Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Stability of Asthma Phenotypes in the Spanish Cohort of the MEGA Project.","authors":"M J Rial, D Betancor, J A Cañas, J M Olaguibel, J M Rodrigo-Muñoz, M J Alvarez-Puebla, E Arismendi, B Barroso, I Bobolea, B Cárdaba, M J Cruz, E Curto, V Del Pozo, J Domínguez-Ortega, A Garcia de la Fuente, F J González-Barcala, J A Luna-Porta, C Martínez-Rivera, J Mullol, X Muñoz, C Picado, V Plaza, S Quirce, L Soto-Retes, M Valverde-Monge, J Sastre","doi":"10.18176/jiaci.1026","DOIUrl":"10.18176/jiaci.1026","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"53-55"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Armelline Almond Allergy: The First Reported Case.","authors":"L Alessi, S Cirrincione, B Aiuto, E Gosso, L Cavallarin, M G Giuffrida, G Monti, C Lamberti","doi":"10.18176/jiaci.1033","DOIUrl":"10.18176/jiaci.1033","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"73-75"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunflower (Helianthus annuus) Seed Allergy.","authors":"C Galleani, M C Diéguez, B Cabanillas, C Martín-Arriscado Arroba, A Enríquez-Matas, J F Crespo","doi":"10.18176/jiaci.0965","DOIUrl":"10.18176/jiaci.0965","url":null,"abstract":"<p><strong>Background and objectives: </strong>Sunflower seed is one of the most common edible seeds. Its consumption is growing. Cases of sunflower seed allergy have been reported since the 1970s. However, there are few data on the prevalence and clinical manifestations of sunflower seed allergy. To improve our understanding of sunflower seed allergy.</p><p><strong>Methods: </strong>We evaluated the clinical and immunological features of patients with sunflower seed allergy diagnosed in the allergy department of a tertiary hospital in Madrid over a 5-year period.</p><p><strong>Results: </strong>Forty-seven patients reported adverse reactions after ingestion of sunflower seed and were sensitized specifically to sunflower seed, as determined by skin prick test (median, 8 mm) or specific IgE (median, 1.10 kUA/L). Most reactions were adult-onset and were preceded by a history of atopy and other food allergies, predominantly to peach, peanut, and nuts. The clinical presentation of sunflower seed allergy ranged from mild to severe, with many patients experiencing severe reactions, in which epinephrine was underused. Repeated exposures to sunflower seed in the same patient showed severity of symptoms to vary. Levels of sunflower seed IgE were strongly correlated with levels of IgE to nonspecific lipid transfer proteins, while the severity of the reactions did not differ significantly according to sensitization to the proteins.</p><p><strong>Conclusion: </strong>Our findings reveal variability in the clinical presentations of sunflower seed allergy on repeated exposures and underuse of epinephrine in anaphylaxis. We highlight the importance of strict avoidance of sunflower seed and accurate prescription and administration of epinephrine in allergic patients.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"32-39"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Nonimmediate Reactions to Oxaliplatin and Docetaxel Confirmed by Lymphocyte Transformation Test and Treated With Successful Rapid Desensitization Procedures.","authors":"M P Berges-Gimeno, A Barra-Castro, C Fernandez-Lozano, E Solano-Solares, N Martinez-Jañez, C Pueyo-Lopez, J Martínez-Botas","doi":"10.18176/jiaci.1030","DOIUrl":"10.18176/jiaci.1030","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"70-72"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin.","authors":"M N Otero-Fernández, E Laffond-Yges, R M Castillo-Loja, A Cabrera-Núñez, M E Mazoteras-Martínez, F J Muñoz-Bellido, I Dávila","doi":"10.18176/jiaci.1031","DOIUrl":"10.18176/jiaci.1031","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"72-73"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Far Are We From Achieving Delabeling of False Penicillin/ß-Lactam Allergy Alerts? A Population Problem.","authors":"M A Tejedor-Alonso, M Perez-Encinas, S Sanz Márquez, J J Martinez Simon, L Moreno-Nuñez, A Gonzalez-Moreno, J Macias-Iglesias, A Rosado-Ingelmo","doi":"10.18176/jiaci.1004","DOIUrl":"10.18176/jiaci.1004","url":null,"abstract":"<p><p>Interest in finding efficient ways to remove penicillin allergy alerts has grown as a result of awareness of the considerable excess of falsenegative diagnoses in patients with penicillin allergy labels (90%-95%), the poorer course with non-ß-lactam antibiotics, the increase in bacterial resistance, and the fact that these problems can affect up to 20% of the population in some countries. The strategies proposed have generated many publications in countries where the number of allergists to conduct such studies is low. In many cases where delabeling is performed, the risk of ß-lactam allergy is low, and a single penicillin challenge is sufficient to delabel the alert. However, other less \"ultrarapid\" strategies can be used to administer a ß-lactam during an admission for infection and thus postpone delabeling until traditional drug allergy consultations. However, the definitive withdrawal of ß-lactam alerts is threatened by nonremoval of alerts in electronic health records and by the reactivation or nonsynchronization of alerts between electronic systems at different levels of care. Allergy departments need to reflect on how to implement practices that enable rapid and efficient delabeling of drug allergy alerts, especially in patients with major comorbidities.