Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Comparative Usefulness of Bronchial Cryobiopsy vs Conventional Incisional Biopsy in Severe Asthma: Histopathological Evaluation.","authors":"Alberto Caballero-Vázquez, Bélgica Márquez-Lobo, Javier L López-Hidalgo, Susana Rojo-Tolosa, Concepción Morales-García","doi":"10.18176/jiaci.1207","DOIUrl":"10.18176/jiaci.1207","url":null,"abstract":"<p><strong>Background: </strong>Histopathological analysis of bronchial tissue in patients with severe asthma makes it possible to characterize inflammatory and remodeling phenomena that are not identifiable using noninvasive biomarkers. Although bronchial cryobiopsy is considered an advantageous technique, its diagnostic utility compared with conventional forceps biopsy has not been clearly established. The objective of the present study was to compare the diagnostic performance of bronchial cryobiopsy and forceps biopsy in the histopathological evaluation of severe asthma.</p><p><strong>Methods: </strong>A prospective comparative study was conducted in 27 patients with severe asthma who underwent bronchoscopy. Samples were obtained using both techniques, and histological and immunohistochemical findings were compared.</p><p><strong>Results: </strong>Both techniques confirmed the high prevalence of remodeling, highlighting smooth muscle hyperplasia (85.2% with incisional biopsy, 81.4% with cryobiopsy) and basement membrane thickening (59.3% with incisional biopsy, 55.6% with cryobiopsy). Nonsignificant differences were observed between the techniques, although diagnostic sensitivity was greater with incisional biopsy. Cryobiopsy showed lower rates of epithelial denudation overall. However, in patients with bronchial obstruction, epithelial loss was consistently observed in cryobiopsy samples, possibly reflecting a technical limitation. The correlation between peripheral eosinophilia and submucosal tissue infiltrate was weak and nonsignificant with both techniques (r=0.168; P=.403).</p><p><strong>Conclusions: </strong>Bronchial cryobiopsy is an effective tool with a yield comparable to that of incisional biopsy for the assessment of deep structural remodeling. However, incisional biopsy maintains superior diagnostic sensitivity and diagnostic yield. The discordance observed between peripheral and tissue eosinophilia underscores the need for histological evaluation to complement peripheral biomarkers for the stratification and personalization of biological therapies in obstructive disease.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunologic Effects of Tezepelumab in Rhinovirus-Triggered Near-Fatal Asthma.","authors":"Pilar Ausín, Francisco Parrilla, Paloma Torres Boso, Eugenia Navarrete Rouco, Àngela García, Daniela Bravo, Ramón Gimeno","doi":"10.18176/jiaci.1204","DOIUrl":"https://doi.org/10.18176/jiaci.1204","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of Reactions in Double-Blind Placebo-Controlled Food Challenges: New Insights From the EuroPrevall Outpatient Clinic Study.","authors":"Rosialzira N Vera-Berrios, Alejandro Gonzalo-Fernández, Barbara K Ballmer-Weber, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frédéric de Blay, Michael Clausen, Monika Jedrzejczak-Czechowicz, André C Knulst, Thuy-My Le, Nikolaos G Papadopoulos, Todor A Popov, Nayade Del Prado, Ashok Purohit, Isabel Reig, Athanasios Sinaniotis, E N Clare Mills, Ronald van Ree, Montserrat Fernández-Rivas","doi":"10.18176/jiaci.1217","DOIUrl":"https://doi.org/10.18176/jiaci.1217","url":null,"abstract":"<p><strong>Background and objectives: </strong>Oral food challenge, particularly double-blind placebo-controlled food challenge (DBPCFC), is the gold standard for diagnosis of food allergy, although safety concerns limit its widespread use. Objectives: To evaluate the severity of reactions during DBPCFCs and to identify predictors of severe reactions.</p><p><strong>Methods: </strong>DBPCFCs from the EuroPrevall outpatient clinic study were analyzed in patients reporting immediate reactions to milk, egg, fish, shrimp, peanut, hazelnut, celeriac, apple, and/or peach. Patients with prior life-threatening anaphylaxis were excluded. Reaction severity (patient-reported and DBPCFC-elicited) was assessed using the Food Allergy Severity Score. A 2-step modeling strategy based on generalized estimating equations was applied to identify predictors of a positive DBPCFC, and, among positive challenges, predictors of anaphylaxis.