Journal of Investigational Allergology and Clinical Immunology最新文献

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-13 DOI: 10.18176/jiaci.1025

D Betancor, A Gómez-López, B Barroso, M Valverde-Monge, J A Cañas, J M Rodrigo-Muñoz, V Del Pozo, J Sastre

引用次数: 0

Occupational Asthma and Rhinoconjunctivitis due to Soybean in a Bakery Worker. 一名面包店工人因大豆引发职业性哮喘和鼻结膜炎。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-13 DOI: 10.18176/jiaci.1035

Ö Özdemir

引用次数: 0

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals. 疟原虫过敏者被蜱虫叮咬后外周免疫学变化的纵向随访揭示。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-13 DOI: 10.18176/jiaci.1028

K Swiontek, J Fischer, F Hedin, D Revets, S Riel, N Chakrapani, U Mackenstedt, T Biedermann, A Kuehn, A Cosma, M Ollert, C Hilger

{"title":"Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals.","authors":"K Swiontek, J Fischer, F Hedin, D Revets, S Riel, N Chakrapani, U Mackenstedt, T Biedermann, A Kuehn, A Cosma, M Ollert, C Hilger","doi":"10.18176/jiaci.1028","DOIUrl":"10.18176/jiaci.1028","url":null,"abstract":"Background and objectives: α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion of mammalian meat. While tick bites are assumed to mediate sensitization, the immune response to tick bites has not yet been investigated. To investigate the peripheral immune response to tick bites in humans over time.Methods: In a longitudinal cohort study, immunological reactions associated with tick bites (Ixodes species) were analyzed within 1 day (V1), 2 weeks (V2), 1 month (V3), and 3 months (V4) after the occurrence of a bite. sIgE, sIgG, and sIgG subclass levels, as well as 10 cytokines, were quantified. Deep immune phenotyping was performed using mass cytometry.Results: A total of 4 controls and 10 patients were bitten by a tick and followed up over 3 months. None of the controls developed sIgE to α-Gal, and sIgE increased in all patients from V1 until V2/V3, as did IL-8 levels. We noted a significant increase in CD19+ B cells and B-cell subpopulations, as well as a decrease in γδ CD56+ T cells in patients between V0 and V1. At V1, frequencies of plasmacytoid dendritic cells (pDCs) and γδ CD56+ T cells were lower in patients than in controls.Conclusion: Our study provides evidence of significant changes in several immune cell populations in α-Gal sensitized patients, along with increased levels of IL-8 and sIgE. This is the first exploratory study to investigate longitudinal peripheral immune profiles in patients and controls bitten by ticks.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin. 氧氟沙星诱发的接触性皮炎对环丙沙星耐受。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-13 DOI: 10.18176/jiaci.1031

M N Otero-Fernández, E Laffond-Yges, R M Castillo-Loja, A Cabrera-Núñez, M E Mazoteras-Martínez, F J Muñoz-Bellido, I Dávila

引用次数: 0

A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10. 从养蜂人体内分离出的全人源单克隆抗体靶向 Api m 10 的免疫显性 IgE 表位。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-12 DOI: 10.18176/jiaci.1029

A Lund, B Dorn, T Jakob, L H Christensen, F Jabs, E Spillner

引用次数: 0

Allergy to Red Mullet and Seabass: Two Newly Identified Red Mullet Allergens. 对红鲻鱼和鲈鱼过敏：两种新发现的红鲻过敏原。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-12 DOI: 10.18176/jiaci.1024

M D Escalante-Carrero, J M Renilla-Arroyo, C Fernández, J Martínez-Botas, D Antolín-Amérigo, B De la Hoz-Caballer

引用次数: 0

Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience. 西班牙马德里一所三级大学医院重症监护室收治的哮喘患者的特征：五年经验。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-12 DOI: 10.18176/jiaci.1021

M Lozano-Espinosa, N Rodríguez-Otero, D Antolín-Amérigo, F Gordo Vidal, A Muriel, R de Pablo, S Quirce

引用次数: 0

Exercise-Dependent Codfish Allergy due to Tropomyosin. 托品肌肽导致的运动依赖性鳕鱼过敏症

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-12 DOI: 10.18176/jiaci.1022

V Faihs, C Kugler, B Eberlein, R Bent, U Darsow, T M Boehm, C Hilger, T Biedermann, A Kuehn, K Brockow

引用次数: 0

Safety, Tolerability, and Feasibility of the Milk Ladder for Reintroduction of Cow's Milk in Infants With IgE-Mediated Cow's Milk Allergy. 在 IgE 引起的牛乳过敏婴儿中重新引入牛奶阶梯的安全性、耐受性和可行性。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-12 DOI: 10.18176/jiaci.1017

I Cerecedo, B de la Hoz, S Infante, N P Freundt Serpa, A Vaquero Rey, A Carrón Herrero, S Vázquez Cortés, A Garban Camero, E Redondo Vegas, A Gonzalo-Fernández, I Serrano García, A López-Picado, M Fernández-Rivas

引用次数: 0

Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients. 小儿实体器官移植后新食物过敏的病理生理学。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-11-12 DOI: 10.18176/jiaci.1027

P Pérez-López, J L López-Guillén

{"title":"Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients.","authors":"P Pérez-López, J L López-Guillén","doi":"10.18176/jiaci.1027","DOIUrl":"https://doi.org/10.18176/jiaci.1027","url":null,"abstract":"De novo food allergy is a common phenomenon among pediatric solid organ recipients (8.5%-57%) when compared with the general population (0.45%-10%). Other associated disorders include non-IgE-mediated immune reactions and clinical predisposition to asthma and alterations in the oral mucosa. Originally, passive mechanisms (passive transfer of IgE and immune cells) were thought to be responsible for acute, transient cases of food allergies with a previous history of sensitization for a specific allergen in the donor. Recently proposed pathophysiological mechanisms to explain de novo allergies include TH2/B-cell imbalance, regulatory T-cell (Treg) disruption, gastrointestinal immaturity, and altered gastrointestinal permeability. Recent studies also suggest that immunosuppressive drugs, especially tacrolimus, promote naïve T-cell differentiation into TH2 cells, IgE-promoting cytokine production, decreased IL-5 and IL-10 levels, increased IgA levels, and Treg disruption. Such immunological interactions, in conjunction with altered intestinal permeability, intestinal immaturity in children, history of viral infection, and a personal history of allergies or eczema, are thought to explain most clinical cases of pediatric de novo food allergy after solid organ transplantation reported in the literature. A better understanding of the immunological mechanisms underpinning organ donors and recipients may unveil some of the caveats concerning therapeutic management and improve the quality of life of affected individuals.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0