Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Tezepelumab in Patients With Severe Asthma: Response at 3 Months.","authors":"J C Miralles-López, R Andújar-Espinosa, F J Bravo-Gutierrez, S Cabrejos-Perotti, M Ramírez-Hernández, C Díaz-Chantar, M J Pajarón Fernández, J Valverde-Molina, V Pérez-Fernández","doi":"10.18176/jiaci.1041","DOIUrl":"10.18176/jiaci.1041","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"132-134"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISO 9001:2015 Certification of the Allergy Laboratory.","authors":"M L Caballero, D Carpio-Hernández, P Parra, J C Giraldo-Sánchez, M Rodríguez-Álvarez, S Quirce","doi":"10.18176/jiaci.1045","DOIUrl":"10.18176/jiaci.1045","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"152-154"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basophil Activation Test: An Additional Diagnostic Tool in Vitamin B12 Allergy.","authors":"A Morales-Hidalgo, M Pérez-Montoya, J A Cañas, M Valverde-Monge, J M Rodrigo-Muñoz, M Gil-Martínez, A Gómez-López, M Otal-Buesa, V Del Pozo Abejón, M Fernández-Nieto","doi":"10.18176/jiaci.1048","DOIUrl":"10.18176/jiaci.1048","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"144-146"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal CAEBV-Associated Vasculitis in ICF Syndrome Type 2.","authors":"T Shigemura, N Kobayashi, T Uehara, Y Nakazawa","doi":"10.18176/jiaci.1037","DOIUrl":"10.18176/jiaci.1037","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"150-152"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Biologics in Patients With Severe Asthma and Psychiatric Comorbidities.","authors":"B Mascaró-Hereza, D Loli-Ausejo, A Valero, E Arismendi, I Bobolea","doi":"10.18176/jiaci.1034","DOIUrl":"10.18176/jiaci.1034","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"147-148"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolving Role of Pulmonary Function Interpretation: Clinical Implications of the New ERS/ATS Standards in Asthma Care.","authors":"F García-Rio","doi":"10.18176/jiaci.1084","DOIUrl":"10.18176/jiaci.1084","url":null,"abstract":"<p><p>Asthma remains a significant public health challenge, requiring precise diagnostic and management strategies. Pulmonary function tests (PFTs) are essential in assessing disease severity, guiding treatment decisions, and monitoring disease progression. The 2022 ERS/ATS technical standards introduced critical updates to enhance the accuracy and standardization of interpretation of pulmonary function findings. These modifications include the adoption of Global Lung Initiative reference values, the transition from race-based to raceneutral equations, the replacement of percent-predicted values with z-scores, and a redefinition of bronchodilator responsiveness criteria. Additionally, new spirometric patterns such as dysanapsis and preserved ratio impaired spirometry have been recognized, improving the detection and characterization of airflow limitation. These updates significantly impact asthma management by refining disease phenotyping, improving diagnostic precision, and tailoring treatment strategies. Furthermore, advancements in artificial intelligence are expected to enhance predictive analytics and early intervention strategies in assessment of pulmonary function. However, challenges remain with respect to the adoption of these modifications in clinical practice, particularly regarding the classification of disease severity and the impact of race-neutral equations on diagnostic thresholds. Future research is necessary to validate the long-term implications of these changes on asthma outcomes. Clinicians must familiarize themselves with evolving standards to optimize patient care and reduce health disparities. The 2022 ERS/ATS guidelines represent a substantial advancement in PFT, with the potential to improve both clinical decision-making and patient prognosis in asthma management.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"76-86"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish Consensus on the Diagnosis and Management of Patients With Activated PI3K Delta Syndrome (APDS).","authors":"O Neth, L Alsina, J G Rivière, E López-Granados, M E Seoane-Reula, L I González Granado, S Sánchez-Ramón, C Rodríguez-Gallego","doi":"10.18176/jiaci.1059","DOIUrl":"10.18176/jiaci.1059","url":null,"abstract":"<p><p>Activated phosphoinositide 3-kinase (PI3K) delta syndrome (APDS) is an ultrarare genetic disorder characterized by overlapping immunodeficiency and immune dysregulation. Its diagnosis poses challenges owing to its clinical similarities with other inborn errors of immunity (IEIs), compounded by the absence of targeted treatments in today's medical landscape. The standard approach involves symptom management, reducing infection through immunoglobulin replacement therapy and prophylactic antimicrobials, and treating immune dysregulation with immunomodulators. This approach considerably hampers effective management of APDS, as the diverse nature of the disease necessitates a personalized strategy, in which the advantages and risks of immunosuppression are weighed against the potential for recurrent infections and lymphoproliferative complications. To address these challenges, a group of Spanish experts in the management of IEIs, including APDS, collaborated to develop Delphi-based consensus recommendations. The primary goal of the initiative was to offer guidance on various aspects of this complex disease, marking a pioneering effort in Europe. The consensus aims to facilitate early diagnosis and provide clues for individual patient-based decisions that could favor balanced risk-benefit estimations for treatment.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"87-102"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological Parameters for Assessing the In Vitro Safety and Efficacy of Allergoid Mixtures for Immunotherapy.","authors":"D Calzada, N Parody, J M Beitia, J Dominguez-Ortega, D Gonzalez-de-Olano, A Renshaw-Calderón, C Osuna, R Moya, J Carnés","doi":"10.18176/jiaci.1061","DOIUrl":"https://doi.org/10.18176/jiaci.1061","url":null,"abstract":"<p><strong>Background and objectives: </strong>Most patients with respiratory allergy are polyallergic. Combining different allergen extracts in the same allergen-specific immunotherapy is a common practice. However, it should be justified. To analyze the stability, safety, and immune response of allergen extract mixtures from nonhomologous groups.