Journal of Investigational Allergology and Clinical Immunology最新文献_第8页

Successful Desensitization to Lenalidomide in Leukocytoclastic Vasculitis. 成功脱敏来那度胺治疗白细胞减少性血管炎

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-07-08 DOI: 10.18176/jiaci.1002

I Fernández-Concha, K Pose, L de Las Vecillas, M Lluch-Bernal, M Tomás-Pérez, T Soto, A López de la Guía, R Cabañas

引用次数: 0

SQ HDM Sublingual Immunotherapy Tablet for the Treatment of HDM Allergic Rhinitis and Asthma Improves Subjective Sleepiness and Insomnia: An Exploratory Analysis of the Real-life CARIOCA Study. 用于治疗HDM过敏性鼻炎和哮喘的SQ HDM舌下免疫治疗片可改善主观嗜睡和失眠：真实生活 CARIOCA 研究的探索性分析。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2023-09-04 DOI: 10.18176/jiaci.0934

D Jaffuel, E Serrano, C Leroyer, A Chartier, P Demoly

{"title":"SQ HDM Sublingual Immunotherapy Tablet for the Treatment of HDM Allergic Rhinitis and Asthma Improves Subjective Sleepiness and Insomnia: An Exploratory Analysis of the Real-life CARIOCA Study.","authors":"D Jaffuel, E Serrano, C Leroyer, A Chartier, P Demoly","doi":"10.18176/jiaci.0934","DOIUrl":"10.18176/jiaci.0934","url":null,"abstract":"Background: Knowledge of the effectiveness of house dust mite (HDM) sublingual immunotherapy (SLIT) in allergic rhinitis (AR) and asthma associated sleep disorders remains incomplete. A noninterventional study was conducted to assess the effect of the standardized quality (SQ) HDM SLIT tablet on safety and symptoms in adults with respiratory allergies caused by HDM. The study also assessed the status of insomnia and daytime sleepiness in patients with AR and/or asthma-associated sleep disorders treated with the SQ HDM SLIT tablet.Methods: This was a 12-month multicenter, longitudinal, and prospective study. Participants started the SQ HDM SLIT tablet for moderateto-severe HDM-induced AR that was persistent despite the use of symptom relieving medication or HDM-induced asthma-associated sleep disorders that were not well controlled with inhaled corticosteroids and were associated with mild-to-severe HDM-induced AR. Sleep symptoms were measured using the Insomnia Severity Index (ISI) questionnaire and the Epworth Sleepiness Scale (ESS).Results: A total of 1526 adult patients were enrolled, and 1483 were eventually included in the analysis. At baseline, 41.5% of patients reported sleep disorders; of these, 77.0% had insomnia and 28.9% experienced excessive daytime sleepiness. Insomnia was significantly more frequent among patients with uncontrolled AR (83.1%) than among those with controlled AR (52.6%) (P<.0001). Over time, 48.3% and 59.7% of patients, respectively, reported an improvement greater than the minimal clinically important difference in the ISI and ESS scales.Conclusion: In patients with HDM-induced AR and/or asthma-associated sleep disorders, an improvement in subjective insomnia and sleepiness was observed after 1 year of treatment with the SQ HDM SLIT tablet in a real-life setting.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"323-330"},"PeriodicalIF":6.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization to Quercus ilex Pollen Is Clinically Relevant in Patients With Seasonal Pollen Allergy. 对柞树花粉过敏与季节性花粉过敏患者的临床症状有关。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-02-21 DOI: 10.18176/jiaci.0998

M Lluch-Bernal, M Pedrosa, J Domínguez-Ortega, M Colque-Bayona, J Correa-Borit, E Phillips-Anglés, C Gómez-Traseira, S Quirce, R Rodríguez-Pérez

引用次数: 0

Nonasthmatic Eosinophilic Bronchitis: A Systematic Review of Current Treatment Options. 非哮喘性嗜酸性支气管炎回顾。当前治疗方案的系统回顾。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2023-12-19 DOI: 10.18176/jiaci.0984

