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Occupational Asthma Caused by Exposure to Alumina. 接触氧化铝导致的职业性哮喘。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2024-02-21 DOI: 10.18176/jiaci.0974
M F Pilia, D Espejo, D Soler, X Muñoz
{"title":"Occupational Asthma Caused by Exposure to Alumina.","authors":"M F Pilia, D Espejo, D Soler, X Muñoz","doi":"10.18176/jiaci.0974","DOIUrl":"10.18176/jiaci.0974","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"270-272"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Atopic Dermatitis in the Adult Population of Catalonia, Spain: A Large-Scale, Retrospective, Population-Based Study. 加泰罗尼亚（西班牙）成人特应性皮炎患病率：一项基于人口的大规模回顾性研究。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-02-23 DOI: 10.18176/jiaci.0899
T Mora, I Sánchez-Collado, J Mullol, R Muñoz-Cano, P Ribó, A Valero
{"title":"Prevalence of Atopic Dermatitis in the Adult Population of Catalonia, Spain: A Large-Scale, Retrospective, Population-Based Study.","authors":"T Mora, I Sánchez-Collado, J Mullol, R Muñoz-Cano, P Ribó, A Valero","doi":"10.18176/jiaci.0899","DOIUrl":"10.18176/jiaci.0899","url":null,"abstract":"<p><strong>Background: </strong>Studies on the prevalence of atopic dermatitis (AD) in adults in general populations are scarce worldwide. We performed a retrospective population-based observational cohort study of 537 098 adult patients diagnosed with AD in Catalonia, Spain, a larger population than in previous studies. Objectives: To study the prevalence of AD by age, sex, disease severity, multimorbidity, serum total immunoglobin E (tIgE), and appropriate medical treatment (AMT) for the population of Catalonia.</p><p><strong>Methods: </strong>The study population comprised adult individuals (≥18 years) diagnosed with AD according to medical records at different health care levels (primary, hospital, emergency) in the Catalan Health System. Statistical analyses were conducted to evaluate sociodemographic characteristics, prevalence, multimorbidity, serum tIgE, and AMT.</p><p><strong>Results: </strong>The prevalence of AD in the adult Catalan population was 8.7%, being higher for nonsevere disease (8.5%) than for severe disease (0.2%) and in females (10.1%) than in males (7.3%). Topical corticosteroids were the most prescribed drug (66.5%), and treatment was prescribed more frequently in severe AD patients, especially systemic corticosteroids (63.8%) and immunosuppressants (60.7%). More than half of severe AD patients (52.2%) had serum tIgE ≥100 kU/L, and higher values were observed for those with multimorbidity. The most frequent comorbid respiratory diseases were acute bronchitis (13.7%), allergic rhinitis (12.1%), and asthma (8.6%).</p><p><strong>Conclusions: </strong>We provide new and robust evidence of the prevalence of AD and related characteristics in adults using a large-scale population-based study and a more significant cohort of individuals.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"225-232"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Subcutaneous Desensitization to Certolizumab Pegol. certolizumab皮下脱敏成功。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2024-01-26 DOI: 10.18176/jiaci.0981
M J Peñalver, S Bautista-Villanueva, R Barranco, J F Crespo, R Mielgo
{"title":"Successful Subcutaneous Desensitization to Certolizumab Pegol.","authors":"M J Peñalver, S Bautista-Villanueva, R Barranco, J F Crespo, R Mielgo","doi":"10.18176/jiaci.0981","DOIUrl":"10.18176/jiaci.0981","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"272-274"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Off-label Use of Mepolizumab: A Potential Therapeutic Option for Eosinophilic Cystitis. 美妥珠单抗的标签外使用：嗜酸性细胞性膀胱炎的潜在治疗方案
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-12-12 DOI: 10.18176/jiaci.0973
G Wang, N Zhuo, Z Liu
{"title":"Off-label Use of Mepolizumab: A Potential Therapeutic Option for Eosinophilic Cystitis.","authors":"G Wang, N Zhuo, Z Liu","doi":"10.18176/jiaci.0973","DOIUrl":"10.18176/jiaci.0973","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"277-278"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Triple Therapy in Asthma: The GEMAFORUM V Task Force. 三联疗法在哮喘中的应用。GEMA-FORUM V 特别工作组。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2024-02-09 DOI: 10.18176/jiaci.0975
V Plaza, J A Trigueros, J A Carretero, I Ojanguren Arranz, J M Vega Chicote, C Almonacid Sánchez, J Bartra Tomás, C Cisneros Serrano, L Domínguez Juncal, J Domínguez-Ortega, J Figueroa Rivero, J G Soto Campos, E Macías Fernández, S Martínez, J Montoro Lacomba, S Quirce
{"title":"Use of Triple Therapy in Asthma: The GEMAFORUM V Task Force.","authors":"V Plaza, J A Trigueros, J A Carretero, I Ojanguren Arranz, J M Vega Chicote, C Almonacid Sánchez, J Bartra Tomás, C Cisneros Serrano, L Domínguez Juncal, J Domínguez-Ortega, J Figueroa Rivero, J G Soto Campos, E Macías Fernández, S Martínez, J Montoro Lacomba, S Quirce","doi":"10.18176/jiaci.0975","DOIUrl":"10.18176/jiaci.0975","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"257-260"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Sphingolipid Metabolites in Infants With Atopic Dermatitis Are Associated With Food Allergy. 特应性皮炎婴儿肠道鞘脂代谢物与食物过敏有关。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-12-22 DOI: 10.18176/jiaci.0979
