Journal of Cytology最新文献

{"title":"Inter- and Intra-observer Reproducibility of Thyroid Fine Needle Aspiration Cytology: An investigation of Bethesda 2023 Using Immunohistochemical BRAFV600E Antibody.","authors":"Erdogan Bahattin, Dündar Emine, Çetin Kısmet Çivi, Yılmaz Fatih","doi":"10.4103/joc.joc_26_24","DOIUrl":"10.4103/joc.joc_26_24","url":null,"abstract":"<p><strong>Background: </strong>The Bethesda System for Reporting Thyroid Cytology (TBSRTC) recommended for the interpretation of needle aspiration cytology of the thyroid, is the most widely used worldwide. Studies have shown that the disagreement between observers, especially in the Bethesda III and IV diagnostic categories, is not insignificant at 10%-40%. In the TBSRTC 2023 version, some definitions were removed and simplified, and molecular pathology was proposed as a complement to cytopathology. The current availability of molecular tests is limited because they can be performed in a few centers and are expensive. Therefore, our study investigated intra- and inter-observer agreement according to TBSRTC 2023 using only immunohistochemically BRAFV600E antibodies.</p><p><strong>Materials and methods: </strong>The study included 173 cases with aspiration cytology evaluated between 2019 and 2022. The immunohistochemical procedure applied BRAFV600E (RM8) monoclonal antibody to cell block sections. All slides were assessed and categorized by three different observers. Data were interpreted using Cohen's kappa and Fleiss's kappa test in the Statistical Package for Social Sciences Windows 2021 program.</p><p><strong>Results: </strong>For the applied RM8 antibody, sensitivity was 64.71% and specificity was 87.27%. In terms of diagnostic categories, inter-observer agreement was good for Bethesda II (<i>K</i> = 0.606) and moderate for Bethesda III (<i>K</i> = 0.429), Bethesda IV (<i>K</i> = 0.523), Bethesda V (<i>K</i> = 0,464), and Bethesda VI (<i>K</i> = 0.544), respectively.</p><p><strong>Conclusion: </strong>In conclusion, the study reveals that the 2023 version of TBSRTC provides improvement, especially in the categories of uncertain diagnosis, but is still insufficient to improve cytological diagnostic accuracy, at which point molecular analyses become even more important.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"41 4","pages":"221-228"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Utility of Squash Smear Cytology in Chordoma: A Tertiary Care Center Experience.","authors":"Anshima Singh, Ram Nawal Rao","doi":"10.4103/joc.joc_201_23","DOIUrl":"10.4103/joc.joc_201_23","url":null,"abstract":"<p><strong>Background and aims: </strong>Chordomas are rare notochordal tumors. They are suitable candidates for squash smear cytology (SSC) owing to their gelatinous consistency and destructive nature. SSC is an important tool for making a quick intra-operative preliminary diagnosis and taking real-time surgical and further management decisions. This study aimed to evaluate the diagnostic accuracy of SSC for chordoma cases.</p><p><strong>Materials and methods: </strong>This retrospective study conducted in a North Indian tertiary care center enrolled chordoma cases histopathologically diagnosed between 01.01.2013 and 31.07.2023, for which SSC was also performed. SSC smears and their corresponding histopathology slides (±immunohistochemistry [IHC] slides) were retrieved. Histo-cytological correlation was performed.</p><p><strong>Results: </strong>In total, 13 such cases were retrieved. The mean age was 34.4 + 5.6 years. The male-female ratio was 1:1.6. The most common location was the spheno-occipital region (10 cases), followed by sacro-coccygeal (two cases) and vertebral regions (1 case). The SSC was positive for chordoma in 10/13 cases. Thus, the calculated accuracy of SSC in chordoma diagnosis was 76.9%. A total of 3/13 (23.1%) cases where SSC was inconclusive for chordoma were difficult to diagnose cases, requiring IHC for ultimate diagnosis. Cytological features such as abundant myxoid matrix and physaliphorous cells help in correct diagnosis of chordoma on SSC.</p><p><strong>Conclusions: </strong>We found the diagnostic accuracy of SSC in chordoma diagnosis to be 76.9%. Features such as abundant myxoid matrix and physaliphorous cells are helpful in correct diagnosis on SSC. Thus, even though chordomas are rare, one should consider them among the differential diagnoses in cases presenting with appropriate clinico-radiological features and characteristic cytological findings.