Journal of Investigational Allergology and Clinical Immunology最新文献

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Generalized Eczema as a Transient Paradoxical Adverse Effect of Dupilumab.
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-20 DOI: 10.18176/jiaci.1051
D Betancor, M Valverde-Monge, J L Díaz-Recuero, M E Jo-Velasco, V Del Pozo, J Sastre
{"title":"Generalized Eczema as a Transient Paradoxical Adverse Effect of Dupilumab.","authors":"D Betancor, M Valverde-Monge, J L Díaz-Recuero, M E Jo-Velasco, V Del Pozo, J Sastre","doi":"10.18176/jiaci.1051","DOIUrl":"https://doi.org/10.18176/jiaci.1051","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10. 从养蜂人体内分离出的全人源单克隆抗体靶向 Api m 10 的免疫显性 IgE 表位。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1029
A Lund, B Dorn, T Jakob, L H Christensen, F Jabs, E Spillner
{"title":"A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10.","authors":"A Lund, B Dorn, T Jakob, L H Christensen, F Jabs, E Spillner","doi":"10.18176/jiaci.1029","DOIUrl":"10.18176/jiaci.1029","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"55-57"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonmandatory Labeled Legumes Are an Emergent Safety Concern: An Illustrative Case Report. 非强制性标签豆类食品是一个紧迫的安全问题:说明性案例报告。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-09-25 DOI: 10.18176/jiaci.1020
R N Vera-Berrios, L Uriarte Vega, G Marco-Martín, M Fernández-Rivas
{"title":"Nonmandatory Labeled Legumes Are an Emergent Safety Concern: An Illustrative Case Report.","authors":"R N Vera-Berrios, L Uriarte Vega, G Marco-Martín, M Fernández-Rivas","doi":"10.18176/jiaci.1020","DOIUrl":"10.18176/jiaci.1020","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"58-60"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Immunological Mechanism Underlying a Cutaneous Adverse Reaction to Enfortumab Vedotin: A Case Report Based on the Lymphocyte Transformation Test. 揭示维多汀皮肤不良反应的免疫学机制:基于淋巴细胞转化试验的一例报告。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-12-02 DOI: 10.18176/jiaci.1023
P Gutiérrez-Canales, C Fernández-Lozano, V Alba-Pérez, A Ruiz-Granados, L Díaz-Montalvo, J Martínez-Botas, E Solano-Solares
{"title":"Unveiling the Immunological Mechanism Underlying a Cutaneous Adverse Reaction to Enfortumab Vedotin: A Case Report Based on the Lymphocyte Transformation Test.","authors":"P Gutiérrez-Canales, C Fernández-Lozano, V Alba-Pérez, A Ruiz-Granados, L Díaz-Montalvo, J Martínez-Botas, E Solano-Solares","doi":"10.18176/jiaci.1023","DOIUrl":"10.18176/jiaci.1023","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"63-65"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are Biosimilars of Biologics the Same as the Reference Drug in Terms of Allergy? Selective Allergy to Tocilizumab Biosimilar. 就过敏而言,生物制剂的生物仿制药与参比药物一样吗?对托珠单抗生物仿制药的选择性过敏。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-11-13 DOI: 10.18176/jiaci.1025
D Betancor, A Gómez-López, B Barroso, M Valverde-Monge, J A Cañas, J M Rodrigo-Muñoz, V Del Pozo, J Sastre
{"title":"Are Biosimilars of Biologics the Same as the Reference Drug in Terms of Allergy? Selective Allergy to Tocilizumab Biosimilar.","authors":"D Betancor, A Gómez-López, B Barroso, M Valverde-Monge, J A Cañas, J M Rodrigo-Muñoz, V Del Pozo, J Sastre","doi":"10.18176/jiaci.1025","DOIUrl":"10.18176/jiaci.1025","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"68-69"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience. 西班牙马德里一所三级大学医院重症监护室收治的哮喘患者的特征:五年经验。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1021
M Lozano-Espinosa, N Rodríguez-Otero, D Antolín-Amérigo, F Gordo Vidal, A Muriel, R de Pablo, S Quirce
