Journal of Cytology最新文献

{"title":"Accuracy of Bronchial Cytological Diagnosis in Lung Lesions in Comparison with Histopathology.","authors":"Shreya Goel,&nbsp;Sunil K Yeshvanth,&nbsp;Ritu Asnani,&nbsp;Divya Joshi","doi":"10.4103/joc.joc_44_22","DOIUrl":"10.4103/joc.joc_44_22","url":null,"abstract":"<p><p>The incidence of lung cancer has been increasing in the recent years. Bronchial cytology using Papanicolaou society of cytopathology (PSC) system is an effective method for triaging patients. The present study attempts to evaluate the bronchial cytological diagnosis with histopathological correlation of lung lesions.</p><p><strong>Aims: </strong>i. To study the cytological features of lung lesions. ii. To assess the sensitivity, specificity, and diagnostic accuracy of bronchial cytology of lung lesions in comparison with histopathology.</p><p><strong>Settings and design: </strong>Prospective study at the tertiary care hospital.</p><p><strong>Methods and material: </strong>It included 63 cases of lung lesions, evaluated using the PSC system for reporting respiratory cytology. The cytological diagnosis was correlated with the final histopathological diagnosis. The study was conducted between January 2019 and June 2020.</p><p><strong>Statistical analysis used: </strong>SPSS 20.0 software.</p><p><strong>Results: </strong>The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of bronchial cytology was 60%, 89%, 90%, 58.62%, and 71.42%, respectively.</p><p><strong>Conclusions: </strong>Bronchial cytology including bronchial wash, bronchial brush, endobronchial ultrasound/transbronchial needle aspiration, and computerized tomography-guided fine needle aspiration cytology can be used to increase the sensitivity and specificity for definitive diagnosis and better management.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 4","pages":"163-168"},"PeriodicalIF":1.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10493312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar Rhabdomyosarcoma with CD 56 Positivity: A Mimic of Extranodal NK/T Cell Lymphoma.","authors":"Uma Kumar,&nbsp;Abhijit Das,&nbsp;Rani Sahu,&nbsp;Pinky Kachhap","doi":"10.4103/joc.joc_211_21","DOIUrl":"10.4103/joc.joc_211_21","url":null,"abstract":"","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 4","pages":"190-192"},"PeriodicalIF":1.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10488595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Cervical HPV Infection and Genotype Distribution in 856,535 Chinese Women with Normal and Abnormal Cervical Lesions: A Systemic Review.","authors":"Yan-Qin Yu,&nbsp;Jin-Qi Hao,&nbsp;Maria J G Mendez,&nbsp;S Bangura Mohamed,&nbsp;Shi-Lan Fu,&nbsp;Fang-Hui Zhao,&nbsp;You-Lin Qiao","doi":"10.4103/joc.joc_42_22","DOIUrl":"10.4103/joc.joc_42_22","url":null,"abstract":"<p><p>Cervical cancer is the commonest cancer affecting women worldwide. During the last decades, the incidence and mortality rates of cervical cancer have increased in China. This research aims to assess the overall and genotype-specific prevalence of the human papillomavirus (HPV) infection among Chinese women with normal cervix, considering age, and geographic location. We selected studies about HPV prevalence in women from Chinese in Mainland China with normal cervix and abnormal cervical lesions, published between January 1995 and December 2020. The HPV prevalence was analyzed using meta-analysis based on the following: cytological and histological diagnoses, regions, and ages. The overall HPV prevalence in 856,535 women was 14.3%, 95% confidence interval (CI) and it increased from 8.2% to 16.5% in studies published from 2006 to 2020. The prevalence of high-risk (HR) and low-risk (LR) HPV types was 11.3% and 2.7%, respectively. The commonest types of HPV in women from Mainland China were HPV 16 (2.6%), 52 (2.4%), 58 (1.7%), 18 (0.9%), and 33 (0.8%). According to the geographical analysis, the prevalence of different HPV genotypes varied by region, Central China had the highest overall HPV prevalence. HPV16 was the commonest type in all the regions except in South China and East China, where HPV52 was found to be common. Regarding diagnosis, the HPV infection led to cervical cancer diagnosis by cytology and histology with 90.1% and 91.5% rates, respectively. HPV16 and HPV18 were common types associated with cervical cancer diagnosed by cytology and histology. HPV 16, 58, 52, 18, and 33 were the commonest types found in women with normal cervixes from Mainland China. The prevalence of different HPV genotypes varied by age group and region.