Journal of Investigational Allergology and Clinical Immunology最新文献_第7页

Clinical Management of Plant Food Allergy in Patients Sensitized to Lipid Transfer Proteins Is Heterogeneous: Identifying the Gaps. 对脂质转移蛋白敏感的患者的植物性食物过敏的临床管理是异质的：确定差距。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2023-10-18 DOI: 10.18176/jiaci.0947

B E García, M B Mateo-Borrega, S Garrido, C M D Amelio, E Compés, O Villarreal, I García-Núñez, M J Goikoetxea

{"title":"Clinical Management of Plant Food Allergy in Patients Sensitized to Lipid Transfer Proteins Is Heterogeneous: Identifying the Gaps.","authors":"B E García, M B Mateo-Borrega, S Garrido, C M D Amelio, E Compés, O Villarreal, I García-Núñez, M J Goikoetxea","doi":"10.18176/jiaci.0947","DOIUrl":"10.18176/jiaci.0947","url":null,"abstract":"Background and objectives: Patients sensitized to lipid transfer protein (LTP) are characterized by wide clinical variability. The lack of practical diagnostic and therapeutic guidelines complicates their management. The aim of the study was to describe the clinical approach of Spanish allergists to sensitization to LTP.Methods: We used a survey designed following the PICO method and subsequent validation using the Delphi approach.Results: The survey was completed by 224 allergists (75% women; 57.1% with >20 years of professional experience). Clinical practice for the main points of diagnosis of LTP allergy was homogeneous, except for patients with suspected hypersensitivity to nonsteroidal anti-inflammatory drugs (44.6% frequently included skin testing with LTP). Oral food challenges were not frequently performed (63.6% occasionally to never) and were generally (75.5%) used to confirm tolerance. It was common to recommend fruit skin avoidance (77.2%) and to maintain consumption of foods to which patients were sensitized but tolerant (99.1%). The results were heterogeneous for other dietary indications, modifications due to cofactors, and trace avoidance. Peach sublingual immunotherapy (SLIT) was considered very/quite effective by 55.9% of allergists. Most (79.5%) consider SLIT indicated in <25% of LTP-allergic patients based on severity (95.2%), frequency of reactions (99.4%), allergy to multiple food families (97.4%), and impairment of quality of life/nutrition (91.5%). Practice with respect to prescription of SLIT varied based on cofactor involvement.Conclusions: These data suggest that there is a need to increase evidence to reduce heterogeneity in the clinical management of LTP allergy.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"395-403"},"PeriodicalIF":6.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of Disease Activity in Adults With Hereditary Angioedema due to C1-Esterase Inhibitor Deficiency. C1-酶抑制剂缺乏导致的遗传性血管性水肿成人患者疾病活动性的决定因素。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-07-26 DOI: 10.18176/jiaci.1009

M Lluncor-Salazar, E Phillips-Anglés, M Pedrosa, D Lamacchia, A Hernanz, N Prior, R Cabañas, T Caballero

引用次数: 0

Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients. 小儿实体器官移植后新食物过敏的病理生理学。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1027

P Pérez-López, J L López-Guillén

{"title":"Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients.","authors":"P Pérez-López, J L López-Guillén","doi":"10.18176/jiaci.1027","DOIUrl":"10.18176/jiaci.1027","url":null,"abstract":"De novo food allergy is a common phenomenon among pediatric solid organ recipients (8.5%-57%) when compared with the general population (0.45%-10%). Other associated disorders include non-IgE-mediated immune reactions and clinical predisposition to asthma and alterations in the oral mucosa. Originally, passive mechanisms (passive transfer of IgE and immune cells) were thought to be responsible for acute, transient cases of food allergies with a previous history of sensitization for a specific allergen in the donor. Recently proposed pathophysiological mechanisms to explain de novo allergies include TH2/B-cell imbalance, regulatory T-cell (Treg) disruption, gastrointestinal immaturity, and altered gastrointestinal permeability. Recent studies also suggest that immunosuppressive drugs, especially tacrolimus, promote naïve T-cell differentiation into TH2 cells, IgE-promoting cytokine production, decreased IL-5 and IL-10 levels, increased IgA levels, and Treg disruption. Such immunological interactions, in conjunction with altered intestinal permeability, intestinal immaturity in children, history of viral infection, and a personal history of allergies or eczema, are thought to explain most clinical cases of pediatric de novo food allergy after solid organ transplantation reported in the literature. A better understanding of the immunological mechanisms underpinning organ donors and recipients may unveil some of the caveats concerning therapeutic management and improve the quality of life of affected individuals.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"367-376"},"PeriodicalIF":6.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Efficacy of Dupilumab in Treating Eosinophilic Esophagitis and Type 2 Asthma. 杜匹单抗治疗嗜酸性粒细胞食管炎和 2 型哮喘的并发疗效

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-05-10 DOI: 10.18176/jiaci.1011

M Tomás-Pérez, A Trisán Alonso, A Montoro-Ferrer, J Domínguez-Ortega, P A Galindo-Bonilla, M Clar Castelló, J E Naves, P Ausín

引用次数: 0

A 1-Bag/4-Step Rapid Desensitization Protocol to Reintroduce Agalsidase a in a Patient With Fabry Disease. 1袋/4步快速脱敏方案在法布里病患者中重新引入Agalsidase A

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-02 DOI: 10.18176/jiaci.1044

T W Jimenez-Rodriguez, V Soriano Gomis, A Burgos San-José, R A Montoyo Antón, M P González Delgado, C P Gallego Velez, S Ortolano, J Fernández, R Sánchez Martínez

引用次数: 0

ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions. 雷尼替丁诱发的 ATAK 复合物：过敏反应中心脏参与的综合概念。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-28 DOI: 10.18176/jiaci.1042

A Lopez-Raigada, F Vega, M V Múgica, C Lopez-Sanz, A Alfranca, C Blanco

引用次数: 0

Drug-induced Kounis Syndrome: A Retrospective Pharmacovigilance Study from the FAERS and JADER Databases. 药物诱发的库尼斯综合征：来自 FAERS 和 JADER 数据库的回顾性药物警戒研究。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-28 DOI: 10.18176/jiaci.1039

H Li, Y Liu, L Tan, C Hu, L Su

引用次数: 0

Effectiveness of Biologics in Patients With Severe Asthma and Psychiatric Comorbidities. 生物制剂对严重哮喘合并精神疾病患者的疗效。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-27 DOI: 10.18176/jiaci.1034

B Mascaró-Hereza, D Loli-Ausejo, A Valero, E Arismendi, I Bobolea

引用次数: 0

Anaphylaxis Caused by a Mouse Bite in a Laboratory Researcher. 一名实验室研究人员被老鼠咬伤引发过敏性休克。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-25 DOI: 10.18176/jiaci.1040

S A Dager-García, A Germán-Sánchez, F Pineda de la Losa, A M Ferrer Franco

引用次数: 0

Tezepelumab in Patients With Severe Asthma: Response at 3 Months. 特珠单抗治疗严重哮喘患者：3个月后的反应

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-25 DOI: 10.18176/jiaci.1041

J C Miralles-López, R Andújar-Espinosa, F J Bravo-Gutierrez, S Cabrejos-Perotti, M Ramírez-Hernández, C Díaz-Chantar, M J Pajarón-Fernández, J Valverde-Molina, V Pérez-Fernández

引用次数: 0