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"41 4","pages":"214-220"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Renal Tumors Other Than Renal Cell Carcinoma with Emphasis on Cytomorphological, Immunohistochemical, and Cytogenetic Study.","authors":"Soumya Alashetty, Priya Dharmalingam, Sindhu Ramamurthy, Bidadi Lingappa Kavitha, Siddappa Shanthala, Rajasab Subhan Ali","doi":"10.4103/joc.joc_162_23","DOIUrl":"10.4103/joc.joc_162_23","url":null,"abstract":"<p><strong>Background: </strong>The role of fine needle aspiration cytology (FNAC) in the diagnosis of renal malignancies is established and has been getting more precise and important over a period of time. Knowledge of the pathology of uncommon renal neoplasms along with radiological and clinical correlations often aids in correct diagnosis.</p><p><strong>Aims: </strong>The present study aims to describe the cytomorphological and immunohistochemical findings in the varied spectrum of renal tumors, other than renal cell carcinomas (RCC).</p><p><strong>Materials and methods: </strong>Data of 238 cases of ultrasound-guided renal FNAC performed in our tertiary cancer institute over 4 years were collected from the department registry. All nondiagnostic cases and cases diagnosed as RCC were excluded from the study, so 57 cases of renal tumors were reviewed along with the cell blocks and ancillary studies.</p><p><strong>Results: </strong>Out of the 57 cases, 35 cases were primary renal neoplasms, which included renal oncocytoma (3.5%), angiomyolipoma (3.5%), rhabdoid tumor (1.8%), Wilms tumor (28.0%), Ewing sarcoma (3.5%), urothelial carcinoma (8.8%), and small round cell tumor unclassified (12.3%). Twenty two cases were metastatic tumors, which included hematolymphoid neoplasm (14%) and metastatic carcinomas (24.6%) from various other primary carcinomas.</p><p><strong>Conclusion: </strong>Our study shows that renal FNAC is safe and fairly accurate in diagnosing a wide spectrum of renal tumors and has high diagnostic accuracy, when performed along with cell block and immunohistochemistry. Awareness of the pathology of uncommon renal tumors along with relevant clinical history and radiological findings may aid in identifying the type of tumor for further appropriate management.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"41 4","pages":"192-200"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Sydney System for Classification and Reporting Lymph Node Cytopathology to Assess the Risk of Malignancy and its Diagnostic Accuracy.","authors":"Sudipta Das, Aseema Das, Bandita Das","doi":"10.4103/joc.joc_168_23","DOIUrl":"10.4103/joc.joc_168_23","url":null,"abstract":"<p><strong>Background: </strong>Fine-needle aspiration cytology (FNAC) of the lymph nodes is the first-line evaluation of lymphadenopathy of unknown etiology. For better diagnostic clarity and proper communication to clinicians, the Sydney System was proposed in 2020 for the performance, classification, and reporting of lymph node cytopathology. The present study was conducted to analyze the diagnostic performance and risk of malignancy (ROM) associated with each of the diagnostic categories of the proposed Sydney System.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted over 2 years. All patients with lymphadenopathy undergoing FNAC during the study period for which subsequent histopathological examination (HPE) reports or clinical follow-up data were available were included in the study. The original diagnoses were reviewed, and each case was assessed according to the first diagnostic level of the Sydney System classification. The diagnostic accuracy and ROM were correlated with FNAC diagnoses. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of lymph node FNAC were calculated using SPSS version 20.0.</p><p><strong>Results: </strong>A total of 456 out of 753 cases were selected in the study as they had subsequent histopathological correlation and/or clinical follow-up data. The majority were females <i>n</i> = 294 (64.4%). The most common lymph node was the cervical group (<i>n</i> = 274, 60%).</p><p><strong>On statistical analysis: </strong>sensitivity 82.8%, specificity 97.5%, PPV 95.3%, NPV 90.1%, and diagnostic accuracy 92%.</p><p><strong>Conclusion: </strong>The sydney system, which introduces a uniform categorization, may increase the lymph node FNAC diagnostic accuracy.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"41 4","pages":"201-206"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Algorithmic Approach to Defining Variants of Papillary Thyroid Carcinoma: Accuracy of Fine Needle Aspiration Cytology.","authors":"Neha Nigam, Neha Kumari, Rishabh Sahai, Nandita Chaudhary, Sabaretnam Mayilvaganan, Pallavi Prasad, Prabhakar Mishra","doi":"10.4103/joc.joc_19_24","DOIUrl":"10.4103/joc.joc_19_24","url":null,"abstract":"<p><strong>Introduction: </strong>Among thyroid malignancies, papillary thyroid carcinoma (PTC) is the most common, with the classical variant being the most common subtype. Some histological variants have aggressive behavior, advanced presentation stages, poor clinical outcomes, and may require additional therapy. Due to overlapping cytologic features and heterogeneity of lesions, the PTC classification is not adhered to in conventional reporting practice. This study aimed to classify the PTC cytology cases into a particular cytological variant by applying an algorithmic approach and correlating these variants with histology.