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 4","pages":"137-147"},"PeriodicalIF":1.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10493306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nalini Bai Thakkar Award","authors":"","doi":"10.4103/0970-9371.359848","DOIUrl":"https://doi.org/10.4103/0970-9371.359848","url":null,"abstract":"","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 1","pages":"S1 - S6"},"PeriodicalIF":1.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44250389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytological Diagnosis of Malignant Mesothelioma: A Case Series.","authors":"Sakshi Dahiya,&nbsp;Meeta Singh,&nbsp;Shyama Jain,&nbsp;Bembem Khuraijam,&nbsp;Naman Suroya,&nbsp;Shramana Mandal","doi":"10.4103/joc.joc_145_21","DOIUrl":"https://doi.org/10.4103/joc.joc_145_21","url":null,"abstract":"<p><strong>Background: </strong>Mesotheliomas are neoplasms of the serosal lining of the body cavities. Diagnosis requires a multimodal approach of clinical findings, cytology, and histopathology with immunohistochemistry (IHC). The published sensitivity of cytology for diagnosing mesothelioma ranges from 30% to 75%.</p><p><strong>Aim and objectives: </strong>This study aimed to calculate the incidence of malignant mesothelioma (MM) at our institute and to study the cytological features of MM.</p><p><strong>Materials and methods: </strong>A retrospective study of pleural, peritoneal, and pericardial fluids submitted at our institute was done. The duration of the study was 8 years (2011-2019). Apart from examining Giemsa smears, a panel of immunocytochemical (ICC) and cell block immunohistochemical (IHC) markers was applied to achieve the diagnosis. These included calretinin, mesothelin, CK5/6, Hector Battifora mesothelial cell antibody (HBME), WT1, MOC31, CK7 and CK20. Histopathological correlation was done wherever possible.</p><p><strong>Result: </strong>In the present study, we compiled four cases of MM over 8 years diagnosed on serous effusion cytology and confirmed by immunocytochemistry (ICC)/cell block immunohistochemistry (IHC)/biopsy. This indicates a rare incidence of MM. The Cytological features of MM were studied.</p><p><strong>Conclusion: </strong>The diagnosis of MM is difficult, especially cytologically. It was found to be a rare entity in the malignant cases diagnosed on effusion cytology.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 3","pages":"105-109"},"PeriodicalIF":1.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FNA Unravelling the Mystery Behind the Cheek Mass to Pivot to a Diagnosis of a Primary Extracranial-Extraspinal-Meningioma with Intracranial Component.","authors":"Megha Murali,&nbsp;Ashitha Nanaiah,&nbsp;C P Arpitha,&nbsp;V Srinivas,&nbsp;Usha Kini","doi":"10.4103/joc.joc_84_21","DOIUrl":"https://doi.org/10.4103/joc.joc_84_21","url":null,"abstract":"","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 3","pages":"131-133"},"PeriodicalIF":1.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CSF Involvement by Nonhematolymphoid Malignancies: A Descriptive Study with Emphasis on Cytomorphological Clues.","authors":"Vidhya Vikashini Balasubramaniam,&nbsp;Saranya Mohan,&nbsp;Suganya Kuppovi Reddy,&nbsp;Jinkala Sree Rekha,&nbsp;Debasis Gochhait,&nbsp;Neelaiah Siddaraju","doi":"10.4103/joc.joc_66_22","DOIUrl":"https://doi.org/10.4103/joc.joc_66_22","url":null,"abstract":"<p><strong>Introduction: </strong>Detection of malignant cells in cerebrospinal fluid (CSF) samples in suspected cases of malignancy is critical for the management of patients. CSF involvement by nonhaematolymphoid malignancies is less common. We aimed to study the cytomorphologic characteristics of various nonhaematolymphoid malignancies in CSF.