D Betancor, M Valverde-Monge, J L Díaz-Recuero, M E Jo-Velasco, V Del Pozo, J Sastre
{"title":"Generalized Eczema as a Transient Paradoxical Adverse Effect of Dupilumab.","authors":"D Betancor, M Valverde-Monge, J L Díaz-Recuero, M E Jo-Velasco, V Del Pozo, J Sastre","doi":"10.18176/jiaci.1051","DOIUrl":"https://doi.org/10.18176/jiaci.1051","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Lund, B Dorn, T Jakob, L H Christensen, F Jabs, E Spillner
{"title":"A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10.","authors":"A Lund, B Dorn, T Jakob, L H Christensen, F Jabs, E Spillner","doi":"10.18176/jiaci.1029","DOIUrl":"10.18176/jiaci.1029","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"55-57"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R N Vera-Berrios, L Uriarte Vega, G Marco-Martín, M Fernández-Rivas
{"title":"Nonmandatory Labeled Legumes Are an Emergent Safety Concern: An Illustrative Case Report.","authors":"R N Vera-Berrios, L Uriarte Vega, G Marco-Martín, M Fernández-Rivas","doi":"10.18176/jiaci.1020","DOIUrl":"10.18176/jiaci.1020","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"58-60"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Gutiérrez-Canales, C Fernández-Lozano, V Alba-Pérez, A Ruiz-Granados, L Díaz-Montalvo, J Martínez-Botas, E Solano-Solares
{"title":"Unveiling the Immunological Mechanism Underlying a Cutaneous Adverse Reaction to Enfortumab Vedotin: A Case Report Based on the Lymphocyte Transformation Test.","authors":"P Gutiérrez-Canales, C Fernández-Lozano, V Alba-Pérez, A Ruiz-Granados, L Díaz-Montalvo, J Martínez-Botas, E Solano-Solares","doi":"10.18176/jiaci.1023","DOIUrl":"10.18176/jiaci.1023","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"63-65"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Betancor, A Gómez-López, B Barroso, M Valverde-Monge, J A Cañas, J M Rodrigo-Muñoz, V Del Pozo, J Sastre
{"title":"Are Biosimilars of Biologics the Same as the Reference Drug in Terms of Allergy? Selective Allergy to Tocilizumab Biosimilar.","authors":"D Betancor, A Gómez-López, B Barroso, M Valverde-Monge, J A Cañas, J M Rodrigo-Muñoz, V Del Pozo, J Sastre","doi":"10.18176/jiaci.1025","DOIUrl":"10.18176/jiaci.1025","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"68-69"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Lozano-Espinosa, N Rodríguez-Otero, D Antolín-Amérigo, F Gordo Vidal, A Muriel, R de Pablo, S Quirce
{"title":"Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience.","authors":"M Lozano-Espinosa, N Rodríguez-Otero, D Antolín-Amérigo, F Gordo Vidal, A Muriel, R de Pablo, S Quirce","doi":"10.18176/jiaci.1021","DOIUrl":"10.18176/jiaci.1021","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"50-52"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M D Escalante-Carrero, J M Renilla-Arroyo, C Fernández, J Martínez-Botas, D Antolín-Amérigo, B De la Hoz-Caballer
{"title":"Allergy to Red Mullet and Sea Bass: Two Newly Identified Red Mullet Allergens.","authors":"M D Escalante-Carrero, J M Renilla-Arroyo, C Fernández, J Martínez-Botas, D Antolín-Amérigo, B De la Hoz-Caballer","doi":"10.18176/jiaci.1024","DOIUrl":"10.18176/jiaci.1024","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"65-67"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Ojanguren, S Quirce, I Bobolea, L Pérez de Llano, V Del Pozo
{"title":"Phenotyping Asthma Exacerbations: One Step Further in the Management of Severe Asthma.","authors":"I Ojanguren, S Quirce, I Bobolea, L Pérez de Llano, V Del Pozo","doi":"10.18176/jiaci.1043","DOIUrl":"10.18176/jiaci.1043","url":null,"abstract":"<p><p>Asthma, a prevalent chronic respiratory disease, manifests in heterogeneous phenotypes and endotypes, necessitating bespoke therapeutic approaches. Asthma exacerbations are characterized by worsening of symptoms and decline in lung function and present substantial challenges despite advances in understanding and treatment. Viral respiratory infections, notably those caused by rhinovirus, serve as primary triggers, with allergic sensitization and environmental exposures increasing susceptibility. Deficient antiviral responses in asthmatic airway epithelial cells, particularly impaired interferon production, perpetuate inflammation and hyperresponsiveness, contributing to exacerbations. Additionally, genetic polymorphisms influence host responses and susceptibility. Recent studies underscore the association between specific inflammatory profiles, particularly eosinophil-mediated inflammation, and the frequency of exacerbations. Biologic therapies targeting inflammatory pathways show promise in reducing the frequency of exacerbations, thus