{"title":"Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience.","authors":"M Lozano-Espinosa, N Rodríguez-Otero, D Antolín-Amérigo, F Gordo Vidal, A Muriel, R de Pablo, S Quirce","doi":"10.18176/jiaci.1021","DOIUrl":"10.18176/jiaci.1021","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"50-52"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergy to Red Mullet and Sea Bass: Two Newly Identified Red Mullet Allergens. 对红鲻鱼和鲈鱼过敏:两种新发现的红鲻过敏原。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1024
M D Escalante-Carrero, J M Renilla-Arroyo, C Fernández, J Martínez-Botas, D Antolín-Amérigo, B De la Hoz-Caballer
{"title":"Allergy to Red Mullet and Sea Bass: Two Newly Identified Red Mullet Allergens.","authors":"M D Escalante-Carrero, J M Renilla-Arroyo, C Fernández, J Martínez-Botas, D Antolín-Amérigo, B De la Hoz-Caballer","doi":"10.18176/jiaci.1024","DOIUrl":"10.18176/jiaci.1024","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"65-67"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotyping Asthma Exacerbations: One Step Further in the Management of Severe Asthma. 哮喘恶化的表型分析:重症哮喘管理更进一步。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-11-28 DOI: 10.18176/jiaci.1043
I Ojanguren, S Quirce, I Bobolea, L Pérez de Llano, V Del Pozo
{"title":"Phenotyping Asthma Exacerbations: One Step Further in the Management of Severe Asthma.","authors":"I Ojanguren, S Quirce, I Bobolea, L Pérez de Llano, V Del Pozo","doi":"10.18176/jiaci.1043","DOIUrl":"10.18176/jiaci.1043","url":null,"abstract":"<p><p>Asthma, a prevalent chronic respiratory disease, manifests in heterogeneous phenotypes and endotypes, necessitating bespoke therapeutic approaches. Asthma exacerbations are characterized by worsening of symptoms and decline in lung function and present substantial challenges despite advances in understanding and treatment. Viral respiratory infections, notably those caused by rhinovirus, serve as primary triggers, with allergic sensitization and environmental exposures increasing susceptibility. Deficient antiviral responses in asthmatic airway epithelial cells, particularly impaired interferon production, perpetuate inflammation and hyperresponsiveness, contributing to exacerbations. Additionally, genetic polymorphisms influence host responses and susceptibility. Recent studies underscore the association between specific inflammatory profiles, particularly eosinophil-mediated inflammation, and the frequency of exacerbations. Biologic therapies targeting inflammatory pathways show promise in reducing the frequency of exacerbations, thus underscoring the importance of understanding inflammatory phenotypes when selecting treatment. Notably, T2 inhibitors may modulate immune responses, potentially mitigating viral exacerbations. Characterizing exacerbations is crucial for optimizing therapeutic strategies. Evidence suggests a dissociation between baseline inflammatory profiles and exacerbation phenotypes, highlighting the need for individualized management. Phenotyping exacerbations using sputum analysis helps to identify predominant inflammatory patterns and thus inform treatment decisions. The varied responses to biologic therapies further emphasize the importance of phenotyping exacerbations in refining treatment algorithms. In conclusion, phenotyping asthma exacerbations provides valuable insights into underlying inflammatory mechanisms and enables personalized therapy. Understanding the complex interplay between viral triggers, inflammatory pathways, and responses to treatment is essential if we are to effectively manage severe asthma and reduce the burden of exacerbations. Further research into the mechanistic actions of biologic therapies in mitigating viral exacerbations is warranted to optimize asthma management strategies.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Affecting the Safety and Effectiveness of Venom Immunotherapy. 毒液免疫疗法安全性和有效性的影响因素。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2023-11-08 DOI: 10.18176/jiaci.0967
