International Journal of Psychiatry in Medicine最新文献_第4页

Decreased Risk of Mental Illness Worsening: Comment on "Glucagon-like Peptide-1 Receptor Agonists in Individuals With Severe Mental Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials". 降低精神疾病恶化的风险：对“胰高血糖素样肽-1受体激动剂在严重精神疾病患者中的应用：随机对照试验的系统回顾和荟萃分析”的评论。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-08-21 DOI: 10.1177/00912174261479866

Muhammad Awais Wajid

引用次数: 0

Antidepressant-Induced Rapid Eye Movement Behavioral Sleep Disorder (RBD): A Scoping Review. 抗抑郁药诱导的快速眼动行为睡眠障碍（RBD）：一项范围综述。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-08-17 DOI: 10.1177/00912174261474772

Sarah Kanj, Lana Kanj, Jessie Joseph, Mehnaz Zafar Ali, Faisal A Nawaz

{"title":"Antidepressant-Induced Rapid Eye Movement Behavioral Sleep Disorder (RBD): A Scoping Review.","authors":"Sarah Kanj, Lana Kanj, Jessie Joseph, Mehnaz Zafar Ali, Faisal A Nawaz","doi":"10.1177/00912174261474772","DOIUrl":"https://doi.org/10.1177/00912174261474772","url":null,"abstract":"ObjectiveRapid Eye Movement sleep behavior disorder (RBD) is a parasomnia characterised by the loss of normal skeletal muscle atonia during REM sleep, leading to the enactment of dreams through complex motor behaviors such as talking, shouting, or violent movements that may result in injury. Emerging evidence suggests that antidepressants may be associated with RBD. This study reviewed the existing literature on the demographic and clinical features of patients with REM sleep behavior disorder (RBD) taking antidepressants, as well as the reported associations between antidepressant use and RBD.MethodsA comprehensive search strategy was implemented using the PRISMA for Scoping Reviews framework. Eligible study designs included cohort, cross-sectional, observational, randomised controlled trials, and case reports. Searches were conducted on Science Direct and PubMed for studies published between 1957 and 2025. Search terms included \"REM sleep behavior disorder,\" \"dream enactment behavior,\" \"antidepressants,\" \"SSRIs,\" \"SNRIs,\" and \"TCAs.\" The scoping review protocol was pre-registered on the Open Science Framework.ResultsTitle and abstract screening yielded 650 studies, with 16 studies meeting the inclusion criteria after full-text review. Data from 500 patients indicated a male predominance (70.2%), with a mean age of 53.9 years. Depression was the most common comorbidity (8 studies). SSRIs were most frequently associated with RBD (in 8 studies), followed by SNRIs (6 studies) and TCAs (6 studies).ConclusionAntidepressant-associated RBD is an emerging clinical concern requiring greater recognition and monitoring to enhance treatment outcomes. A clearer understanding of these relationships will ultimately improve risk stratification, patient counseling, and individualized treatment strategies in clinical settings.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261474772"},"PeriodicalIF":1.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Changes in Composite Insulin-Resistance Indices After Adjunctive Probiotic Treatment in Olanzapine-Treated Schizophrenia: A Longitudinal Secondary Analysis. 奥氮平治疗的精神分裂症患者辅助益生菌治疗后复合胰岛素抵抗指标的早期变化：一项纵向二次分析。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-08-14 DOI: 10.1177/00912174261474760

Cuiping Luo, Guangwei Qing, Jing Zhang, Hongfei Wan, Simin Xiong, Yuxin Zhou, Kun Yan, Yongzhi Xiong

