Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Revealing the Complexity of Allergies in Spain: A Multicenter Study on Sensitization Patterns and Clinical Implications.","authors":"Cristina Cacheiro-Llaguno, Javier Domínguez-Ortega, Ignacio Dávila, Juan M Beitia, Juan M de la Borbolla, Francisco J Carballada, Alberto Caso, Sendy Chugo Gordillo, Javier Figueroa, Fernando García, Ignacio Garcia Nuñez, Jose C García Robaina, María J Goikoetxea, Francisco J Hernández Arbeiza, María D Del Pozo, Francisco Moreno Benítez, Ana Pérez Montero, Isabela Raducan, Fernando Rodríguez Fernández, María Rueda García, David Calzada, Cristina Osuna, Sandra González-de la Fuente, Jerónimo Carnés","doi":"10.18176/jiaci.1147","DOIUrl":"10.18176/jiaci.1147","url":null,"abstract":"<p><strong>Background and objectives: </strong>Defining a patient´s allergic profile by identifying the allergens that cause symptoms is essential for the design of specific, tailored immunotherapy, ensuring greater effectiveness in cases of polyallergy. Objective: This observational, multicenter study aimed to demonstrate the heterogeneity of the Spanish population with respiratory allergy by analyzing specific immunoglobulin E (sIgE) patterns for aeroallergens and exploring the relationship between sensitization and clinical symptoms.</p><p><strong>Patients and methods: </strong>A total of 474 patients with respiratory allergy from different regions of Spain were recruited based on their case histories and skin prick test data for aeroallergens. Serum samples were analyzed using ImmunoCAPTM assays to determine sIgE levels for 33 allergenic sources and 43 molecular allergens.</p><p><strong>Results: </strong>Ninety percent of patients were polysensitized. Pollen was the most common cause of sensitization, followed by mites. Interestingly, polysensitization was significantly associated with the severity of rhinitis symptoms. The molecular diagnosis revealed Phl p 1 as the most prevalent pollen sensitizer. Sensitization to mites was mainly driven by Der p 2. Fel d 1 and Alt a 1 were the most frequently recognized allergens among patients sensitized to animal epithelia and molds, respectively. Moreover, sensitization to mite and animal epithelia allergens was significantly associated with more severe asthma symptoms.</p><p><strong>Conclusions: </strong>Our findings show a high prevalence of polysensitization and highlight the importance of molecular diagnosis for improving diagnostic accuracy and designing immunotherapy tailored to patients in the region.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Recombinant Tissue-Type Plasminogen Activator on Peripheral Blood Mononuclear Cells of Patients With Alteplase-Associated Angioedema.","authors":"Francesco Palestra, Maria Bova, Giovanna Servillo, Massimiliano Chetta, Renato Ciardi, Paolo Candelaresi, Marina Tarsitano, Chiara Suffritti, Roberta Gualtierotti, Stefania Miniello, Anne L Ferrara, Gilda Varricchi, Raimondo Cavallaro, Vincenzo Andreone, Stefania Loffredo","doi":"10.18176/jiaci.1146","DOIUrl":"https://doi.org/10.18176/jiaci.1146","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recombinant tissue-type plasminogen activator (R-tPA) is a thrombolytic agent used to treat acute ischemic stroke (IS). A rare but serious adverse effect of R-tPA is angioedema, which is characterized by plasma extravasation and increased release of vasoactive factors such as bradykinin, vascular endothelial growth factor A (VEGF-A), CXCL8, angiopoietin-1 (ANGPT-1), and ANGPT-2. Objective: To investigate whether R-tPA modulates immune cell activity differently in IS patients with and without angioedema, focusing on the release of vasoactive mediators from human peripheral blood mononuclear cells (PBMCs).</p><p><strong>Methods: </strong>PBMCs were isolated from 7 healthy controls (HCs), 7 IS patients without angioedema, and 7 IS patients who developed angioedema during R-tPA treatment (ISAE). The production and/or release of CXCL8, VEGF-A, ANGPT-1, and ANGPT-2 following ex vivo stimulation with R-tPA was measured. Plasma levels of these mediators were also assessed in ISAE patients during both angioedema attacks and remission.</p><p><strong>Results: </strong>R-tPA inhibited the spontaneous release of VEGF-A, ANGPT-1, and ANGPT-2 from the PBMCs of HCs and IS patients. In contrast, a significant increase in the release of these mediators after stimulation with R-tPA was observed in PBMCs from ISAE patients. Plasma concentrations of all 4 mediators were higher during angioedema attacks than in remission, with a statistically significant elevation recorded for ANGPT-2.</p><p><strong>Conclusions: </strong>These preliminary data suggest that R-tPA-related angioedema may result from abnormal immune cell activation, leading to increased release of vasoactive mediators. This immune dysregulation may contribute to the pathophysiology of angioedema in susceptible IS patients treated with R-tPA.