Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Comparison of the value of transvaginal ultrasonography and MRI in the diagnosis of cesarean scar pregnancy: a meta-analysis.","authors":"Xiao Han, Boyang Zhang","doi":"10.1080/14767058.2024.2445661","DOIUrl":"https://doi.org/10.1080/14767058.2024.2445661","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic value of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) in cesarean scar pregnancy (CSP) by a method of meta-analysis.</p><p><strong>Methods: </strong>Studies on TVS and MRI for CSP were collected from PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang data, and Chinese Scientific Journal Database (VIP database) until April 1, 2024. Stata 15.0 software was used for data analysis. Mann-Whitney U-test was applied to compare the diagnostic efficiency of the TVS and MRI groups.</p><p><strong>Results: </strong>Nine articles with 713 subjects were involved in this review. The pooled sensitivity (0.96, 95%CI: 0.94-0.97), specificity (0.90, 95%CI: 0.84-0.94), and DOR (197.28, 95%CI: 99.71-390.31) in the MRI group were higher than those (Sensitivity = 0.83, 95%CI: 0.77-0.87; Specificity= 0.74, 95%CI: 0.63-0.83; DOR = 13.66, 95%CI: 7.84-23.79) in the TVS group. The positive likelihood ratio and negative likelihood ratio of the MRI group were 9.56 (95%CI: 8.82-15.72) and 0.05 (95%CI: 0.03-0.07), while those of the TVS group were 3.21 (95%CI:2.18-4.74) and 0.24 (95%CI: 0.18-0.31), respectively. In the MRI and TVS groups, the area under the curve (AUC) of the summary receiver operating characteristic was 0.9497 and 0.86, respectively. The results of Mann-Whitney U-tests of the two groups showed significant differences in the pooled sensitivity (Z= -3.311, <i>p</i> < 0.001), specificity (Z= -2.123, <i>p</i> = 0.034), and DOR (Z= -3.272, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Both MRI and TVS can effectively diagnose CSP. However, compared with TVS, MRI has better diagnostic accuracy for CSP, with higher sensitivity and specificity. Considering the good diagnostic accuracy of ultrasound, patients with ultrasound suspicion of CSP should be sent to a reference center where MRI can express its full diagnostic potential regarding depth, topography of invasion and myometral residue, which is useful for subsequent management.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2445661"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral vein thrombosis: management tactics with a focus on pregnancy, the use of hormone therapy and assisted reproductive technologies.","authors":"Svetlana Akinshina, Viktoria Bitsadze, Jamilya Khizroeva, Maria Tretyakova, Kristina Grigoreva, Nilufar Gashimova, Alexander Vorobev, Vladislav Zubenko, Nataliya Makatsariya, Lala Valikhanova, Daredzhan Kapanadze, Marina Zainulina, Alina Solopova, Tamara Mashkova, Fidan Yagubova, Valentina Tsibizova, Jean-Christophe Gris, Ismail Elalamy, Grigoris Gerotziafas, Alexander Makatsariya","doi":"10.1080/14767058.2024.2447349","DOIUrl":"https://doi.org/10.1080/14767058.2024.2447349","url":null,"abstract":"<p><p><b>Purpose:</b> Cerebral vein thrombosis is a rare, life-threatening condition that has now become more commonly diagnosed due to advancements in imaging techniques. Our purpose is to improve understanding of pathogenesis, diagnosis and pregnancy and IVF management in patients with a history of cerebral thrombosis.</p><p><p><b>Materials and methods:</b> We present an overview of the modern tactics of anticoagulant therapy for cerebral thrombosis with a focus on pregnancy, the use of hormone therapy, and assisted reproductive technologies.</p><p><p><b>Results:</b> The most common risk factors for cerebral vein thrombosis are pregnancy, the postpartum period, and the use of oral contraceptives, which explains the high incidence of this pathology in women. The development of cerebral thrombosis is a vivid example of the interaction and synergetic effects of persistent factors that cause an increased risk of thrombotic complications, which include thrombophilia and acquired risk factors. Despite the possible risks, pregnancy after previously suffered cerebral thrombosis is not contraindicated provided adequate anticoagulant therapy.</p><p><p><b>Conclusions:</b> The most common provoking factors for the development of cerebral thrombosis in women are pregnancy and the use of estrogen-containing drugs. The issue of thromboprophylaxis during pregnancy, when using ART methods and the possibility of using hormonal therapy after cerebral vein thrombosis requires further study.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2447349"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the clinical efficacy of one-day outpatient management of patients with gestational diabetes mellitus.","authors":"Jingwen Xu, Qian Jing, Huixia Shi, Hui Qian, Li Shi","doi":"10.1080/14767058.2024.2436086","DOIUrl":"https://doi.org/10.1080/14767058.2024.2436086","url":null,"abstract":"<p><strong>Objective: </strong>A comprehensive management model called the one-day care clinic has been established and implemented throughout the hospitals as well as maternal and child health care centers for gestational diabetes mellitus (GDM) in China. However, there is still a lack of high-level evidence for this management model. The objective of this study was to describe the one-day outpatient management model and assess its efficacy in managing GDM.