Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Two Immediate Hypersensitivity Reactions to Isatuximab Confirmed by the Complement Activation Test and Treated With Successful Rapid Desensitization.","authors":"A Cardenas Herrero, C Fernandez-Lozano, E Ramirez-Mateo, M G Alcalá-Rodriguez, E Solano-Solares, M J Blanchard-Rodriguez, C Pueyo-Lopez, B De La Hoz, J Martínez-Botas","doi":"10.18176/jiaci.1089","DOIUrl":"https://doi.org/10.18176/jiaci.1089","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Drug Allergy Labeling in China: Half of All Labels Are Attributed to b-Lactams.","authors":"W Shi, M Ch Low, J Cl To, A Kc Kan, N Liu, J-X Huang, P Pai, P H Li","doi":"10.18176/jiaci.1106","DOIUrl":"https://doi.org/10.18176/jiaci.1106","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired Angioedema due to C1-Esterase Inhibitor Deficiency: A Diagnostic and Therapeutic Challenge.","authors":"A Callero, C Gonzalez-Colino, G Hernandez-Santana, E Rodríguez-Plata, S de Las Heras, E Calderoni-Tibau, M González-Afonso, E Perez-Rodriguez, J C Garcia-Robaina","doi":"10.18176/jiaci.1100","DOIUrl":"https://doi.org/10.18176/jiaci.1100","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sting Challenge Test Shows High Negative Predictive Value in Patients Receiving Venom Immunotherapy.","authors":"T Alfaya Arias, A Vega Castro, D Garnica-Velandia, J Macías Iglesias, J Pereira González, N Blanco Toledano, A Puig Fuentes, G Vicens-Novell, M Bermúdez Bejarano, A Tsopana, L Marquès, D González-de-Olano, E Pérez-Fernández, B Ruiz-León","doi":"10.18176/jiaci.1086","DOIUrl":"https://doi.org/10.18176/jiaci.1086","url":null,"abstract":"<p><strong>Background and objectives: </strong>The sting challenge test (SCT) is regarded as the most reliable method for assessing the effectiveness of venom immunotherapy (VIT). However, its predictive value in patients undergoing VIT is unclear. This study aims to evaluate the predictive value of the SCT.</p><p><strong>Methods: </strong>A multicenter retrospective observational study was conducted on patients receiving VIT who underwent SCT. The study gathered data on patient demographics, diagnosis, immunotherapy details, outcomes of the SCT, and subsequent field stings.</p><p><strong>Results: </strong>A total of 261 patients were included, and 372 SCTs were recorded. Most patients (75.1%) were men. Mastocytosis was confirmed in 7.7%. The final diagnosis was allergy to Apis mellifera (48.7%), Polistes dominula (36.8%), Vespula species (2.7%), and P dominula plus Vespula species (10.7%). SCTs were performed with Apis in 61.6% overall, Polistes in 34.1%, and Vespula in 4.3%. Most of the SCT results were negative (95.7%). A total of 306 field stings were recorded for 146 patients (56.2%); of these, 95.1% were negative. Among these 146 affected patients, 137 had a negative SCT result, and 130 of these also had a subsequent negative field sting, resulting in a negative predictive value (NPV) for the SCT of 94.9%. Of the patients who experienced a field sting, 9 had a positive SCT, and only 3 had a positive field sting, resulting in a positive predictive value of 33.3%.</p><p><strong>Conclusions: </strong>SCT is safe, and the high NPV emphasizes the usefulness of this test in assessing the effectiveness of VIT.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthropod Bite and Churg-Strauss Syndrome.","authors":"Ö Özdemir","doi":"10.18176/jiaci.1099","DOIUrl":"https://doi.org/10.18176/jiaci.1099","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass Spectrometry Detects Api m 10 in Venom Immunotherapy Products With Suspected Absence of Api m 10.","authors":"K E Paulus-Tremel, J Spiric, A C Junker, L Schwaben, F Führer, J Lidholm, S Vieths, A Reuter, V Mahler","doi":"10.18176/jiaci.1093","DOIUrl":"https://doi.org/10.18176/jiaci.1093","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 5-Grass Pollen Liquid Sublingual Allergen Immunotherapy for Seasonal Allergic Rhinoconjunctivitis: A Systematic Review and Meta-analysis.","authors":"D Di Bona, G Paoletti, J Cognet-Sicé, S Scurati, G Serviddio, G W Canonica","doi":"10.18176/jiaci.1076","DOIUrl":"https://doi.org/10.18176/jiaci.1076","url":null,"abstract":"<p><p>The efficacy and safety of allergen immunotherapy (AIT) have been demonstrated in randomized controlled trials (RCTs). However, differences in study protocols, populations, and AIT products lead to variability in outcomes. The World Allergy Organization and the European Academy of Allergy and Clinical Immunology advise assessing individual AIT products rather than assuming a universal class effect. We conducted