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Medicine in Allergic Rhinitis and Conjunctivitis: Integrative Molecular Mapping of the Allergic Exposome in Spain (EXPOMOL Study).","authors":"Ruperto González-Pérez, Paloma Poza-Guedes, Juan M Igea Aznar, Carmen Rondón Segovia, Almudena Testera Montes, Beatriz Fernández Parra, Melvin Vásquez-Suero, Ana M Navarro Pulido, María C Sánchez Hernández, Jose A Lemus Calderón, Ana Montoro-Ferrer, María T Dordal Culla, Jaume Martí-Garrido, Magdalena Lluch Bernal, Antonio Letrán Camacho, Guillermo Ojea Sánchez, Lluis Marques, Silvia Lara Alcón, María Nieto Cid, David El-Qutob, Fernando Rodríguez, Ángel Albarracín Contreras, María J Martínez, Elena Santano Guillén, Eva Abel-Fernández, Tania Galán Díez, Fernando Pineda de la Losa","doi":"10.18176/jiaci.1157","DOIUrl":"https://doi.org/10.18176/jiaci.1157","url":null,"abstract":"<p><strong>Introduction: </strong>Exposomic determinants substantially influence the variability of molecular IgE-mediated sensitization in allergic rhinitis and conjunctivitis across bioclimatic regions, underscoring their relevance in precision allergology. This study aimed to characterize molecular sensitization profiles in Spanish patients with respiratory allergy from distinct geographic and climatic areas.</p><p><strong>Methods: </strong>A cross-sectional, multicenter study was performed in 12 Spanish cities. The study population comprised 291 patients diagnosed with allergic rhinitis and/or conjunctivitis according to the modified ARIA/DECA criteria. Participants underwent skin prick testing with standardized allergen extracts and multiplex molecular IgE analysis. Clinical, demographic, and regional bioclimatic variables were integrated to define exposomic sensitization patterns. Patients previously treated with allergen immunotherapy or biologics were excluded. Regional pooled sera were analyzed by ELISA and IgE immunoblotting to validate molecular data and identify IgE binding to nonrecombinant or poorly characterized allergenic components.</p><p><strong>Results: </strong>Distinct regional sensitization profiles were identified. Grass pollen allergens predominated in oceanic and continental climates, while olive and cypress pollens were more frequent in Mediterranean areas. Sensitization to house dust mite, particularly Dermatophagoides pteronyssinus and Blomia tropicalis, was highly prevalent in subtropical and humid zones. Molecular assays confirmed skin test findings and identified major allergenic molecules, including Phl p 1, Ole e 1, Der p 1, and Der p 2, along with region-specific components such as Der p 23, Cup a 1, Alt a 1, and Pla a 2.</p><p><strong>Conclusions: </strong>This multicenter exposomic study demonstrated that climatic diversity modulates allergen sensitization in Spain, supporting region-tailored precision diagnostic and therapeutic strategies in respiratory allergy.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to Bee Pollen Supplement: Identification of Major Royal Jelly Protein 1 as the Culprit Allergen.","authors":"Alejandro De la Torre Carrión, Estela S Castromil-Benito, Jorge Parrón-Ballesteros, Luisa Iglesias-Pena, Carlos Pastor-Vargas, Montserrat Fernandez-Rivas","doi":"10.18176/jiaci.1124","DOIUrl":"10.18176/jiaci.1124","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"72-74"},"PeriodicalIF":4.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding \"Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Induced by Meropenem in a Patient Receiving Avelumab and Subsequent Flare-up\".","authors":"Öner Özdemir","doi":"10.18176/jiaci.1133","DOIUrl":"10.18176/jiaci.1133","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"81-82"},"PeriodicalIF":4.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Desensitization to Vedolizumab in a Patient with Ulcerative Colitis.","authors":"Cristina Juárez Rodríguez, María José J Peñalver, Ruth Mielgo","doi":"10.18176/jiaci.1117","DOIUrl":"10.18176/jiaci.1117","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"68-69"},"PeriodicalIF":4.