Journal of Investigational Allergology and Clinical Immunology最新文献_第8页

Tezepelumab in Patients With Severe Asthma: Response at 3 Months. 特珠单抗治疗严重哮喘患者：3个月后的反应

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-25 DOI: 10.18176/jiaci.1041

J C Miralles-López, R Andújar-Espinosa, F J Bravo-Gutierrez, S Cabrejos-Perotti, M Ramírez-Hernández, C Díaz-Chantar, M J Pajarón-Fernández, J Valverde-Molina, V Pérez-Fernández

引用次数: 0

Fatal CAEBV-Associated Vasculitis in ICF Syndrome Type 2. ICF 综合征 2 型中致命的 CAEBV 相关性血管炎。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-25 DOI: 10.18176/jiaci.1037

T Shigemura, N Kobayashi, T Uehara, Y Nakazawa

引用次数: 0

Occupational Asthma and Rhinoconjunctivitis due to Soybean in a Bakery Worker. 一名面包店工人因大豆引发职业性哮喘和鼻结膜炎。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-13 DOI: 10.18176/jiaci.1035

Ö Özdemir

引用次数: 0

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals. 疟原虫过敏者被蜱虫叮咬后外周免疫学变化的纵向随访揭示。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-13 DOI: 10.18176/jiaci.1028

K Swiontek, J Fischer, F Hedin, D Revets, S Riel, N Chakrapani, U Mackenstedt, T Biedermann, A Kuehn, A Cosma, M Ollert, C Hilger

{"title":"Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals.","authors":"K Swiontek, J Fischer, F Hedin, D Revets, S Riel, N Chakrapani, U Mackenstedt, T Biedermann, A Kuehn, A Cosma, M Ollert, C Hilger","doi":"10.18176/jiaci.1028","DOIUrl":"10.18176/jiaci.1028","url":null,"abstract":"Background and objectives: α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion of mammalian meat. While tick bites are assumed to mediate sensitization, the immune response to tick bites has not yet been investigated. To investigate the peripheral immune response to tick bites in humans over time.Methods: In a longitudinal cohort study, immunological reactions associated with tick bites (Ixodes species) were analyzed within 1 day (V1), 2 weeks (V2), 1 month (V3), and 3 months (V4) after the occurrence of a bite. sIgE, sIgG, and sIgG subclass levels, as well as 10 cytokines, were quantified. Deep immune phenotyping was performed using mass cytometry.Results: A total of 4 controls and 10 patients were bitten by a tick and followed up over 3 months. None of the controls developed sIgE to α-Gal, and sIgE increased in all patients from V1 until V2/V3, as did IL-8 levels. We noted a significant increase in CD19+ B cells and B-cell subpopulations, as well as a decrease in γδ CD56+ T cells in patients between V0 and V1. At V1, frequencies of plasmacytoid dendritic cells (pDCs) and γδ CD56+ T cells were lower in patients than in controls.Conclusion: Our study provides evidence of significant changes in several immune cell populations in α-Gal sensitized patients, along with increased levels of IL-8 and sIgE. This is the first exploratory study to investigate longitudinal peripheral immune profiles in patients and controls bitten by ticks.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Desensitization to Lenalidomide in Leukocytoclastic Vasculitis. 成功脱敏来那度胺治疗白细胞减少性血管炎

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-07-08 DOI: 10.18176/jiaci.1002

I Fernández-Concha, K Pose, L de Las Vecillas, M Lluch-Bernal, M Tomás-Pérez, T Soto, A López de la Guía, R Cabañas

引用次数: 0

SQ HDM Sublingual Immunotherapy Tablet for the Treatment of HDM Allergic Rhinitis and Asthma Improves Subjective Sleepiness and Insomnia: An Exploratory Analysis of the Real-life CARIOCA Study. 用于治疗HDM过敏性鼻炎和哮喘的SQ HDM舌下免疫治疗片可改善主观嗜睡和失眠：真实生活 CARIOCA 研究的探索性分析。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2023-09-04 DOI: 10.18176/jiaci.0934

