Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Vitellogenin Identified as a Novel Allergen in Tenebrio molitor: Evidence from an Occupational Asthma Case.","authors":"Leyre Baptista-Serna, Manuel De Las Heras-Gozalo, Dinara Korshunova, Elena Santano, Maria J Martínez, Fernando Pineda, Jose A Cañas, Victoria Del Pozo, Joaquín Sastre","doi":"10.18176/jiaci.1175","DOIUrl":"10.18176/jiaci.1175","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"326-328"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker-Based Treatment Response After Switching From Benralizumab to Tezepelumab in Refractory Allergic Bronchopulmonary Mycosis.","authors":"Yasuhito Suzuki, Junpei Saito, Mami Rikimaru, Ryuki Yamada, Tetsuya Egawa, Takahiro Kumanaka, Ryutaro Tanaka, Kentaro Kazama, Koshi Saito, Rina Harigane, Riko Sato, Hikaru Tomita, Natsumi Watanabe, Takashi Umeda, Ryuichi Togawa, Yuki Sato, Xintao Wang, Kenya Kanazawa, Yoshinori Tanino, Yoko Shibata","doi":"10.18176/jiaci.1174","DOIUrl":"10.18176/jiaci.1174","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"324-326"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission of Eosinophilic Otitis Media With Tezepelumab.","authors":"Diana Betancor, William Aragonés Sanzen-Baker, Virginia Vasallo, Jaime Bernaola, Jesica Santillan, Jose M Villacampa, Joaquin Sastre","doi":"10.18176/jiaci.1177","DOIUrl":"10.18176/jiaci.1177","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"329-331"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mepolizumab Reduces Inflammatory Eosinophils in Nasal Polyp Tissue and Restores Histological Alterations.","authors":"Andrea Matucci, Mato Accinno, Giandomenico Maggiore, Barbara Brugnoli, Emanuele Vivarelli, Lorenzo Cosmi, Paola Parronchi, Margherita Perlato, Maria Elena Milanese, Giuseppe Licci, Oliviero Rossi, Alberto Minzoni, Pietro Orlando, Oreste Gallo, Annarita Palomba, Carlo Ammatuna, Tiziana Tatti, Alessandra Vultaggio","doi":"10.18176/jiaci.1095","DOIUrl":"10.18176/jiaci.1095","url":null,"abstract":"<p><strong>Background and objectives: </strong>Eosinophilic inflammation and IL-5 are key therapeutic targets in type 2 chronic rhinosinusitis with nasal polyposis (CRSwNP). Based on surface expression of CD62L, 2 eosinophil subpopulations, homeostatic and inflammatory, were recently described. Objectives: First, we aimed to investigate the association between these subpopulations and the severity of CRSwNP, and second, to analyze the impact of mepolizumab on tissue eosinophil subpopulations.</p><p><strong>Methods: </strong>Flow cytometry of nasal polyp (NP) tissue eosinophil subpopulations (CD62Llow, iEos; CD62Lbright, rEos) was performed in 15 CRSwNP patients (with and without severe asthma) treated with mepolizumab for a median of 7.5 months. NP tissue was analyzed at baseline and after the start of therapy. The correlation between the proportion of tissue iEos and the severity of CRSwNP and treatment response was assessed.</p><p><strong>Results: </strong>The proportion of tissue iEos correlated with higher CRSwNP severity scores and quality of life questionnaire scores (SNOT-22, L-K score) at baseline. A higher and significant improvement in NPS was observed in patients who had been taking mepolizumab for longer than 6 months. Mepolizumab significantly reduced the proportion of iEos in nasal polyp tissue, although a significantly higher number of rEos remained. A greater reduction in tissue iEos was associated with a more significant improvement in quality of life (SNOT-22) and severity (L-K) scores. Finally, in addition to the reduction in tissue eosinophils, mepolizumab induced histological changes characterized by the decrease in edema and goblet cell hyperplasia.</p><p><strong>Conclusions: </strong>Tissue iEos values correlate with poor sinonasal control in CRSwNP and are reduced by treatment with mepolizumab. A greater decrease in iEos is associated with a significantly greater therapeutic effect of mepolizumab.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"292-302"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond \"Pancake Syndrome\": Oral Mite Anaphylaxis Caused by High-Protein Fish Stock Powder.","authors":"Makoto Nojo, Shintaro Suzuki, Tomoki Uno, Hironori Sagara, Akihiko Tanaka","doi":"10.18176/jiaci.1167","DOIUrl":"10.18176/jiaci.1167","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"332-334"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tezepelumab in Allergic Bronchopulmonary Aspergillosis With Severe Uncontrolled Asthma: A Retrospective 4-Case Series.","authors":"Belén Sanz-Sanjosé, Daniel Laorden, David Romero, Leticia De Las Vecillas, Elena Villamañán, Javier Domínguez-Ortega, Santiago Quirce, Rodolfo Álvarez-Sala","doi":"10.18176/jiaci.1173","DOIUrl":"10.18176/jiaci.1173","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"314-316"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grass Pollen Exposure in an Environmental Exposure Chamber vs Natural Exposure: A Clinical Comparison of Symptoms.","authors":"Irene García-Gutiérrez, Elena Ramirez-Mateo, Cristina Mato-De Prada, Cristiana