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of the Specific Role of Biological Therapies in Aspirin-Exacerbated Respiratory Disease.","authors":"Milagros Lázaro-Sastre, Esther Moreno-Rodilla, Cristina Martín-García, Juan Maza-Solano, María Gil-Melcon, Ignacio Dávila","doi":"10.18176/jiaci.1155","DOIUrl":"10.18176/jiaci.1155","url":null,"abstract":"<p><p>Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs). Although high-dose aspirin therapy after desensitization (ATAD) and surgery are effective, adverse effects and high dropout rates limit its use. The emergence of biologics for asthma and/or CRSwNP entails rethinking the management of AERD. There is no consensus on choosing between ATAD and biologics. This systematic review evaluates current evidence on the role of biologics in the management of AERD, focusing on their potential to induce NSAID tolerance and proposing a management algorithm. A systematic literature search was conducted across PubMed, Embase, and Scopus up to March 2025. Studies were selected based on predefined criteria, excluding editorials, reviews, case reports, guidelines, and publications not in English. Data were extracted from clinical trials, real-world studies, and retrospective analyses. The various inflammatory pathways targeted by biologics included immunoglobulin E (omalizumab), subunit alpha of the interleukin 4 receptor (IL-4Ra) (dupilumab), IL-5/IL-5Ra (mepolizumab, benralizumab), and thymic stromal lymphopoietin (tezepelumab). These drugs have demonstrated efficacy in improving asthma and CRSwNP in AERD. The most consistent evidence seems to favor omalizumab and dupilumab for enhancing tolerance to NSAIDs. Although evidence remains inconclusive, the combination of ATAD and biologics may offer additive benefits in selected patients. Biologics represent a promising alternative in the management of AERD, particularly for patients with poor tolerance to aspirin. Further prospective, controlled studies are needed to define optimal treatment algorithms and identify biomarkers predictive of therapeutic response.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"12-24"},"PeriodicalIF":6.6,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component-Resolved IgE and IgG4 Profiling Reveals Robust IgG4 Responses Primarily to Abundant Hymenoptera Allergens During Venom Immunotherapy and in Beekeepers.","authors":"Simon Blank, Britta Dorn, Peter Seiringer, Johanna Grosch, Benjamin O Slusarenko, Michael Dittmar, Robert Kaczmarcyk, Danielle Rogner, Andreas Jung, Laura Plail, Bernadette Eberlein, Tilo Biedermann, Ulf Darsow, Knut Brockow, Carsten B Schmidt-Weber, Thilo Jakob","doi":"10.18176/jiaci.1072","DOIUrl":"10.18176/jiaci.1072","url":null,"abstract":"<p><strong>Background and objectives: </strong>Venom immunotherapy (VIT) and natural exposure to Hymenoptera venom induce immune tolerance in allergic patients and beekeepers, respectively. Specific IgE (sIgE) and IgG4 (sIgG4) antibodies play crucial roles in allergic reactions and immune tolerance. Objective: To investigate the dynamics of sIgE and sIgG4 responses to Hymenoptera venom in patients undergoing VIT and in nonallergic beekeepers at a component-resolved level.</p><p><strong>Methods: </strong>Serum samples from patients allergic to honeybee venom (HBV) or yellow jacket venom (YJV) and from beekeepers were collected during the first year of VIT and before and after the beekeeping season, respectively. sIgE and sIgG4 levels to whole venom and molecular allergens were measured using the ImmunoCAP platform.</p><p><strong>Results: </strong>Pronounced sIgE and sIgG4 responses to Ves v 1 and 5 in YJV-allergic patients were accompanied by more frequent sensitization to Ves v 1 after up-dosing. While sIgE profiles in HBV-allergic patients were highly diverse, with a marked contribution of Api m 1 and Api m 10 sIgE, the sIgG4 response during VIT was strongly dominated by Api m 1. Different VIT preparations did not significantly affect the sIgG4 response to low-abundance HBV allergens. In beekeepers, induction of sIgG4 was dependent on sting frequency and was dominated by Api m 1.</p><p><strong>Conclusion: </strong>Robust induction of IgG4 during VIT and natural venom exposure occurs primarily to abundant allergens and is unaffected by the choice of VIT preparation. The effectiveness of VIT and beekeepers´ tolerance to HBV indicate that strong sIgG4 responses to lowabundance allergens are not crucial for immune tolerance.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"25-35"},"PeriodicalIF":4.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Prophylaxis With Lanadelumab in Patients With Angioedema Due to C1 Inhibitor Deficiency: A Real-life Study in Spain.","authors":"Isamar De Agrela-Mendes, Ana Entrala, Elsa Phillips-Angles, Tamara Pérez-Robles, Rosario Cabañas, Teresa Caballero","doi":"10.18176/jiaci.1120","DOIUrl":"10.18176/jiaci.1120","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"77-79"},"PeriodicalIF":4.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chicory-Induced Anaphylaxis: Characterization of Peroxidase as a Novel Allergen.","authors":"María Otal-Buesa, Leyre Baptista-Serna, Emilio Nuñez-Borque, Sergio Fernández-Bravo, Vanesa Esteban, Joaquín Sastre","doi":"10.18176/jiaci.1113","DOIUrl":"10.18176/jiaci.1113","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"64-65"},"PeriodicalIF":4.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}