{"title":"Early Changes in Composite Insulin-Resistance Indices After Adjunctive Probiotic Treatment in Olanzapine-Treated Schizophrenia: A Longitudinal Secondary Analysis.","authors":"Cuiping Luo, Guangwei Qing, Jing Zhang, Hongfei Wan, Simin Xiong, Yuxin Zhou, Kun Yan, Yongzhi Xiong","doi":"10.1177/00912174261474760","DOIUrl":"https://doi.org/10.1177/00912174261474760","url":null,"abstract":"ObjectiveOlanzapine is effective for schizophrenia but commonly causes metabolic dysregulation. This study examined whether adjunctive probiotic treatment was associated with short-term changes in composite insulin-resistance-related indices during olanzapine therapy.MethodsThis longitudinal secondary analysis included 84 patients with schizophrenia receiving olanzapine: 40 received adjunctive Bifidobacterium tetravaccine live tablets and 44 received olanzapine alone. The triglyceride-glucose index (TyG), triglyceride-glucose-body mass index (TyG-BMI), metabolic score for insulin resistance (METS-IR), single-point insulin sensitivity estimator (SPISE), and triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) were assessed at baseline, Week 2, and Week 4. Baseline-adjusted linear mixed-effects models evaluated group × visit interactions and visit-specific contrasts. False discovery rate (FDR) correction and sensitivity analyses were applied.ResultsSignificant group × visit interactions were observed for TyG-BMI (P < 0.001; FDR <0.001) and SPISE (P = 0.005; FDR = 0.012), but not for TyG, METS-IR, or TG/HDL-C. At Week 2, TyG-BMI was lower in the probiotic group (adjusted difference, -16.76; 95% CI, -23.78 to -9.74; P < 0.001; FDR <0.001), whereas SPISE was higher (adjusted difference, 0.54; 95% CI, 0.16 to 0.93; P = 0.006; FDR = 0.016). No index differed significantly between groups at Week 4.ConclusionsAdjunctive probiotic treatment was associated with early favorable differences in TyG-BMI and SPISE, but these were not sustained at Week 4. TyG, METS-IR, and TG/HDL-C showed no significant primary-analysis effects. Larger, longer studies with direct insulin-based measurements are needed to determine reproducibility and clinical significance.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261474760"},"PeriodicalIF":1.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal Diseases and Persistent Depressive Trajectories in Older Adults Across Four International Aging Cohorts. 四个国际老龄化队列中老年人的胃肠道疾病和持续抑郁轨迹

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-08-06 DOI: 10.1177/00912174261475436

Fangli Wu, Ning Wang, Jiahui Yang

{"title":"Gastrointestinal Diseases and Persistent Depressive Trajectories in Older Adults Across Four International Aging Cohorts.","authors":"Fangli Wu, Ning Wang, Jiahui Yang","doi":"10.1177/00912174261475436","DOIUrl":"https://doi.org/10.1177/00912174261475436","url":null,"abstract":"ObjectiveTo examine associations between gastrointestinal and hepatic diseases (GIHD) and long-term depressive symptom trajectories in older adults across diverse cultural and healthcare settings.MethodsLongitudinal data from four aging cohorts were harmonized: CHARLS (China), SHARE (Europe), HRS (United States), and KLOSA (South Korea), comprising 40,161 adults aged ≥60 years with 4-6 follow-up waves. Group-based trajectory modeling (GBTM) identified distinct depressive symptom trajectories. Multinomial logistic regression, adjusted for baseline depressive symptoms and covariates, estimated odds of trajectory membership. Random-effects meta-analysis with Hartung-Knapp correction pooled cohort-specific estimates. Inverse probability weighting (IPW) and E-values assessed robustness to confounding.ResultsThree trajectories were identified in all cohorts: Stable Low, Increasing Mild, and Stable High. After adjustment for baseline depressive symptoms, GIHD independently predicted Stable High trajectory membership (pooled OR = 1.73, 95% CI: 1.31-2.28; I2 = 21.2%). Upper gastrointestinal disorders showed exceptional cross-cultural consistency (pooled OR = 1.80, 95% CI: 1.69-1.92; I2 = 0%). Liver disease was significantly associated in CHARLS (OR = 2.64, 95% CI: 1.15-6.07) but not in KLOSA. Associations were consistent across sexes (P for interaction = 0.417). IPW confirmed robustness (CHARLS OR = 1.40; SHARE OR = 1.11), and E-values indicated resistance to unmeasured confounding (E-value = 1.97).ConclusionsChronic gastrointestinal conditions independently predict persistent severe depressive trajectories in older adults across four countries. The zero heterogeneity for upper gastrointestinal disorders suggests a gut-brain axis mechanism, supporting systematic depression screening in geriatric gastroenterology practice.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261475436"},"PeriodicalIF":1.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of the Combination of Schema Therapy and ACT in the Treatment of Compulsive Overeating in Clinical Practice. 图式疗法与ACT联合治疗强迫性暴饮暴食的临床疗效观察。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-07-31 DOI: 10.1177/00912174261474935

