Journal of Investigational Allergology and Clinical Immunology最新文献_第2页

Obese Asthma Syndrome: Multiple Inflammatory Patterns and A Key Solution. 肥胖哮喘综合征：多种炎症模式和关键解决方案。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-03-05 DOI: 10.18176/jiaci.1071

M Bantulà, A García, C Picado, E Arismendi

引用次数: 0

Prioritization of Children With Anaphylaxis in Pediatric Emergency Departments: Results of a National Survey From Spain. 儿科急诊科对过敏反应儿童的优先排序：来自西班牙的一项全国调查结果。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-03-19 DOI: 10.18176/jiaci.1064

E Arroabarren Aleman, T M de Vicente Jimenez, O Alvarez García, K Baynova, R Candón Morillo, M Reche Frutos

引用次数: 0

Successful Desensitization to Ramucirumab in Signet Cell Gastric Adenocarcinoma. Ramucirumab成功脱敏治疗印戒细胞胃腺癌。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-03-13 DOI: 10.18176/jiaci.1066

R V Villarreal-González, M Madrazo-Morales, K S Sáenz-Cantú, C García Rosas, A Burguete-Torres, O Vidal-Gutiérrez

引用次数: 0

Perspectives in the Molecular Mechanisms Underlying Anaphylaxis. 过敏反应的分子机制展望。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-06-27 DOI: 10.18176/jiaci.1080

V Esteban, F Skrabski, C Perales-Chorda, Y Puente-Crespo, R Muñoz-Cano, V Cardona

{"title":"Perspectives in the Molecular Mechanisms Underlying Anaphylaxis.","authors":"V Esteban, F Skrabski, C Perales-Chorda, Y Puente-Crespo, R Muñoz-Cano, V Cardona","doi":"10.18176/jiaci.1080","DOIUrl":"10.18176/jiaci.1080","url":null,"abstract":"The complexity of anaphylaxis in terms of clinical features and etiology-pathogenesis makes it difficult to establish precise endotypes that correspond to specific phenotypes. Therefore, interest in unravelling the cellular and molecular mechanisms underlying anaphylactic reactions has grown. A large group of anaphylactic reactions are characterized by the classical immunological mechanism of type I hypersensitivity, which leads to IgE-mediated activation of mast cells and basophils. However, in recent decades, other relevant signaling pathways have emerged. These include IgG-associated neutrophil activation, complement activation, cyclooxygenase metabolism, and direct mast cell activation. In drug-induced anaphylaxis, the Mas-related G protein-coupled receptor (MRGPRX2) plays an interesting role by directly triggering mast cell degranulation. In addition, contact, coagulation, and metabolic systems are activated, while homeostasis is altered, as evidenced by the modulation of proteins such as albumin, phospholipids, and apo- and lipoproteins. In all cases, the release of mediators and/or dysregulation of the systems has an impact on the endothelium, which is actively involved in the pathophysiology of the reactions. Furthermore, recent evidence points to extracellular vesicle- and microRNA-mediated communication between cellular compartments in anaphylaxis, and genetic factors, such as hereditary a-tryptasemia, are associated with risk of severe reaction. In summary, the recognition of cellular and molecular signaling mechanisms will enable better patient phenotyping and management in clinical practice.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"251-266"},"PeriodicalIF":4.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Induced by Meropenem in a Patient Receiving Avelumab and Subsequent Flare-Up. 在接受Avelumab治疗的患者中，美罗南诱导的嗜酸性粒细胞增多和全身症状（DRESS）的药物反应和随后的突发事件。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-07-01 DOI: 10.18176/jiaci.1083

J Aulenbacher, M Mockenhaupt, T Biedermann, K Brockow

引用次数: 0

Sensitization to Pru p 7 in Peach-Allergic Patients Sensitized to Pru p 3 in Areas of High Exposure to Cypress Pollen. 在柏树花粉高暴露地区，桃子过敏患者对prp7致敏。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-03-05 DOI: 10.18176/jiaci.1065

M Tomás-Pérez, R N Vera-Berrios, R Casas-Saucedo, C Galleani, L González-Bravo, A Gonzalo-Fernández, A González-Pérez, E Rodríguez-Mazariego, M Ruano-Zaragoza, G Zambrano-Ibarra, J Bartra-Tomás

引用次数: 0

Cytokine Release Reaction After Subcutaneous Daratumumab: Possible Relationship With Hymenoptera Allergy. 皮下达拉单抗后细胞因子释放反应：可能与膜翅目过敏有关。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-04-23 DOI: 10.18176/jiaci.1078

M C Torres Górriz, J Borrás Cuartero, T Valls Ten, S Beltrán Agost, E Enrique

引用次数: 0

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in α-Gal-Sensitized Individuals. 疟原虫过敏者被蜱虫叮咬后外周免疫学变化的纵向随访揭示。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2024-11-13 DOI: 10.18176/jiaci.1028

