Journal of Investigational Allergology and Clinical Immunology最新文献_第6页

Adrenaline: A Lifeline for Rapid Drug Desensitization in Hypersensitive Patients. 肾上腺素：过敏患者快速药物脱敏的生命线。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-25 DOI: 10.18176/jiaci.1075

J Gil-Serrano, P Galvan-Blasco, J Pereira-Gonzalez, A Salvany-Pijuan, M Gonzalez Di-Paolo, M Guilarte, O Luengo, A Sala-Cunill, V Cardona, M Labrador-Horrillo

{"title":"Adrenaline: A Lifeline for Rapid Drug Desensitization in Hypersensitive Patients.","authors":"J Gil-Serrano, P Galvan-Blasco, J Pereira-Gonzalez, A Salvany-Pijuan, M Gonzalez Di-Paolo, M Guilarte, O Luengo, A Sala-Cunill, V Cardona, M Labrador-Horrillo","doi":"10.18176/jiaci.1075","DOIUrl":"https://doi.org/10.18176/jiaci.1075","url":null,"abstract":"Background and objective: Chemotherapeutic agents (CMTs) and monoclonal antibodies (mAbs) are common causes of drug allergy, which is often managed using rapid drug desensitization (RDD). Despite its effectiveness, RDD can be hampered by severe breakthrough reactions (BTRs), potentially leading to failure of the procedure. To evaluate the usefulness and safety of adrenaline infusion (AI) as an adjuvant during RDD in patients who experience severe drug hypersensitivity reaction (DHR) during standard desensitization protocols.Methods: Retrospective observational study, analyzing data from patients who underwent RDD to CMTs or mAbs in a tertiary hospital from January 2015 to June 2024. We included patients who required AI to safely achieve RDD after a severe initial DHR or failure of a standard RDD protocol due to repeated DHRs. Comorbidities, adrenaline doses, and adverse events (AEs) were assessed.Results: RDD with AI was administered in 42 patients. Of these, 77% (n=32) were women, and the mean age was 57 years. The most frequently involved drugs were platinum salts (58%), mAbs (26%), and taxanes (14%). A total of 151 RDDs were performed with AI. Skin tests were positive in 69% of patients. The most frequent initial BTR (65%) was moderate or severe anaphylaxis. The most common AEs induced by AI were tremor (14%) and tachycardia (7%), which resolved after reducing the AI infusion rate. The median (IQR) cumulative dose of adrenaline administered throughout the RDD procedure was 0.76 mg (0.4-1.2mg), with a median infusion rate of 8 mL/h (4- 15ml/h), and median maximum AI rate of 3.33 μg/min (2-5.3 μg/min).Conclusions: AI is a useful and safe therapeutic tool for selected high-risk desensitization procedures, mitigating severe DHR with mostly minor AEs.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphocyte-Stimulation Test for Diagnosis of Wheat- Induced Enterocolitis Syndrome in Children. 淋巴细胞刺激试验诊断小麦致儿童小肠结肠炎综合征。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-23 DOI: 10.18176/jiaci.1085

N Kajita, G Kusakawa, K Hirao, S Yokoyama, E Morikawa, K Morita, M Narita, K Yoshida

引用次数: 0

Basophil Activation Test With Progressively Less Heated Forms of Egg Distinguishes Egg-Allergic From Egg-Tolerant Children. 用逐渐减少加热的鸡蛋形式进行的嗜碱性粒细胞激活试验将鸡蛋过敏儿童和耐受儿童区分开来。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2023-11-08 DOI: 10.18176/jiaci.0964

L De Vlieger, L Nuyttens, T Ieven, M Diels, L Coorevits, J Cremer, R Schrijvers, D Ma Bullens

{"title":"Basophil Activation Test With Progressively Less Heated Forms of Egg Distinguishes Egg-Allergic From Egg-Tolerant Children.","authors":"L De Vlieger, L Nuyttens, T Ieven, M Diels, L Coorevits, J Cremer, R Schrijvers, D Ma Bullens","doi":"10.18176/jiaci.0964","DOIUrl":"10.18176/jiaci.0964","url":null,"abstract":"Background and objectives: Diagnosis of egg allergy based on basophil activation testing (BAT) has mainly been performed with an egg white extract or individual egg allergens rather than with clinically more representative whole-egg extracts. The impact of heating on the allergenicity of a whole-egg extract remains unassessed. To validate BAT with gradually less heated whole-egg extracts in the diagnosis of egg allergy and as a marker of tolerance.Methods: CD63-based BAT was performed with 5 progressively less heated extracts from cake, hard-boiled egg, omelet, soft-boiled egg, and raw egg in 10 egg-allergic (EA), 10 complete egg-tolerant (ET), and 12 non-egg-sensitized nonallergic (NEA) children. Cut-offs and diagnostic accuracy measures were established through receiver operating characteristic curve analysis. Changes in basophil response were assessed in 12 baked egg-tolerant children undergoing an 8-month gradual egg reintroduction protocol with BAT and oral food challenges prior to each reintroduction step.Results: Basophil responses to all egg extracts were increased in EA children, but not in ET and NEA children. Responses decreased progressively with more heated egg extracts. Compared to ET children, EA children showed higher basophil sensitivity for all egg extracts. Negative BAT responses predicted clinical tolerance with 90%-100% sensitivity, 100% specificity, and a false positive rate of 2.78%. In comparison, the specificity of egg sIgE (<0.35 kUA/L) was lower (50%-78%), with a false positive rate of 40%. Basophil reactivity and sensitivity tended to decrease in baked egg-tolerant children undergoing gradual egg reintroduction, concurrent with tolerance development.Conclusion: BAT with progressively less heated egg preparations is a sensitive and highly specific tool to discriminate EA from ET children.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"103-113"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 1-Bag/4-Step Rapid Desensitization Protocol to Reintroduce Agalsidase α in a Patient With Fabry Disease. 1袋/4步快速脱敏方案在法布里病患者中重新引入Agalsidase A