Oksana Martsyniak-Dorosh

{"title":"Effectiveness of the Combination of Schema Therapy and ACT in the Treatment of Compulsive Overeating in Clinical Practice.","authors":"Oksana Martsyniak-Dorosh","doi":"10.1177/00912174261474935","DOIUrl":"https://doi.org/10.1177/00912174261474935","url":null,"abstract":"ObjectiveSchema therapy (ST) and acceptance and commitment therapy (ACT) have been shown to be effective in treating eating disorders, including compulsive overeating, but evidence for the effectiveness of their combined use remains insufficient. This study evaluated the effectiveness of ST, ACT, and their combination in reducing compulsive overeating symptoms.MethodsThis 12-week randomised controlled trial included 100 participants diagnosed with compulsive overeating, divided into four groups. Outcomes were assessed by questionnaires at baseline, post-treatment, and at 3 and 6 months.ResultsAll active psychotherapeutic interventions demonstrated effectiveness, but the most pronounced and persistent changes occurred in the combination therapy group. After 12 weeks, average episode frequency decreased to 1.6 in the ST group, 1.5 in the ACT group, and 0.9 in the combination group, compared to 2.8 in the control group (P < 0.001). Compulsive overeating scores declined from a baseline of 27.0 to 21.0, 20.5, and 17.2 respectively, while the control group remained at 25.9. Follow-ups at 3 and 6 months confirmed sustained effects, with the combined group meeting remission criteria.ConclusionsThe combination of SC and ACT produced stronger, more durable reductions in episode frequency, symptom severity, and key psychological mechanisms than did either treatment alone. The integration of these two treatments represents a promising approach for addressing compulsive overeating in clinical practice.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261474935"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Adverse Childhood Experiences and Intrinsic Capacity Trajectories Among Older People in China: Evidence From CHARLS. 中国老年人不良童年经历与内在能力轨迹的关系：来自CHARLS的证据

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-07-18 DOI: 10.1177/00912174261469840

Xinyue Zhang, Wenyang Han, Yiqun Li, Xiaowei Zheng, Yuqing Chen

{"title":"Association Between Adverse Childhood Experiences and Intrinsic Capacity Trajectories Among Older People in China: Evidence From CHARLS.","authors":"Xinyue Zhang, Wenyang Han, Yiqun Li, Xiaowei Zheng, Yuqing Chen","doi":"10.1177/00912174261469840","DOIUrl":"https://doi.org/10.1177/00912174261469840","url":null,"abstract":"ObjectiveThis study explored the effects of adverse childhood experiences (ACEs) in older adults on long-term intrinsic capacity (IC) and trajectories of change in IC over 5 years from 2011 to 2015.MethodsA total of 2847 participants aged 60 years and older from the China Health and Retirement Longitudinal Study (CHARLS) were included in analyses. Twelve ACEs were retrospectively assessed by questionnaire in 2014. The number of ACEs was summed and categorized into 5 groups: 0, 1, 2, 3, and 4 or more ACEs. IC was assessed using a measure that examined five domains: locomotor, cognitive, sensory, vitality, and psychological.ResultsOverall, 87.4% of participants reported exposure to at least 1 of the 12 ACEs (Group 2) and 16.6% had experienced 4 or more ACEs (Group 5). Compared to participants without ACEs exposure (Group 1), those experiencing 1, 2, 3 and 4 or more ACEs (Groups 2-5) predicted worse IC (β = 0.085, 95% CI = -0.169 to -0.001, P < 0.05, to β = -0.44, 95 % CI = -0.54 to -0.34, P < 0.001, respectively across the four groups, demonstrating a dose-effect response. Three IC trajectories were identified (low-stable, moderate-stable, and high stable). Individuals with experience 2, 3 and 4 or more ACEs (Groups 3-5) predicted a significantly increased risk of moderate-stable and low-stable IC trajectories. In addition, physical abuse, household mental illness, domestic violence, bullying and parental disability was negatively related to IC and predicted an increased risk of moderate-stable and low-stable trajectory in long-term follow-up.ConclusionExposure to ACEs negatively impacts IC and predicts increased risk of moderate-stable and low-stable IC trajectory (vs. high stable) over time.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261469840"},"PeriodicalIF":1.9,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Outcomes After Percutaneous Coronary Intervention in Patients With Serious Mental Illness. 严重精神疾病患者经皮冠状动脉介入治疗后的心血管结局。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-07-10 DOI: 10.1177/00912174261467881

Ali Awad, Peter Kamash, Mohammad Abed Alhaleem, Abdul Rasheed Bahar, Mariam Chalhoub, Muhammad Burhan, M Chadi Alraies