Y M Park, H J Yoo, S-J Hong, S-Y Lee
{"title":"Gut Sphingolipid Metabolites in Infants With Atopic Dermatitis Are Associated With Food Allergy.","authors":"Y M Park, H J Yoo, S-J Hong, S-Y Lee","doi":"10.18176/jiaci.0979","DOIUrl":"10.18176/jiaci.0979","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"263-265"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mepolizumab for the Treatment of Eosinophilic Cystitis: Reply. 治疗嗜酸性细胞性膀胱炎的美泊利珠单抗：答复。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-12-12 DOI: 10.18176/jiaci.0980
L Trefond, J E Kahn
{"title":"Mepolizumab for the Treatment of Eosinophilic Cystitis: Reply.","authors":"L Trefond, J E Kahn","doi":"10.18176/jiaci.0980","DOIUrl":"10.18176/jiaci.0980","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"278-279"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-Induced Enterocolitis Syndrome due to Acetaminophen in an Adult: A Call for Diagnostic Tools and Accurate Management. 成人对乙酰氨基酚引起的药物性小肠结肠炎综合征：需要诊断工具和准确的处理方法。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-12-12 DOI: 10.18176/jiaci.0970
J Laiseca García, E Moreno Mata, C García Rodríguez, M González Muñoz, M Barrios Albajar, A M Burgos Montero, L A González Sánchez
{"title":"Drug-Induced Enterocolitis Syndrome due to Acetaminophen in an Adult: A Call for Diagnostic Tools and Accurate Management.","authors":"J Laiseca García, E Moreno Mata, C García Rodríguez, M González Muñoz, M Barrios Albajar, A M Burgos Montero, L A González Sánchez","doi":"10.18176/jiaci.0970","DOIUrl":"10.18176/jiaci.0970","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"266-267"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlighting the Need for Each Excipient to Appear Under a Single Name in All Products That Contain it to Guarantee Identification. 强调在所有含有辅料的产品中，每种辅料都必须有一个独特的名称，以保证其识别性。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-12-12 DOI: 10.18176/jiaci.0976
M L Caballero, S Quirce
{"title":"Highlighting the Need for Each Excipient to Appear Under a Single Name in All Products That Contain it to Guarantee Identification.","authors":"M L Caballero, S Quirce","doi":"10.18176/jiaci.0976","DOIUrl":"10.18176/jiaci.0976","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"280-281"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory Microbiome Profiles Are Associated With Distinct Inflammatory Phenotype and Lung Function in Children With Asthma. 呼吸道微生物组特征与哮喘患儿不同的炎症表型和肺功能有关。
IF 6.1 3区 医学
Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-07-29 Epub Date: 2023-06-01 DOI: 10.18176/jiaci.0918
Y H Kim, M R Park, S Y Kim, M J Kim, K W Kim, M H Sohn
{"title":"Respiratory Microbiome Profiles Are Associated With Distinct Inflammatory Phenotype and Lung Function in Children With Asthma.","authors":"Y H Kim, M R Park, S Y Kim, M J Kim, K W Kim, M H Sohn","doi":"10.18176/jiaci.0918","DOIUrl":"10.18176/jiaci.0918","url":null,"abstract":"<p><strong>Background: </strong>Respiratory microbiome studies have improved our understanding of the various phenotypes and endotypes in heterogeneous asthma. However, the relationship between the respiratory microbiome and clinical phenotypes in children with asthma remains unclear. We aimed to identify microbiome-driven clusters reflecting the clinical features of asthma and their dominant microbiotas in children with asthma.</p><p><strong>Methods: </strong>Induced sputum was collected from children with asthma, and microbiome profiles were generated via sequencing of the V3-V4 region of the 16S rRNA gene. Cluster analysis was performed using the partitioning around medoid clustering method. The dominant microbiota in each cluster was determined using linear discriminant effect size analysis. Each cluster was analyzed to identify associations between the dominant microbiota, clinical phenotype, and inflammatory cytokines.</p><p><strong>Results: </strong>We evaluated 83 children diagnosed with asthma. Among 4 clusters reflecting the clinical characteristics of asthma, cluster 1, dominated by the genera Haemophilus and Neisseria, demonstrated lower postbronchodilator (BD) forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) than the other clusters and more mixed granulocytic asthma. Neisseria correlated negatively with pre-BD and post-BD FEV1/FVC. Haemophilus and Neisseria correlated positively with programmed death-ligand (PD-L) 1.</p><p><strong>Conclusions: </strong>To our knowledge, this study is the first to analyze the relationship between an unbiased microbiome-driven cluster and clinical phenotype in children with asthma. The cluster dominated by Haemophilus and Neisseria was characterized by fixed airflow obstruction and mixed granulocytic asthma, which correlated with PD-L1 levels. Thus, unbiased microbiome-driven clustering can help identify new asthma phenotypes related to endotypes in childhood asthma.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"246-256"},"PeriodicalIF":6.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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