Journal of Investigational Allergology and Clinical Immunology最新文献

{"title":"Severe Asthma and Chronic Rhinosinusitis With Nasal Polyps: Simultaneous Response to Dupilumab.","authors":"Paula López-González, María Vázquez de la Torre, Ismael García-Moguel, Cristina Juárez Rodríguez, Jorge Correa-Borit, Mar Gandolfo-Cano, Beatriz González-Cano, Mar Moro-Moro, Ana Rosado-Ingelmo, David González-de-Olano, Javier Domínguez-Ortega","doi":"10.18176/jiaci.1150","DOIUrl":"10.18176/jiaci.1150","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"239-242"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Kounis Syndrome Induced by Mustard Protein (Sin a 2) in an Adult With Lipid Transfer Protein Syndrome: A Novel Case Report.","authors":"Carla Monerris-Aguilar, Mariona Pascal, Mayte Villalba, Rubén G Gordo, María Ruano-Zaragoza, Sònia Gelis, Carlota Badia-Santolaria, Rosa Muñoz-Cano, Joan Bartra, Giovanna Araujo-Sánchez","doi":"10.18176/jiaci.1148","DOIUrl":"10.18176/jiaci.1148","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"245-247"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Single Subcortical Infarction and Atypical Purpura in Eosinophilic Granulomatosis with Polyangiitis: A Case Report.","authors":"Keying Wu, Tingyu Chen, Wei Song, Deren Wang","doi":"10.18176/jiaci.1151","DOIUrl":"10.18176/jiaci.1151","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"250-251"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between b-Lactam Drug Allergy Assessments in an Allergy Department and Labeling of Allergy to b-Lactam Drugs: Room for Improvement.","authors":"Miguel Angel Tejedor-Alonso, Ana Gonzalez-Moreno, Maria Dolores Alonso-Diaz-Durana, Maria Angeles Gonzalez-Labrador, Ana Belen Pastor-Magro, Maria Angeles Pizarro-Jaraiz, Yesenia Peña-Acevedo, Ana Rosado-Ingelmo","doi":"10.18176/jiaci.1158","DOIUrl":"10.18176/jiaci.1158","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"242-244"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of an Allergy Study Including Rapid Provocation Tests to Identify a Safe Alternative Contrast Agent and Phenotyping of Patients With a History of Hypersensitivity to Iodinated Contrast Media.","authors":"Francisco Vega, Azahara Lopez-Raigada, Marina Soria, Maria Catala, Carlos Blanco-Mota, Victoria Mugica, Carlos Blanco","doi":"10.18176/jiaci.1091","DOIUrl":"10.18176/jiaci.1091","url":null,"abstract":"<p><strong>Background and objective: </strong>Provocation tests with contrast media are increasingly necessary to complete an allergy work-up. However, they are not standardized. Objective: We aimed to evaluate a rapid provocation test in patients with a history of anaphylaxis. Our secondary objectives included phenotyping the study population and proposing a predictive methodology for allergy test outcomes.</p><p><strong>Methods: </strong>We performed an allergy study using iohexol, iodixanol, ioversol, and iobitridol in patients ≥18 years of age with previous hypersensitivity reactions to iodinated contrast media. A rapid provocation test (100 cc administered in 12 minutes) was performed using a noninvolved iodinated contrast medium that had yielded negative skin test results. The statistical analysis comprised binary logistic regression and cluster analysis.</p><p><strong>Results: </strong>A total of 130 patients were enrolled. Ninety-six patients (74%) developed cutaneous symptoms exclusively, while 17 patients (13%) experienced anaphylaxis. Nine patients (7%) had positive skin test results, and 20 of 141 provocation tests performed were positive. All patients developed mild cutaneous symptoms, including those with a history of anaphylaxis. A safe alternative contrast medium was recommended to 122 patients (94%), with good tolerance in 50 patients in a new radiological examination. We identified 3 patient phenotypes, each associated with a different risk of a positive drug provocation test result. A predictive model for allergy test outcomes was developed, although its statistical predictive capacity was low.