D Betancor, M Valverde-Monge, B Barroso, A Gomez-Lopez, J Sastre

{"title":"Nonasthmatic Eosinophilic Bronchitis: A Systematic Review of Current Treatment Options.","authors":"D Betancor, M Valverde-Monge, B Barroso, A Gomez-Lopez, J Sastre","doi":"10.18176/jiaci.0984","DOIUrl":"10.18176/jiaci.0984","url":null,"abstract":"Nonasthmatic eosinophilic bronchitis is characterized by persistent dry or barely productive cough and bronchial eosinophilia without airway obstruction or bronchial hyperreactivity. It is primarily a chronic disease, in which some patients have clinical and pathophysiological relapses, while others progress to asthma or chronic obstructive pulmonary disease. It accounts for 5% to 30% of cases referred for chronic cough. Exposure to common inhalants and occupational sensitizers has been proposed as a possible cause of the disease, although the etiology and underlying mechanisms are uncertain. Some features are similar to those of asthma, such as airway eosinophilia, inflammatory mediator levels, and airway remodeling. Differences in airway pathophysiology, such as the location of airway inflammation and levels of IL-13 and PGE-2, have been reported. Sputum cell count is the gold standard test for diagnosis, and other biomarkers, such as exhaled nitric oxide, could support the diagnosis. A systematic review of treatments for the disease shows that while inhaled corticosteroids are the primary option, the appropriate dose, the type of corticosteroid, and the duration of treatment remain unknown. Treatment duration is inversely correlated with the relapse rate. Increased doses of inhaled corticosteroids, oral corticosteroids, and leukotriene receptor antagonists are recommended in persistent disease. Anti-IL-5 biologics could be promising in this disease. Studies that investigate biomarkers for diagnosis and prognosis are necessary, as are randomized controlled studies for second-line treatments.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"282-292"},"PeriodicalIF":6.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold Urticaria due to Amoxicillin-Clavulanic Acid. 阿莫西林-克拉维酸引起的寒冷性荨麻疹。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-02-14 DOI: 10.18176/jiaci.0999

Ö Özdemir

引用次数: 0

Buckwheat-Induced Refractory Anaphylaxis in a Hospitalized Patient. 一名住院病人因荞麦引发的难治性过敏性休克

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-05-10 DOI: 10.18176/jiaci.1001

A Domínguez Estirado, C Cuevas Bravo, F Skrabski, L Baptista Serna, B Bartolomé Zavala, M Labrador-Horrillo, P Tornero Molina

引用次数: 0

Role of Thymic Stromal Lymphopoietin in the Pathophysiology of Asthma and Clinical and Biological Effects of Blockade With Tezepelumab. 胸腺基质淋巴细胞生成素在哮喘病理生理学中的作用以及使用特珠单抗阻断的临床和生物学效应

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-07-26 DOI: 10.18176/jiaci.1012

