Clinical and Preventive Medicine最新文献

{"title":"THE IMPACT OF PERMANENT STRESS CAUSED BY THE WAR IN UKRAINE ON THE STATE OF PATIENTS WITH PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS","authors":"V. Petrushenko, D. Grebeniuk, Ihor P. Martsynkovskyi, Dmytro P. Slobodianiuk, Iaroslav V. Radoha, Serhii A. Sidorov, V. Mosondz","doi":"10.31612/2616-4868.2.2024.11","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.11","url":null,"abstract":"The aim of the study was to evaluate the impact of permanent stress and features of medical care in martial law on the indicators of liver function and quality of life of patients with portal hypertension due to liver cirrhosis. \u0000Materials and methods. The study included 37 patients with a confirmed diagnosis of liver cirrhosis complicated by portal hypertension and esophageal variceal bleeding. According to performed interventions all patients were divided into 3 groups: Group 1 – endoscopic band ligation and partial splenic artery embolization; Group 2 – endoscopic band ligation; Group 3 – endoscopic band ligation. The difference between Group 2 and Group 3 patients was that Group 2 patients were in a state of permanent stress due to the war. There were 4 visits with an interval of 1 month. At each time point, the levels of laboratory parameters of functional state of the liver and quality of life using RAND SF-36 questionnaire were evaluated. \u0000Results. Patients in all three groups during the first month showed an improvement in both laboratory indicators of liver function and integrated quality of life. In patients of Group 1 there was a progressive improvement in both the functional status of the liver and quality of life. In Group 2 the lack of any manipulations and maintenance therapy led to a lack of positive dynamics in patients. Staying in a state of permanent stress led to a progressive deterioration in the condition of patients in Group 3 starting from the second visit. Initially, the deterioration affected only the quality of life, but later it also manifested itself as a violation of the indicators of the functional state of the liver. \u0000Conclusions. The cumulative effect of permanent stress in patients with liver cirrhosis complicated by portal hypertension is manifested by an early deterioration in the quality of life with later violations of liver function.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MARKERS OF COMPLICATIONS AFTER LAPAROSCOPIC GASTRIC BYPASS IN PATIENTS WITH OBESITY","authors":"O. Ioffe, V. O. Nevmerzhytskyi, M. Kryvopustov, Yurii A. Dibrova, Y. Tsiura","doi":"10.31612/2616-4868.2.2024.03","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.03","url":null,"abstract":"Introduction. Bariatric surgery is one of the most effective methods of treating morbid obesity, which allows for a long-lasting result. Along with the increase in the number of operative methods of obesity treatment, the relevance of issues related to postoperative complications is increasing. In recent years, the issue of using special checklists after surgery has been actively investigated. This will help optimize the process of monitoring patients' condition in the postoperative period. \u0000The aim of the study: to develop a check-list model to prevent the detection of complications after laparoscopic gastric bypass in obese patients. \u0000Materials and methods. On the basis of the developed checklist, a study of the condition of obese patients, who underwent laparoscopic gastric bypass during 2019-2023, was conducted on the basis of the Department of General Surgery No. 2 of the Bogomolets National Medical University. The checklist included the following criteria: the level of pain on the VAS scale, the level of nausea, eating, mobility, whether there is a desire to be discharged home, abdominal muscle tension, pain in the calf muscles, heart rate, oxygen saturation in the blood, the number drainage discharge within 24 hours, temperature, systolic blood pressure, central venous pressure, laboratory diagnosis, decrease in hemoglobin concentration, leukocyte level after surgery, C-reactive protein level after surgery, blood procalcitonin level, erythrocyte sedimentation rate level, the presence of a shift in the leukocyte formula to the left. The presence of complications was assessed, the parameters of the checklist were analyzed using univariate logistic regression and ROC analysis for early detection of complications and determination of the chance of complications in the future. \u0000Results. Complications occurred in 18/218 (8.2%). The most frequent complication was bleeding