Association of uremic toxins and systemic inflammation with depression and anxiety among hemodialysis patients in Montenegro.

IF 1.1 4区医学 Q4 PSYCHIATRY

International Journal of Psychiatry in Medicine Pub Date : 2024-11-05 DOI:10.1177/00912174241298837

Batric Babovic, Natasa Belada Babovic, Filip Tomovic, Snezana Radovanovic, Mladen Debeljevic, Jelena Djordjevic, Olgica Mihaljevic

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引用次数: 0

Abstract

Objective: The purpose of this study was to examine the association between uremic toxins, inflammation, depression and anxiety among hemodialysis patients in Montenegro.

Method: The cross-sectional study included 88 patients undergoing hemodialysis. Depression and anxiety symptoms were assessed by Patient Health Questionnaire (PHQ-9) and Beck Anxiety Inventory (BAI). The standard laboratory methods were used to measure uremic toxins and systemic inflammation (C-reactive protein, Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR)).

Results: Clinically significant depression (PHQ-9 ≥ 10) and anxiety (BAI ≥16) were found in 55.7% and 27.2%, respectively. Logistic regression analyses revealed that serum urea, beta 2-microglobulin (B2M), and systemic inflammation (CRP, NLR, PLR) were significantly and independently associated with depressive symptoms, whereas serum urea, creatinine, uric acid, B2M, and systemic inflammation (CRP nad NLR) were associated with anxiety symptoms.

Conclusions: Depressive symptoms and anxiety are common among hemodialysis patients in Montenegro, and are associated with increased levels of systematic inflammation, serum urea, and beta 2-microglobulin.

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黑山血液透析患者的尿毒症毒素和全身炎症与抑郁和焦虑的关系。

研究目的本研究旨在探讨黑山血液透析患者中尿毒症毒素、炎症、抑郁和焦虑之间的关系：这项横断面研究包括 88 名接受血液透析的患者。抑郁和焦虑症状通过患者健康问卷（PHQ-9）和贝克焦虑量表（BAI）进行评估。标准实验室方法用于测量尿毒症毒素和全身炎症（C反应蛋白、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR））：结果：55.7%和 27.2%的患者有明显的抑郁症（PHQ-9 ≥ 10）和焦虑症（BAI ≥ 16）。逻辑回归分析表明，血清尿素、β2-微球蛋白（B2M）和全身炎症（CRP、NLR、PLR）与抑郁症状明显独立相关，而血清尿素、肌酐、尿酸、B2M和全身炎症（CRP nad NLR）与焦虑症状相关：结论：抑郁症状和焦虑在黑山的血液透析患者中很常见，并且与系统性炎症、血清尿素和 beta 2-微球蛋白水平的升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Medicine 医学-精神病学

CiteScore

3.00

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...