</p><p><strong>Methods: </strong>A retrospective review was performed on patients who were admitted to the obstetrics clinic and diagnosed as GDM at our centers from July 2017 to June 2022. All enrolled patients were divided into two groups: the experimental group that participated in the one-day outpatient management and the control group that only received routine education on gestational diabetes in the outpatient department. Baseline characteristics and clinical data of enrolled patients were reviewed. Blood glucose level before and after attending one-day outpatient management, blood glucose and HbA1c before delivery, weight gain at the end of pregnancy, complications during pregnancy and pregnancy outcomes were collected.</p><p><strong>Results: </strong>A total of 546 patients were finally included in this study, with 276 in the experimental group and 270 in the control group. There were no significant differences between the two groups in terms of baseline characteristics. The 1h postprandial blood glucose (PBG) and 2h PBG levels were significantly lower after participating in the one-day outpatient management compared to before (all <i>p</i> value < 0.01). Before delivery, the FBG, 2hPBG, and HbA1c levels in the experimental group were significantly lower than those in the control group (all <i>p</i> value < 0.01). The experimental group experienced less weight gain and had a higher rate of achieving weight gain goals compared to the control group. In terms of complications during pregnancy, the incidence of premature rupture of fetal membranes, pregnancy induced hypertension, and hydramnion did not differ significantly between the two groups. In terms of pregnancy outcomes, the incidence of macrosomia and neonatal hypoglycemia in the experimental group was significantly lower than in the control group (all <i>p</i> value < 0.05).</p><p><strong>Conclusion: </strong>The adoption of the one-day outpatient management is more beneficial for controlling blood glucose levels and weight target during pregnancy in GDM patients. Additionally, this management can decrease the occurrence of adverse pregnancy outcomes, and improve the prognosis of both GDM patients and offspring.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2436086"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proof of concept testing of a vascular closure device for use in fetal surgery.","authors":"Braxton Forde, Samuel Martin, Marc Oria, Jordan Kapke, Eyal Krispin, Jose L Peiro","doi":"10.1080/14767058.2024.2435468","DOIUrl":"https://doi.org/10.1080/14767058.2024.2435468","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Prior clinical findings have demonstrated that maternal laparotomy with trans-amniotic trans-uterine suturing of the fetoscopic port site during in utero myelomeningocele repair reduces the risk of membrane rupture. However, due to laparotomy-associated morbidity, we aimed to explore the feasibility of using a vascular closure device for percutaneous trans-amniotic trans-uterine suturing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This IRB and IACUC-exempt study utilized 2 strategies for proof-of-concept testing of using the Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; Device for suture placement; 1. Ultrasound guided application on a high fidelity maternal abdominal uterus model used for fetal procedures and 2. Placement under direct visualization with sheep undergoing cesarean delivery for other research purposes. In the high-fidelity uterus model, the Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device was used to place a transuterine/transamniotic stitch with accompanying video recording of the approach (https://go.screenpal.com/watch/cZfhoDVsYvW password: perclose). Regarding the second approach, at the time of a cesarean section, 12 French Checkflo&lt;sup&gt;®&lt;/sup&gt; cannulas were inserted into the sheep amniotic space &lt;i&gt;via&lt;/i&gt; different approaches: (1) Seldinger technique, (2) Seldinger technique insertion of Checkflo&lt;sup&gt;®&lt;/sup&gt; cannula and subsequent use of the Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device to suture the port site after check flow removal, (3) Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device utilized in what is described as a \"pre-close\" technique, where prior to cannula placement, trans-uterine trans-amniotic stitches are placed followed by the insertion of a 12 French Checkflo&lt;sup&gt;®&lt;/sup&gt; cannula over the same guidewire. Samples of the sutured uterine wall were sent to pathology and H&E staining was performed to assess uterine hole closure and amnion-to-uterus fixation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The high-fidelity model confirmed that the Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; Device was easily visualized by ultrasound and suture deployment was without complication. In the animal model, the Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device effectively sutured the amnion to the uterus in both the pre- and post-close approach. The pre-close technique achieved better amnion-to-uterus approximation and more appropriate uterine hole closure. H&E staining revealed that without suturing, amnion separation from the chorion layer occurred, and the uterine hole persisted. The post-close technique showed partial connection between the amnion and chorion, but inadequate uterine hole closure with amnion shift into the defect. Optimal closure, with secure amnion-to-chorion fixation and uterine closure, was achieved through the pre-close technique.