</p><p><strong>Materials and methods: </strong>An analysis of all histopathologically confirmed cases of PTC who had previously been diagnosed with fine needle aspiration cytology (FNAC) from January 2014 to December 2019 was conducted. FNAC samples of thyroid nodules were blindly reviewed and classified into different morphological variants using a stepwise algorithmic approach based on architectural, nuclear, and cytoplasmic features.</p><p><strong>Results: </strong>A review of 77 histologically proven cases of PTC variants or with a predominant area of variant histomorphology was done. One case was inadequate (TBSRTC I), nine cases were benign (TBSRTC II), two were follicular lesions of undetermined significance (TBSRTC III), and 65 cases were suspicious or definite for PTC (TBSRTC V/VI). Retrospective algorithmic cytopathological analysis of 65 cases that are suspicious or definite of PTC (TBSRTC V/VI) showed classical PTC (5), follicular variant-PTC (35), tall cell variant (20), diffuse sclerosing variant (1), warthin-like variant (2), and solid variant (2). Diagnostic accuracy of cytopathology in diagnosing the PTC variants when compared with histopathological diagnosis varied from 81.3% to 100% (mean 78.9%). Cluster analysis justified that our classification showed good agreement with the actual classification based on the cytopathological features identified by the cluster analysis.</p><p><strong>Conclusion: </strong>An awareness of cytomorphological features of aggressive variants may facilitate early and accurate diagnosis and appropriate clinical management with better patient outcomes. FNAC can subclassify PTC into different variants based on this algorithmic approach or aggressive and nonaggressive variants based on certain more frequently observed features.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"27-36"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Cells Out for a Swim! A Study on Myelomatous Involvement of Effusion Fluid and Cerebrospinal Fluid: A 10-Year Experience from a Tertiary Cancer Center.","authors":"Sayantan De, Satarupa Samanta, Majal Shah","doi":"10.4103/joc.joc_87_24","DOIUrl":"10.4103/joc.joc_87_24","url":null,"abstract":"<p><strong>Background: </strong>Multiple myeloma (MM), a hematological malignancy marked by clonal plasma cells in the bone marrow, occasionally presents with myelomatous effusion-a rare condition with a median survival of <4 months. Central nervous system involvement (CNS-MM), characterized by plasma cell infiltration in the CNS, leptomeninges, or cerebrospinal fluid (CSF), is similarly rare and associated with dismal outcomes.</p><p><strong>Aims: </strong>To analyze the plasma cell involvement in body fluids and CSF in plasma cell neoplasms, correlating these findings with treatment strategies and patient outcomes.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted in the Oncopathology Department of a tertiary state cancer institute over 10 years (2013-July 2024). It included cases of plasma cell neoplasms with confirmed involvement of body cavity fluids or CSF. Data reviewed included epidemiological profiles, biochemical and hematological findings, immunohistochemistry results, treatment regimens, and follow-up information.</p><p><strong>Results: </strong>A total of 16 cases demonstrated neoplastic plasma cell involvement: 12 cases in pleural fluid and 4 cases in CSF. Of these, nine cases were diagnosed with MM, five cases with plasmacytoma, and two cases with plasma cell leukemia. Treatment included chemotherapy (10 patients), palliative radiotherapy (4 patients), combined palliative radiotherapy and chemotherapy (1 patient), and curative radiotherapy with chemotherapy (1 patient). Despite these interventions, the mean survival was only 2 months.</p><p><strong>Conclusion: </strong>Myelomatous involvement of effusion fluids and CSF is associated with a grim prognosis. These findings underscore the urgent need for multidisciplinary research and the development of innovative therapeutic strategies to improve outcomes for these patients.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"48-53"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ProExC and p16ink4a Biological Markers in Lesional Smears With the Immunocytochemical Method and Relationship With Human Papillomavirus in Liquid-based Cervicovaginal Specimens.","authors":"Zeynep Turkmen Usta, Zeynep Sagnak Yilmaz, Safak Ersoz, Sevdegul Aydin Mungan, Umit Cobanoglu, Suleyman Guven","doi":"10.4103/joc.joc_57_24","DOIUrl":"10.4103/joc.joc_57_24","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the determination of human papillomavirus (HPV) types in smears with and without lesions, and the sensitivity, specificity, positive predictive value, and negative predictive value of the ProExC and p16 biomarkers in smears with lesions.