in 6/18 (33.3%). Reoperation was performed in 12 cases of 12/18 (66.6%), endoscopic treatment was performed in 1 case, and conservative methods were used in 5 cases. According to the checklist, 31.81% had a positive predictive value (PPV) and 99.56% had a negative predictive value (NPV). The optimal cut-off point of the total score of the checklist was 6. Patients with a positive prognosis of the checklist have a higher chance of developing complications of VSH – 4.5 (95% CI 1.8-9.72), p <0.001. \u0000Conclusions. The complication rate was 18/218 (8.2%). According to the checklist, heart rate, systolic blood pressure and mobility are very good predictors of postoperative complications. The checklist is the best option for determining the readiness of patients to be discharged from the hospital due to a high prognostic negative result. Due to the low prognostic positive result, the evaluated checklist needs additional modification and optimization taking into account the results already obtained.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"27 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF AUTOMESOCONCENTRATE OF PLATELETS ON THE STAGES OF REGENERATION OF THE LIVER REMNANT OF RATS UNDER THE CONDITIONS OF PERFORMING VOLUMETRIC EXPERIMENTAL LIVER RESECTIONS","authors":"R. Salyutin, K.O. Yuzvyk","doi":"10.31612/2616-4868.2.2024.05","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.05","url":null,"abstract":"Introduction. Liver regeneration occurs in three stages, each of which is regulated by different factors: the initiation phase is regulated by interleukin 6 (IL-6) and tumor necrosis factor (TNFα); expansion phase – by hepatocyte growth factor (HGF) and transforming growth factor alpha (TGFα); the terminal phase – transforming growth factor beta (TGFβ) and activins. The work determined the level of markers of the main stages of liver regeneration after resection of 65-70% of the parenchyma of this organ in rats under the conditions of using different doses and schemes of administration of automesoconcentrate of platelets (AMС). The purpose of the study is to establish the characteristics of changes in the level of cytokines and growth factors in the homogenate of the liver of rats after resection of 65-70% of the parenchyma of this organ under the conditions of the use of different doses and schemes of AMС administration. \u0000Materials and methods. The study was conducted on white Wistar rats aged 1.5-2 months, weighing 150-180 g. AMС was injected: into the parenchyma of the liver remnant during resection at a dose of 0.5 ml/kg (group I); into the tail vein in the postoperative period at a dose of 0.5 ml/kg 3 hours and 48 hours after liver resection (group II); into the tail vein in the postoperative period at a dose of 1.0 ml/kg 3 hours and 48 hours after resection. \u0000Research results and discussion. It was shown that on the 7th day after liver resection, the level of TNF-α and IL-6 increased in all experimental groups, followed by a decrease on the 10th day to control values in the group of animals that received AMA intravenously at a dose of 1 ml/kg masses of animals. It was established that the values of HGF and TGFα in the liver homogenate of animals that underwent liver resection were significantly higher than in the control group on the 7th day of the experiment. At the later stages of the experiment, a decrease in the levels of HGF and TGFα in the liver homogenate was observed in the animals of groups I and III, but the studied indicators did not reach control values. In animals of group II, indicators of HGF and TGFα content remained at the highest level. The increase in the content of TGFβ and activins in the homogenate of the liver of rats in all experimental groups indicates the intensification of the terminal phase of liver regeneration on the 10th day after liver resection. \u0000Conclusions. Therefore, under the action of a dose of АМС equal to 1 ml/kg, the regeneration processes occur most intensively, the peak of which occurs 7-10 days after the resection. Administration of AMA into the liver parenchyma at a lower dose of 0.5 ml/kg or intravenous administration of the same dose does not contribute to the complete restoration of regenerative processes in the liver, as indicated by increased levels of TGFα and HGF on the 10th day after liver resection and administration of AMA.