L Arzt-Gradwohl, S A Herzog, W Aberer, T Alfaya Arias, D Antolín-Amérigo, P Bonadonna, E Boni, A Bożek, M Chełmińska, B Ebner, N Frelih, R Gawlik, A Gelincik, T Hawranek, W Hoetzenecker, A Jiménez Blanco, K Kita, R Kendirlinan, M Košnik, K Laipold, R Lang, F Marchi, M Mauro, M Nittner-Marszalska, I Poziomkowska-Gęsicka, V Pravettoni, D Preziosi, O Quercia, N Reider, M Rosiek-Biegus, B Ruiz-Leon, C Schrautzer, P Serrano, A Sin, B A Sin, J Stoevesandt, A Trautmann, M Vachová, G J Sturm
{"title":"Factors Affecting the Safety and Effectiveness of Venom Immunotherapy.","authors":"L Arzt-Gradwohl, S A Herzog, W Aberer, T Alfaya Arias, D Antolín-Amérigo, P Bonadonna, E Boni, A Bożek, M Chełmińska, B Ebner, N Frelih, R Gawlik, A Gelincik, T Hawranek, W Hoetzenecker, A Jiménez Blanco, K Kita, R Kendirlinan, M Košnik, K Laipold, R Lang, F Marchi, M Mauro, M Nittner-Marszalska, I Poziomkowska-Gęsicka, V Pravettoni, D Preziosi, O Quercia, N Reider, M Rosiek-Biegus, B Ruiz-Leon, C Schrautzer, P Serrano, A Sin, B A Sin, J Stoevesandt, A Trautmann, M Vachová, G J Sturm","doi":"10.18176/jiaci.0967","DOIUrl":"10.18176/jiaci.0967","url":null,"abstract":"<p><strong>Background: </strong>The safety profile of venom immunotherapy (VIT) is a relevant issue, and considerable differences have been reported in the safety and efficacy of this treatment modality. The primary aim of this study was to evaluate the safety of angiotensin-converting enzyme inhibitors and ß-blockers during VIT. In a second analysis, we evaluated data on premedication and venom preparations and their association with systemic adverse events (AEs) during the up-dosing phase and the first year of the maintenance phase, as well as the outcome of field stings and sting challenges.</p><p><strong>Methods: </strong>Ours was an open, prospective, observational, multicenter study that recruited 1425 patients, of whom 1342 underwent VIT.</p><p><strong>Results: </strong>Premedication with oral antihistamines was taken by 52.1% of patients during up-dosing and 19.7% of patients during the maintenance phase. Antihistamines had no effect on the frequency of systemic AEs (P=.11), although large local reactions (LLRs) were less frequent (OR, 0.74; 95%CI, 0.58-0.96; P=.02). Aqueous preparations were preferred for up-dosing (73.0%), and depot preparations were used for the maintenance phase (64.5%). The type of venom preparation had no influence on the frequency of systemic AEs or on the effectiveness of VIT (P=.26 and P=.80, respectively), while LLRs were less frequent with depot preparations (P<.001).</p><p><strong>Conclusions: </strong>Pretreatment with oral antihistamines during VIT significantly reduces the frequency of LLRs but not systemic AEs. All venom preparations were equally effective and did not differ in terms of the frequency of systemic AEs.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"40-49"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise-Dependent Codfish Allergy due to Tropomyosin. 托品肌肽导致的运动依赖性鳕鱼过敏症
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-02-18 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1022
V Faihs, C Kugler, B Eberlein, R Bent, U Darsow, T M Boehm, C Hilger, T Biedermann, A Kuehn, K Brockow
{"title":"Exercise-Dependent Codfish Allergy due to Tropomyosin.","authors":"V Faihs, C Kugler, B Eberlein, R Bent, U Darsow, T M Boehm, C Hilger, T Biedermann, A Kuehn, K Brockow","doi":"10.18176/jiaci.1022","DOIUrl":"10.18176/jiaci.1022","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"60-62"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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