Journal of Cytology最新文献

{"title":"Evaluation of Fine-Needle Aspiration of Lymph Nodes and Assessment of Risk of Malignancy Based on the Sydney System of Reporting Lymph Node Cytology.","authors":"Shreshtha Ghosh, Priyadarshini Guha, Shweta Verma, Neelima Gupta, Jitendra Kumar Vimal, Pallavi Prasad, Gitika Pant","doi":"10.4103/joc.joc_20_24","DOIUrl":"10.4103/joc.joc_20_24","url":null,"abstract":"<p><strong>Background: </strong>Fine-needle aspiration cytology (FNAC) being the first-line of technique is considered the most popular method for diagnosing lymphadenopathy. Diagnosis of a lymph node lesion is challenging due to the vast diversity in lymph node cytology. There has been a lack of standard guidelines for cytopathological reporting of lymph nodes. Sydney System has been recently proposed to provide consensus guidelines for the classification and reporting of lymph node FNAC and to maintain uniformity in reporting.</p><p><strong>Aims: </strong>The present study aimed to analyze the utility of the proposed Sydney System.</p><p><strong>Materials and methods: </strong>We retrospectively studied lymph node FNAC cases which were retrieved from hospital records with relevant clinical and radiological details along with the histopathological follow-up to assess the risk of malignancy in each category.</p><p><strong>Results: </strong>A total of 1572 cases from lymph nodes were reclassified according to the Sydney System. The most common site was cervical lymph nodes followed by intrabdominal, mediastinal, inguinal, and axillary. The risk of malignancy was found to be highest for category V (93.5%) and least for category II (13.7%) followed by category IV (66.6%), category III (33.3%), and category I (25%). The diagnostic accuracy of our study was 90.1%.</p><p><strong>Conclusions: </strong>The proposed Sydney System is helpful in the systematization and standardization of lymph node FNA diagnosis and reporting. It provides increased efficacy in clinical management with enhanced communication between clinicians and cytopathologists. Moreover, clinical practice would also benefit from management recommendations specific to diagnostic categories with increasing risk of malignancy.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"11-19"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of High-risk Human Papillomavirus Genotypes in Cervical Smear Samples and Evaluation of ASC-US, LSIL, and HSIL Results.","authors":"Eylul Beren Tanik, Ayfer Bakir, Tugba Taskin Turkmenoglu, Gul Erdem","doi":"10.4103/joc.joc_70_24","DOIUrl":"10.4103/joc.joc_70_24","url":null,"abstract":"<p><strong>Context: </strong>High-risk human papillomavirus (hrHPV) is the most common viral pathogen responsible for cervical cancers. Determining the rates of HPV positivity, genotypic distribution, and obtaining regional epidemiological data can provide guidance for preventive strategies.</p><p><strong>Aims: </strong>This study aims to assess HPV positivity rates, age distribution, genotyping in abnormal cytologies, and then obtain regional epidemiological data.</p><p><strong>Settings and design: </strong>Descriptive study.</p><p><strong>Materials and methods: </strong>This study included 3510 women aged ≥18, whose cervical smear samples were examined at the Microbiology Laboratory. HPV detection and genotyping in cervical smear samples were performed using the polymerase chain reaction (PCR) method. Pap smears were evaluated according to the Bethesda system.</p><p><strong>Statistical analysis used: </strong>SPSS 23 (IBM Corp.) software was utilized for the statistical analysis of the data.</p><p><strong>Results: </strong>The positivity rate for hrHPV infection was 10%. The most common genotype was other hrHPV. The rate of multiple hrHPV positive infections was 13.6%. The highest hrHPV positivity was observed in the age group ranging from 18 to 24 age group (28.7%). HPV infections were higher in abnormal cytologies (<i>P</i> < 0.001), with the highest positivity in LSIL (<i>P</i> < 0.001). The risk of having LSIL and HSIL cytology in HPV-positive individuals was 32.59 times higher than that in HPV-negative individuals (OR = 32.59; 95% CI 16.42-64.66).</p><p><strong>Conclusions: </strong>The hrHPV positivity was 10%, with other hrHPV strain infections being the most detected, followed by HPV 16. Due to the high detection of other hrHPV strain positivity in patients with abnormal cytology, conducting regional studies determining each hrHPV type separately, monitoring the natural course of infection with types other than HPV 16 and HPV 18, and benefiting vaccine studies are considered essential.