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"12-23"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen.","authors":"I García-Gutiérrez, C Solórzano-Zepeda, V Sánchez-García, E Ramírez-Mateo, D Antolín-Amérigo, Y Zheng, A Rioja Carrera, I León Hernando, M E Hernando Pérez, B De la Hoz Caballer","doi":"10.18176/jiaci.1036","DOIUrl":"https://doi.org/10.18176/jiaci.1036","url":null,"abstract":"<p><strong>Background: </strong>An environmental exposure chamber (EEC) is a health facility that enables allergic symptoms to be induced in a controlled manner in persons sensitized to a dispersed allergen. We performed a study at our institution to technically and clinically validate an EEC in patients allergic to grass pollen.</p><p><strong>Methods: </strong>We developed a new EEC inside a clean room (ISO-8 class) measuring 15.6 m². During the technical validation, the patient's exposure conditions were simulated by ensuring homogeneous distribution of the allergen with a particle disperser and monitoring both particle and pollen grain concentrations. Temperature, pressure, and humidity were also registered. A total of 31 volunteers were exposed to Phleum pratense pollen in the EEC. Of these, 25 were allergic (cases), with symptoms of rhinoconjunctivitis with or without asthma, and 6 were not (controls). One control and 2 cases were exposed twice to check reproducibility, generating a total of 34 challenges. The test was stopped once the positivity criterion was reached or the patient completed 90 minutes in the EEC.</p><p><strong>Results: </strong>Both the stability of particle concentrations and approximation to the pollen sample concentration were guaranteed. All challenges with controls were negative. Among the cases, 15% of challenges were negative and 85% were positive. No severe or late reactions were observed. Volunteers exposed twice to the same pollen had the same result in both challenges.</p><p><strong>Conclusion: </strong>Our EEC proved to be a specific, safe, and reproducible tool for the diagnosis of grass pollen allergy.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effect Between Gut Microbiota, Gut Bacterial Pathway, and Chronic Spontaneous Urticaria: A Large-Scale Bidirectional Mendelian Randomization Analysis.","authors":"Y Yao, J Chen, H Cao, Z Lu, H Shen, J Ji, Q Jiao","doi":"10.18176/jiaci.1054","DOIUrl":"https://doi.org/10.18176/jiaci.1054","url":null,"abstract":"<p><strong>Background: </strong>To analyze causality between gut microbiota and chronic spontaneous urticaria (CSU) and to investigate the mediating effect of metabolic pathways.</p><p><strong>Methods: </strong>We extracted genome-wide association study summary statistics for 211 microbiota taxa from the MiBioGen consortium (N=18 340), 205 microbiota metabolic pathways from the Dutch Microbiome Project (N=7738), and CSU from the FinnGen genomics initiative (N=450). Bidirectional Mendelian randomization (MR) was performed to detect genetic causality between gut microbiota, gut bacterial pathways, and CSU. Sensitivity analyses were performed to validate the robustness of the results. Mediation MR investigated mediators in the association between gut microbiota and CSU.</p><p><strong>Results: </strong>MR analysis suggested that the family Peptococcaceae and its child taxon, the genus Peptococcus, were risk factors for CSU. In addition, the genera Collinsella, Lachnospiraceae UCG004, Ruminococcaceae UCG004, and Sellimonas were also risk factors for CSU, whereas Family XIII UCG001, Lachnospiraceae UCG010, and Methanobrevibacter had protective effects on CSU. As for metabolic pathways, NONMEVIPP-PWY, PWY-5022, and PWY-7221 were positively associated with CSU, although others, such as KDO-NAGLIPASYN-PWY, PWY- 6353, and PWY-7400 presented a suggestive association with CSU. Moreover, PWY-7400 was a mediator in causality between the family Peptococcaceae and CSU. These results were based on nominal significance (P<.05). None of the Bonferroni corrected P values were <.05.