{"title":"Cardiovascular Outcomes After Percutaneous Coronary Intervention in Patients With Serious Mental Illness.","authors":"Ali Awad, Peter Kamash, Mohammad Abed Alhaleem, Abdul Rasheed Bahar, Mariam Chalhoub, Muhammad Burhan, M Chadi Alraies","doi":"10.1177/00912174261467881","DOIUrl":"https://doi.org/10.1177/00912174261467881","url":null,"abstract":"ObjectiveSerious mental illness is associated with excess cardiovascular risk, but outcomes after contemporary percutaneous coronary intervention (PCI) remain unclear. The purpose of this paper is to examine PCI outcomes among those with serious mental illness.MethodsUsing TriNetX database, adults undergoing PCI with schizophrenia, bipolar disorder, or major depressive disorder were compared with propensity-matched controls without psychiatric diagnoses in this retrospective cohort study. Outcomes included statin and P2Y12 inhibitor prescription, cardiac rehabilitation referral, major adverse cardiovascular events, all-cause mortality, and repeat revascularization at 30 days and 1 year. Hazard ratios are reported as controls relative to psychiatric cohorts.ResultsAfter matching, 6766 patients with bipolar disorder, 52 375 with depression, and 5685 with schizophrenia were analyzed. Use of statins was higher, and antiplatelet therapy was similar in psychiatric cohorts. Compared with controls, bipolar disorder (n = 6766) was associated with higher MACE at 30 days (HR 1.12, P < 0.001) and 1 year (HR 1.10, P < 0.001). Depression (n = 52 375) was associated with higher MACE at 30 days (HR 1.14, P < 0.001) and 1 year (HR 1.13, P < 0.001). Schizophrenia (n = 5685) was associated with higher MACE at 30 days (HR 1.15, P < 0.001) and 1 year (HR 1.19, P < 0.001). Repeat revascularization was higher in bipolar disorder and depression but not different in schizophrenia. All-cause mortality was lower in bipolar disorder and depression but was comparable in schizophrenia relative to matched controls without psychiatric diagnoses.ConclusionsSerious mental illness is associated with worse cardiovascular outcomes after PCI despite similar or higher rates of documented post-PCI prescription and cardiac rehabilitation referral.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261467881"},"PeriodicalIF":1.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Chopra Wellbeing Index: Examination of Psychometric Properties. 乔普拉幸福指数：心理测量特性的检验。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-07-07 DOI: 10.1177/00912174261465740

Jennifer S Wortham, Daniel Martin, Stewart I Donaldson, Caroline G Howley

{"title":"The Chopra Wellbeing Index: Examination of Psychometric Properties.","authors":"Jennifer S Wortham, Daniel Martin, Stewart I Donaldson, Caroline G Howley","doi":"10.1177/00912174261465740","DOIUrl":"https://doi.org/10.1177/00912174261465740","url":null,"abstract":"ObjectiveChopra Wellbeing Index (CWI) was developed as a multidimensional measure of wellbeing, integrating physical, emotional, social, and spiritual domains consistent with contemporary models of human flourishing. The purpose of this study was to systematically evaluate the psychometric properties of this measure.MethodsThe psychometric properties of the CWI were assessed in 1637 participants (ages 18-83) who completed the CWI alongside established comparator measures of wellbeing, mental health, and quality of life. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to test the dimensionality of the instrument. Internal consistency was assessed using Cronbach's alpha and McDonald's omega. Criterion validity was assessed via correlations with validated scales. Measurement invariance testing was conducted with respect to several demographic dimensions to assess generalizability of the scale's underlying factor structure.ResultsThe 24-item CWI demonstrated strong internal consistency across subscales. Factor analyses supported a multidimensional structure with four correlated subscales: physical, psychological, social, and spiritual wellbeing. Evidence of criterion validity was found via positive correlations with wellbeing and life satisfaction measures along with negative correlations with measures of depression, anxiety, and negative emotions. Partial measurement invariance was supported with respect to gender, education, marital status, employment status, income, race/ethnicity, and country.ConclusionsThe Chopra Wellbeing Index is a reliable and valid tool for assessing multidimensional wellbeing in adults. Its integration of spiritual and existential domains alongside traditional health indicators distinguishes it from existing instruments, making it suitable for use in holistic health research, clinical practice, and population wellbeing monitoring.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261465740"},"PeriodicalIF":1.9,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide Deaths Among Hospitalized Patients With Delirium: A Case Series From a Nationwide Database in Japan. 谵妄住院患者的自杀死亡：来自日本全国数据库的病例系列。