</p><p><strong>Methods: </strong>We analyzed 2 depigmented-polymerized mixture extracts (DPmixEs): cat dander grass pollen and Alternaria alternata-grass pollen. The stability of the mixtures was investigated by studying proteolysis and degradation effects. The allergenicity and humoral and cellular immune responses of DPmixEs were also evaluated using various technical approaches, including the Bradford assay, enzyme-linked immunosorbent assay, rabbit immunization, peripheral blood mononuclear cell culture, and flow cytometry. The results were compared with those of individual depigmented-polymerized extracts (DPEs) and native mixture extracts (NmixEs).</p><p><strong>Results: </strong>The proteolytic activity of DPmixEs was lower than that of NmixEs. The protein content of DPmixEs remained stable for 18 months, whereas that of NmixEs decreased significantly during the first month. The allergenicity of DPmixEs was similar to that of DPEs and lower than that of NmixEs. Regarding the immune response, DPmixEs induced functional specific IgG antibodies in rabbits and blocked sIgEallergen binding. Moreover, DPmixEs induced IL-10 secretion in peripheral blood mononuclear cells from polyallergic patients, improving the Treg/TH2 cell balance.</p><p><strong>Conclusion: </strong>These findings support the use of DPmixE as a promising formulation for allergen immunotherapy, combining stability, reduced enzymatic activity, and enhanced immunological stimulation, while preserving in vitro safety and efficacy comparable to separated depigmented-polymerized extracts.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(R)-Mandelonitrile Lyase, a Homolog of Pru du 10, Is a Major Peach Allergen.","authors":"M A López-Matas, F Vílchez-Sánchez, F Álvarez, R Rodriguez-Perez, J Dominguez-Ortega, J Carnés, M Pedrosa","doi":"10.18176/jiaci.0972","DOIUrl":"https://doi.org/10.18176/jiaci.0972","url":null,"abstract":"<p><strong>Background: </strong>Peach allergy is a prevalent cause of food allergy. Despite the repertoire of allergens available for molecular diagnosis, IgE to individual peach allergens may still be undetectable in some patients who present symptoms after ingestion. The objective of this study was to investigate the allergen profile of patients with symptoms induced by peach.</p><p><strong>Methods: </strong>We performed an exploratory retrospective study of 42 patients presenting symptoms after ingestion of peach. The allergen profile of individual patients was investigated using immunoblot. A serum pool was prepared with sera that recognized a 70-kDa band. The pool was used to detect this protein in peach peel and pulp and to identify the 70-kDa protein in 2D immunoblot. Spots recognized in the 2D immunoblot were sequenced using LC-MS/MS. Inhibition studies were performed with peach peel and almond.</p><p><strong>Results: </strong>The immunoblot revealed that 22 patients (52.4%) recognized the 70-kDa protein in peach peel and pulp. Two spots were observed in 2D-PAGE, and both were identified as (R)-mandelonitrile lyases (RMLs) showing high amino acid similarity with Pru du 10. The RMLs were partially inhibited with an almond extract. No association was found between symptoms and sensitization to RML. RMLsensitized patients were older and reported pollen-associated respiratory symptoms more frequently than patients whose results were negative for this protein.</p><p><strong>Conclusions: </strong>We identified a new peach allergen, an RML, which was a homolog of Pru du 10 and was recognized by 52% of the population.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"35 2","pages":"122-129"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the Sensitization Profiles to Parvalbumins From 12 Freshwater Fish Species to Improve Diagnosis of Fish Allergy.","authors":"T Kalic Kamath, T Djukic, S D Kamath, N Lengger, S Ottersbach, K Uranowska-Kostrubala, M Mladenovic Stokanic, K H Park, P Forstenlechner, M Aumayr, G Lamorte, T Velickovic Cirkovic, W Hemmer, H Breiteneder, C Hafner","doi":"10.18176/jiaci.1069","DOIUrl":"https://doi.org/10.18176/jiaci.1069","url":null,"abstract":"<p><strong>Background and objectives: </strong>Many fish-allergic patients only react to certain fish species and may tolerate others, mostly because of IgE-mediated recognition of specific epitopes on the major allergen parvalbumin. However, the considerable number of fish species consumed makes it challenging to identify which species are allergenic and which are tolerated by individual patients. In order to improve the diagnosis of fish allergy, we investigated IgE-mediated reactivity to parvalbumins from 12 freshwater fish species that are largely underrepresented in diagnostic tests.</p><p><strong>Methods: </strong>Parvalbumins were purified from 12 freshwater fish species belonging to 8 families, and their isoform composition was analyzed using mass spectrometry. IgE specific for each parvalbumin was quantified in serum samples from 66 fish allergic individuals, and basophil activation tests were performed for 5 patients. Crosswise inhibition assays were carried out for all parvalbumins for 7 patients to investigate cross-reactivity between the parvalbumins from the different species.</p><p><strong>Results: </strong>IgE binding and cross-linking potency of the parvalbumins differed, with the strongest reactivities observed for 4 parvalbumins from the salmonid family (results positive for 89%-95% of patients) and the weakest for parvalbumins from Wels catfish, European eel, and tench (results negative for ≥50% of patients). Ninety percent of the patients with negative results for Wels catfish parvalbumin also had negative results for additional parvalbumins from multiple species. Inhibition assays revealed variable recognition of epitopes by several patients, with the primary sensitizers most frequently being parvalbumins from salmonids and percids.</p><p><strong>Conclusion: </strong>Including freshwater salmonids in the diagnostic work-up for fish allergy may help to identify most fish-allergic patients. IgE to Wels catfish could help distinguish between polysensitized and oligosensitized patients.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}