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; Device seems to be a feasible device for use of uterin","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2435468"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in short-term variation of antenatal cardiotocography to identify intraamniotic infection: a historical cohort study.","authors":"Brynhildur Tinna Birgisdottir, Tomas Andersson, Ingela Hulthén Varli, Sissel Saltvedt, Ke Lu, Farhad Abtahi, Ulrika Åden, Malin Holzmann","doi":"10.1080/14767058.2024.2434059","DOIUrl":"https://doi.org/10.1080/14767058.2024.2434059","url":null,"abstract":"<p><strong>Introduction: </strong>Intraamniotic infection (IAI) is one of the main possible complications of preterm prelabor rupture of membranes (PPROM) and can lead to severe consequences for the neonate, such as early onset neonatal sepsis (EONS). Available diagnostic tools for IAI have poor diagnostic performance, which may result in both over- and underdiagnoses of IAI. In a search for better diagnostic tools, we have examined short-term variation (STV) in fetal heart rate. We have previously shown that in IAI exposed pregnancies, the STV was more than 20% lower in the last cardiotocography trace before the start of labor, as compared to those not exposed to IAI. The association between IAI and STV needs further evaluation and we therefore continued by examining the longitudinal change in STV in association with IAI.</p><p><strong>Material and methods: </strong>We performed a historical cohort study on 628 singleton pregnancies with PPROM, delivering between 24 + 0 to 33 + 6 gestational weeks. The main exposure of the study was IAI, using EONS as a proxy as no easily available method exists for confirming IAI antepartum, and IAI and EONS are strongly associated. The main outcome was STV in fetal heart rate. At least two available cardiotocography traces per fetus were required as a minimum, from PPROM or from seven days before birth, whichever came later, until the start of labor or planned cesarean birth. A total of 9 690 cardiotocography traces were analyzed.</p><p><strong>Results: </strong>Fetuses exposed to IAI had a 26.5% steeper decline in their STV during the last 24 h before the start of labor when compared to fetuses not exposed (95% CI -32.9% to -19.4%; <i>p</i> < 0.001). After adjustment for antenatal corticosteroids, the decline remained significant. The decline became less prominent but the significance remained when also adjusting for the baseline frequency (-12.7% [95% CI -19.3% to -5.5%], <i>p</i> < 0.001). In the IAI-exposed group, the baseline frequency increased by 11.1 bpm during the last 12 h before the start of labor, beyond those who were not exposed (95% CI 8.3 bpm to 13.8 bpm; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>In pregnancies affected by IAI the STV declines steeper in the last 24 h before the start of labor as compared to pregnancies not affected by IAI, even after adjustment for increasing baseline frequency. The association of STV in relation to IAI needs to be further studied in order to evaluate and establish STVs usefulness in monitoring patients for IAI.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2434059"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of ultrasound parameters and clinical factors in predicting successful labor induction among nulliparous women.","authors":"Laura Rācene, Līva Ķīse, Ieva Pitkēviča, Zane Rostoka, Beāte Sārta, Maija Priedniece, Agnija Vecvagare, Ļubova Lapidus, Anda Ķīvīte-Urtāne, Dace Rezeberga, Natālija Vedmedovska","doi":"10.1080/14767058.2025.2450405","DOIUrl":"https://doi.org/10.1080/14767058.2025.2450405","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the values of ultrasound and clinical parameters for predicting outcomes of induction of labor (IOL) among healthy nulliparous women with a singleton, term cephalic pregnancy.</p><p><strong>Methods: </strong>The cervical length, cervical strain elastography, posterior cervical angle, head-perineum distance, Bishop score, and maternal parameters were assessed before IOL with a combined method-Foley catheter and Misoprostol perorally. The main outcome was vaginal delivery.