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-07-07 DOI: 10.1177/00912174261468113

Keisuke Inoue, Yoshinori Cho, Kotaro Otsuka, Hideki Onishi, Chiaki Kawanishi

{"title":"Suicide Deaths Among Hospitalized Patients With Delirium: A Case Series From a Nationwide Database in Japan.","authors":"Keisuke Inoue, Yoshinori Cho, Kotaro Otsuka, Hideki Onishi, Chiaki Kawanishi","doi":"10.1177/00912174261468113","DOIUrl":"https://doi.org/10.1177/00912174261468113","url":null,"abstract":"ObjectiveDelirium is a common psychiatric condition in general hospitals and a known risk factor for suicidal ideation. However, little is known about suicide deaths among patients with delirium. This study examined the clinical characteristics of hospitalized patients with delirium who died by suicide.MethodsAnalyzed were anonymized medical incident data reported to the Japan Council for Quality Health Care from 2010 to 2022. Among reported inpatient suicide deaths, cases with documented delirium were identified and analyzed.ResultsA total of 403 inpatient suicides were identified during the study period, of which 12 (5.1%) involved patients with delirium, all of whom were admitted to medical wards. The most common methods of suicide were jumping from a height and hanging, often occurring in hospital rooms. Suicidal ideation and distress related to physical illness, including depression, anxiety, and pain, were frequently observed. However, only about half of the patients had received specialist interventions, such as psychiatric consultation. Patient characteristics, including sex and primary illness, were consistent with previous studies of inpatient suicide, with the exception of age.ConclusionsWhile this study cannot determine whether delirium independently contributes to suicide risk, the findings suggest that recognizing and managing delirium-together with timely specialist interventions, such as psychiatric consultation, and standard inpatient safety measures, including restricting access to means and making appropriate decisions regarding patient leave-may be important components of suicide prevention in general hospital settings. Further research is needed to better understand how delirium influences suicide risk.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261468113"},"PeriodicalIF":1.9,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Duration and the Association Between Systemic Inflammatory Response Index and Depressive Symptoms Among Emerging Adults: Evidence from NHANES 2005-2023. 新生成人睡眠时间和全身炎症反应指数与抑郁症状之间的关系：来自NHANES 2005-2023的证据

IF 1.9 4区医学

International Journal of Psychiatry in Medicine Pub Date : 2026-07-06 DOI: 10.1177/00912174261464297

Yingying Zhang, Yunyun Zheng, Yuting Zhang, Wangtao Meng, Chao Chen

{"title":"Sleep Duration and the Association Between Systemic Inflammatory Response Index and Depressive Symptoms Among Emerging Adults: Evidence from NHANES 2005-2023.","authors":"Yingying Zhang, Yunyun Zheng, Yuting Zhang, Wangtao Meng, Chao Chen","doi":"10.1177/00912174261464297","DOIUrl":"https://doi.org/10.1177/00912174261464297","url":null,"abstract":"ObjectiveThis study examined the association between the Systemic Inflammatory Response Index (SIRI) and depressive symptoms among emerging adults aged 18-25 years, with an emphasis on the indirect role of sleep duration.MethodThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2005-2023. A total of 6563 participants with complete data on the Patient Health Questionnaire-9 (PHQ-9), complete blood count parameters for SIRI calculation, and self-reported sleep duration were included. Depressive symptoms were defined as a PHQ-9 score ≥10. Weighted multivariable logistic regression, restricted cubic spline analysis, and bootstrap-based exploratory mediation analysis (n = 1000) were employed.ResultsOverall, 604 participants (9.2%) met the criteria for depressive symptoms. After full adjustment for covariates, SIRI demonstrated a significant positive association with depressive symptoms (Model 4: OR = 1.16, 95% CI = 1.02-1.33, P = 0.03). Participants in the highest SIRI quartile (Q4) exhibited 33% higher odds of depressive symptoms compared to the lowest quartile (Q1) (OR = 1.33, 95% CI = 1.09-1.61, P = 0.005). No significant nonlinearity was observed (P for nonlinearity = 0.066). Exploratory mediation analysis revealed a negative indirect effect through sleep duration (β = -0.009), accounting for approximately 6.2% of the total effect.ConclusionsHigher SIRI levels were associated with increased odds of depressive symptoms among emerging adults. Sleep duration played a modest suppressor role in this relationship, suggesting complex interactions between inflammation, sleep, and mental health warranting further investigation through prospective studies.","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174261464297"},"PeriodicalIF":1.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0