D Jaffuel, E Serrano, C Leroyer, A Chartier, P Demoly

{"title":"SQ HDM Sublingual Immunotherapy Tablet for the Treatment of HDM Allergic Rhinitis and Asthma Improves Subjective Sleepiness and Insomnia: An Exploratory Analysis of the Real-life CARIOCA Study.","authors":"D Jaffuel, E Serrano, C Leroyer, A Chartier, P Demoly","doi":"10.18176/jiaci.0934","DOIUrl":"10.18176/jiaci.0934","url":null,"abstract":"Background: Knowledge of the effectiveness of house dust mite (HDM) sublingual immunotherapy (SLIT) in allergic rhinitis (AR) and asthma associated sleep disorders remains incomplete. A noninterventional study was conducted to assess the effect of the standardized quality (SQ) HDM SLIT tablet on safety and symptoms in adults with respiratory allergies caused by HDM. The study also assessed the status of insomnia and daytime sleepiness in patients with AR and/or asthma-associated sleep disorders treated with the SQ HDM SLIT tablet.Methods: This was a 12-month multicenter, longitudinal, and prospective study. Participants started the SQ HDM SLIT tablet for moderateto-severe HDM-induced AR that was persistent despite the use of symptom relieving medication or HDM-induced asthma-associated sleep disorders that were not well controlled with inhaled corticosteroids and were associated with mild-to-severe HDM-induced AR. Sleep symptoms were measured using the Insomnia Severity Index (ISI) questionnaire and the Epworth Sleepiness Scale (ESS).Results: A total of 1526 adult patients were enrolled, and 1483 were eventually included in the analysis. At baseline, 41.5% of patients reported sleep disorders; of these, 77.0% had insomnia and 28.9% experienced excessive daytime sleepiness. Insomnia was significantly more frequent among patients with uncontrolled AR (83.1%) than among those with controlled AR (52.6%) (P<.0001). Over time, 48.3% and 59.7% of patients, respectively, reported an improvement greater than the minimal clinically important difference in the ISI and ESS scales.Conclusion: In patients with HDM-induced AR and/or asthma-associated sleep disorders, an improvement in subjective insomnia and sleepiness was observed after 1 year of treatment with the SQ HDM SLIT tablet in a real-life setting.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"323-330"},"PeriodicalIF":6.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization to Quercus ilex Pollen Is Clinically Relevant in Patients With Seasonal Pollen Allergy. 对柞树花粉过敏与季节性花粉过敏患者的临床症状有关。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-02-21 DOI: 10.18176/jiaci.0998

M Lluch-Bernal, M Pedrosa, J Domínguez-Ortega, M Colque-Bayona, J Correa-Borit, E Phillips-Anglés, C Gómez-Traseira, S Quirce, R Rodríguez-Pérez

引用次数: 0

Nonasthmatic Eosinophilic Bronchitis: A Systematic Review of Current Treatment Options. 非哮喘性嗜酸性支气管炎回顾。当前治疗方案的系统回顾。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2023-12-19 DOI: 10.18176/jiaci.0984

D Betancor, M Valverde-Monge, B Barroso, A Gomez-Lopez, J Sastre

{"title":"Nonasthmatic Eosinophilic Bronchitis: A Systematic Review of Current Treatment Options.","authors":"D Betancor, M Valverde-Monge, B Barroso, A Gomez-Lopez, J Sastre","doi":"10.18176/jiaci.0984","DOIUrl":"10.18176/jiaci.0984","url":null,"abstract":"Nonasthmatic eosinophilic bronchitis is characterized by persistent dry or barely productive cough and bronchial eosinophilia without airway obstruction or bronchial hyperreactivity. It is primarily a chronic disease, in which some patients have clinical and pathophysiological relapses, while others progress to asthma or chronic obstructive pulmonary disease. It accounts for 5% to 30% of cases referred for chronic cough. Exposure to common inhalants and occupational sensitizers has been proposed as a possible cause of the disease, although the etiology and underlying mechanisms are uncertain. Some features are similar to those of asthma, such as airway eosinophilia, inflammatory mediator levels, and airway remodeling. Differences in airway pathophysiology, such as the location of airway inflammation and levels of IL-13 and PGE-2, have been reported. Sputum cell count is the gold standard test for diagnosis, and other biomarkers, such as exhaled nitric oxide, could support the diagnosis. A systematic review of treatments for the disease shows that while inhaled corticosteroids are the primary option, the appropriate dose, the type of corticosteroid, and the duration of treatment remain unknown. Treatment duration is inversely correlated with the relapse rate. Increased doses of inhaled corticosteroids, oral corticosteroids, and leukotriene receptor antagonists are recommended in persistent disease. Anti-IL-5 biologics could be promising in this disease. Studies that investigate biomarkers for diagnosis and prognosis are necessary, as are randomized controlled studies for second-line treatments.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"282-292"},"PeriodicalIF":6.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold Urticaria due to Amoxicillin-Clavulanic Acid. 阿莫西林-克拉维酸引起的寒冷性荨麻疹。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-02-14 DOI: 10.18176/jiaci.0999

Ö Özdemir

引用次数: 0

Buckwheat-Induced Refractory Anaphylaxis in a Hospitalized Patient. 一名住院病人因荞麦引发的难治性过敏性休克

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-10-23 Epub Date: 2024-05-10 DOI: 10.18176/jiaci.1001

A Domínguez Estirado, C Cuevas Bravo, F Skrabski, L Baptista Serna, B Bartolomé Zavala, M Labrador-Horrillo, P Tornero Molina

引用次数: 0