Solórzano-Zepeda, Violeta Sánchez-García, María E Hernando, Darío Antolín-Amérigo, Belén de la Hoz-Caballer","doi":"10.18176/jiaci.1166","DOIUrl":"10.18176/jiaci.1166","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"311-313"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Asthma: From Diagnosis to Management.","authors":"Carlos Almonacid, Ignacio Dávila, Vicente Plaza, Javier Dominguez-Ortega, José L Izquierdo, Santiago Quirce","doi":"10.18176/jiaci.1171","DOIUrl":"10.18176/jiaci.1171","url":null,"abstract":"<p><p>Artificial intelligence (AI) offers new opportunities to improve asthma management across the care process. This review synthesizes evidence on AI applications in diagnosis, classification, monitoring, and treatment. We conducted a narrative review based on a PubMed search (1995-2025). Eligible studies included peer-reviewed reports on AI applied to diagnosis, monitoring, prediction, and treatment of asthma. Outcomes of interest included diagnostic accuracy, risk prediction, adherence, and clinical decision support. Of 943 records screened, 32 studies met the inclusion criteria. Diagnostic tools integrating clinical data and data from objective tests performed best: deep neural networks combining spirometry and bronchial challenge tests achieved up to 98% accuracy, and automated pulmonary function test interpretation outperformed specialists in consistency and accuracy. Acoustic analyses of cough and respiratory sounds demonstrated sensitivity and specificity above 90%, supporting remote monitoring. In prediction of exacerbations, the electronic health record combining peak expiratory flow and symptom data achieved areas under the curve of up to 0.85. Unsupervised clustering approaches provided clinically meaningful asthma phenotypes. Evidence on treatment optimization remains scarce. AI has the potential to enhance diagnostic accuracy, phenotyping, and monitoring in asthma. However, most studies remain proof-of-concept, with limited external validation and little evidence of clinical impact. Future research should prioritize pragmatic trials, responder stratification, and real-world implementation to confirm clinical and cost-effectiveness.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"260-273"},"PeriodicalIF":6.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Coordination Between Primary Care and Allergists: A Delphi Consensus on Referral Recommendations for Moderate-To-Severe Allergic Rhinitis.","authors":"Carlos Colás, Ruperto González-Pérez, Ana M Navarro-Pulido, Mar Martínez-Vázquez, Antonio Valero","doi":"10.18176/jiaci.1194","DOIUrl":"https://doi.org/10.18176/jiaci.1194","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mast Cell Activation Profiles in Perioperative Immediate Hypersensitivity Reactions: A GERAP Network Study.","authors":"Charles Tacquard, Julien Serrier, Aurélie Gouel-Chéron, Juliette Caron, Luc Colas, Luc De Chaisemartin, Sébastien Franchina, Brigitte Le Mauff, Catherine Neukirch, Diane Pelletier de Chambure, Magdalena Smilov, Simon Viville, Pascal Demoly, Paul Michel Mertes","doi":"10.18176/jiaci.1179","DOIUrl":"https://doi.org/10.18176/jiaci.1179","url":null,"abstract":"<p><strong>Background and objective: </strong>Perioperative immediate hypersensitivity reactions (POHRs) are potentially fatal complications of anesthesia. Although tryptase is a cornerstone biomarker for mast cell activation (MCA), its diagnostic limitations call for a better understanding of the underlying mechanisms and phenotypes of POHRs to guide management. Objective: Compare the phenotypes of patients who experience POHRs based on their MCA profiles using tryptase and histamine assays.</p><p><strong>Methods: </strong>This retrospective multicenter study included patients assessed by the GERAP Network who experienced POHRs from 2017 to 2024. Clinical characteristics and biomarker correlation were analyzed across MCA profiles. MCA profiles were determined based on the presence of MCA (peak tryptase >1.2×baseline tryptase+2 μg/L; NoMCA vs MCA) and a peak tryptase value (elevated if ≥8 μg/L; low tryptase [LT] vs high tryptase [HT]) or histamine release (elevated if ≥10 nmol/L).</p><p><strong>Results: </strong>MCA was recorded in 626 of the 930 patients (67%). HT-MCA and LT-NoMCA were the most frequent profiles, detected in 60% and 27% of patients, respectively. POHRs were more severe in the HT-MCA group than in the LT-NoMCA group (85% vs 43%; P<.0001). Skin test results were positive in 26% of patients in the LT-NoMCA group, and some patients exhibited histamine release only. The MCA profile differed depending on the drugs used during the perioperative period, indicating the involvement of various mechanisms.</p><p><strong>Conclusions: </strong>While most reactions involving high tryptase concentrations and MCA are consistent with an IgE-mediated mechanism, our results showed that identifying the underlying mechanism of POHRs with a high degree of certainty is still not possible using the tools currently applied in daily clinical practice.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}