</p><p><strong>Conclusions: </strong>We confirmed the efficacy and safety of a protocol including rapid provocation tests in patients with hypersensitivity reactions to iodinated contrast media of varying severity. Three patient clusters were identified, each showing a different risk level for a positive provocation test result.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"226-236"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to Procambarus clarkii: Possible Involvement of Myosin Light Chain.","authors":"Rocío Picos Baliña, Remedios Cárdenas Contreras, María José Martínez Martínez, Fernando Pineda de la Losa, Stefan Cimbollek, Manuel Prados-Castaño, Joaquin Quiralte Enríquez","doi":"10.18176/jiaci.1178","DOIUrl":"10.18176/jiaci.1178","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"257-259"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitization to Blomia tropicalis Across Climatic Zones: A Comparison Between Mediterranean and Tropical Regions.","authors":"David Calzada, Joan Bartra, Carlos Serrano, Silvia Riggioni, Edgar Moran, Juan Pablo Maseli, Diana L Silva, Luis Fernando Ramirez, Mariona V Pascal, Jerónimo Carnés, Antonio Valero","doi":"10.18176/jiaci.1145","DOIUrl":"10.18176/jiaci.1145","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"237-239"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purinergic Receptors as Emerging Targets in the Management of Chronic Cough: From Pathophysiology to Clinical Application.","authors":"Manuel Jorge Rial, Paula Galván, Darío Antolín Amérigo, Remedios Cárdenas-Contreras, Ana Montoro Ferrer, Juan Carlos Miralles López","doi":"10.18176/jiaci.1170","DOIUrl":"10.18176/jiaci.1170","url":null,"abstract":"<p><p>Chronic cough is a prevalent and debilitating condition that significantly impairs quality of life and remains a therapeutic challenge owing to the limited efficacy and unfavorable adverse effect profiles of existing treatments. In recent years, a deeper understanding of the neurobiology of the cough reflex has unveiled the pivotal role of purinergic signaling in the pathophysiology of cough hypersensitivity. Extracellular adenosine triphosphate, released in response to airway inflammation and irritation, activates the P2X3 and P2X2/3 receptors on vagal sensory nerves, triggering and sensitizing the cough reflex. This has led to the emergence of P2X3 receptor antagonists as a promising new class of targeted therapies. This comprehensive review of the pathophysiology of chronic cough focuses on the role of purinergic signaling, with an examination of the preclinical and clinical evidence supporting the efficacy of P2X3 antagonists, such as gefapixant, in reducing cough frequency. Furthermore, we discuss the clinical and safety considerations of these novel drugs, including the main challenge of taste-related adverse effects, and explore future perspectives, such as the development of more selective molecules and the identification of biomarkers to guide personalized treatment strategies. The advent of purinergic receptor modulation marks a significant milestone in the management of chronic cough, offering new hope for patients with this refractory condition.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"185-197"},"PeriodicalIF":4.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jun o 1, a Cross-reactive Juniperus oxycedrus Allergen With Unique Structural and Immunogenic Properties.","authors":"Sandra Sivill, Marcos Viñuela, Irene Real-Arévalo, Miriam Morán-Morales, Lucia Moreno-Serna, Celia López-Sanz, Emilio Nuñez-Borque, Rodrigo Jiménez-Saiz, Jose C Hernández-Walias, Sarai Martínez-Cano, Juan M Igea, Jose A Lemus Calderon, Ana M Navarro-Pulido, Carmen Rondon, Enrique Fernandez-Caldas, Fernando Pineda, Jose L Subiza, Salvador Iborra, Jose F Cantillo","doi":"10.18176/jiaci.1186","DOIUrl":"https://doi.org/10.18176/jiaci.1186","url":null,"abstract":"<p><strong>Background and objective: </strong>Juniperus oxycedrus, from the Cupressaceae family, is widespread in the Mediterranean. However, the allergenic relevance of its pollen remains underexplored. Objective: This study aimed to characterize Jun o 1, an allergen of J oxycedrus that is homologous to major allergens in related species.