</p><p><strong>Conclusions: </strong>Our study confirmed a causal association between gut microbiota and CSU, with the metabolic pathway being a potential mediator. Our findings provide new insights for further mechanistic and clinical studies in CSU.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.","authors":"B Sousa-Pinto, M Savouré, R J Vieira, R Amaral, W Czarlewski, A Bedbrook, A Valiulis, V Kvedariene, L Brussino, B Gemicioglu, T Haahtela, L Klimek, H Kraxner, D E Larenas-Linnemann, O Pfaar, F S Regateiro, B Samolinski, L Taborda-Barata, S Toppila-Salmi, M T Ventura, I J Ansotegui, F Braido, G W Canonica, L Cecchi, A A Cruz, P Devillier, W J Fokkens, S Gil-Mata, A Fm Giuliano, J C Ivancevich, P Kuna, M Kupczyk, G Louis, R Louis, M Makris, M Morais-Almeida, J Mullol, R Nadif, M Niedoszytko, Y Okamoto, M Ollert, N G Papadopoulos, V Patella, R Pawankar, A M Pereira, B Pétré, N Pham-Thi, N Roche, P W Rouadi, J Sastre, N Scichilone, A Sheikh, M Sova, A Todo-Bom, A Yorgancioglu, M Zidarn, J M Anto, T Zuberbier, J A Fonseca, J Bousquet","doi":"10.18176/jiaci.1047","DOIUrl":"10.18176/jiaci.1047","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as \"intermittent\" or \"persistent\" and \"mild\" or \"moderate-severe\". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.</p><p><strong>Methods: </strong>We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months. We assessed the frequency of users according to the ARIA classes and compared these classes in terms of rhinitis symptoms, use of comedication, frequency of comorbid asthma, and the association between comorbid asthma and rhinitis control.</p><p><strong>Results: </strong>A total of 2273 users (180 796 days) were assessed. Most users had moderate-severe rhinitis (n=2003; 88.1%) and persistent rhinitis (n=1144; 50.3%). The frequency of patients with probable asthma was 35.7% (95%CI, 34.5%-37.0%) for intermittent rhinitis and 48.5% (95%CI, 47.1%-49.9%) for persistent rhinitis. The maximum values on the visual analog scale (VAS) for rhinitis symptoms and the combined symptom medication score were lower in patients with mild rhinitis than in those with moderate-severe rhinitis (irrespective of whether they had persistent or intermittent rhinitis). In most ARIA classes, VAS nose and VAS eye and rhinitis comedication were more frequent in patients with rhinitis+asthma than in those with rhinitis alone.</p><p><strong>Conclusion: </strong>This study suggests that the presence of asthma is more closely related to persistence of rhinitis than to severity and that the presence of comorbid asthma may be associated with poorer control of rhinitis across the different ARIA classes.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Urinary Protein Biomarkers in Hereditary Angioedema.","authors":"J Wu, X Tang, N Zhou, X Wang, P Liu, Z Zhang, S Zhang, Y Zhi","doi":"10.18176/jiaci.1032","DOIUrl":"https://doi.org/10.18176/jiaci.1032","url":null,"abstract":"<p><strong>Background: </strong>Hereditary angioedema (HAE) is a rare and potentially life-threatening disease, and diagnosis is often missed or delayed. We aimed to identify noninvasive urinary protein biomarkers and to evaluate their potential roles in diagnosis and evaluation of disease severity.</p><p><strong>Methods: </strong>Using data-independent acquisition (DIA)-based urinary proteomics, we identified proteins that were differentially expressed between patients with HAE and healthy control (HC) groups. Then, the parallel reaction monitoring (PRM)-targeted proteomics method was used to validate promising biomarker candidates in other HAE patients and HCs. Furthermore, enzyme-linked immunosorbent assay (ELISA) was conducted to verify levels of several key proteins in HAE, histamine-mediated angioedema, and HCs.</p><p><strong>Results: </strong>Differential expression between HAE patients and HCs was observed in 269 of the 2562 urinary proteins identified. In the biofunction analysis, these differentially expressed proteins were significantly enriched in leukocyte migration, adhesion of immune cells, endothelial cell development, permeability of the vascular system, and death of immune cells. Moreover, a biomarker panel (C1 esterase inhibitor, pro-epidermal growth factor, and kininogen-1) was validated in 2 independent clinical cohorts with area under the curve values of 0.910 and 0.949 for a diagnosis of HAE. Additionally, the urinary clusterin level was found to be significantly correlated with HAE severity scores (R=-0.758, P<.01).</p><p><strong>Conclusions: </strong>This study describes the first application of a DIA-PRM-ELISA workflow to identify noninvasive urine biomarkers of HAE. The results will contribute to our understanding of the pathogenesis of HAE and may also provide a potential alternative method for diagnosis and evaluation of disease severity.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}