</p><p><strong>Methods: </strong>A retrospective cytomorphological analysis of 27 CSF cytology smears reported as positive or suspicious for nonhematolymphoid malignancies from January 2010 to April 2020 over 10 years was carried out. Smears in all cases were prepared by cytospin technique and stained with May-Grunwald-Giemsa (MGG) and papanicolaou (Pap) staining procedures. Cell immunohistochemistry/immunocytochemistry was done wherever cell block/extra slides were available.</p><p><strong>Results: </strong>Twenty-four of 27 cases were interpreted as \"positive,\" while three were reported as \"suspicious\" of malignancy. Nineteen of 27 cases were metastatic adenocarcinomas including three suspicious malignancy cases with the primary sites of origin being the breast (10), stomach (2), rectum (1), gall bladder (1), lung (1), and four cases of unknown primary. Of the remaining positive cases, there were five cases of metastatic medulloblastoma, two cases of metastatic pineoblastomas, and one case of metastatic extraskeletal Ewings sarcoma. Each of these metastatic malignancies had at least a single diagnostic cytomorphological clue, similar to those observed in other body cavities and primary malignancy sites.</p><p><strong>Conclusion: </strong>Nonhematolymphoid malignancies are readily diagnosable on CSF cytology, most of them are metastatic. Identification of malignant cells in CSF is critical, as it has therapeutic and prognostic implications.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 3","pages":"126-130"},"PeriodicalIF":1.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reclassification of Salivary Gland Aspirates Based on \"The Milan System for Reporting Salivary Gland Cytology\": A Five-Year Retrospective Study.","authors":"Saloni Pahwa,&nbsp;Poonam Panjwani,&nbsp;V Gnanapriya","doi":"10.4103/joc.joc_106_21","DOIUrl":"https://doi.org/10.4103/joc.joc_106_21","url":null,"abstract":"<p><strong>Introduction: </strong>The Milan System for reporting salivary gland cytopathology helps standardize reporting systems across institutions, improve communication between clinicians and pathologists and guide the clinical management of patients.</p><p><strong>Aims: </strong>This study was undertaken to evaluate the utility of the Milan system classification in cytology reporting.</p><p><strong>Settings and design: </strong>The present study is a retrospective study conducted over a period of five years in tertiary care centre.</p><p><strong>Methods and materials: </strong>All the cases of salivary gland aspirates were reviewed and reclassified into six diagnostic categories according to the Milan system of reporting salivary gland cytology (MSRSGC). Cytological diagnosis was correlated with the histopathological diagnosis wherever available.</p><p><strong>Results: </strong>A total of 258 cases were classified using the Milan system as non-diagnostic (20.9%), non-neoplastic (26.3%), atypia of undetermined significance (4.7%), neoplasm benign (37.5%), neoplasm of uncertain malignant potential (3.5%), suspicious for malignancy (0.4%), and malignancy (6.6%). Cytohistological discordance was noted among 8/76 cases (10.5%). The sensitivity and specificity of FNAC were 75% and 98.5%, respectively. The risk of malignancy was 14.2% for Category I, 9% for II, 50% for III, zero for IVA and IVB, and 83.3% for category VI.</p><p><strong>Conclusions: </strong>The new classification system helps pathologists to standardize reporting leading to better clinical and surgical management.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 3","pages":"98-104"},"PeriodicalIF":1.