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2024-12-02 DOI: 10.18176/jiaci.1044

T W Jimenez-Rodriguez, V Soriano Gomis, A Burgos San-José, R A Montoyo Antón, M P González Delgado, C P Gallego Velez, S Ortolano, J Fernández, R Sánchez Martínez

引用次数: 0

Occupational Rhinoconjunctivitis Induced by Flaxseed: Identification of Novel Allergenic Proteins From Cupin, Chaperonin, and Enzyme Families. 亚麻籽致职业性鼻结膜炎：从铜蛋白、伴侣蛋白和酶家族中鉴定新的致敏蛋白。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2025-01-23 DOI: 10.18176/jiaci.1046

A Gambelunghe, E Chiaradia, S Buratta, E Calzoni, A Tognoloni, E Prosperi, A Giuliani, C Emiliani, M dell'Omo, I Folletti

引用次数: 0

ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions. 雷尼替丁诱发的 ATAK 复合物：过敏反应中心脏参与的综合概念。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2024-11-28 DOI: 10.18176/jiaci.1042

A Lopez-Raigada, F Vega, M V Múgica, C Lopez-Sanz, A Alfranca, C Blanco

引用次数: 0

Drug-induced Kounis Syndrome: A Retrospective Pharmacovigilance Study from the FAERS and JADER Databases. 药物诱发的库尼斯综合征：来自 FAERS 和 JADER 数据库的回顾性药物警戒研究。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2024-11-27 DOI: 10.18176/jiaci.1039

H Li, Y Liu, L Tan, C Hu, L Su

引用次数: 0

Anaphylaxis Caused by a Mouse Bite in a Laboratory Researcher. 一名实验室研究人员被老鼠咬伤引发过敏性休克。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2024-11-25 DOI: 10.18176/jiaci.1040

S A Dager-García, A Germán-Sánchez, F Pineda de la Losa, A M Ferrer Franco

引用次数: 0

Occupational Asthma and Rhinoconjunctivitis due to Soybean in a Bakery Worker. 一名面包店工人因大豆引发职业性哮喘和鼻结膜炎。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2024-11-13 DOI: 10.18176/jiaci.1035

Ö Özdemir

引用次数: 0

Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients. 西班牙和拉丁美洲螨虫过敏症患者的分子致敏特征差异。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2025-04-22 Epub Date: 2024-01-04 DOI: 10.18176/jiaci.0968

D Calzada, J Bartra, C D Serrano, S Riggioni, E Moran, J P Maselli, D L Silva, L F Ramirez, M Pascal, J Carnés, A Valero

{"title":"Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients.","authors":"D Calzada, J Bartra, C D Serrano, S Riggioni, E Moran, J P Maselli, D L Silva, L F Ramirez, M Pascal, J Carnés, A Valero","doi":"10.18176/jiaci.0968","DOIUrl":"10.18176/jiaci.0968","url":null,"abstract":"Background and objectives: To analyze sensitization to Dermatophagoides pteronyssinus and to investigate the association between diagnostic findings and clinical severity in 218 allergic patients from 2 continents.Methods: Mite-allergic patients were recruited by allergology departments in Latin America (n=88: Colombia, Costa Rica, and Guatemala) and Spain (n=130). All patients had allergic rhinitis with or without asthma and positive skin prick test results to D pteronyssinus. Specific IgE levels to D pteronyssinus, Dermatophagoides farinae, Der p 1, Der p 2, and Der p 23 were quantified using ImmunoCAP (Thermo Fisher Scientific). The allergenic profile was also determined by Western blotting. A comparative statistical analysis was performed using GraphPad software.Results: Patients most frequently recognized Der p 2 (79%), followed by Der p 1 (73%) and Der p 23 (69%). The percentage of patients with asthma increased with the number of sensitizations; however, no statistically significant differences were found. Interestingly, patients with asthma presented the highest median levels of total IgE and specific IgE for D pteronyssinus and molecular allergens, mainly Der p 2. Analysis of both populations revealed that Spanish patients were predominantly sensitized to Der p 2 (88.46%) and Der p 1 (83.84%), whereas Latin American patients were more sensitized to Der p 23.Conclusions: Our data support the relevance of Der p 2 as the major allergen in mite allergy. A large percentage of patients are sensitized to this allergen, which plays a key role in the development of asthma. Sensitization to Der p 23 was more relevant in Latin America.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"114-121"},"PeriodicalIF":6.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0