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF THE EFFECT OF TWO REHABILITATION PROGRAMS ON SPINAL MOBILITY AND PAIN INTENSITY IN PATIENTS WITH SPINAL DISCOPATHY","authors":"Andrii O. Goliachenko","doi":"10.31612/2616-4868.2.2024.14","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.14","url":null,"abstract":"Introduction. Approximately 80% of people experience back pain throughout their lives. A common problem of patients with low back pain is a significant limitation of mobility. Rehabilitation programs are usually recommended. Programs should include exercises that build flexibility, endurance, and strength. Kinesiotherapy is complemented by physiotherapy procedures, which are mainly aimed at analgesic and relaxing effects. \u0000The aim of the study was to compare the effect of two rehabilitation programs that differ in the type of kinesiotherapy on the mobility of the lumbar spine and the level of pain intensity in people with L5-S1 segment discopathy. \u0000Materials and methods. The study involved 30 patients undergoing 14 days of rehabilitation treatment. The criterion for dividing the subjects into groups was the method of kinesitherapy. The first group (Gr1) consisted of 15 patients who did gymnastics in the pool twice a day, and the second group (Gr2) consisted of 15 patients who attended therapeutic gymnastics classes in the gym twice a day. The exercises were aimed at improving the range of motion of the spine, strength and endurance of postural muscles. A visual analog scale was used to assess the intensity of pain. The distance between standard anthropometric points in the resting position and in the extreme position of movement was measured to assess the range of spinal movements. \u0000Results. After rehabilitation, the amplitude of movements of the lumbar spine increased in most patients. In Gr1, an increase in the range of forward spinal flexion by 9.2 cm (p = 0.001), rotation to the right by 0.63 cm (p = 0.03), and to the left by 1.33 cm (p = 0.007) was detected. In Gr2, the range of forward flexion increased by 12.6 cm (p = 0.005), left rotation by 0.94 cm (p = 0.035), and right flexion by 1.41 cm (p = 0.002). In the case of other movements, no statistically significant changes were found. \u0000In Gr1, the average pain intensity according to the VAS was 4.9 ± 2.3 points before the start of the physiotherapy program and 3.6 ± 1.7 points after its completion (p = 0.04). In Gr2, the VAS values were 5.1 ± 2.5 points and 3.9 ± 1.8 points, respectively (p = 0.03). The magnitude of changes in pain intensity was similar (-1.3 points and -1.2 points) for both programs. \u0000Conclusions. 1. The applied rehabilitation programs increased the mobility of the lumbar spine and reduced pain in patients with L5-S1 segment discopathy. 2. Both the hydrokinesitherapy program and the gym program were equally effective in increasing the range of motion of the spine and reducing the intensity of pain.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"26 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDICATORS OF MUC 5AC AND MUC 1 MUCOPOLYSACCHARIDE EXPRESSION IN THE NASAL MUCOSA OF PATIENTS WITH POSTNASAL DRIP SYNDROME AND NASAL SEPTUM DEVIATION","authors":"Natalia V. Babchenko, Y. Dieieva, Serhii E. Konovalov, Oleksii V. Motailo","doi":"10.31612/2616-4868.2.2024.06","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.06","url":null,"abstract":"Introduction. Determining the cause of postnasal drip syndrome can be quite challenging. Nasal septum deformation has been recognized as one possible factor. Understanding the fundamental processes of postnasal drip syndrome is crucial for developing targeted therapeutic strategies for treating this pathology. In our study, we examined the clinical and histological features of postnasal drip syndrome in individuals with nasal septum deformation and investigated the expression of mucopolysaccharides, specifically the indicators of MUC 5AC and MUC 1. \u0000The aim. This study aims to investigate the clinical and histological aspects of postnasal drip syndrome (PNDS) in patients with nasal septum deformation. Specifically, the study aims to explore the expression levels of MUC5AC and MUC1 in biopsies of the nasal turbinate mucosa. \u0000Materials and methods. A total of 29 samples of nasal mucosa from the lower nasal turbinates were collected. These samples were divided into two groups: patients with nasal septum deviation with and without postnasal drip syndrome. Levels of MUC5AC and MUC1 were determined using Western blot analysis. \u0000Results. Upon analysis of histological sections, we identified a significant increase in tissue metaplasia and lymphoid infiltration in the nasal mucosa of patients with postnasal drip syndrome compared to the control group. The levels of mucopolysaccharides, MUC5AC and MUC1, were higher in the nasal mucosa of the research group compared to the control group. \u0000Conclusions. The obtained data suggest that anatomical changes in the nasal cavity may play a role in the development of postnasal drip syndrome through alterations in mucin secretion.