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Lung Adenocarcinoma with Clear Cell Features in Pleural Effusion: Cytomorphologic Features, Immunocytochemical Studies, and Differential Diagnosis.","authors":"Senay Erdogan-Durmus,&nbsp;Ozden Yulek,&nbsp;Zeynep Betul Erdem","doi":"10.4103/joc.joc_48_22","DOIUrl":"https://doi.org/10.4103/joc.joc_48_22","url":null,"abstract":"<p><p>Clear cell adenocarcinoma (CCA) of the lungs is no longer referred to as a subtype in recent classifications of lung adenocarcinoma. Like signet ring features, clear cell features are regarded as cytological features rather than histological subtypes. Additionally, in serous fluids, adenocarcinoma metastasis with clear cell features is a diagnostic challenging entity due to other tumors that come to mindfirst during the differential diagnosis. Here we report a case, diagnosed as CCA of lung metastasis in pleural fluid and evaluated its differential diagnosis.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 3","pages":"134-136"},"PeriodicalIF":1.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Fine-Needle Aspiration Cytology, Cell Block Cytology, and Histopathology in the Diagnosis of Thyroid Lesions.","authors":"Mohit Jambhulkar,&nbsp;Jasvinder K Bhatia,&nbsp;Samresh K Singh","doi":"10.4103/joc.joc_80_21","DOIUrl":"https://doi.org/10.4103/joc.joc_80_21","url":null,"abstract":"<p><strong>Context: </strong>Fine-needle aspiration cytology is considered the gold standard screening test in the evaluation of a thyroid nodule. We studied whether cell block cytology can be used in addition to conventional smears for the evaluation of tissue from fine-needle aspirations or fluid aspirations and also compared it with histopathological diagnosis.</p><p><strong>Aims: </strong>The primary aim of this study was to know the utility of cell blocks in the diagnosis of thyroid lesions.</p><p><strong>Settings and design: </strong>This was a prospective observational study conducted from June 2018 to September 2020 at a tertiary Care Hospital in Eastern India. Ethical approval was obtained from the Ethics Committee of the institution. Patients above 18 years who presented with goiter were included in the study. Thirty patients were enrolled in the study after informed consent.</p><p><strong>Methods and material: </strong>Smears prepared from the aspirates were stained with Leishman-Giemsa (LG) and Pap stain. The remnant from the needle hub was transferred to a sterile container. Cell blocks were prepared from the remnants. Smears were scored based on cell obscuration by blood, cellularity, cell degeneration, and cell architecture. The results were compared with histopathology.</p><p><strong>Statistical analysis used: </strong>Data were recorded using Microsoft Excel. Descriptive statistics, frequency, and proportion were used to describe demographic variables.</p><p><strong>Results: </strong>The majority of the patients (23.3%) were in their third decade of life, followed by 16.7% of the patients in their fourth and fifth decades. The patient age ranged from 25 to 80 years, with a mean age of 50.83 years and a standard deviation of 16.72. The largest number of patients were females accounting for 80% (24/30) of the total participants. The majority of the patients (36.7%) (11/30) had thyroid gland enlargement for a period of 15 days to three months. 14% of the participants were not able to recall its duration. The majority (60%) (18/30) had left lobe lesions, followed by 33.3% (10/30) who had right lobe lesions, and 6.7% (2/30) who had bilateral lobe swelling. The mean size of the lesion was 2.84 cm. 50% were found to be Bethesda II lesions, while 13.3% were Bethesda IV, and 36.7% were found to be Bethesda VI lesions. The cell block score (7) was found to be better compared to Fine Needle Aspiration Cytology (FNAC) (4.7). Tissue Coagulum Clot and Clot Scrape methods were found to yield better results compared to the Cytocentrifuge method. The <i>P</i> value was found to be significant (<0.001).</p><p><strong>Conclusions: </strong>Cell blocks were found to improve the cell morphology compared to FNAC alone and can be used as an adjunct to FNAC in the diagnosis of various thyroid lesions.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"39 3","pages":"91-97"},"PeriodicalIF":1.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}