</p><p><strong>Results: </strong>Among 514 DBPCFCs performed, 190 (36.9%) were negative, 30 (5.8%) uncertain, and 294 (57.2%) positive (102 mild oropharyngeal reactions [19.8%] and 192 systemic reactions [37.4%], of which 160 were moderate and 32 severe). The 32 severe reactions comprised 30 cases (30/514 [5.8%]) with lower respiratory involvement (16/30 with cough or dyspnea) and 2 anaphylaxis with hypotension (2/514 [0.4%]). DBPCFC reactions were less severe than patient-reported reactions (P<.01). Atopic dermatitis and food-specific IgE >0.35 kUA/L predicted positivity, whereas prior reaction severity and egg challenge were predictors of anaphylaxis.</p><p><strong>Conclusion: </strong>While systemic reactions during DBPCFCs were frequent, severe anaphylaxis was rare, supporting the safety profile of DBPCFCs when appropriately conducted. Key predictors of reactivity include atopic dermatitis and food-specific sensitization, while prior severity points to a risk of anaphylaxis. These findings may help risk stratification and patient selection in clinical practice.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhinoconjunctivitis and Probable Bronchial Asthma Due to Sensitization to Transglutaminase.","authors":"Paola Carrillo Fernández-Paredes, Laura Victorio Puche, Borja Bartolomé, María Pilar López-Sáez","doi":"10.18176/jiaci.1199","DOIUrl":"https://doi.org/10.18176/jiaci.1199","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Treatment Trajectories, and Environmental Exacerbation Factors in Asthma: A Regional Study in Andalusia.","authors":"Alberto Moreno-Conde, Jesús Moreno-Conde, Pedro Guardia-Martínez, Ángel Vilches-Arenas, Claudia Rodríguez, Virginia De Luque-Piñana","doi":"10.18176/jiaci.1096","DOIUrl":"10.18176/jiaci.1096","url":null,"abstract":"<p><strong>Background and objective: </strong>Asthma is a chronic respiratory condition whose prevalence varies across different regions and populations. In Andalusia, detailed data on the characteristics of asthma patients are lacking, thus limiting effective clinical management and health care planning. Objective: Our objective was to characterize patients diagnosed with asthma in Andalusia.</p><p><strong>Materials and methods: </strong>To our knowledge, this study comprises the largest cohort of asthma patients in Spain. We characterized 726 006 asthma patients based on prevalence, exacerbations, comorbidities, and pharmacological treatment. We covered the whole population, with subanalyses comparing rural-urban settings and coastal-inland regions.</p><p><strong>Results: </strong>The overall prevalence of asthma in Andalusia was 8.57%. The disease was more prevalent in females, although it was more common in males until the age of 15 years. The most frequent comorbidities were arthrosis and spondylosis. Almost three-quarters (70.73%) of newly diagnosed asthma patients received treatment, the most common being SABAs (31.56%), LTRAs (16.13%), and systemic corticosteroids (13.94%). After initial treatment, 35.15% of patients did not receive follow-up care. Treatment was stepped up in 28.68%, stepped down in 20.75%, and switched in 15.43%.</p><p><strong>Conclusions: </strong>Our results provide a detailed characterization of the Andalusian population in terms of prevalence, comorbidities, and treatment trajectories and proved consistent with findings from other Spanish regions. We also observed geographical discrepancies in asthma prevalence when comparing rural-urban settings and coastal-inland regions.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"303-310"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Review of Occupational Asthma in the 21st Century Work Environment.","authors":"César A Galván, Rafael Durán, Santiago Quirce","doi":"10.18176/jiaci.1123","DOIUrl":"10.18176/jiaci.1123","url":null,"abstract":"<p><strong>Background and objective: </strong>Occupational asthma (OA) is an increasingly relevant respiratory disease in modern workplaces. Epidemiological evidence highlights its considerable prevalence among the global working population, with recent increases following an initial decline in the early 21st century. Objective: To critically review the pathophysiological mechanisms, risk factors, clinical presentations, and emerging challenges associated with OA, focusing on novel exposures, biomarker development, and translation of scientific findings into preventive and clinical practice.</p><p><strong>Methods: </strong>A literature review was conducted through a bibliographic search in PubMed (MEDLINE) and Web of Science. Articles were selected and analyzed using the Rayyan collaborative platform. Empirical studies on prevalence, risk factors, diagnosis, and management of OA were included.