Journal of Investigational Allergology and Clinical Immunology最新文献_第6页

Hypersensitivity to Bismuth Subcitrate. 对硝酸亚铋过敏。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-09-05 DOI: 10.18176/jiaci.1018

B Andrés-López, M T Dordal Culla, R Lleonart Bellfill

引用次数: 0

Allergy to White Perilla and Cross-reactivity With Sesame. 对白紫苏过敏以及与芝麻的交叉反应。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-09-25 DOI: 10.18176/jiaci.1016

E Ramírez-Mateo, I Elías-Sáenz, C Fernández-Lozano, A Carrón-Herrero, E Solano-Solares, D González-De-Olano

引用次数: 0

Eosinophilic Granulomatosis With Polyangiitis Triggered by an Arthropod Bite and Complicated by Renal and Hepatic Infarction and Pulmonary Embolism: A Case Report. 嗜酸性粒细胞性多血管炎由节肢动物咬伤引发，并发肾、肝梗塞和肺栓塞：病例报告。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-07-29 DOI: 10.18176/jiaci.1013

Y Yu, H Wang, W Weng, L Ma

引用次数: 0

Successful Desensitization to Tezepelumab in a Polysorbate-Allergic Patient. 一位对聚山梨醇酯过敏的患者成功脱敏使用特珠单抗

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-07-29 DOI: 10.18176/jiaci.1007

S Bautista-Villanueva, M Mateos-Salvador, R Arrojo Fuentes, M J Rial

引用次数: 0

Cross-reactivity to Hydroxypropyl Methylcellulose and Hydroxyethyl Cellulose in a Patient Allergic to Carboxymethylcellulose: A Case Report. 一名对羧甲基纤维素过敏的患者对羟丙基甲基纤维素和羟乙基纤维素的交叉反应：病例报告。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-09-25 DOI: 10.18176/jiaci.1019

A Méar, M Babin, F Tisserand, C André, P Beriziky, H Maillard

引用次数: 0

Safety, Tolerability, and Feasibility of the Milk Ladder for Reintroduction of Cow's Milk in Infants With IgE-Mediated Cow's Milk Allergy. 在 IgE 引起的牛乳过敏婴儿中重新引入牛奶阶梯的安全性、耐受性和可行性。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1017

I Cerecedo, B de la Hoz, S Infante, N P Freundt Serpa, A Vaquero Rey, A Carrón Herrero, S Vázquez Cortés, A Garban Camero, E Redondo Vegas, A Gonzalo-Fernández, I Serrano García, A López-Picado, J Martínez-Botas, M Fernández-Rivas

引用次数: 0

Bilastine 0.6% Preservative-Free Eye Drops as an Effective Once-Daily Treatment for the Signs and Symptoms of Allergic Conjunctivitis: A Pooled Analysis of 2 Randomized Clinical Trials. 0.6%不含防腐剂的比拉斯汀滴眼液，一种每天一次的有效治疗方法，可减少过敏性结膜炎的体征和症状：两项随机临床试验的汇总分析。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2023-09-21 DOI: 10.18176/jiaci.0940

P J Gomes, J B Ciolino, P Arranz, A Gonzalo, N Fernández, G Hernández

{"title":"Bilastine 0.6% Preservative-Free Eye Drops as an Effective Once-Daily Treatment for the Signs and Symptoms of Allergic Conjunctivitis: A Pooled Analysis of 2 Randomized Clinical Trials.","authors":"P J Gomes, J B Ciolino, P Arranz, A Gonzalo, N Fernández, G Hernández","doi":"10.18176/jiaci.0940","DOIUrl":"10.18176/jiaci.0940","url":null,"abstract":"Background and objectives: Allergic conjunctivitis is the most common type of ocular allergy. The objective of this study was to evaluate the efficacy of a new once-daily, preservative-free, bilastine 0.6% eye drop formulation for the treatment of allergic conjunctivitis.Methods: Two double-masked, vehicle-controlled, clinical studies (a phase 2 dose-ranging study and a phase 3 efficacy study) were conducted to assess the efficacy of bilastine ophthalmic solution for treatment of the signs and symptoms of allergic conjunctivitis. Both studies used the Ora-CAC® Conjunctival Allergen Challenge (CAC) model to enable observation of allergic responses under controlled conditions. Each study was analyzed separately and then combined to create an integrated data set.Results: Efficacy was achieved for the primary efficacy endpoint of ocular itching with 3 bilastine concentrations (0.2%, 0.4%, and 0.6%) at 15 minutes and 8 hours after instillation. Bilastine 0.6% ophthalmic solution was also efficacious at 16 hours after instillation. Bilastine 0.6% ophthalmic solution demonstrated noninferiority to ketotifen 0.025% at the onset of action. According to the integrated data set, differences between vehicle and bilastine 0.6% after instillation were significant at all time points both at onset (15 minutes) and after a prolonged duration (16 hours).Conclusion: This multitrial assessment suggests that bilastine 0.6% ophthalmic solution is efficacious for the treatment of the signs and symptoms of allergic conjunctivitis, with a rapid onset and prolonged duration of action, and has a favorable safety profile. The added convenience of once-daily dosing may contribute to adherence and improve quality of life.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"385-394"},"PeriodicalIF":6.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41141039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Management of Plant Food Allergy in Patients Sensitized to Lipid Transfer Proteins Is Heterogeneous: Identifying the Gaps. 对脂质转移蛋白敏感的患者的植物性食物过敏的临床管理是异质的：确定差距。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2023-10-18 DOI: 10.18176/jiaci.0947