underscoring the importance of understanding inflammatory phenotypes when selecting treatment. Notably, T2 inhibitors may modulate immune responses, potentially mitigating viral exacerbations. Characterizing exacerbations is crucial for optimizing therapeutic strategies. Evidence suggests a dissociation between baseline inflammatory profiles and exacerbation phenotypes, highlighting the need for individualized management. Phenotyping exacerbations using sputum analysis helps to identify predominant inflammatory patterns and thus inform treatment decisions. The varied responses to biologic therapies further emphasize the importance of phenotyping exacerbations in refining treatment algorithms. In conclusion, phenotyping asthma exacerbations provides valuable insights into underlying inflammatory mechanisms and enables personalized therapy. Understanding the complex interplay between viral triggers, inflammatory pathways, and responses to treatment is essential if we are to effectively manage severe asthma and reduce the burden of exacerbations. Further research into the mechanistic actions of biologic therapies in mitigating viral exacerbations is warranted to optimize asthma management strategies.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Arzt-Gradwohl, S A Herzog, W Aberer, T Alfaya Arias, D Antolín-Amérigo, P Bonadonna, E Boni, A Bożek, M Chełmińska, B Ebner, N Frelih, R Gawlik, A Gelincik, T Hawranek, W Hoetzenecker, A Jiménez Blanco, K Kita, R Kendirlinan, M Košnik, K Laipold, R Lang, F Marchi, M Mauro, M Nittner-Marszalska, I Poziomkowska-Gęsicka, V Pravettoni, D Preziosi, O Quercia, N Reider, M Rosiek-Biegus, B Ruiz-Leon, C Schrautzer, P Serrano, A Sin, B A Sin, J Stoevesandt, A Trautmann, M Vachová, G J Sturm
{"title":"Factors Affecting the Safety and Effectiveness of Venom Immunotherapy.","authors":"L Arzt-Gradwohl, S A Herzog, W Aberer, T Alfaya Arias, D Antolín-Amérigo, P Bonadonna, E Boni, A Bożek, M Chełmińska, B Ebner, N Frelih, R Gawlik, A Gelincik, T Hawranek, W Hoetzenecker, A Jiménez Blanco, K Kita, R Kendirlinan, M Košnik, K Laipold, R Lang, F Marchi, M Mauro, M Nittner-Marszalska, I Poziomkowska-Gęsicka, V Pravettoni, D Preziosi, O Quercia, N Reider, M Rosiek-Biegus, B Ruiz-Leon, C Schrautzer, P Serrano, A Sin, B A Sin, J Stoevesandt, A Trautmann, M Vachová, G J Sturm","doi":"10.18176/jiaci.0967","DOIUrl":"10.18176/jiaci.0967","url":null,"abstract":"<p><strong>Background: </strong>The safety profile of venom immunotherapy (VIT) is a relevant issue, and considerable differences have been reported in the safety and efficacy of this treatment modality. The primary aim of this study was to evaluate the safety of angiotensin-converting enzyme inhibitors and ß-blockers during VIT. In a second analysis, we evaluated data on premedication and venom preparations and their association with systemic adverse events (AEs) during the up-dosing phase and the first year of the maintenance phase, as well as the outcome of field stings and sting challenges.</p><p><strong>Methods: </strong>Ours was an open, prospective, observational, multicenter study that recruited 1425 patients, of whom 1342 underwent VIT.</p><p><strong>Results: </strong>Premedication with oral antihistamines was taken by 52.1% of patients during up-dosing and 19.7% of patients during the maintenance phase. Antihistamines had no effect on the frequency of systemic AEs (P=.11), although large local reactions (LLRs) were less frequent (OR, 0.74; 95%CI, 0.58-0.96; P=.02). Aqueous preparations were preferred for up-dosing (73.0%), and depot preparations were used for the maintenance phase (64.5%). The type of venom preparation had no influence on the frequency of systemic AEs or on the effectiveness of VIT (P=.26 and P=.80, respectively), while LLRs were less frequent with depot preparations (P<.001).</p><p><strong>Conclusions: </strong>Pretreatment with oral antihistamines during VIT significantly reduces the frequency of LLRs but not systemic AEs. All venom preparations were equally effective and did not differ in terms of the frequency of systemic AEs.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"40-49"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Faihs, C Kugler, B Eberlein, R Bent, U Darsow, T M Boehm, C Hilger, T Biedermann, A Kuehn, K Brockow
{"title":"Exercise-Dependent Codfish Allergy due to Tropomyosin.","authors":"V Faihs, C Kugler, B Eberlein, R Bent, U Darsow, T M Boehm, C Hilger, T Biedermann, A Kuehn, K Brockow","doi":"10.18176/jiaci.1022","DOIUrl":"10.18176/jiaci.1022","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"60-62"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}