Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin.","authors":"M N Otero-Fernández, E Laffond-Yges, R M Castillo-Loja, A Cabrera-Núñez, M E Mazoteras-Martínez, F J Muñoz-Bellido, I Dávila","doi":"10.18176/jiaci.1031","DOIUrl":"10.18176/jiaci.1031","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"72-73"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Far Are We From Achieving Delabeling of False Penicillin/ß-Lactam Allergy Alerts? A Population Problem.","authors":"M A Tejedor-Alonso, M Perez-Encinas, S Sanz Márquez, J J Martinez Simon, L Moreno-Nuñez, A Gonzalez-Moreno, J Macias-Iglesias, A Rosado-Ingelmo","doi":"10.18176/jiaci.1004","DOIUrl":"10.18176/jiaci.1004","url":null,"abstract":"<p><p>Interest in finding efficient ways to remove penicillin allergy alerts has grown as a result of awareness of the considerable excess of falsenegative diagnoses in patients with penicillin allergy labels (90%-95%), the poorer course with non-ß-lactam antibiotics, the increase in bacterial resistance, and the fact that these problems can affect up to 20% of the population in some countries. The strategies proposed have generated many publications in countries where the number of allergists to conduct such studies is low. In many cases where delabeling is performed, the risk of ß-lactam allergy is low, and a single penicillin challenge is sufficient to delabel the alert. However, other less \"ultrarapid\" strategies can be used to administer a ß-lactam during an admission for infection and thus postpone delabeling until traditional drug allergy consultations. However, the definitive withdrawal of ß-lactam alerts is threatened by nonremoval of alerts in electronic health records and by the reactivation or nonsynchronization of alerts between electronic systems at different levels of care. Allergy departments need to reflect on how to implement practices that enable rapid and efficient delabeling of drug allergy alerts, especially in patients with major comorbidities.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"12-23"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors and Optimization of Omalizumab in Chronic Spontaneous Urticaria: A Multicenter Study of 257 Patients.","authors":"J Ceravalls, A M Giménez-Arnau, V Expósito-Serrano, N Fernández Chico, A Lara Moya, I Bielsa, P Ribó, B Mascaró-Hereza, M Bonfill-Ortí, J Spertino, E Serra, C Baliu-Piqué, G Melé-Ninot","doi":"10.18176/jiaci.1053","DOIUrl":"https://doi.org/10.18176/jiaci.1053","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen.","authors":"I García-Gutiérrez, C Solórzano-Zepeda, V Sánchez-García, E Ramírez-Mateo, D Antolín-Amérigo, Y Zheng, A Rioja Carrera, I León Hernando, M E Hernando Pérez, B De la Hoz Caballer","doi":"10.18176/jiaci.1036","DOIUrl":"https://doi.org/10.18176/jiaci.1036","url":null,"abstract":"<p><strong>Background: </strong>An environmental exposure chamber (EEC) is a health facility that enables allergic symptoms to be induced in a controlled manner in persons sensitized to a dispersed allergen. We performed a study at our institution to technically and clinically validate an EEC in patients allergic to grass pollen.</p><p><strong>Methods: </strong>We developed a new EEC inside a clean room (ISO-8 class) measuring 15.6 m². During the technical validation, the patient's exposure conditions were simulated by ensuring homogeneous distribution of the allergen with a particle disperser and monitoring both particle and pollen grain concentrations. Temperature, pressure, and humidity were also registered. A total of 31 volunteers were exposed to Phleum pratense pollen in the EEC. Of these, 25 were allergic (cases), with symptoms of rhinoconjunctivitis with or without asthma, and 6 were not (controls). One control and 2 cases were exposed twice to check reproducibility, generating a total of 34 challenges. The test was stopped once the positivity criterion was reached or the patient completed 90 minutes in the EEC.</p><p><strong>Results: </strong>Both the stability of particle concentrations and approximation to the pollen sample concentration were guaranteed. All challenges with controls were negative. Among the cases, 15% of challenges were negative and 85% were positive. No severe or late reactions were observed. Volunteers exposed twice to the same pollen had the same result in both challenges.</p><p><strong>Conclusion: </strong>Our EEC proved to be a specific, safe, and reproducible tool for the diagnosis of grass pollen allergy.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of the First Venom Immunotherapy for Allergy to Vespa velutina nigrithorax: Interim Analysis of the W-STING Study.","authors":"F Carballada, A Parra, T Liñares, N Giangrande, S Varela, Á Meijide, M Castro, A I Tabar","doi":"10.18176/jiaci.1058","DOIUrl":"https://doi.org/10.18176/jiaci.1058","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics-Based Prediction of B- and T-Cell Epitopes in R-Mandelonitrile Lyase, a Recently Described Peach Allergen.","authors":"M A López-Matas, L Martín-López, F Vílchez-Sánchez, M Pedrosa, R Rodríguez-Pérez, J Domínguez-Ortega, J Carnés","doi":"10.18176/jiaci.1052","DOIUrl":"https://doi.org/10.18176/jiaci.1052","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ongoing Concerns With Honeybee Venom Immunotherapy.","authors":"S Khan","doi":"10.18176/jiaci.1060","DOIUrl":"https://doi.org/10.18176/jiaci.1060","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effect Between Gut Microbiota, Gut Bacterial Pathway, and Chronic Spontaneous Urticaria: A Large-Scale Bidirectional Mendelian Randomization Analysis.","authors":"Y Yao, J Chen, H Cao, Z Lu, H Shen, J Ji, Q Jiao","doi":"10.18176/jiaci.1054","DOIUrl":"https://doi.org/10.18176/jiaci.1054","url":null,"abstract":"<p><strong>Background: </strong>To analyze causality between gut microbiota and chronic spontaneous urticaria (CSU) and to investigate the mediating effect of metabolic pathways.