Journal of Investigational Allergology and Clinical Immunology最新文献_第5页

Measurement of Fecal Calprotectin and Zonulin as Biomarkers in Adults With Fish-Induced Food Protein-Induced Enterocolitis Syndrome. 鱼类诱导的食物蛋白诱导的肠结肠炎综合征成人粪便钙保护蛋白和Zonulin作为生物标志物的测定。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-01-15 DOI: 10.18176/jiaci.1049

A Entrala, M M Lluch-Bernal, J Domínguez-Ortega, M Molero-Luis, G Crespo Sánchez, S Quirce, R Rodríguez-Pérez

引用次数: 0

ISO 9001:2015 Certification of the Allergy Laboratory. ISO 9001:2015过敏实验室认证。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-01-15 DOI: 10.18176/jiaci.1045

M L Caballero, D Carpio-Hernández, P Parra, J C Giraldo-Sánchez, M Rodríguez-Álvarez, S Quirce

引用次数: 0

Position Paper on the Treatment of Eosinophilic Esophagitis With Dupilumab. Dupilumab治疗嗜酸性食管炎的立场文件。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-19 DOI: 10.18176/jiaci.1038

M Tomás-Pérez, J Domenech-Witek, M R Ávila-Castellano, C Carballas-Vázquez, A A Vásquez-Bautista, V Jover-Cerdá, R González-Mendiola

引用次数: 0

Study of Urinary Protein Biomarkers in Hereditary Angioedema. 遗传性血管性水肿尿蛋白生物标志物的研究。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-11 DOI: 10.18176/jiaci.1032

J Wu, X Tang, N Zhou, X Wang, P Liu, Z Zhang, S Zhang, Y Zhi

{"title":"Study of Urinary Protein Biomarkers in Hereditary Angioedema.","authors":"J Wu, X Tang, N Zhou, X Wang, P Liu, Z Zhang, S Zhang, Y Zhi","doi":"10.18176/jiaci.1032","DOIUrl":"https://doi.org/10.18176/jiaci.1032","url":null,"abstract":"Background: Hereditary angioedema (HAE) is a rare and potentially life-threatening disease, and diagnosis is often missed or delayed. We aimed to identify noninvasive urinary protein biomarkers and to evaluate their potential roles in diagnosis and evaluation of disease severity.Methods: Using data-independent acquisition (DIA)-based urinary proteomics, we identified proteins that were differentially expressed between patients with HAE and healthy control (HC) groups. Then, the parallel reaction monitoring (PRM)-targeted proteomics method was used to validate promising biomarker candidates in other HAE patients and HCs. Furthermore, enzyme-linked immunosorbent assay (ELISA) was conducted to verify levels of several key proteins in HAE, histamine-mediated angioedema, and HCs.Results: Differential expression between HAE patients and HCs was observed in 269 of the 2562 urinary proteins identified. In the biofunction analysis, these differentially expressed proteins were significantly enriched in leukocyte migration, adhesion of immune cells, endothelial cell development, permeability of the vascular system, and death of immune cells. Moreover, a biomarker panel (C1 esterase inhibitor, pro-epidermal growth factor, and kininogen-1) was validated in 2 independent clinical cohorts with area under the curve values of 0.910 and 0.949 for a diagnosis of HAE. Additionally, the urinary clusterin level was found to be significantly correlated with HAE severity scores (R=-0.758, P<.01).Conclusions: This study describes the first application of a DIA-PRM-ELISA workflow to identify noninvasive urine biomarkers of HAE. The results will contribute to our understanding of the pathogenesis of HAE and may also provide a potential alternative method for diagnosis and evaluation of disease severity.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population. 基于成分评估西班牙过敏人群中蜂毒的主要过敏原

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-11 DOI: 10.18176/jiaci.1050

F Carballada González, E Abel-Fernández, L A González Guzmán, F Pineda de la Losa

引用次数: 0

Validation of a Visual Analog Scale for Loss of Smell as a Quick Test in Chronic Rhinosinusitis With Nasal Polyps. 嗅觉丧失的视觉模拟量表作为慢性鼻窦炎伴鼻息肉的快速测试的验证。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-05 Epub Date: 2023-09-06 DOI: 10.18176/jiaci.0937

I Alobid, C Calvo-Henríquez, P Viveros-Díez, M López-Chacón, M J Rojas-Lechuga, C Langdon, C Marin, J Mullol

