鼻后滴流综合征和鼻中隔偏曲患者鼻黏膜中黏液5ac和黏液1黏多糖的表达指标

Natalia V. Babchenko, Y. Dieieva, Serhii E. Konovalov, Oleksii V. Motailo
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引用次数: 0

摘要

简介确定鼻后滴流综合征的病因相当具有挑战性。鼻中隔变形被认为是一个可能的因素。了解鼻后滴流综合征的基本过程对于制定治疗该病症的靶向治疗策略至关重要。在我们的研究中,我们检查了鼻中隔变形患者鼻后滴流综合征的临床和组织学特征,并研究了粘多糖的表达,特别是 MUC 5AC 和 MUC 1 的指标。目的本研究旨在探讨鼻中隔变形患者鼻后滴流综合征(PNDS)的临床和组织学方面。具体而言,本研究旨在探讨鼻甲粘膜活检组织中 MUC5AC 和 MUC1 的表达水平。材料和方法。共收集了 29 份来自下鼻甲的鼻黏膜样本。这些样本被分为两组:有鼻中隔偏曲并伴有鼻后滴流综合征和无鼻后滴流综合征的患者。采用 Western 印迹分析法测定 MUC5AC 和 MUC1 的水平。结果通过对组织切片的分析,我们发现与对照组相比,鼻后滴流综合征患者的鼻粘膜组织变性和淋巴细胞浸润明显增加。与对照组相比,研究组鼻粘膜中的粘多糖、MUC5AC 和 MUC1 含量更高。结论获得的数据表明,鼻腔解剖结构的变化可能通过改变粘蛋白分泌在鼻后滴流综合征的发病过程中发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
INDICATORS OF MUC 5AC AND MUC 1 MUCOPOLYSACCHARIDE EXPRESSION IN THE NASAL MUCOSA OF PATIENTS WITH POSTNASAL DRIP SYNDROME AND NASAL SEPTUM DEVIATION
Introduction. Determining the cause of postnasal drip syndrome can be quite challenging. Nasal septum deformation has been recognized as one possible factor. Understanding the fundamental processes of postnasal drip syndrome is crucial for developing targeted therapeutic strategies for treating this pathology. In our study, we examined the clinical and histological features of postnasal drip syndrome in individuals with nasal septum deformation and investigated the expression of mucopolysaccharides, specifically the indicators of MUC 5AC and MUC 1. The aim. This study aims to investigate the clinical and histological aspects of postnasal drip syndrome (PNDS) in patients with nasal septum deformation. Specifically, the study aims to explore the expression levels of MUC5AC and MUC1 in biopsies of the nasal turbinate mucosa. Materials and methods. A total of 29 samples of nasal mucosa from the lower nasal turbinates were collected. These samples were divided into two groups: patients with nasal septum deviation with and without postnasal drip syndrome. Levels of MUC5AC and MUC1 were determined using Western blot analysis. Results. Upon analysis of histological sections, we identified a significant increase in tissue metaplasia and lymphoid infiltration in the nasal mucosa of patients with postnasal drip syndrome compared to the control group. The levels of mucopolysaccharides, MUC5AC and MUC1, were higher in the nasal mucosa of the research group compared to the control group. Conclusions. The obtained data suggest that anatomical changes in the nasal cavity may play a role in the development of postnasal drip syndrome through alterations in mucin secretion.
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