THE INFLUENCE OF TREATMENT TACTICS ON THE LEVEL OF QUALITY OF LIFE AND THE CONDITION OF THE NASAL CAVITY IN PATIENTS WITH CHRONIC ATROPHIC RHINITIS PROVOKED BY HARMFUL PRODUCTION CONDITIONS

Andrii V. Lupyr, Oleksii V. Poliakov
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Abstract

Introduction. Various types of occupational hazards can cause the development of occupational atrophic rhinitis (AR). Researches determine the high prevalence of professional AR among workers in various fields of production. Drug treatment of RA is an important issue. The effectiveness of the use of autologous platelet-enriched plasma is determined. Determining the possibilities of increasing the effectiveness of treatment of professional AR with platelet-enriched plasma is a very relevant issue of modern medicine. The aim. To evaluate the use of autologous platelet-rich plasma in occupational chronic AR compared to standard treatment (irrigation with oil solutions). Materials and methods. 141 patients were examined: I group (32.6%) received irrigation with oil solutions, II (39.7%) – injections of platelet-rich plasma, and III (27.7%) – injections of platelet-rich plasma and irrigation with oil solutions. Results. Significant (p < 0.001) chances of improvement in quality of life levels were found in groups I and II compared to III one month after treatment, based on decreases in the values of the NOSE scale (respectively by 0.946 points and by 5.285 points) and increases values in the SF-36 questionnaire (RE scale and RR by 13.899 points; p = 0.004 and by 15.914 points only with combined treatment; MH scale – by 4.028 points and by 17.880 points; VT scale – by 5.136 points; p = 0.005 and by 24.158 points). Significant (p < 0.001) chances of an increase in nasocytogram indicators were determined in groups I and II compared to III: respectively, the pH of mucus (by 1.029 and by 1.333), the quantitative composition of neutrophils (by 18.958% and by 21.078%) and eosinophils (by 3.540%) combined treatment only) and saccharin test indicators (at 0.3 min; p = 0.005 and at 1.696 min). Conclusions. An improvement in the quality of life and parameters of the nasocytogram and saccharin test was determined when injections of platelet-rich plasma were used (both separately and in combination with irrigation with oil solutions) in patients with occupational chronic AR. Reliable chances of a decrease in NOSE scale values and an increase in SF-36 questionnaire indicators and chances of an increase in nasocytogram and saccharin test indicators were established.
治疗策略对有害生产条件引发的慢性萎缩性鼻炎患者的生活质量水平和鼻腔状况的影响
导言。各种类型的职业危害都可能导致职业性萎缩性鼻炎(AR)的发生。研究表明,在各生产领域的工人中,职业性萎缩性鼻炎的发病率很高。RA的药物治疗是一个重要问题。研究确定了使用自体血小板浓缩血浆的有效性。确定使用血小板浓缩血浆提高专业 AR 治疗效果的可能性是现代医学的一个非常重要的问题。目的是评估自体富血小板血浆与标准治疗(用油溶液灌洗)相比在职业性慢性 AR 中的应用。材料和方法。对 141 名患者进行了检查:I 组(32.6%)接受油液灌洗,II 组(39.7%)注射富血小板血浆,III 组(27.7%)注射富血小板血浆和油液灌洗。结果显示与 III 组相比,I 组和 II 组在治疗一个月后的生活质量水平有明显提高(p < 0.001),其依据是 NOSE 量表值的下降(分别为 0.946 分和 5.285分),SF-36调查问卷中的数值增加(RE量表和RR分别增加13.899分;P = 0.004和15.914分,仅在联合治疗时增加;MH量表--分别增加4.028分和17.880分;VT量表--分别增加5.136分;P = 0.005和24.158分)。与 III 组相比,I 组和 II 组的鼻细胞图指标明显增加(p < 0.001):分别是粘液的 pH 值(增加 1.029 和 1.333)、中性粒细胞(增加 18.958% 和 21.078%)和嗜酸性粒细胞(增加 3.540%)的数量组成(仅联合治疗)以及糖精试验指标(0.3 分钟时;p = 0.005 和 1.696 分钟时)。结论职业性慢性 AR 患者在注射富血小板血浆(单独使用或与油液灌洗联合使用)后,生活质量以及鼻细胞图和糖精试验指标均有所改善。确定了 NOSE 量表值下降和 SF-36 问卷指标上升的可靠几率,以及鼻细胞图和糖精试验指标上升的几率。
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