B E García, M B Mateo-Borrega, S Garrido, C M D Amelio, E Compés, O Villarreal, I García-Núñez, M J Goikoetxea

{"title":"Clinical Management of Plant Food Allergy in Patients Sensitized to Lipid Transfer Proteins Is Heterogeneous: Identifying the Gaps.","authors":"B E García, M B Mateo-Borrega, S Garrido, C M D Amelio, E Compés, O Villarreal, I García-Núñez, M J Goikoetxea","doi":"10.18176/jiaci.0947","DOIUrl":"10.18176/jiaci.0947","url":null,"abstract":"Background and objectives: Patients sensitized to lipid transfer protein (LTP) are characterized by wide clinical variability. The lack of practical diagnostic and therapeutic guidelines complicates their management. The aim of the study was to describe the clinical approach of Spanish allergists to sensitization to LTP.Methods: We used a survey designed following the PICO method and subsequent validation using the Delphi approach.Results: The survey was completed by 224 allergists (75% women; 57.1% with >20 years of professional experience). Clinical practice for the main points of diagnosis of LTP allergy was homogeneous, except for patients with suspected hypersensitivity to nonsteroidal anti-inflammatory drugs (44.6% frequently included skin testing with LTP). Oral food challenges were not frequently performed (63.6% occasionally to never) and were generally (75.5%) used to confirm tolerance. It was common to recommend fruit skin avoidance (77.2%) and to maintain consumption of foods to which patients were sensitized but tolerant (99.1%). The results were heterogeneous for other dietary indications, modifications due to cofactors, and trace avoidance. Peach sublingual immunotherapy (SLIT) was considered very/quite effective by 55.9% of allergists. Most (79.5%) consider SLIT indicated in <25% of LTP-allergic patients based on severity (95.2%), frequency of reactions (99.4%), allergy to multiple food families (97.4%), and impairment of quality of life/nutrition (91.5%). Practice with respect to prescription of SLIT varied based on cofactor involvement.Conclusions: These data suggest that there is a need to increase evidence to reduce heterogeneity in the clinical management of LTP allergy.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"395-403"},"PeriodicalIF":6.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of Disease Activity in Adults With Hereditary Angioedema due to C1-Esterase Inhibitor Deficiency. C1-酶抑制剂缺乏导致的遗传性血管性水肿成人患者疾病活动性的决定因素。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-07-26 DOI: 10.18176/jiaci.1009

M Lluncor-Salazar, E Phillips-Anglés, M Pedrosa, D Lamacchia, A Hernanz, N Prior, R Cabañas, T Caballero

引用次数: 0

Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients. 小儿实体器官移植后新食物过敏的病理生理学。

IF 6.1 3区医学

Journal of Investigational Allergology and Clinical Immunology Pub Date : 2024-12-03 Epub Date: 2024-11-12 DOI: 10.18176/jiaci.1027

P Pérez-López, J L López-Guillén

{"title":"Pathophysiology of De Novo Food Allergies After Solid Organ Transplant in Pediatric Patients.","authors":"P Pérez-López, J L López-Guillén","doi":"10.18176/jiaci.1027","DOIUrl":"10.18176/jiaci.1027","url":null,"abstract":"De novo food allergy is a common phenomenon among pediatric solid organ recipients (8.5%-57%) when compared with the general population (0.45%-10%). Other associated disorders include non-IgE-mediated immune reactions and clinical predisposition to asthma and alterations in the oral mucosa. Originally, passive mechanisms (passive transfer of IgE and immune cells) were thought to be responsible for acute, transient cases of food allergies with a previous history of sensitization for a specific allergen in the donor. Recently proposed pathophysiological mechanisms to explain de novo allergies include TH2/B-cell imbalance, regulatory T-cell (Treg) disruption, gastrointestinal immaturity, and altered gastrointestinal permeability. Recent studies also suggest that immunosuppressive drugs, especially tacrolimus, promote naïve T-cell differentiation into TH2 cells, IgE-promoting cytokine production, decreased IL-5 and IL-10 levels, increased IgA levels, and Treg disruption. Such immunological interactions, in conjunction with altered intestinal permeability, intestinal immaturity in children, history of viral infection, and a personal history of allergies or eczema, are thought to explain most clinical cases of pediatric de novo food allergy after solid organ transplantation reported in the literature. A better understanding of the immunological mechanisms underpinning organ donors and recipients may unveil some of the caveats concerning therapeutic management and improve the quality of life of affected individuals.","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"367-376"},"PeriodicalIF":6.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0