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Acute Generalized Exanthematous Pustulosis due to Benznidazole With Safe Use of Nifurtimox in a Pediatric Patient. 苯并硝唑引起的急性全发性脓疱病患儿安全使用硝呋替莫。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 DOI: 10.18176/jiaci.1203
Luis Morejón, Marta Fernández-Izquierdo, Teresa Bellón, Mar Gandolfo-Cano, Carmen Gómez-Traseira
{"title":"Acute Generalized Exanthematous Pustulosis due to Benznidazole With Safe Use of Nifurtimox in a Pediatric Patient.","authors":"Luis Morejón, Marta Fernández-Izquierdo, Teresa Bellón, Mar Gandolfo-Cano, Carmen Gómez-Traseira","doi":"10.18176/jiaci.1203","DOIUrl":"https://doi.org/10.18176/jiaci.1203","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Rituximab-Induced Cytokine Release Syndrome After Desensitization Successfully Treated With Tocilizumab: A Case Report. 托珠单抗成功治疗脱敏后严重利妥昔单抗诱导的细胞因子释放综合征：一例报告。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2026-06-25 DOI: 10.18176/jiaci.1185
Paula Viedma Ayllon, Julián Borrás Cuartero, Salvador Almela Rambla, Mario Montagud Porta, María Cruz Torres Gorriz, Ernesto Enrique
{"title":"Severe Rituximab-Induced Cytokine Release Syndrome After Desensitization Successfully Treated With Tocilizumab: A Case Report.","authors":"Paula Viedma Ayllon, Julián Borrás Cuartero, Salvador Almela Rambla, Mario Montagud Porta, María Cruz Torres Gorriz, Ernesto Enrique","doi":"10.18176/jiaci.1185","DOIUrl":"10.18176/jiaci.1185","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"406-408"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Berotralstat During Pregnancy in a Patient With Hereditary Angioedema. 妊娠期遗传性血管性水肿患者的贝曲司他。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2026-07-29 DOI: 10.18176/jiaci.1163
Andrea Zanichelli, Daniele Scaramuzzi, Lorenzo Dagna
{"title":"Berotralstat During Pregnancy in a Patient With Hereditary Angioedema.","authors":"Andrea Zanichelli, Daniele Scaramuzzi, Lorenzo Dagna","doi":"10.18176/jiaci.1163","DOIUrl":"10.18176/jiaci.1163","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"401-403"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and Risk Factors of Pollen-Food Allergy Syndrome in Patients With Hay Fever: A Digital Cross-Sectional Cohort Study Using AllerSearch. 花粉热患者花粉食物过敏综合征的特征和危险因素：一项使用AllerSearch的数字横断面队列研究
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2025-09-09 DOI: 10.18176/jiaci.1101
Takenori Inomata, Ken Nagino, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Takeya Adachi, Hiroyuki Kobayashi, Shintaron Nakao
{"title":"Characteristics and Risk Factors of Pollen-Food Allergy Syndrome in Patients With Hay Fever: A Digital Cross-Sectional Cohort Study Using AllerSearch.","authors":"Takenori Inomata, Ken Nagino, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Takeya Adachi, Hiroyuki Kobayashi, Shintaron Nakao","doi":"10.18176/jiaci.1101","DOIUrl":"10.18176/jiaci.1101","url":null,"abstract":"<p><strong>Background and objective: </strong>Pollen-food allergy syndrome (PFAS) is a frequent comorbidity in individuals with hay fever. Identifying risk factors and allergen clusters can aid targeted interventions and management strategies. Objective: This study characterizes PFAS in patients with hay fever and identifies associated risk factors using the mobile health platform, AllerSearch.</p><p><strong>Methods: </strong>A digital cross-sectional cohort study was conducted in Japan from August 2020 to September 2024. Participants provided demographic, medical, lifestyle, and environmental data via AllerSearch. PFAS was identified based on self-reported allergic reactions to specific fruits and vegetables. Allergen patterns were analyzed using Uniform Manifold Approximation and Projection clustering, and risk factors were assessed via multivariable logistic regression.