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEASIBILITY OF USING A PROBIOTIC BACTERIAL COMPLEX IN THE FORM OF A THROAT SPRAY IN THE LOCAL TREATMENT OF ACUTE VIRAL TONSILLITIS","authors":"M.I. Bezega, Serhii B. Bezshapochnyi, S. Zachepylo, V. P. Polyanska, Nelya O. Bobrova","doi":"10.31612/2616-4868.2.2024.07","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.07","url":null,"abstract":"The aim of the study was to determine the feasibility of using a probiotic bacterial complex in the form of a throat spray in the local treatment of acute viral tonsillitis based on the analysis of its clinical and microbiological efficacy. \u0000Materials and methods. The randomized controlled trial involved 46 people with acute tonsillitis diagnosed on the basis of clinical and pharyngoscopic signs. According to the treatment received, patients were divided into 2 groups. Patients in the control group (23 people) were treated according to the unified clinical protocol \"Tonsillitis\". The main group included 23 patients who, in addition to the protocol treatment, received a probiotic agent in the form of a throat spray containing a complex of bacteria of the genus Bacillus. To exclude the bacterial etiology of acute tonsillitis, a modified Centor scale (McIsaac scale) was used. Evaluation of the effectiveness of treatment was based on the study of the dynamics of clinical and pharyngoscopic signs of the disease, as well as the establishment of quantitative and qualitative changes in the microbiota of the palatine tonsils during treatment. \u0000Results. The analysis of the dynamics of the main clinical and pharyngoscopic parameters indicates a more significant and rapid normalization in patients of the main group. The results of microbiological studies show that the use of a probiotic bacterial complex in the treatment of acute tonsillitis in patients of the main group contributed to the elimination of dysbiotic changes, restoration of the population level of the main representatives of the palatine tonsils microbiome and colonization resistance of the oropharynx. \u0000Conclusions. It has been established that acute viral inflammation of the palatine tonsils occurs under conditions of quantitative and qualitative changes in the species composition of the microbiota of this biotope and is accompanied by an increase in dysbiotic disorders during the course of the disease. It has been confirmed that the use of a probiotic bacterial complex in the form of a spray in the local treatment of acute viral tonsillitis is appropriate due to its proven clinical and microbiological efficacy, and also makes it possible to refrain from premature administration of antibacterial chemotherapy.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"32 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPLEMENTATION OF PATIENT-CENTERED MEDICAL CARE MODEL: ANALYSIS OF THE ATTITUDES OF PATIENTS WITH CORONARY ARTERY DISEASE AND COMORBIDITIES","authors":"Galina Z. Moroz, Iryna M. Hidzynska, O. Tkalenko, I. Tkachuk, A. K. Sokolyuk","doi":"10.31612/2616-4868.2.2024.09","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.09","url":null,"abstract":"The aim: to evaluate the attitude of patients with coronary artery disease and comorbidities to the implementation of patient-centered care in clinical practice. \u0000Materials and methods. We carried out questionnaire survey of two groups of patients with coronary artery disease and comorbidities. The first one consisted of 30 patients with coronary artery disease aged 61-75 (mean age 67,2±5,1 years) who were followed by the cardiologist in the therapeutic department of the State Institution of Sciences “Research and Practical Center of Preventive and Clinical Medicine” State Administrative Department. The second one – 33 military personnel with coronary artery disease aged 50-58 years (mean age 53,2±2,4 years) who came for a scheduled appointment with a general practitioner at the Outpatient Care Clinic of the National military medical clinical center “GVKG”. Methods: system analysis, questionnaire survey, statistical. \u0000Results. According to patient`s opinion cardiologists give much more information about pharmacological treatment, including side effects of medications used (83,3±6,8% in the Ist group vs 33,3±8,2% in the 2nd group, p<0,05) and actions to increase patients` compliance (83,3±6,8% in the Ist group vs 42,4± 8,6% in the 2nd group, p<0,05). This is related to the peculiarities of management of patients with chronic diseases in the State Institution of Science “Research and Practical Center of Preventive and Clinical Medicine” State Administrative Department, in particular, with the follow-up of high-risk cardiac patients, including scheduled appointments and monitoring of patient`s clinical conditions by a cardiologist. Emotional support was given to 93,3±4,6% of patients in the Ist group and to 18,2±6,7% of patients in the 2nd group (p<0,05). 