Journal of Infectious Diseases最新文献_第4页

Impact of Dolutegravir Plus Lamivudine as First-line Antiretroviral Treatment on the Human Immunodeficiency Virus Type 1 Reservoir and Inflammatory Markers in Peripheral Blood. 多罗替韦加拉米夫定作为一线抗逆转录病毒治疗对外周血中 HIV-1 储库和炎症标记物的影响

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae530

Lucía Bailón, Maria C Puertas, Maria C García-Guerrero, Igor Moraes-Cardoso, Ester Aparicio, Yovaninna Alarcón-Soto, Angel Rivero, Elias P Rosen, Jacob D Estes, Julià Blanco, Alex Olvera, Beatriz Mothe, Javier Martinez-Picado, José Moltó

{"title":"Impact of Dolutegravir Plus Lamivudine as First-line Antiretroviral Treatment on the Human Immunodeficiency Virus Type 1 Reservoir and Inflammatory Markers in Peripheral Blood.","authors":"Lucía Bailón, Maria C Puertas, Maria C García-Guerrero, Igor Moraes-Cardoso, Ester Aparicio, Yovaninna Alarcón-Soto, Angel Rivero, Elias P Rosen, Jacob D Estes, Julià Blanco, Alex Olvera, Beatriz Mothe, Javier Martinez-Picado, José Moltó","doi":"10.1093/infdis/jiae530","DOIUrl":"10.1093/infdis/jiae530","url":null,"abstract":"Background: To compare the effects of first-line antiretroviral therapy (ART) with dolutegravir plus lamivudine (DTG + 3TC) versus dolutegravir plus emtricitabine/tenofovir alafenamide (DTG + FTC/TAF) on the human immunodeficiency virus type 1 (HIV-1) reservoir and immune activation biomarkers in people with HIV (PWH).Methods: DUALITY was a 48-week, single-center, randomized, open-label clinical trial in ART-naive PWH, randomized (1:1) to receive ART with DTG + 3TC (2DR group) or DTG + FTC/TAF (3DR group). We measured total and intact proviral HIV-1 DNA, cell-associated RNA in CD4+ T cells, frequency of HIV-infected CD4+ T cells able to produce p24, plasma soluble inflammatory markers, and activation and exhaustion markers in CD4+ and CD8+ T cells.Results: Forty-four participants (22 per study arm) were enrolled, with baseline mean (standard deviation) log10 plasma viral load (pVL) 4.4 (0.7) copies/mL and CD4+ T-cell counts of 493 (221) cells/μL. At week 48, all participants had pVL <50 copies/mL at week 48, except for 1 participant in the 2DR group who was resuppressed after treating syphilis. Changes from baseline in reservoir parameters and immune biomarkers were comparable between groups.Conclusions: First-line ART with DTG + 3TC showed similar reductions of HIV-1 persistence parameters and immune markers as DTG + FTC/TAF, supporting DTG/3TC among preferred first-line ART options for PWH.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"600-610"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccine Effectiveness Against Anal HPV Among Men Who Have Sex With Men Aged 18-45 Years Attending Sexual Health Clinics in 3 United States Cities, 2018-2023. 2018-2023 年在美国三个城市性健康诊所就诊的 18-45 岁男男性行为者接种肛门 HPV 疫苗的有效性。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae394

Carla L DeSisto, Rachel L Winer, Troy D Querec, Damilola Dada, Preeti Pathela, Lenore Asbel, John Lin, Jennifer Tang, Alfred Iqbal, Elissa Meites, Elizabeth R Unger, Lauri E Markowitz