</p>","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"42 1","pages":"37-42"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Study on Micronuclei and Metanuclear Abnormalities in Exfoliated Buccal Cells of COVID-19 Suspected Patients","authors":"B. Vishnu, Senthil Murugan, V. Kalidoss, Kishore Sesham, Sarah Ramamurthy, S. S. Bakshi, Yuvaraj M. Francis, Sankaran Ponnusamy Kasirajan","doi":"10.4103/joc.joc_53_23","DOIUrl":"https://doi.org/10.4103/joc.joc_53_23","url":null,"abstract":"SARS-CoV-2 virus causes COVID-19 by infecting nasal and oral cavities primarily by attaching its spike proteins to ACE 2 receptors expressed in epithelial cells. This study was done to evaluate the micronucleated cell count, metanuclear abnormalities, and genotoxic factor in exfoliated buccal mucosal cell among the COVID-19 suspected patients. This cross-sectional study was conducted at AIIMS, Mangalagiri, between August and October 2022. One hundred COVID-19 suspected patients were recruited for this study after obtaining informed and written consent; buccal smear was obtained and stained for papanicolaou test (PAP). The PAP-stained slides were analyzed for micronuclei (MN), pyknotic, karyolytic, and karyorrhexic cell count, respectively. Based on their reverse transcription-polymerase chain reaction (RT-PCR) report, the patients were grouped into COVID-19 positive and negative groups. The genotoxicity factor was calculated using the micronucleated cell count from both the groups using mean and standard deviation. The MN, micronucleated cell, pyknotic, karyolitic, and karyorrhexic cell count in COVID-19 positive patients were 24.12, 15.24, 3.08, 2.88 and 4.40, respectively, than COVID-19 negative patients 5.69, 8.17, 1.08, 1.00 and 2.43, respectively. The genotoxicity factor for SARS-CoV-2 was 2.68 which is a positive genotoxic effect on buccal mucosal cells. SARS-CoV-2 increases the expression of micronucleated cells, pyknotic cells, karyolytic cells, and karyorhexic cells and concludes SARS-CoV-2 is having cytogenotoxic effect on the buccal mucosal cells. This can be used as a reliable marker in identifying the early carcinogenic effects of virus causing COVID-19.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"22 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomorphologic Features of Orbital Myeloid Sarcoma – A Rare Case and Diagnostic Clue","authors":"Niraj Prasad, Ummiti Muniswari, Pritinanda Mishra, Pradeep Pradhan, M. Sethy, Chinmayee Panigrahi, P. Ayyanar","doi":"10.4103/joc.joc_65_23","DOIUrl":"https://doi.org/10.4103/joc.joc_65_23","url":null,"abstract":"","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"54 10","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of Imprint Cytology for the Rapid Diagnosis of Mucormycosis in the COVID-19 Pandemic Setting – A Pilot Study","authors":"Varna Menon, Ahmed Al Salami, Maryam Al Balushi, Faisal Israr, Noora Al Balushi, Sheikha Al Anboori","doi":"10.4103/joc.joc_81_22","DOIUrl":"https://doi.org/10.4103/joc.joc_81_22","url":null,"abstract":"The second wave of the coronavirus disease 2019 (COVID-19) pandemic recorded a surge in rhino-orbital-cerebral mucormycosis (ROCM) infection in COVID-19-positive patients with diabetes and on concomitant steroid therapy. The rapidly progressive and devastating nature of the disease necessitated prompt diagnosis and early intervention to improve patient outcomes. Histopathology and fungal culture remain essential tools; however, these investigations have long and variable turn-around times (TATs) and may delay the initiation of treatment. Frozen section is not widely available and should be avoided in COVID-19-positive cases due to the risk of aerosol production and droplet exposure. In cases with high clinicoradiologic suspicion for mucormycosis, imprint cytologic evaluation provides a rapid diagnosis. Familiarity with fungal cytomorphology, awareness of morphologic pitfalls, and implementation of a standardized reporting format aid in diagnostic accuracy. Eighteen COVID-19-positive patients, who were admitted to our hospital with clinical suspicion of mucormycosis during June and July 2021, were included in the study. We used nasal or oral imprint cytology for the initial, rapid detection of Mucor. Cytology findings were correlated with histopathology and fungal culture results. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. The sensitivity, specificity, PPV, and NPV were 100%, 100%, 100% and 100%, respectively. This study showed that imprint cytology can be a rapid, cost-effective, first-line diagnostic modality in Mucor diagnosis.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucormycosis: Cytomorphological Spectrum in Fine-Needle Aspiration Cytology","authors":"Malvika Shastri, Radhika Srinivasan, R. Kundu, Pranab Dey, Nalini Gupta, Parikshaa Gupta, Manish Rohilla, Mandeep Kang, Naveen Kalra, H. Kaur, S. Rudramurthy","doi":"10.4103/joc.joc_107_23","DOIUrl":"https://doi.org/10.4103/joc.joc_107_23","url":null,"abstract":"Mucormycosis is a fungal infection that can affect multiple organs. