Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Mast Cell Activation Profile and TFH13 Detection Discriminate Between Food Anaphylaxis and Sensitization.","authors":"L Ollé, L García-García, M Ruano-Zaragoza, J Bartra, E A González-Navarro, M Pérez, J Roca-Ferrer, M Pascal, M Martín, R Muñoz-Cano","doi":"10.18176/jiaci.0995","DOIUrl":"10.18176/jiaci.0995","url":null,"abstract":"<p><strong>Background and objective: </strong>The prevalence of food allergy (FA) has increased significantly, and the risk of developing anaphylaxis is unpredictable. Thus, discriminating between sensitized patients and those at risk of a severe reaction is of utmost interest. To explore the mast cell (MC) activation pattern and the presence of T follicular helper (TFH) 13 cells in sensitized patients and patients who experience food anaphylaxis.</p><p><strong>Methods: </strong>Patients sensitized to lipid transfer protein (LTP) were classified as being at risk of anaphylaxis or sensitized depending on the symptoms elicited by the LTP-containing food. CD34+- derived MCs were obtained from patients and controls, sensitized with pooled sera, and challenged with Pru p 3 (peach LTP). Degranulation, prostaglandin (PG) D2, and cytokine/chemokine release were measured. The TFH13 population was examined using flow cytometry of the peripheral blood of all groups. In parallel, LAD2 cells were activated in the same way as patients' MCs.</p><p><strong>Results: </strong>A distinguishable pattern of MC activation was found in anaphylaxis patients but not in sensitized patients. Robust degranulation, PGD2, and release of IL-8 and granulocyte-macrophage colony-stimulating factor were more frequent in anaphylaxis patients, whereas secretion of TFG-ß and CCL2 was more frequent in sensitized patients. Anaphylaxis patients also had a larger TFH13 population. The MC activation profile was dependent on the sera rather than the MC source. Consistent with this observation, LAD2 cells reproduce the same pattern as MCs from anaphylactic and sensitized patients.</p><p><strong>Conclusion: </strong>The distinct profile of MC activation makes it possible to discriminate between patients at risk of an anaphylactic reaction and sensitized patients. Pooled sera may determine MC activation independently of MC origin. Besides, the presence of TFH13 cells in anaphylaxis patients points to an essential role for the affinity of IgE.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"203-215"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Fecal Calprotectin and Zonulin as Biomarkers in Adults With Fish-Induced Food Protein-Induced Enterocolitis Syndrome.","authors":"A Entrala, M M Lluch-Bernal, J Domínguez-Ortega, M Molero-Luis, G Crespo Sánchez, S Quirce, R Rodríguez-Perez","doi":"10.18176/jiaci.1049","DOIUrl":"10.18176/jiaci.1049","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"230-232"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Sensitization to Novel Foods: A Real-Life Prevalence Study of IgE-Mediated Reactivity to Cricket, Locust, and Mealworm in Insect Food-Naïve Allergic Individuals.","authors":"E Scala, D Abeni, V Villella, D ViIlalta, L Cecchi, E Caprini, R Asero","doi":"10.18176/jiaci.0986","DOIUrl":"10.18176/jiaci.0986","url":null,"abstract":"<p><strong>Background and objective: </strong>With the global population on the rise, edible insects are considered a potential solution to food security, although concerns about risks such as anaphylaxis have been expressed.</p><p><strong>Methods: </strong>We tested 2014 participants using the ALEX (Allergen Explorer) test, version 2 (ALEX2, Macroarray Diagnostics) and extracts of 3 novel foods: Acheta domesticus, Locusta migratoria, and Tenebrio molitor. IgE-mediated sensitization status was investigated in participants who had never knowingly consumed these insects. Data were recorded using an electronic database.</p><p><strong>Results: </strong>A total of 195 individuals (9.7% of all participants) were sensitized to insects. Tropomyosin was corecognized by 34%, and 18.5% of results were positive for arginine kinase. Reactivity to sarcoplasmic calcium-binding protein, troponin C, paramyosin, or myosin light chain proteins was recorded in less than 5% of the population, whereas 108 individuals (55.4%) did not react to invertebrate panallergens. A further 33 individuals (16.9%) exhibited monosensitization exclusively to insects. Multivariate analysis revealed an inverse association between reactivity to arachnids and sensitization to insect allergens, while a direct association was identified between Mollusca and Blattoidea and reactivity to tropomyosin. Furthermore, reactivity to myosin light chain protein correlated with sensitization to A domesticus and L migratoria, and reactivity to troponin C with sensitization to A domesticus and T molitor.</p><p><strong>Conclusion: </strong>IgE-mediated sensitization to edible insect extract was observed in individuals with no prior exposure to these foods. Mites were unlikely to be primary sensitizers owing to their inverse association with insect reactivity. Conversely, the direct association between sensitization to insect extract and reactivity to mollusk and cockroach extract suggests their potential as primary sensitizers in these participants. A positive association was consistently observed for tropomyosin, with reactivity to all studied insects, thus supporting its role as a primary sensitizer.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"197-202"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors and Optimization of Omalizumab in Chronic Spontaneous Urticaria: A Multicenter Study of 257 Patients.","authors":"J Ceravalls, A M Giménez-Arnau, V Expósito-Serrano, N Fernández Chico, A Lara Moya, I Bielsa, P Ribó, B Mascaró-Hereza, M Bonfill-Ortí, J Spertino, E Serra, C Baliu-Piqué, G Melé-Ninot","doi":"10.18176/jiaci.1053","DOIUrl":"10.18176/jiaci.1053","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"218-220"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Eczema as a Transient Paradoxical Adverse Effect of Dupilumab.","authors":"D Betancor, M Valverde-Monge, J L Díaz-Recuero, M E Jo-Velasco, V Del Pozo, J Sastre","doi":"10.18176/jiaci.1051","DOIUrl":"10.18176/jiaci.1051","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"216-217"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population.","authors":"F Carballada González, E Abel-Fernández, L A González Guzmán, F Pineda de la Losa","doi":"10.18176/jiaci.1050","DOIUrl":"10.18176/jiaci.1050","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"237-238"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis Induced by Milk Thistle (Silybum marianum) Seed Ingestion: A Case Report.","authors":"M Planas-Vinos, A Sala-Cunill, O Luengo, M Castillo Fernandez, P Galvan-Blasco, V Cardona, M Guilarte, M Labrador-Horrillo, J Gil-Serrano","doi":"10.18176/jiaci.1057","DOIUrl":"10.18176/jiaci.1057","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"235-236"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of the First Venom Immunotherapy for Allergy to Vespa velutina nigrithorax: Interim Analysis of the W-STING Study.","authors":"F Carballada, A Parra, T Liñares, N Giangrande, S Varela, Á Meijide, M Castro, A I Tabar","doi":"10.18176/jiaci.1058","DOIUrl":"10.18176/jiaci.1058","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"225-227"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Dangers of Oral Contrast Media: Delayed Hypersensitivity to Sodium Amidotrizoate and Meglumine Amidotrizoate (Gastrografin).","authors":"V Pardo-Manrique, V Amat-Samaranch, M Pascal, D Loli-Ausejo, M C Sánchez-Fernández, M Ruano-Zaragoza","doi":"10.18176/jiaci.1055","DOIUrl":"10.18176/jiaci.1055","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"232-234"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ongoing Concerns With Honeybee Venom Immunotherapy.","authors":"S Khan","doi":"10.18176/jiaci.1060","DOIUrl":"10.18176/jiaci.1060","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"239-0"},"PeriodicalIF":6.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}