</p><p><strong>Results: </strong>OA is primarily categorized as sensitizer- or irritant-induced, each exhibiting unique molecular pathways and clinical courses. Transcriptomic research has identified specific microRNA profiles as innovative biomarkers with significant diagnostic capacity. Studies document risks in traditionally non-high-risk sectors, such as offices and educational environments. Factors such as work chronobiology (night shifts), sex, and socioeconomic status influence the development and prognosis of OA, potentially leading to loss of productivity and employment.</p><p><strong>Conclusion: </strong>OA is a significant challenge in occupational health, with complex epidemiological patterns. While advances in molecular characterization and identification of emerging risk factors have improved our understanding of the condition, diagnostic and management challenges persist. Future research should focus on developing specific biomarkers and accessible diagnostic tools for primary care, along with evidence-based preventive strategies for emerging labor sectors.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"274-281"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk Neoallergen in Orange Cheese Rinds?","authors":"Nicolas Guillot, Marina Bazziconi, Héloise Pottier, Delphine Maurice, Jean M Devoisins, Margot Delin, Sylvie Leroy","doi":"10.18176/jiaci.1164","DOIUrl":"10.18176/jiaci.1164","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"317-319"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Eosinophilic Pustular Folliculitis Induced by Azithromycin in an Oncology Patient.","authors":"Viviana Mendoza, Francisco Vega, Azahara Lopez-Raigada, María Victoria Mugica, Carlos Blanco","doi":"10.18176/jiaci.1165","DOIUrl":"10.18176/jiaci.1165","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"319-321"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and Immune Effects of Pollution: Comparison Between Patients With Asthma and Healthy Individuals.","authors":"David Soler-Segovia, Christian Romero-Mesones, David Espejo, Florencia Pilia, Iñigo Ojanguren, Carlos Martinez-Rivera, Xavier Muñoz, Mª Jesus Cruz","doi":"10.18176/jiaci.1094","DOIUrl":"10.18176/jiaci.1094","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to assess inflammatory and immune responses in patients with asthma and healthy controls exposed to a polluted and a nonpolluted environment over a short period.</p><p><strong>Material and methods: </strong>We performed a randomized crossover study in patients with asthma (n=20) and in healthy controls (n=15). Participants were exposed for 2 hours to a polluted environment and, after 14 days, to a nonpolluted environment. Pollution levels were assessed at each exposure. Subsequently, serum levels of 8-isoprostane and glutathione peroxidase were measured as markers of oxidative stress, as were 48 cytokines involved in inflammation and the immune response.</p><p><strong>Results: </strong>In the polluted environment, significantly higher levels of PM1, PM10, NO2, NO, and CO were observed (P=.0026, .0337, <.0001, <.0001, and .0004, respectively) than in the nonpolluted environment. After exposure to a polluted environment, both groups (healthy controls and asthma patients) presented higher values of IL-17F (P=.0285 and .0348, respectively) and CSF2 (P=.0425 and 0.0305, respectively). After exposure to high levels of pollution, healthy controls presented reductions in glutathione peroxidase (with antioxidant activity), CSF3, HGF, and OSM (P=.0038, P=.0123, 0.0353, and 0.0256, respectively) and increased levels of IL-7, CXCL8, and CCL2 (P=.0015, 0.0119 and 0.0215, respectively). Asthma patients had higher serum levels of IL-1ß and IL-15 (P=.0232 and 0.0497, respectively).</p><p><strong>Conclusion: </strong>Healthy individuals and asthma patients respond differently to exposure to pollutants. Healthy individuals are characterized by adaptive suppression of immune activity, whereas asthma patients present a more marked inflammatory response.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"282-291"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psyllium as a Hidden Food Allergen in a Gluten-Free Product: A Case Report.","authors":"María Reverter Morales, Teresa Villamor Martín, Gaspar Dalmau Duch, Javier Alcover Díaz, Alan Hernández Llamazares, Vanessa Gázquez García","doi":"10.18176/jiaci.1172","DOIUrl":"10.18176/jiaci.1172","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"321-323"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}