36,7±8,8% of patients in the Ist group and 84,8±6,3% in the 2nd group ( p<0,05) indicated, that they need more information about their treatment plan and involvement in clinical decision-making. 93,3±4,6% of patients in the Ist group and 4,8±6,3 % in the 2nd group were ready to perform self-monitoring of their health conditions and participate in the decision-making process regarding their treatment. \u0000Conclusions. Our survey demonstrated, that the majority of interviewed patients with coronary artery disease and comorbidities are ready to use basic principles of patient-centered care. The necessity to improve patient`s information and education about clinical decision-making and physician`s practical skills in the field of implementation of patient-centered care was substantiated.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"16 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140739030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INFLUENCE OF TREATMENT TACTICS ON THE LEVEL OF QUALITY OF LIFE AND THE CONDITION OF THE NASAL CAVITY IN PATIENTS WITH CHRONIC ATROPHIC RHINITIS PROVOKED BY HARMFUL PRODUCTION CONDITIONS","authors":"Andrii V. Lupyr, Oleksii V. Poliakov","doi":"10.31612/2616-4868.2.2024.02","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.02","url":null,"abstract":"Introduction. Various types of occupational hazards can cause the development of occupational atrophic rhinitis (AR). Researches determine the high prevalence of professional AR among workers in various fields of production. Drug treatment of RA is an important issue. The effectiveness of the use of autologous platelet-enriched plasma is determined. Determining the possibilities of increasing the effectiveness of treatment of professional AR with platelet-enriched plasma is a very relevant issue of modern medicine. \u0000The aim. To evaluate the use of autologous platelet-rich plasma in occupational chronic AR compared to standard treatment (irrigation with oil solutions). \u0000Materials and methods. 141 patients were examined: I group (32.6%) received irrigation with oil solutions, II (39.7%) – injections of platelet-rich plasma, and III (27.7%) – injections of platelet-rich plasma and irrigation with oil solutions. \u0000Results. Significant (p < 0.001) chances of improvement in quality of life levels were found in groups I and II compared to III one month after treatment, based on decreases in the values of the NOSE scale (respectively by 0.946 points and by 5.285 points) and increases values in the SF-36 questionnaire (RE scale and RR by 13.899 points; p = 0.004 and by 15.914 points only with combined treatment; MH scale – by 4.028 points and by 17.880 points; VT scale – by 5.136 points; p = 0.005 and by 24.158 points). Significant (p < 0.001) chances of an increase in nasocytogram indicators were determined in groups I and II compared to III: respectively, the pH of mucus (by 1.029 and by 1.333), the quantitative composition of neutrophils (by 18.958% and by 21.078%) and eosinophils (by 3.540%) combined treatment only) and saccharin test indicators (at 0.3 min; p = 0.005 and at 1.696 min). \u0000Conclusions. An improvement in the quality of life and parameters of the nasocytogram and saccharin test was determined when injections of platelet-rich plasma were used (both separately and in combination with irrigation with oil solutions) in patients with occupational chronic AR. Reliable chances of a decrease in NOSE scale values and an increase in SF-36 questionnaire indicators and chances of an increase in nasocytogram and saccharin test indicators were established.