</p><p><strong>Methods: </strong>We extracted genome-wide association study summary statistics for 211 microbiota taxa from the MiBioGen consortium (N=18 340), 205 microbiota metabolic pathways from the Dutch Microbiome Project (N=7738), and CSU from the FinnGen genomics initiative (N=450). Bidirectional Mendelian randomization (MR) was performed to detect genetic causality between gut microbiota, gut bacterial pathways, and CSU. Sensitivity analyses were performed to validate the robustness of the results. Mediation MR investigated mediators in the association between gut microbiota and CSU.</p><p><strong>Results: </strong>MR analysis suggested that the family Peptococcaceae and its child taxon, the genus Peptococcus, were risk factors for CSU. In addition, the genera Collinsella, Lachnospiraceae UCG004, Ruminococcaceae UCG004, and Sellimonas were also risk factors for CSU, whereas Family XIII UCG001, Lachnospiraceae UCG010, and Methanobrevibacter had protective effects on CSU. As for metabolic pathways, NONMEVIPP-PWY, PWY-5022, and PWY-7221 were positively associated with CSU, although others, such as KDO-NAGLIPASYN-PWY, PWY- 6353, and PWY-7400 presented a suggestive association with CSU. Moreover, PWY-7400 was a mediator in causality between the family Peptococcaceae and CSU. These results were based on nominal significance (P<.05). None of the Bonferroni corrected P values were <.05.</p><p><strong>Conclusions: </strong>Our study confirmed a causal association between gut microbiota and CSU, with the metabolic pathway being a potential mediator. Our findings provide new insights for further mechanistic and clinical studies in CSU.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Rhinoconjunctivitis Induced by Flaxseed: Identification of Novel Allergenic Proteins From Cupin, Chaperonin, and Enzyme Families.","authors":"A Gambelunghe, E Chiaradia, S Buratta, E Calzoni, A Tognoloni, E Prosperi, A Giuliani, C Emiliani, M dell'Omo, I Folletti","doi":"10.18176/jiaci.1046","DOIUrl":"https://doi.org/10.18176/jiaci.1046","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.","authors":"B Sousa-Pinto, M Savouré, R J Vieira, R Amaral, W Czarlewski, A Bedbrook, A Valiulis, V Kvedariene, L Brussino, B Gemicioglu, T Haahtela, L Klimek, H Kraxner, D E Larenas-Linnemann, O Pfaar, F S Regateiro, B Samolinski, L Taborda-Barata, S Toppila-Salmi, M T Ventura, I J Ansotegui, F Braido, G W Canonica, L Cecchi, A A Cruz, P Devillier, W J Fokkens, S Gil-Mata, A Fm Giuliano, J C Ivancevich, P Kuna, M Kupczyk, G Louis, R Louis, M Makris, M Morais-Almeida, J Mullol, R Nadif, M Niedoszytko, Y Okamoto, M Ollert, N G Papadopoulos, V Patella, R Pawankar, A M Pereira, B Pétré, N Pham-Thi, N Roche, P W Rouadi, J Sastre, N Scichilone, A Sheikh, M Sova, A Todo-Bom, A Yorgancioglu, M Zidarn, J M Anto, T Zuberbier, J A Fonseca, J Bousquet","doi":"10.18176/jiaci.1047","DOIUrl":"10.18176/jiaci.1047","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as \"intermittent\" or \"persistent\" and \"mild\" or \"moderate-severe\". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.</p><p><strong>Methods: </strong>We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months. We assessed the frequency of users according to the ARIA classes and compared these classes in terms of rhinitis symptoms, use of comedication, frequency of comorbid asthma, and the association between comorbid asthma and rhinitis control.</p><p><strong>Results: </strong>A total of 2273 users (180 796 days) were assessed. Most users had moderate-severe rhinitis (n=2003; 88.1%) and persistent rhinitis (n=1144; 50.3%). The frequency of patients with probable asthma was 35.7% (95%CI, 34.5%-37.0%) for intermittent rhinitis and 48.5% (95%CI, 47.1%-49.9%) for persistent rhinitis. The maximum values on the visual analog scale (VAS) for rhinitis symptoms and the combined symptom medication score were lower in patients with mild rhinitis than in those with moderate-severe rhinitis (irrespective of whether they had persistent or intermittent rhinitis). In most ARIA classes, VAS nose and VAS eye and rhinitis comedication were more frequent in patients with rhinitis+asthma than in those with rhinitis alone.</p><p><strong>Conclusion: </strong>This study suggests that the presence of asthma is more closely related to persistence of rhinitis than to severity and that the presence of comorbid asthma may be associated with poorer control of rhinitis across the different ARIA classes.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}