C Venegas Garrido, P Nair, I Dávila, L Pérez de Llano

{"title":"Role of Thymic Stromal Lymphopoietin in the Pathophysiology of Asthma and Clinical and Biological Effects of Blockade With Tezepelumab.","authors":"C Venegas Garrido, P Nair, I Dávila, L Pérez de Llano","doi":"10.18176/jiaci.1012","DOIUrl":"10.18176/jiaci.1012","url":null,"abstract":"The airway epithelium is the first line of defense of the respiratory system against the external environment. It plays an active role in the initiation of immune and allergic responses against potential hazards. Among the various specialized cells and cytokines that participate in epithelium-induced responses, alarmins are particularly interesting, given their ample role in mediating T2 and non-T2 inflammatory mechanisms involved in the pathogenesis of asthma. Thymic stromal lymphopoietin (TSLP) is an alarmin with broad effects in asthma that result from its widespread action on multiple cell types, including eosinophils, mast cells, dendritic cells, and group-2 innate lymphoid cells. Its role in allergy-mediated responses, eosinophilic inflammation, airway hyperresponsiveness, mucus hyperproduction, viral tolerance, and airway remodeling is of the utmost importance, as more comprehensive asthma assessments have been developed to explore these pathogenic features. Therefore, blockade with targeting molecules, such as monoclonal antibodies, has emerged as a promising therapeutic option, particularly in patients with multiple pathogenic pathways. In this review, we examine the roles of alarmins (mainly TSLP) in the pathogenesis of asthma and clinical expression and discuss the effects of inhibiting TSLP on several inflammatory and clinical outcomes. We also review the literature supporting treatment with anti-TSLP biologics and the unanswered questions and unmet needs associated with targeting alarmins in asthma.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"293-302"},"PeriodicalIF":6.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age and Geographical Location Determine the Molecular Pattern of Walnut Allergy in Madrid, Spain. 年龄和地理位置决定了西班牙马德里核桃过敏的分子模式。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-07-08 DOI: 10.18176/jiaci.1005

L Ortega-Martín, S Fernández-Bravo, E Nuñez-Borque, V Esteban, C Pastor-Vargas, M de Las Heras, J Sastre, J Cuesta-Herranz

引用次数: 0

Contact System Activation and Bradykinin Generation in Patients With Idiopathic Angioedema. 特发性血管性水肿患者的接触系统激活和缓激肽生成。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-02-21 DOI: 10.18176/jiaci.0996

C Suffritti, P Calzari, F Depetri, S Griffini, E Grovetti, R Santacroce, M Margaglione, M Cugno

引用次数: 0

Allergy to Cypress and Olive Pollen: Clinical Phenotypes and Allergen Recognition. 柏树和橄榄花粉过敏：临床表型和过敏原识别。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2023-08-04 DOI: 10.18176/jiaci.0917

M D Alonso-Díaz de Durana, E Pérez-Fernández, M Villalba, L Martín-Pedraza, M Fernández-Rivas

{"title":"Allergy to Cypress and Olive Pollen: Clinical Phenotypes and Allergen Recognition.","authors":"M D Alonso-Díaz de Durana, E Pérez-Fernández, M Villalba, L Martín-Pedraza, M Fernández-Rivas","doi":"10.18176/jiaci.0917","DOIUrl":"10.18176/jiaci.0917","url":null,"abstract":"Background and objectives: Background: Cypress and olive pollen are the most prevalent sensitizers in the Mediterranean area. Some patients exhibit dual sensitization, which has not been well documented to date. Objective: To identify the allergens involved in dual cypress and olive allergy (C+O) and to study the relationship between phenotype and allergen sensitization.Methods: C+O patients were selected. Those monosensitized to olive or cypress were used as a reference. Specific IgE to whole extracts and purified allergens from olive and cypress was determined. Immunoblotting was performed to analyze IgG and IgE binding using olive polyclonal antibodies and patients' sera, respectively. Mutual immunoblotting inhibition of olive and cypress extracts and inhibition of cypress extract immunoblotting with olive allergens were performed. Multiple correspondence analysis and hierarchical cluster classifications were conducted to analyze the relationships between the clinical presentation of C+O (symptoms, seasonality) and allergen profile.Results: C+O patients were clustered in 4 phenotypes. The most frequent one (58.4%) was rhinoconjunctivitis in winter (February) and spring (May), with asthma in 38% of patients. Ole e 1 and Cup s 1 were the major allergens. Proteins homologous to Ole e 1, Ole e 9, and Ole e 11 in cypress pollen were identified and shown to inhibit IgE binding to cypress extract.Conclusions: The exclusive C+O results from cosensitization to Cup s 1 and Ole e 1 and cross-reactivity due to previously unreported Ole e 1-like, Ole e 9-like, and Ole e 11-like allergens in cypress pollen. Our findings point to 4 clinical phenotypes of winter and/or spring or perennial rhinoconjunctivitis with and without asthma.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"313-322"},"PeriodicalIF":6.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0