nancy M Gonzalez, Vishwa S Shah, Dafe Jessa, Reza Safavi
{"title":"Probable Autoimmune Encephalitis Presenting With Catatonia in a Young Woman: A Case Report and Review of the Literature.","authors":"Nancy M Gonzalez, Vishwa S Shah, Dafe Jessa, Reza Safavi","doi":"10.1177/00912174251380668","DOIUrl":"10.1177/00912174251380668","url":null,"abstract":"<p><p>ObjectiveTo describe a case of probable autoimmune encephalitis initially misdiagnosed as a primary psychiatric disorder.MethodReview and description of probable autoimmune encephalitis presenting with catatonia in a young woman 6 months post-partum.ResultsA young woman was initially admitted to an outside hospital and was diagnosed with a primary psychiatric condition. She was referred for psychiatric inpatient care, but was denied admission due to labile hypertension. After admission to the medical service (and ICU), she responded to a lorazepam challenge, and made a complete recovery after several weeks of combined treatment with IV methylprednisolone, IV immunoglobulin (IVIG), and rituximab, and was discharged with a diagnosis of autoimmune encephalitis.ConclusionAutoimmune encephalitis should be suspected in patients presenting with labile vital signs, family history of autoimmunity, and new psychosis without a prior history of psychiatric problems. Other important diagnostic considerations include neuroleptic malignant syndrome, substance-induced psychosis, or catatonia secondary to post-infectious immune-mediated encephalitis. While a first psychotic break should always be considered, the presence of autonomic instability, catatonia, seizures, or dyskinesias in a young woman postpartum should prompt a thorough medical and neurological work-up.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"515-528"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Effects of Psychological Intervention During Radiotherapy on Anxiety, Depression and Quality of Life among Women with Breast Cancer. 放疗期间心理干预对乳腺癌患者焦虑、抑郁及生活质量的纵向影响
IF 1.3 4区 医学
International Journal of Psychiatry in Medicine Pub Date : 2026-07-01 Epub Date: 2025-12-19 DOI: 10.1177/00912174251408971
Junli Liang, Laiyou Li, Fan Yang, Xinhua Xu, Lihua Guo, Jing Zhi, Jing Zhao, Ruili Zhang, Zhiguo Zhou
{"title":"Longitudinal Effects of Psychological Intervention During Radiotherapy on Anxiety, Depression and Quality of Life among Women with Breast Cancer.","authors":"Junli Liang, Laiyou Li, Fan Yang, Xinhua Xu, Lihua Guo, Jing Zhi, Jing Zhao, Ruili Zhang, Zhiguo Zhou","doi":"10.1177/00912174251408971","DOIUrl":"10.1177/00912174251408971","url":null,"abstract":"<p><p>ObjectiveBreast cancer patients undergoing radiotherapy frequently experience psychological distress that negatively impacts treatment outcomes and quality of life. Evidence for structured psychological interventions during radiotherapy remains limited. This study evaluated the longitudinal effects of a structured education plus entertainment therapy intervention on anxiety, depression, and quality of life among women with breast cancer in mainland China during and after radiotherapy using linear mixed models analyses.MethodsThis single-center, parallel-group, assessor-blinded randomized controlled trial enrolled 280 female breast cancer patients (aged 18-75 years) receiving adjuvant radiotherapy. Participants were randomized 1:1 to intervention (structured education plus entertainment therapy) or a control group (standard care). Primary outcomes were trajectories of change on the Self-rated Anxiety Scale (SAS) and Self-rated Depression Scale (SDS) from baseline (T0) to mid-radiotherapy (T1), to the end of radiotherapy (T2), and 1, 3, and 6 months post-radiotherapy (T3-T5). Secondary outcomes included quality of life (EORTC QLQ-C30/BR23 domains), acute toxicity (CTCAE v5.0), and adherence. Linear mixed models with group × time interaction assessed intervention effects.ResultsOf 280 randomized patients, 252 (90%) completed the T5 assessment. The Of 280 randomized patients, 252 (90%) completed the T5 assessment. The intervention group showed significantly improved SAS trajectory (group × time interaction β = -1.82, 95% CI = -3.14 to 0.50, <i>P</i> = 0.007) with estimated marginal mean difference of -3.45 points at T5. SDS trajectory improvement was marginally significant (β = -1.56, 95% CI = -3.12 to 0.01, <i>P</i> = 0.051). Minimal clinically important difference Of 280 randomized patients, 252 (90%) completed the T5 assessment. The intervention group showed significantly improved SAS trajectory (group × time interaction β = -1.82, 95% CI = -3.14 to 0.50, <i>P</i> = 0.007) with estimated marginal mean difference of -3.45 points at T5. SDS trajectory improvement was marginally significant (β = -1.56, 95% CI = -3.12 to 0.01, <i>P</i> = 0.051), indicating a minimal clinically important difference.ConclusionsA structured education plus entertainment therapy intervention demonstrated small-to-moderate clinically meaningful improvements in anxiety, depression, and quality of life during radiotherapy, with effects persisting through 6- months of follow-up. Inclusion of this intervention as part of routine radiotherapy care of breast cancer patients in China appears feasible and effective.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"445-466"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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