{"title":"Validation of a Visual Analog Scale for Loss of Smell as a Quick Test in Chronic Rhinosinusitis With Nasal Polyps.","authors":"I Alobid, C Calvo-Henríquez, P Viveros-Díez, M López-Chacón, M J Rojas-Lechuga, C Langdon, C Marin, J Mullol","doi":"10.18176/jiaci.0937","DOIUrl":"10.18176/jiaci.0937","url":null,"abstract":"Background and objectives: The diagnostic criteria of chronic rhinosinusitis with nasal polyps (CRSwNP) include olfactory dysfunction. We hypothesize that patients with CRSwNP can self-assess their sense of smell better using a visual analog scale (VAS) than using smell tests.Methods: A controlled cross-sectional study was performed. Adults diagnosed with severe CRSwNP waiting for endoscopic sinus surgery were included. A cohort of healthy controls was also studied. All participants completed the Barcelona Smell Test 24 (BAST-24), the 22-item Sinonasal Outcomes Test 22 (SNOT-22), and a VAS for loss of smell. Patients with CRSwNP underwent blood testing (eosinophil count, total serum IgE), computed tomography (Lund-Mackay Score), and nasal endoscopy.Results: The study population comprised 138 patients with severe CRSwNP and 40 controls. The BAST-24 identification score was strongly correlated with the VAS score in the CRSwNP group (p=-0.79, P<.001) but not in the control group (p=-0.14; P=.39), this difference between groups being statistically significant (P<.001). A significant correlation was found between SNOT-22 item 21 (loss of smell) and BAST-24 identification (p=-0.65, P<.001), this difference being statistically significant (Z=-2.43; P=.015). The area under the receiver operating curve was 0.85, with 72.5% sensitivity and 93.1% specificity.Conclusion: This study demonstrates a potential role of the VAS score for the screening of olfactory dysfunction in severe CRSwNP in daily clinical practice.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"377-384"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10524499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Allergic Rhinitis on Academic Performance in Adolescents and Adults: a Bayesian Analysis of MASK-air® Real-world Direct Patient Data. 过敏性鼻炎对青少年和成人学习成绩的影响：对 MASK-air® 真实世界直接患者数据的贝叶斯分析。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-05 Epub Date: 2024-09-25 DOI: 10.18176/jiaci.1010

R J Vieira, A M Pereira, N G Papadopoulos, T Zuberbier, N Pham-Thi, M Giovannini, E Melén, L F Azevedo, J A Fonseca, J Bousquet, B Sousa-Pinto

引用次数: 0

Gastrointestinal Symptoms: Under the Tip of the Iceberg in Lipid Transfer Protein Food Allergy. 胃肠道症状：脂转移蛋白食物过敏的冰山一角。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-05 Epub Date: 2024-07-30 DOI: 10.18176/jiaci.1006

M Ruano-Zaragoza, G Araujo-Sanchez, S Gelis, D Loli-Ausejo, P Mir-Ihara, B Mascaró-Hereza, M C Sánchez-Fernández, M Pascal, R Muñoz-Cano, J Bartra

引用次数: 0

Impact of Climate Change-Related Environmental Factors on Allergen Production and the Epidemiology and Severity of Allergic Diseases. 与气候变化相关的环境因素对过敏原的产生以及过敏性疾病的流行病学和严重程度的影响。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-05 Epub Date: 2024-01-15 DOI: 10.18176/jiaci.0988

J Montoro, D Antolín-Amérigo, M Artés, A Izquierdo-Domínguez, J J Zapata, P Mur, T Carrillo, I Antépara, F Feo, A Moral, A Valero

{"title":"Impact of Climate Change-Related Environmental Factors on Allergen Production and the Epidemiology and Severity of Allergic Diseases.","authors":"J Montoro, D Antolín-Amérigo, M Artés, A Izquierdo-Domínguez, J J Zapata, P Mur, T Carrillo, I Antépara, F Feo, A Moral, A Valero","doi":"10.18176/jiaci.0988","DOIUrl":"10.18176/jiaci.0988","url":null,"abstract":"Background: Allergic disease affects up to 40% of the adult population worldwide. This percentage is increasing as a result of environmental changes related to global warming.Methods: We undertook a systematic review of the literature to identify and evaluate current evidence on the impact of climate change-related environmental factors on allergen production and the epidemiology and severity of allergic diseases. We applied the Population, Exposure, Comparison, Outcome (PECO) criteria to guide our literature searches of the PubMed and Cochrane databases (January 1, 2016 to December 31, 2021). Study outcomes were categorized and grouped to facilitate data synthesis. Outcomes were classified as significant (P<.05), nonsignificant (P>.05), or undetermined (P value not reported). Study quality was assessed using the Mixed Methods Appraisal Tool.Results: Of 195 studies, 40 were considered relevant, and 9 provided data that could be included in the quantitative data synthesis. Environmental factors, including the presence of pollutants, temperature, and drought influenced the type, volume, and timing of exposure to local aeroallergens. The most relevant environmental factor was the presence of environmental pollutants, of which tropospheric ozone was the most frequently associated with changes in allergen production and prevalence and severity of allergic disease. Several publications also demonstrated the impact of environmental factors on health care burden.Conclusions: Climate change-related environmental factors worsened allergic disease in terms of prevalence, severity, and health care burden owing to alterations in allergen exposure (volume and type), with the presence of pollutants such as ozone being the most common drivers of this increase.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"358-366"},"PeriodicalIF":6.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescents and Vaping: The Essentials. 青少年与吸烟：要点》。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-05 Epub Date: 2024-07-30 DOI: 10.18176/jiaci.1014

H R Hernández-Suárez, I Bartha, E Lasa-Luaces, M Rodríguez-Álvarez, T Garriga-Baraut

引用次数: 0