</p><p><strong>Methods: </strong>Native Jun o 1, its nonglycosylated Escherichia coli-expressed form (rJun o 1), and Cup a 1 were purified by affinity chromatography. Jun o 1 was characterized by SDS-PAGE, 2D-electrophoresis, Western blot (WB), and mass spectrometry and compared with the homologous cypress allergen, Cup a 1. Enzymatically and chemically deglycosylated Jun o 1 was also analyzed. Specific IgE binding and cross-reactivity were evaluated using ELISA, WB, and mast cell activation assays with sera from 57 Spanish cypress-allergic patients. IgG binding was tested using sera from rJun o 1-immunized mice.</p><p><strong>Results: </strong>Jun o 1 exists as multiple isoforms and assembles into oligomers, whereas Cup a 1 comprises multiple isoforms without oligomerization. IgE binding to Jun o 1, including mast cell activation, is critically influenced by the combined presence of protein and carbohydrate determinants. Compared to Cup a 1, Jun o 1 exhibited greater IgE-binding inhibition for J oxycedrus extract in sera from Cupressaceae-sensitized allergic patients from this tree's autochthonous regions. The highest rate of monosensitization in this group was to J oxycedrus.</p><p><strong>Conclusion: </strong>Jun o 1 is a relevant and potential major allergen in cypress allergy. Structural and immunogenic similarities with Cup a 1 lead to cross-reactivity, although it also exhibits unique properties, resulting from combined IgE-reactive protein and glycan determinants.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Multicenter Cohort Study on the Effectiveness of Triple Inhaled Therapy in Severe Asthma.","authors":"David Dacal Rivas, Nagore Blanco Cid, Daniel Pérez Ortiz, Mar Mosteiro Añon, Coral Gonzalez Fernández, Jose M Alvarez Torres, Abel Pallares Sanmartin, Abraham Ali-Munive, Carlos A Torres-Duque, Raquel Ruiz Ferreras, Andrés Blanco Hortas, Carmen Vidal, Luis Pérez de Llano","doi":"10.18176/jiaci.1181","DOIUrl":"https://doi.org/10.18176/jiaci.1181","url":null,"abstract":"<p><strong>Background and objectives: </strong>Triple therapy (TT) is effective for asthma patients whose disease remains uncontrolled with dual therapy. However, relevant questions remain unanswered. Objectives: To evaluate the long-term effectiveness of TT in a real-world setting; to determine the extent to which it prevents escalation to oral corticosteroids (OCS), azithromycin, or biologics; and to identify factors related to failure.</p><p><strong>Methods: </strong>Retrospective multicenter cohort study. Data were collected at baseline, 16-24 weeks, 52 weeks, and at the last visit. Follow-up extended to treatment escalation or the last visit. Effectiveness of TT was defined as no treatment escalation plus asthma control (Asthma Control Test [ACT] ≥20 and no severe exacerbations in the preceding 12 months).</p><p><strong>Results: </strong>A total of 390 patients were analyzed (median follow-up 40.0 months). Of these, 83 (22.5%) escalated treatment; TT was effective in 54% at the last visit. Complete remission (control plus FEV1 ≥80%) was achieved in 20.6%. Severe exacerbations, OCS load, symptoms, and FEV1 improved significantly. The factors associated with failure of TT in the previous year were smoking history (HR 1.84), lack of asthma control at 16-24 weeks (HR 3.41), bronchiectasis (HR 1.91), baseline ACT ≤15 (HR 1.81), ≥2 severe exacerbations in the previous year (HR 2.01), and low eosinophil count (HR 2.58). FEV1 declined >30 mL/year in 25.3% of patients in whom TT was effective.</p><p><strong>Conclusions: </strong>TT achieved sustained control in a significant proportion of patients whose disease was not controlled with dual therapy. Bronchiectasis, smoking history, greater clinical severity at initiation of TT, and lack of control at 16-24 weeks predicted poorer outcome.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}