a meta-analysis on the efficacy and safety of 5-grass pollen liquid sublingual immunotherapy (SLIT) (5-grass SLIT-liquid) in patients affected by allergic rhinoconjunctivitis (ARC) with and without asthma. We searched computerized databases (MEDLINE, ISI Web of Science, LILACS, the Cochrane Library, ClinicalTrial.gov) up to June 2023, supplemented our approach with manual literature searches, and included RCTs comparing 5-grass SLIT-liquid to placebo, irrespective of primary endpoints or treatment duration. Efficacy was assessed based on standardized mean differences (SMDs) in symptom score (SS) and medication score (MS). Subgroup analyses included age and sensitization status, while meta-regression was applied to evaluate asthma comorbidity, dose, and treatment duration. Bias and certainty of evidence were assessed using the Cochrane Risk of Bias 2 tool and the Grading of Recommendations Assessment, Development and Evaluation approach. Data from 8 RCTs for SS (621 patients) and 6 RCTs for MS (507 patients) showed a significant benefit for SLIT over placebo in SS (SMD, -0.34; 95%CI, -0.62 to -0.06; P<.05) and MS (SMD, -0.54; 95%CI, -0.97 to -0.10; P<.05). Subgroup analyses showed no differences based on age or sensitization status. Meta-regression revealed no significant impact of cumulative dose, treatment duration, or asthma on efficacy. No safety issues were observed. This meta-analysis confirms that 5-grass SLIT-liquid offers significant clinical benefits and is safe, providing an effective option for treating the cause of ARC in patients with and without asthma.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mepolizumab Reduces Inflammatory Eosinophils in Nasal Polyp Tissue and Restores Histological Alterations.","authors":"A Matucci, M Accinno, G Maggiore, B Brugnoli, E Vivarelli, L Cosmi, P Parronchi, M Perlato, M E Milanese, G Licci, O Rossi, A Minzoni, P Orlando, O Gallo, A Palomba, C Ammatuna, T Tatti, A Vultaggio","doi":"10.18176/jiaci.1095","DOIUrl":"https://doi.org/10.18176/jiaci.1095","url":null,"abstract":"<p><strong>Background and objectives: </strong>Eosinophilic inflammation and IL-5 are key therapeutic targets in type 2 chronic rhinosinusitis with nasal polyposis (CRSwNP). Based on surface expression of CD62L, 2 eosinophil subpopulations, homeostatic and inflammatory, were recently described. Objectives: First, we aimed to investigate the association between these subpopulations and the severity of CRSwNP, and second, to analyze the impact of mepolizumab on tissue eosinophil subpopulations.</p><p><strong>Methods: </strong>Flow cytometry of nasal polyp (NP) tissue eosinophil subpopulations (CD62Llow, iEos; CD62Lbright, rEos) was performed in 15 CRSwNP patients (with and without severe asthma) treated with mepolizumab for a median of 7.5 months. NP tissue was analyzed at baseline and after the start of therapy. The correlation between the proportion of tissue iEos and the severity of CRSwNP and treatment response was assessed.</p><p><strong>Results: </strong>The proportion of tissue iEos correlated with higher CRSwNP severity scores and quality of life questionnaire scores (SNOT-22, L-K score) at baseline. A higher and significant improvement in NPS was observed in patients who had been taking mepolizumab for longer than 6 months. Mepolizumab significantly reduced the proportion of iEos in nasal polyp tissue, although a significantly higher number of rEos remained. A greater reduction in tissue iEos was associated with a more significant improvement in quality of life (SNOT-22) and severity (L-K) scores. Finally, in addition to the reduction in tissue eosinophils, mepolizumab induced histological changes characterized by the decrease in edema and goblet cell hyperplasia.</p><p><strong>Conclusions: </strong>Tissue iEos values correlate with poor sinonasal control in CRSwNP and are reduced by treatment with mepolizumab. A greater decrease in iEos is associated with a significantly greater therapeutic effect of mepolizumab.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypereosinophilic Syndrome With Sialadenitis and Orbital Inflammation: A Case Report.","authors":"S Thapaliya, J Matz","doi":"10.18176/jiaci.1105","DOIUrl":"https://doi.org/10.18176/jiaci.1105","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Differences in Molecular Sensitization Profiles Between a Spanish and Latin American Mite Allergic Patients\".","authors":"M J Rial, R González-Pérez, D El-Qutob, J Alcover","doi":"10.18176/jiaci.1092","DOIUrl":"https://doi.org/10.18176/jiaci.1092","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}