</p><p><strong>Results: </strong>Variation in cervical tissue elasticity, represented by elasticity index (E), was significantly different between outcome groups-vaginal delivery and cesarean section (CS) in internal os, in the anterior lip near the cervical canal and the midpoint of the anterior and posterior lip (<i>p</i> < 0.05). The E was higher-softer in the vaginal delivery group. The overall elasticity was significantly higher in the middle part of the cervix in the vaginal delivery group. However, other ultrasound metrics did not differ significantly across the outcome groups. Overall, women who delivered vaginally were taller and had a lower pre-pregnancy BMI (<i>p</i> = 0.02 for both variables). Univariate and multivariate analyses showed maternal height was the significant independent predictor of CS (AOR 0.91, 95% CI 0.84-0.98). The prognostic value for vaginal delivery, based on cervical length, maternal height, Bishop score, and parameters of cervical strain elastography, was poor (AUC < 0.7).</p><p><strong>Conclusion: </strong>The study underscores the importance of cervical tissue elasticity in predicting vaginal delivery outcomes, while also highlighting that maternal height is a significant independent predictor of cesarean delivery. However, evaluated metrics in the study have limited prognostic value for predicting vaginal delivery. This suggests a need for further research to identify more reliable predictors of delivery outcomes.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2450405"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization analysis of blood uric acid and risk of preeclampsia: based on GWAS and eQTL data.","authors":"Jiao Wang, Xiaohu Liu, Youmou Fu, Baosheng Zhu, Jinman Zhang","doi":"10.1080/14767058.2024.2443673","DOIUrl":"https://doi.org/10.1080/14767058.2024.2443673","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The causal association between blood uric acid and preeclampsia (Preeclampsia, PE) has not been conclusively established based on the literature reviewed to date. This bi-directional Mendelian randomization study aimed to investigate the bi-directional causal association between blood uric acid concentration and PE at different genetic levels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Pooled data on preeclampsia (sample size = 82,085) and blood uric acid (sample size = 129,405) were conducted based on publicly available genome-wide association analysis (Genome-Wide Association Study, GWAS) on the East Asian populations regarding preeclampsia and blood uric acid, respectively. We assessed blood uric acid and PE associations using two-sample Mendelian randomization (TSMR) analyses based on GWAS pooled statistics using inverse variance weighted (Inverse variance weighted), MR-Egger, and Weighted median (Weighted median) to examine the association between blood uric acid and pre-eclampsia. Causal relationship between blood uric acid and pre-eclampsia.Cochran's Q statistic was used to quantify the heterogeneity of instrumental variables among other methods. Subsequently, we extracted the expression quantitative trait loci (eQCTL, Expression quantitative trait loci) data corresponding to each gene as the instrumental variables using the genes corresponding to the intersecting instrumental variables of the exposure and the outcome in the respective analyses of the forward and backward TSMR respectively, so as to analyze the genetic causality of the genes with the different forward and backward TSMR methods further. Inverse variance weighted (IVW) was used to analyze the genetic causality of genes with different positive and negative outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Genetically determined blood uric acid level IVW method, ratio (OR) 1.30, 95% confidence interval (CI): [0.6, 2.83], &lt;i&gt;p&lt;/i&gt; = 0.51 was not risk associated with PE. In addition according to the inverse MR analysis, we found an OR of 0.99, 95% CI [0.99, 1.0], &lt;i&gt;p&lt;/i&gt; = 0.999) for PE on blood uric acid level IVW method and no significant heterogeneity in instrumental variables or level polytropy was found. (ii) Although GWAS data suggested no risk association between PE and uric acid, gene association analysis of eQTL data at blood uric acid levels with PE suggested a risk effect of the TP53INP1 gene for PE (IVW, OR = 11.476, 95% CI 2.511-52.452, &lt;i&gt;p&lt;/i&gt; = 1.648 × 10&lt;sup&gt;-3&lt;/sup&gt;) and a protective effect of CTSZ (IVW, OR = 0.011, 95% CI 0.001-0.189, &lt;i&gt;p&lt;/i&gt; = 1.804 × 10&lt;sup&gt;-3&lt;/sup&gt;), while a risk effect of ETV7 on hyperuricemia was suggested in a genetic association analysis of PE eQTL data with blood uric acid levels (OR = 1.018, 95% CI 1.007-1.029, &lt;i&gt;p&lt;/i&gt; = 1.289 × 10&lt;sup&gt;-3&lt;/sup&gt;).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our MR (Mendelian Randomization) study based on the GWAS database did not support a bidirectional causal effect between blood uric acid leve","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2443673"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of nano platinum-hydrogen saline on oxygen-induced retinopathy in neonatal rats.","authors":"Yangcan Ming, Wanyi Xu, Zhe Yang, Zi Wang, Na Wang","doi":"10.1080/14767058.2025.2454374","DOIUrl":"https://doi.org/10.1080/14767058.2025.2454374","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to assess the impact of nano platinum-hydrogen saline (Pt NPs + H₂) on oxygen-induced retinopathy (OIR) in neonatal rats, with the goal to contribute new insights into the therapeutic strategies for retinopathy of prematurity.