Doxycycline post-exposure prophylaxis and off-target antimicrobial resistance: potential amplification within sexual networks.

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-08-20 DOI:10.1093/infdis/jiaf439

Manon Roberts, Peter Davis

引用次数: 0

Abstract

Doxycycline post-exposure prophylaxis (doxyPEP) is now included in many clinical guidelines, yet concerns remain regarding antimicrobial resistance (AMR), particularly off-target effects on commensal bacteria in the oropharynx, with intimate behaviours potentially facilitating resistance transmission within sexual networks.

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多西环素暴露后预防和脱靶抗微生物药物耐药性：在性网络中的潜在放大。

多西环素暴露后预防（doxyPEP）现已列入许多临床指南，但对抗菌素耐药性（AMR），特别是对口咽部共生菌的脱靶效应，以及亲密行为可能促进性网络内耐药性传播的担忧仍然存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.