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is not well documented. The objective of this study was to describe the detailed cytomorphologic features of mucormycosis on FNAC samples. A retrospective analysis of all cases diagnosed as mucormycosis on FNAC between January 2014 and July 2021 was performed for detailed cytomorphological evaluation and correlation to clinical data and microbiological studies wherever available. FNA was computed tomography-guided (n = 38), ultrasonography-guided (n = 31) or palpation-guided (n = 12), and slides were reviewed in two cases. A total of 83 cases of mucormycosis were evaluated. An immunocompromised setting was observed in 48 cases. The most common site of FNA was the lung (n = 57) followed by liver, soft tissue, palate, mediastinum, orbital/ocular region, and lymph node. Isolated renal involvement, a unique feature, was seen in seven cases. The aspirates were necrotic to pus-like or blood-mixed particulate. Broad, nonseptate, foldable, ribbon-like fungal hyphae showing right-angled branching were seen. The tissue reaction was predominantly necro-inflammatory (n = 36), bland necrotic (n = 22), mixed inflammatory (n = 16), suppurative (n = 5), necrotizing granulomatous (n = 3), and granulomatous (n = 1). Immunocompromised patients showed mixed inflammatory responses more frequently. Fungal culture was positive for Rhizopus species in 2/13 cases and molecular testing in two additional cases corresponding to Rhizopus and Syncephalastrum spp. FNA provides quick and conclusive diagnosis of mucormycosis from varied anatomic sites enabling prompt institution of therapy. The tissue response is variable and to some extent dependent on the immune status of the patient.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"61 11","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Circulating Tumor Cells by Cell Block Technique in Malignant Tumors","authors":"Jahnvi Vijay, B. D. Kumar, V. S. Murthy","doi":"10.4103/joc.joc_123_23","DOIUrl":"https://doi.org/10.4103/joc.joc_123_23","url":null,"abstract":"Cancer is a leading cause of death worldwide and is a major cause of morbidity. To deal with this magnitude of cancers and their diagnostic and prognostics, a multitude of prognostic biomarkers for various cancers have been explored over the decades, with detection of circulating tumor cells (CTCs) in the peripheral blood being one of them. This study was undertaken to explore the routine procedure of cell block in the cytopathology lab to isolate and detect CTCs. In this cross-sectional study, 112 peripheral blood samples sent for routine blood investigations of various cancer patients were utilized for the preparation of cell block. The sections from the cell block were stained routinely and evaluated for the presence of CTCs. The statistical analysis was done using Mac Statplus software version 8.0. The malignancies were tabulated as per the International Classification of Diseases for Oncology, third edition (ICD-O-3). The maximum number of cases were from C 50 (breast) - 41/112 (36.6%), followed by C15–C26 (Digestive organs) - 19/112 (16.9%), and C00–C14 (lip, oral cavity, and pharynx) - 18/112 (16.07%) cases. CTC was detected in six (5.35%) out of 112 cases, out of which three were from the breast and one each from category C6.9 (mouth), C32.0 (glottis), and C53.8 (cervix uteri). Among various advanced and molecular techniques available for the detection of CTCs, the cell block technique proves to be one of the effective methods, especially in resource-limited settings as these can further be utilized for additional diagnostic techniques similar to the ones employed for routine paraffin blocks.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"12 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraepithelial Inclusions on Urinalysis Screening among COVID-19 Cases: Are they Covicytes?—A Hospital-Based Cohort Study with Narrative Review","authors":"Pushpanjali R. Ojha, Rakesh Kumar","doi":"10.4103/joc.joc_102_23","DOIUrl":"https://doi.org/10.4103/joc.joc_102_23","url":null,"abstract":"“Intraepithelial inclusions on urinalysis screening among COVID-19 cases: Are they Covicytes?—A hospital-based cohort study with narrative review.” Coronavirus disease 2019 (COVID-19)-associated delayed acute kidney injury (AKI) is often reported in subsequent waves of the pandemic. Early intervention and regular follow-up influence the outcome and inhibit progression into chronic kidney disease (CKD). This is the first study to identify urinary cytomorphological abnormalities ( Covicytes ) and predict COVID-19-associated delayed AKI with a narrative review of the possible etiologies for intraepithelial inclusions. A hospital-based cohort study with a narrative review. Screening urinalysis to assess the cytomorphology of epithelial cells (ECs) and inclusions in Leishman and periodic acid–Schiff (PAS)-stained smears