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"17 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DYNAMICS ASSESSMENT OF PSYCHOPATHOLOGICAL CHARACTERISTICS OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA","authors":"Y. Kushnir","doi":"10.31612/2616-4868.2.2024.08","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.08","url":null,"abstract":"The aim of the study. To determine the dynamics of the psychopathological structure and severity of negative symptoms depending on the stage of the disease in patients with negative symptoms in schizophrenia in order to improve the diagnosis and treatment of patients with schizophrenia. \u0000Materials and methods: 252 patients with negative symptoms of schizophrenia took part in the study: 83 patients with the first episode of schizophrenia, 88 patients with schizophrenia in a state of exacerbation, and 81 patients with schizophrenia in a state of remission. A comprehensive approach, which consisted from clinical-psychopathological, psychometric (Scale for Evaluating Negative Disorders, G.V. Logvinovych, 1990) and statistical research methods, were used in the study. \u0000Results. Features of the dynamics of negative symptoms in patients with negative symptoms in schizophrenia at different stages of the disease were established: patients with the first episode of schizophrenia were characterized by mild quantitative and qualitative impairments in the emotional sphere, slight quantitative and qualitative changes in the associative sphere, and mild quantitative impairments in the volitional sphere in combination with moderate qualitative changes in the volitional sphere. Patients with schizophrenia in a state of exacerbation were characterized by moderate quantitative impairments of the emotional sphere and manifested distortion of the emotional sphere, manifested quantitative and qualitative impairments in the associative sphere and minor quantitative and qualitative impairments of the volitional sphere. Patients with schizophrenia in a state of remission were characterized by moderate and manifested quantitative and qualitative impairments in the emotional-volitional sphere and moderate quantitative and qualitative impairments in the associative sphere. \u0000Conclusions. The obtained data can be used to establish diagnostic criteria for patients with negative symptoms in schizophrenia, depending on the dynamics of the disease.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"39 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEDICAL LITERACY DEVELOPMENT OF ADULT POPULATION IN SLOVAKIA AND UKRAINE","authors":"Olena V. Voliarska, Július Matulčík, Olga V. Puchyna, L. Zadorozhna-Kniahnytska","doi":"10.31612/2616-4868.2.2024.12","DOIUrl":"https://doi.org/10.31612/2616-4868.2.2024.12","url":null,"abstract":"Introduction. The diagnosis results of medical literacy levels among different groups of adult population in Slovakia are given in this article. This research was done by the scientists of Pedagogy Department, Philosophy Faculty, Comenius University in Bratislava, together with Ukrainian colleagues. \u0000The aim of research. The objective of the article was aimed at studying the specifics of medical literacy development in European countries and making a comparative research analysis for determining the levels of medical literacy among adult population in Slovakia and Ukraine and making up the recommendations. \u0000Materials and methods. The diagnostic surveying of adults was made according to the modification of European Health Literacy Survey Questionnaire (HLS_EU_Q47), which was offered to the respondents to fill out in the format of a Google form. The methodological approaches used in the study are as follows: andragogical, competency-based, cultural, person-centered, and systems-based. \u0000Results. The majority of the respondents in the European countries were found to have the insufficient level of medical literacy. In Slovakia, the youth aged 18-24 turned out to be more active and conscious of health issues. It was specified that the comprehensive study of medical literacy issues among adults was not carried out in Ukraine at all. Positively estimating the research experience of medical literacy levels among adult population in Slovakia, it is worthwhile to single out the progressive ideas of its implementation in an area of support, maintenance and restoration of health for adults in Ukraine. The recommendations were made up for increasing medical literacy of different groups of adult population at the national and regional levels as well as at the level of healthcare and educational institutions and universities. \u0000Conclusions. The research results of medical literacy among adult population can be recommended to the representatives of governmental institutions, universities, healthcare institutions so as to update legislation, prepare teaching and methodological materials for universities and postgraduate education.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}