{"title":"Vaccine Effectiveness Against Anal HPV Among Men Who Have Sex With Men Aged 18-45 Years Attending Sexual Health Clinics in 3 United States Cities, 2018-2023.","authors":"Carla L DeSisto, Rachel L Winer, Troy D Querec, Damilola Dada, Preeti Pathela, Lenore Asbel, John Lin, Jennifer Tang, Alfred Iqbal, Elissa Meites, Elizabeth R Unger, Lauri E Markowitz","doi":"10.1093/infdis/jiae394","DOIUrl":"10.1093/infdis/jiae394","url":null,"abstract":"Background: We assessed human papillomavirus (HPV) vaccine effectiveness (VE) against anal HPV among men who have sex with men (MSM) in 2018-2023.Methods: Residual anal specimens from MSM without HIV aged 18-45 years were tested for HPV. We calculated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) for associations between vaccination (≥1 dose) and quadrivalent vaccine (4vHPV)-type prevalence adjusting for city, race/ethnicity, and nonvaccine-type HPV prevalence, stratified by age group (18-26, 27-45 years). VE was calculated as (1 - aPR) × 100.Results: Among 2802 persons aged 18-26, 4vHPV-type prevalence was lower in those vaccinated at age <18 (aPR = 0.13; 95% CI, .08-.22; VE = 87%) and those vaccinated ≥2 years before specimen collection (aPR = 0.52; 95% CI, .42-.64; VE = 48%) compared with unvaccinated persons. Among 3548 persons aged 27-45, 4vHPV-type prevalence was lower in those vaccinated at ages 18-26 (aPR = 0.68; 95% CI, .57-.82; VE = 32%) and those vaccinated ≥2 years before specimen collection (aPR = 0.66; 95% CI, .57-.77; VE = 33%) compared with unvaccinated persons. While we observed no VE in persons vaccinated at age >26 overall, 4vHPV-type prevalence was lower in the subgroup vaccinated ≥2 years before specimen collection (aPR = 0.71; 95% CI, .56-.89; VE = 29%).Conclusions: We found high VE against anal 4vHPV-type prevalence among MSM aged 18-26 who were vaccinated at age <18. Lower VE was observed among MSM aged 27-45 who were vaccinated at age 18-26 or ≥2 years before specimen collection. While ideally vaccination should be given at younger ages, vaccination can prevent some future infections in this population.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"751-761"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Half-life Estimation of Pertussis-Specific Maternal Antibodies in (Pre)Term Infants After In-Pregnancy Tetanus, Diphtheria, Acellular Pertussis Vaccination. 更正：妊娠期内接种破伤风、白喉和无细胞百日咳疫苗后（早产儿）体内百日咳特异性母体抗体的半衰期估计。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae565

引用次数: 0

Impact of Multicohort Human Papillomavirus Vaccination on Cervical Cancer in Women Below 30 Years of Age: Lessons Learned From the Scandinavian Countries. 多队列 HPV 疫苗接种对 30 岁以下女性宫颈癌的影响：斯堪的纳维亚国家的经验教训。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae584

Ståle Nygård, Thea Eline Hetland Falkenthal, Tina Sture, Elsebeth Lynge, Miriam Elfström, Mari Nygård

引用次数: 0

Correction to: Natural Boosting and the Immunogenicity of the XBB.1.5 Monovalent Vaccine in the Coronavirus Disease 2019 Endemic Era: A Longitudinal Observational Study.

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiaf073

引用次数: 0

The ABCDs of Nutritional Assessment in Infectious Diseases Research. 传染病研究中营养评估的 ABCDs。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae540

Lindsey M Locks, Aneri Parekh, Katharine Newell, Madolyn R Dauphinais, Chelsie Cintron, Kimberly Maloomian, Elaine A Yu, Julia L Finkelstein, Saurabh Mehta, Pranay Sinha

引用次数: 0

Effective Real-time Transmission Estimations Incorporating Population Viral Load Distributions Amid SARS-CoV-2 Variants and Preexisting Immunity. 结合 SARS-CoV-2 变体和原有免疫力中的人群病毒载量分布进行有效的实时传播估计。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae592

Yu Meng, Yun Lin, Weijia Xiong, Eric H Y Lau, Faith Ho, Jessica Y Wong, Peng Wu, Tim K Tsang, Benjamin J Cowling, Bingyi Yang