</p><p><strong>Results: </strong>Among 2874 participants, 2352 had hay fever, and 1788 (23.9%) reported PFAS. The most common triggers were melon (22.9%), kiwi (18.3%), and tomato (11.7%). Significant risk factors included a history of allergic disease (OR, 1.58), asthma (1.44), atopic dermatitis (1.90), urticaria (2.73), contact lens discontinuation during hay fever season (1.50), sensitivity to yellow sand or particulate matter 2.5 (3.42), and drug allergy (3.04). Seven allergen clusters were identified, with Cluster 6 exhibiting broad allergen sensitivity and the remaining clusters each associated with a single food. Onset of hay fever was earlier in Clusters 1, 4, and 6 than in non-PFAS individuals (P=.002, P=.002, and P=.002, respectively).</p><p><strong>Conclusion: </strong>This study highlights key factors and allergen clusters associated with PFAS using a mobile health approach. Our findings may facilitate tailored interventions and improve quality of life for affected individuals.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"353-374"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dupilumab Rapidly Reduces IgE and Eosinophil Values in Kimura Disease: Sustained Remission Achieved. Dupilumab迅速降低木村病的IgE和嗜酸性粒细胞值：实现持续缓解。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2025-11-05 DOI: 10.18176/jiaci.1126
Boyun Yang, Hanxiao Yu, Minyue Jia, Bingjie Wang, Wo Yao, Huiying Wang
{"title":"Dupilumab Rapidly Reduces IgE and Eosinophil Values in Kimura Disease: Sustained Remission Achieved.","authors":"Boyun Yang, Hanxiao Yu, Minyue Jia, Bingjie Wang, Wo Yao, Huiying Wang","doi":"10.18176/jiaci.1126","DOIUrl":"10.18176/jiaci.1126","url":null,"abstract":"<p><strong>Background and objective: </strong>Kimura disease (KD) is a rare chronic inflammatory disorder characterized by type 2 immune dysregulation. Conventional treatments have shown limited efficacy, whereas biologics targeting type 2 cytokines show therapeutic potential. Objective: This study aimed to evaluate the efficacy and safety of dupilumab, a monoclonal antibody targeting interleukin (IL) 4 and IL-13, in the treatment of KD.</p><p><strong>Methods: </strong>A retrospective case series comprising 8 patients with KD was studied at the Allergy Clinic of the Second Affiliated Hospital of Zhejiang University School of Medicine from October 2021 to June 2024. Patients received dupilumab according to the approved regimen for atopic dermatitis, starting with a 600-mg loading dose followed by 300 mg every 2 weeks. The dosage was gradually tapered based on the clinical response to 300 mg monthly, then every 6 weeks, and finally every 2 months until the drug was eventually discontinued. Clinical outcomes, including mass reduction, serum IgE levels, eosinophil counts, and allergic comorbidities, were assessed.</p><p><strong>Results: </strong>Mass volume was reduced considerably in all 8 patients, with 7 achieving complete remission and 1 attaining partial remission. Both serum IgE levels and eosinophil counts decreased markedly. No clinically significant adverse drug reactions were observed. Several patients remained in remission after discontinuation, with follow-up extending up to 1 year.</p><p><strong>Conclusion: </strong>Dupilumab showed rapid and sustained efficacy in KD, suggesting its potential as a disease-modifying and corticosteroidsparing treatment option. Further controlled studies are warranted to validate these findings.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"382-388"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic Allergy Labels in Hospitalized Patients: Results of a Multicenter Cross-Sectional Study. 住院患者的抗生素过敏标签：一项多中心横断面研究的结果
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2026-05-13 DOI: 10.18176/jiaci.1189
Ana Rosado, Javier Fernández, Rosa Muñoz-Cano, Mónica Venturini, Elia Perez, Leticia De Las Vecillas, Olalla Verdeguer-Segarra, Pilar Gajate-Fernández, Ruth Barranco, Esther Barrionuevo, Ruth Mielgo, M Carmen García-Avilés, Concepción Vila, M José Sanchez-Gonzalez, Jose Julio Laguna, Isabela Raducan, Ignacio García-Nuñez, Teodorikez Jiménez-Rodríguez, Ana Fernández-Barragán, Esther Moreno