K Swiontek, J Fischer, F Hedin, D Revets, S Riel, N Chakrapani, U Mackenstedt, T Biedermann, A Kuehn, A Cosma, M Ollert, C Hilger

{"title":"Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in α-Gal-Sensitized Individuals.","authors":"K Swiontek, J Fischer, F Hedin, D Revets, S Riel, N Chakrapani, U Mackenstedt, T Biedermann, A Kuehn, A Cosma, M Ollert, C Hilger","doi":"10.18176/jiaci.1028","DOIUrl":"10.18176/jiaci.1028","url":null,"abstract":"Background and objectives: α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion of mammalian meat. While tick bites are assumed to mediate sensitization, the immune response to tick bites has not yet been investigated. Objective: To investigate the peripheral immune response to tick bites in humans over time.Methods: In a longitudinal cohort study, immunological reactions associated with tick bites (Ixodes species) were analyzed within 1 day (V1), 2 weeks (V2), 1 month (V3), and 3 months (V4) after the occurrence of a bite. sIgE, sIgG, and sIgG subclass levels, as well as 10 cytokines, were quantified. Deep immune phenotyping was performed using mass cytometry.Results: A total of 4 controls and 10 patients were bitten by a tick and followed up over 3 months. None of the controls developed sIgE to α-Gal, and sIgE increased in all patients from V1 until V2/V3, as did IL-8 levels. We noted a significant increase in CD19+ B cells and B-cell subpopulations, as well as a decrease in γδ CD56+ T cells in patients between V0 and V1. At V1, frequencies of plasmacytoid dendritic cells (pDCs) and γδ CD56+ T cells were lower in patients than in controls.Conclusions: Our study provides evidence of significant changes in several immune cell populations in α-Gal-sensitized patients, along with increased levels of IL-8 and sIgE. This is the first exploratory study to investigate longitudinal peripheral immune profiles in patients and controls bitten by ticks.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"288-300"},"PeriodicalIF":4.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Strongyloidiasis Mimicking a Drug Hypersensitivity Reaction to Imatinib. 拟伊马替尼药物超敏反应的圆线虫病1例。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2025-04-23 DOI: 10.18176/jiaci.1068

F Z El Rhermoul, S Slater, R Madrigal-Burgaleta

引用次数: 0

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients. 粪便 IgE 分析揭示了花生过敏症患者分层的作用。

IF 4.8 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-07-29 Epub Date: 2024-07-26 DOI: 10.18176/jiaci.1008

R Czolk, F Codreanu-Morel, L de Nies, S B Busi, R Halder, O Hunewald, T M Boehm, F Q Hefeng, C De Beaufort, P Wilmes, M Ollert, A Kuehn

{"title":"Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients.","authors":"R Czolk, F Codreanu-Morel, L de Nies, S B Busi, R Halder, O Hunewald, T M Boehm, F Q Hefeng, C De Beaufort, P Wilmes, M Ollert, A Kuehn","doi":"10.18176/jiaci.1008","DOIUrl":"10.18176/jiaci.1008","url":null,"abstract":"Background and objectives: Peanut allergy (PA) is an IgE-mediated food allergy with variable clinical outcomes. Mild to-severe symptoms affect various organs and, often, the gastrointestinal tract. The role of intestine-derived IgE antibodies in gastrointestinal PA symptoms is poorly understood. Objective: This study aimed to examine fecal IgE responses in PA as a novel approach to patient endotyping.Methods: Feces and serum samples were collected from peanut-allergic and healthy children (n=26) to identify IgE and cytokines using multiplex assays. Shotgun metagenomics DNA sequencing and allergen database comparisons made it possible to identify microbial peptides with homology to known allergens.Results: Compared to controls, fecal IgE signatures showed broad diversity and increased levels for 13 allergens, including food, venom, contact, and respiratory allergens (P<.01-.0001). Overall, fecal IgE patterns were negatively correlated compared to sera IgE patterns in PA patients, with the greatest differences recorded for peanut allergens (P<.0001). For 83% of the allergens recognized by fecal IgE, we found bacterial homologs from PA patients' gut microbiome (eg, thaumatin-like protein Acinetobacter baumannii vs Act d 2, 109/124 aa identical). Compared to controls, PA patients had higher levels of fecal IgA, IL-22, and auto-IgE binding to their own fecal proteins (P<.001). Finally, levels of fecal IgE correlated with abdominal pain scores (P<.0001), suggesting a link between local IgE production and clinical outcomes.Conclusions: Fecal IgE release from the intestinal mucosa could be an underlying mechanism of severe abdominal pain through the association between leaky gut epithelia and anticommensal TH2 responses in PA.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"276-287"},"PeriodicalIF":4.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0