</p><p><strong>Methods: </strong>Pt NPs + H₂ formulation was synthesized to address OIR in a rat model. Subsequent examination included the assessment of retinal blood vessel distribution and morphology through hematoxylin and eosin (HE) and isolectin B4 (IB4) staining techniques. The levels of reactive oxygen species (ROS), malondialdehyde(MDA), and superoxide dismutase (SOD) were measured to reflect the oxidative stress in rats. Additionally, the protein expression of vascular endothelial growth factor (VEGF) in each experimental group was assessed using western blot analysis, while the gene expression of VEGF in retinal neovascularization tissues was assessed using reverse transcription-polymerase chain reaction (RT-PCR). Furthermore, the extent of retinal cell apoptosis was measured using a TdT-mediated dUTP Nick-End Labeling (TUNEL) apoptosis kit.</p><p><strong>Results: </strong>HE staining and IB4 staining revealed positive retinal neovascularization in the OIR group, whereas neovascularization in the Pt NPs + H₂ group exhibited reduced severity. Significantly fewer capillary globules and capillary tubules were observed in the Pt NPs + H₂ group compared to the OIR group (<i>p</i> < 0.05). Also, the Pt NPs + H₂ group demonstrated significant reductions in ROS and MDA levels within retinal tissues (<i>p</i> < 0.05, <i>p</i> < 0.001), along with a significant increase in SOD level (<i>p</i> < 0.05). Notably, the MDA level in the Pt NPs + H₂ group was notably lower than that in the OIR group (<i>p</i> < 0.01, <i>p</i> < 0.05), and even lower than that in the H₂ group. Pt NPs + H₂ intervention was associated with decreased protein and mRNA expression of VEGF, with statistical significance (<i>p</i> < 0.05). While the H₂ group exhibited a decreasing trend in apoptotic cell count in the retinal ganglion cell layer (<i>p</i> < 0.05), the Pt NPs + H₂ group demonstrated a more pronounced reduction, with a significant difference (<i>p</i> < 0.01). No significant discrepancy in apoptosis within the inner nuclear layer was observed (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The synergistic effect of hydrogen saline and nano platinum manifests as enhanced antioxidant, anti-apoptotic, and anti-neovascular properties. Nano platinum-hydrogen saline demonstrates inhibitory effects on OIR in rats.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2454374"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angle of progression for predicting second-stage cesarean delivery complications.","authors":"Yossi Geron, Asaf Romano, Anat Shmueli, Ran Matot, Sharon Sigal-Kaplun, Sharon Daniel, Ron Charach, Yinon Gilboa","doi":"10.1080/14767058.2025.2463394","DOIUrl":"https://doi.org/10.1080/14767058.2025.2463394","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between the angle of progression (AOP) and maternal surgical complications following a second-stage cesarean delivery.</p><p><strong>Methods: </strong>We retrospectively evaluated singleton pregnancies at term (≥37 weeks) who underwent cesarean delivery for arrest of descent at the second stage of labor from January 2022 to December 2023. Only cases with recorded AOP were included. The fetal head position was confirmed by transabdominal ultrasound, and the fetal head station was assessed manually by digital examination. The main outcome was defined as a composite adverse maternal outcome, including challenging fetal extraction, uterine extension, requirement for blood transfusions, postpartum fever, ileus, and re-hospitalization due to endometritis or surgical site infection.</p><p><strong>Results: </strong>Twenty-five cases met the inclusion criteria, of whom 10 (40%) experienced the composite adverse maternal outcome. These patients had wider mean AOP compared to those without maternal morbidity (136.7 ± 7.4 vs. 124.7 ± 12.5, <i>p</i> = .017<b>).</b> Univariate logistic regression analysis showed a significant correlation between measured AOP and composite adverse maternal outcome (OR = 1.15, 95% CI 1.01-1.30, <i>p</i> = .028). The predicted probability for composite adverse maternal outcome by receiver-operating characteristics curve yielded an area under the curve of 0.79 (95% CI 0.60-0.98) for AOP, compared to an area under the curve of 0.53 (95% CI 0.30-0.75) for the manually measured fetal head station.</p><p><strong>Conclusions: </strong>We found a correlation between the angle of progression and maternal complications following second-stage cesarean delivery. Assessing the angle of progression before surgery may be of help to the obstetrical team to better identify susceptible cases and allow for appropriate preparation.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2463394"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of progesterone in the prevention of the \"great obstetrical syndromes\": current evidence.","authors":"Gian Carlo Di Renzo, Valentina Tosto, Valentina Tsibizova, Paola Bianchi, Giuseppe Benagiano","doi":"10.1080/14767058.2025.2451664","DOIUrl":"https://doi.org/10.1080/14767058.2025.2451664","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2451664"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}