{"title":"Antibiotic Allergy Labels in Hospitalized Patients: Results of a Multicenter Cross-Sectional Study.","authors":"Ana Rosado, Javier Fernández, Rosa Muñoz-Cano, Mónica Venturini, Elia Perez, Leticia De Las Vecillas, Olalla Verdeguer-Segarra, Pilar Gajate-Fernández, Ruth Barranco, Esther Barrionuevo, Ruth Mielgo, M Carmen García-Avilés, Concepción Vila, M José Sanchez-Gonzalez, Jose Julio Laguna, Isabela Raducan, Ignacio García-Nuñez, Teodorikez Jiménez-Rodríguez, Ana Fernández-Barragán, Esther Moreno","doi":"10.18176/jiaci.1189","DOIUrl":"10.18176/jiaci.1189","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"398-400"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of Mast Cell Prostaglandin in Food Anaphylaxis. 肥大细胞前列腺素在食物过敏反应中的失调。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2026-06-25 DOI: 10.18176/jiaci.1180
Laia Ollé, Lucía García-García, María Pérez, Jordi Roca-Ferrer, Margarita Martín, Rosa Muñoz-Cano
{"title":"Dysregulation of Mast Cell Prostaglandin in Food Anaphylaxis.","authors":"Laia Ollé, Lucía García-García, María Pérez, Jordi Roca-Ferrer, Margarita Martín, Rosa Muñoz-Cano","doi":"10.18176/jiaci.1180","DOIUrl":"10.18176/jiaci.1180","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"389-391"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inverted Takotsubo Cardiomyopathy Triggered by Corticosteroid Administration in a Patient With Undiagnosed Pheochromocytoma. 未确诊嗜铬细胞瘤患者经皮质类固醇治疗引发的倒Takotsubo心肌病。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2026-07-29 DOI: 10.18176/jiaci.1188
Viviana Mendoza, Tania Ramos García, Ana Novalbos, Francisco Vega, Carlos Blanco
{"title":"Inverted Takotsubo Cardiomyopathy Triggered by Corticosteroid Administration in a Patient With Undiagnosed Pheochromocytoma.","authors":"Viviana Mendoza, Tania Ramos García, Ana Novalbos, Francisco Vega, Carlos Blanco","doi":"10.18176/jiaci.1188","DOIUrl":"10.18176/jiaci.1188","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"409-411"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine-Release Syndrome Due to Intravenous Trastuzumab With Good Tolerance to Subcutaneous Administration. 静脉注射曲妥珠单抗引起的细胞因子释放综合征对皮下给药具有良好的耐受性。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2026-07-31 DOI: 10.18176/jiaci.1187
Leticia Sánchez-Morillas, Guadalupe Marco-Martín, María Polo, Paula Padín, Ana Ascaso Del Rio, María Dolores Zamora Barrios, Alfonso López de Sá Lorenzo, Antonio Portoles-Pérez, Montserrat Fernández-Rivas
{"title":"Cytokine-Release Syndrome Due to Intravenous Trastuzumab With Good Tolerance to Subcutaneous Administration.","authors":"Leticia Sánchez-Morillas, Guadalupe Marco-Martín, María Polo, Paula Padín, Ana Ascaso Del Rio, María Dolores Zamora Barrios, Alfonso López de Sá Lorenzo, Antonio Portoles-Pérez, Montserrat Fernández-Rivas","doi":"10.18176/jiaci.1187","DOIUrl":"10.18176/jiaci.1187","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"395-397"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extract-Negative Cofactor-Dependent Shrimp Anaphylaxis Caused by IgE Reactivity to Insoluble Muscle Proteins. IgE对不溶性肌肉蛋白的反应性引起的提取物阴性辅助因子依赖性虾过敏反应。
IF 6.6 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2026-10-20 Epub Date: 2025-06-26 DOI: 10.18176/jiaci.1191
Timo Buhl, Prasad Dasari, Moritz M Hollstein, Tillmann Schill, Marie C Schuppe, Ryohei Ogino, Tomoharu Yokooji, Hiroaki Matsuo
{"title":"Extract-Negative Cofactor-Dependent Shrimp Anaphylaxis Caused by IgE Reactivity to Insoluble Muscle Proteins.","authors":"Timo Buhl, Prasad Dasari, Moritz M Hollstein, Tillmann Schill, Marie C Schuppe, Ryohei Ogino, Tomoharu Yokooji, Hiroaki Matsuo","doi":"10.18176/jiaci.1191","DOIUrl":"10.18176/jiaci.1191","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"411-413"},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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