</p><p><strong>Materials and methods: </strong>A total of 192 cervicovaginal smears were included in the study. ProExC (BD) and p16ink4a antibodies were applied to the lesion-containing samples by immunocytochemical method. If HPV was present, its type was determined. Patient biopsy specimens were used as a gold standard to confirm the lesion type. In addition, atypical squamous cells of undetermined significance, low-grade squamous intraepithelial lesion (SIL), atypical squamous cells, cannot exclude high-grade SIL (HSIL), and HSIL, atypical glandular cells, and the relationship between two biomarkers in cases diagnosed with squamous cell carcinoma were investigated.</p><p><strong>Results: </strong>Of these, 192 cases included in our study, 119 had lesional smears and 73 had no lesional cells. Of the 191 cases in which HPV was investigated, 105 were negative and 86 were positive for HPV types 16, 18, and others. A statistically significant difference was found between HPV positivity and smears with lesions (<i>P</i> = 0.0001). p16 and ProExC positivity was extensive in cases with more severe lesions. A strong correlation was observed between high-risk HPV (+) and HSIL-detected cases.</p><p><strong>Conclusion: </strong>ProExC and p16 are biomarkers that facilitate the diagnosis of HSIL. Nuclear staining for the ProExC marker is easier to apply to cytological samples than p16.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"20-26"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic Neutrophilic Granulomatous Mastitis: A Cytological Evaluation.","authors":"Aatish Saraswat, Vikram Singh, Chinmay Shrikrishna Pendharkar, Somasundaram Venkatesan","doi":"10.4103/joc.joc_47_24","DOIUrl":"10.4103/joc.joc_47_24","url":null,"abstract":"","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"54-56"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FNAC Diagnosis Giant Cell Reparative Granuloma of the Orbit Masquerading as Malignancy.","authors":"Subhashini Ramamoorthi, Vidya Vikasini Balasubramaniam, Disha Agarwal, Nirupama Kasturi, Debasis Gochhait","doi":"10.4103/joc.joc_167_23","DOIUrl":"10.4103/joc.joc_167_23","url":null,"abstract":"","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"57-60"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Second Edition of the Milan System for Reporting Salivary Gland Cytopathology: System Application, Outcome, and Cytohistological Correlation.","authors":"Magdalena Onyszczuk, Bogna Drozdzowska","doi":"10.4103/joc.joc_24_24","DOIUrl":"10.4103/joc.joc_24_24","url":null,"abstract":"<p><strong>Background: </strong>Fine needle aspiration (FNA) cytology for salivary gland lesions is sensitive and specific for diagnosing and treating salivary gland pathologies. The objective of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is to organize the diagnostic information from the FNA into a uniform reporting terminology.</p><p><strong>Aims: </strong>The study was conducted retrospectively to reclassify previous diagnoses into the MSRSGC categories to determine the cytohistological concordance and assess the risk stratification by calculating the risk of malignancy (ROM) for different categories.</p><p><strong>Materials and methods: </strong>A total of 248 FNA cases of salivary gland lesions were analyzed and reclassified according to the second edition of the MSRSGC. The histological diagnosis was considered the gold standard. The ROM for each category was calculated based on 101 histopathologic follow-up cases.</p><p><strong>Results: </strong>Of the 248 patients, 1.2% were classified as nondiagnostic, 37.9% as nonneoplastic, 1.2% as atypia of undetermined significance (AUS), 52.8% as benign neoplasm, 0.4% as uncertain malignant potential (SUMP), 0.4% as suspicious of malignancy (SFM), and 6.1% as malignant neoplasm. Histopathological correlation was available in 101 cases. The ROM was 0% for nonneoplastic lesions and benign neoplasms, and 100% for AUS, SUMP, SFM, and malignant categories. The sensitivity, specificity, positive predictive value, and negative predictive value of FNA cytology in diagnosing salivary gland lesions using MSRSGC were found to be 76.5%, 100%, 100%, and 95.3%, respectively.</p><p><strong>Conclusion: </strong>The use of the MSRSGC helps in triaging patients with salivary gland lesions, increases the effectiveness of communication between clinicians and pathologists, and thus facilitates individualized patient management.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"1-10"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}