{"title":"Effective Real-time Transmission Estimations Incorporating Population Viral Load Distributions Amid SARS-CoV-2 Variants and Preexisting Immunity.","authors":"Yu Meng, Yun Lin, Weijia Xiong, Eric H Y Lau, Faith Ho, Jessica Y Wong, Peng Wu, Tim K Tsang, Benjamin J Cowling, Bingyi Yang","doi":"10.1093/infdis/jiae592","DOIUrl":"10.1093/infdis/jiae592","url":null,"abstract":"Background: Population-level cycle threshold (Ct) distribution allows for Rt estimation for SARS-CoV-2 ancestral strain, however, its generalizability under different circulating variants and preexisting immunity remains unclear.Methods: We obtained the first Ct record of local COVID-19 cases from July 2020 to January 2023 in Hong Kong. The log-linear regression model, fitting on daily Ct mean and skewness to Rt estimated by case count, was trained with data from ancestral-dominated wave (minimal population immunity), and we predicted the Rt for Omicron waves (>70% vaccine coverage). Cross-validation was performed by training on other waves. Stratification analysis was conducted to retrospectively evaluate the impact of the changing severity profiles.Results: Model trained with the ancestral-dominated wave accurately estimated whether Rt was >1, with areas under the receiver operating characteristic curve of 0.98 (95% CI, 0.96-1.00), 0.62 (95% CI, 0.53-0.70), and 0.80 (95% CI, 0.73-0.88) for Omicron-dominated waves, respectively. Models trained on other waves also had discriminative performance. Stratification analysis suggested the potential impact of case severity on model estimation, which coincided with sampling delay.Conclusions: Incorporating population viral shedding can provide timely and accurate transmission estimation with evolving variants and population immunity, though model application should consider sampling delay.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"684-691"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-lived Plasma Cells Can't Forget the Original Antigenic Sin. 长寿浆细胞不能忘记原始抗原原罪。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae621

Chika Edward Uzoigwe

引用次数: 0

Correction to: Predictive Markers of Incident Tuberculosis in Close Contacts in Brazil and India.

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiaf078

引用次数: 0

Phylodynamics for Human Immunodeficiency Virus Prevention: A Miami-Dade County Case Study. HIV预防的系统动力学：迈阿密-戴德案例研究。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-03-17 DOI: 10.1093/infdis/jiae605

Sanjay R Mehta, Alan B Wells, Colby Cohen, Angela Campbell, Michelle Truong, Susan J Little, Antoine Chaillon

{"title":"Phylodynamics for Human Immunodeficiency Virus Prevention: A Miami-Dade County Case Study.","authors":"Sanjay R Mehta, Alan B Wells, Colby Cohen, Angela Campbell, Michelle Truong, Susan J Little, Antoine Chaillon","doi":"10.1093/infdis/jiae605","DOIUrl":"10.1093/infdis/jiae605","url":null,"abstract":"Background: To date, human immunodeficiency virus (HIV) molecular epidemiology has been primarily used to identify clusters of related infections (cluster detection and response) and then address interventions to these clusters. Community groups have raised concern regarding cluster detection and response related to privacy and ethical concerns. Here we demonstrate how an alternative approach to HIV molecular epidemiology can provide public health benefit.Methods: A limited data set for Miami-Dade County provided by the Florida Department of Health was curated and annotated by neighborhood health district (NBHD) and genetic linkage (using a genetic distance threshold of ≤0.5%) and phylodynamic analyses were performed. Phylodynamic analyses were used to infer viral transmissions into Miami-Dade County and between NBHDs within the county.Results: A total of 7274 HIV sequences from unique persons collected between 1 January 2015 and 31 December 2021 were analyzed, including 50% of the 7894 new diagnoses during this period. The proportion of sequences in local clusters increased over time. Higher ratios of local introductions, compared to viral egress (ie, source of local clusters in other NBHDs) were observed in 3 NBHDs in North Miami (range, 1.9-2.5), suggesting earlier diagnosis, but high numbers of susceptible persons not receiving preexposure prophylaxis. South Dade/Homestead had a low ratio (0.3) of local introductions compared with egress, suggesting later diagnosis and less durable suppression.Conclusions: Phylodynamic and genetic linkage analyses can highlight populations and geographic regions that might benefit more from particular types of HIV prevention interventions. These findings will need to be explored by evaluating the impact of scaling up interventions informed by these analyses.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"643-652"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0