by two independent pathologists was performed in reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases at a tertiary care center. Basic statistical tools were used for descriptive statistical analysis, and data were expressed in mean, proportion, and frequency. Cytomorphological abnormalities (48/188) were predominant among adult males. Leukocyturia (39/48) with positive nitrite test (28/39), high ECs (27/48) and squamous cell-to-tubular EC (SC:TEC) ratio, intraepithelial intracytoplasmic inclusions predominantly in TECs (Covicytes), and multiple well-visualized, perinuclear PAS-negative neutrophilic vacuoles (17/39) were found. The association with preexisting diabetes (31/48), hypertension (10/48), and disease severity was noted. This study reported COVID-19-associated urinary cytomorphological abnormalities and interesting unique inclusions (Covicytes) that may be a result of underlying inflammatory changes, reactive hyperplasia, degenerative changes, or defective endocytosed vacuoles. The possible etiologies for renal inclusions were reviewed. We recommend compulsory baseline and follow-up urinary cytology screening for all COVID-19-suspected patients to detect and predict delayed AKI before clinical and biochemical manifestation during disease endemicity.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"49 11","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environment Friendly Rehydrants for Air-Dried Oral Buccal Smears – A Comparative Study with Conventional Method","authors":"Tanvi Handa, Shally Gupta, Anubha Gulati, Simranjit Singh","doi":"10.4103/joc.joc_98_23","DOIUrl":"https://doi.org/10.4103/joc.joc_98_23","url":null,"abstract":"Cytopathology is defined as a branch of pathology which involves studying diseases and their diagnosis. The conventional method involves fixing the cells in alcohol, but its poor availability in ill-equipped areas can pose problems. One solution to this problem is air-drying of smears followed by rehydration. In this study, we intend to assess the cytomorphologic changes in air-dried smears rehydrated using various agents and to correlate them with the smears prepared using conventional wet technique. Also, we attempt to find the alternative to alcohol which can be used in less equipped areas. Three smears each were prepared from 24 patients (12 healthy and 12 with habits). A total of 72 smears were prepared. One smear from each patient was used as control group (alcohol fixation - total number: 24 smears). The remaining two smears were air-dried and rehydrated and were taken as the test group (test group A - rehydrated with aq. glycerine; total number: 24 smears, test group B - rehydrated with coconut oil; total number: 24 smears) for 5–10 minutes. Then, all 72 slides were stained by standard Papanicolaou stain. The slides were examined for cytomorphologic changes and a score was assigned from 0 to 3. Our study proved aq. glycerine to be a superior rehydrant in comparison to conventional wet fixed smears or coconut oil. Also, in studies where cytoplasmic evaluation is required, coconut oil can be used due to its superior quality.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"17 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Infarcted Breast Lesions on FNAC, a Blustering Fool: Short Case Series","authors":"Sachin R. Chaudhari, N. Meshram, M. Bhatkule, R. Gadkari","doi":"10.4103/joc.joc_88_23","DOIUrl":"https://doi.org/10.4103/joc.joc_88_23","url":null,"abstract":"Fine-needle aspiration cytology (FNAC) is often used as a screening tool. Cytopathologist should be aware of various mimickers of the malignancy. One of these is infarction of benign breast lesions. Careful examination of cytomorphological features will avoid the misdiagnosis of malignancy in such cases. Six cases were diagnosed as benign breast lesion for 4 years and 5 months in our newly established tertiary referral center. Histopathology follow-up was available in one case. Of six cases, three cases (50%) were reported as fibroadenoma with infarction, two cases (33%) as benign breast lesion with infarction favor fibroadenoma, and one as breast lesion with infarction favor phyllodes tumor in view of recurrence. Most were in the second or third decade of their life. All cases showed dyscohesive cells with pyknotic nuclei. Monolayered sheets of necrotic cells were seen in the four cases (66%). Viable cells were seen in four cases. FNAC provides a rapid and accurate diagnosis of benign breast lesions with infarction in the hands of experienced pathologists who can help in better patient care. Small-sized uniform pyknotic nuclei of dyscohesive cells and regular nuclear membranes help to differentiate them from inflammatory and malignant lesions.","PeriodicalId":50217,"journal":{"name":"Journal of Cytology","volume":"47 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}