Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Meta-analysis of the efficacy of different blue light therapy methods for neonatal jaundice.","authors":"Ruoya Wu, Lingling Wen","doi":"10.1080/14767058.2024.2430649","DOIUrl":"https://doi.org/10.1080/14767058.2024.2430649","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and evaluate the efficacy of different blue light therapy methods and provide evidence-based recommendations for their selection in clinical practice.</p><p><strong>Methods: </strong>Clinical randomized controlled trials (RCTs) evaluating the efficacy of various blue light therapy methods for neonatal jaundice were retrieved from both domestic and international databases. The search period covered the inception of each database until November 2023. After screening, the quality of the included studies was assessed using the Cochrane Risk of Bias tool. Literature management was conducted with NoteExpress 3.2, while data collection and extraction were performed using Excel 2003. Statistical analysis was carried out using RevMan 5.4.1. Heterogeneity was assessed using the <i>Q</i> test (<i>p</i> value), and the OR value of the combined effect was calculated using either a fixed-effects or random effects model, depending on the presence of heterogeneity. A forest plot was generated to visualize the results. Sensitivity analysis was performed by excluding the largest-weighted study, and the potential for bias in outcome indicators was assessed using a funnel plot.</p><p><strong>Results: </strong>A total of 652 articles were retrieved, with 16 clinical RCTs meeting the inclusion criteria. The meta-analysis results indicated that, compared to continuous blue light therapy in the control group, intermittent blue light therapy achieved a higher total effective rate (OR = 1.82, 95%CI (1.25-2.64), <i>p</i> = .002), significantly lower serum bilirubin levels post-treatment (OR = -14.59, 95%CI (-26.11 to -3.08), <i>p</i> = .01), and a shorter time to jaundice resolution (OR = -2.35, 95%CI (-3.83 to -0.87), <i>p</i> = .002). Additionally, the incidence of adverse reactions was lower in the intermittent therapy group compared to the control group (OR = 0.27, 95%CI (0.19-0.36), <i>p</i> < .00001). Sensitivity analysis confirmed that the combined effect size was stable and reliable (OR (95%CI) = -16.23 (-28.67 to -3.79), <i>p</i> = .01). The funnel plot suggested potential publication bias.</p><p><strong>Conclusions: </strong>Intermittent blue light therapy is effective and demonstrates significant clinical benefits, making it a valuable treatment option for neonatal jaundice in clinical practice.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2430649"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: A sandwich technique (N&H variation technique) to reduce blood loss during cesarean delivery for complete placenta previa: a randomized controlled trial.","authors":"","doi":"10.1080/14767058.2025.2440150","DOIUrl":"https://doi.org/10.1080/14767058.2025.2440150","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2440150"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and prediction model for postpartum psychiatric disorders: a retrospective cohort study of 1418 Chinese women from 2020 to 2022.","authors":"Wenxi Chen, Huan Ge, Jing Cong, Wenjie Zhou, Xiaoxia Chang, Xiaojie Quan, Jing Xia, Xincheng Tao, Danhua Pu, Jie Wu","doi":"10.1080/14767058.2024.2438756","DOIUrl":"https://doi.org/10.1080/14767058.2024.2438756","url":null,"abstract":"<p><strong>Background: </strong>Postpartum psychiatric disorders (PPDs) have been deemed as a significant public health concern, affecting both maternal health and family dynamics. This study aimed to examine the current status of PPDs, identify the potential risk factors of PPDs, and further develop a clinical nomogram model for predicting PPDs in Chinese women.</p><p><strong>Method: </strong>In this retrospective cohort study, 1418 postpartum women attending the routine postpartum examination at the 42nd day after delivery in Jiangsu Women and Children Health Hospital were recruited as participants from December 2020 to December 2022. The Symptom Checklist-90 (SCL-90) was utilized to assess the status of postpartum psychiatric disorders. A prediction model was constructed by multivariate logistic regression and presented as a nomogram. The performance of nomogram was measured by the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). The relationships between predictive factors of PPDs and SCL-90 were also evaluated using Pearson correlation analysis. The relationships between predictive factors of PPDs and SCL-90 were evaluated using Pearson correlation analysis.</p><p><strong>Results: </strong>With the SCL-90 cutoff value of 160, the incidence of postpartum psychiatric disorders was 9.17% among Chinese urban women. The univariate and multivariate logistic regression analyses indicated that age ≤ 25 years old (OR = 10.07, 95%CI = 1.83-55.33), prenatal mood disorder (OR = 4.12, 95%CI = 1.99-8.53), invasive prenatal diagnostic procedures (OR = 4.39, 95%CI = 1.16-16.56), poor relationship with husband (OR = 2.86, 95%CI = 1.58-5.16) and poor relationship with mother-in-law (OR = 5.10, 95%CI = 2.70-9.64) were significantly associated with PPDs. A nomogram prediction model for PPDs was further constructed based on these five independent risk factors, and the area under the receiver operating characteristic curve (AUC) of the nomogram model was 0.823 (95% CI = 0.781-0.865). The calibration curves showed remarkable accuracy of the nomogram and the DCA exhibited high clinical net benefit of the nomogram. Besides, we also explored the relationships between the five risk factors and different symptom dimensions of PPDs and found that the five risk factors were almost associated with increased levels of all symptom dimensions.</p><p><strong>Conclusions: </strong>Five psychosocial risk factors for PPDs were identified in Chinese women and the nomogram prediction model constructed based on these five risk factors could predict the risk of PPDs intuitively and individually. Systematic screening these risk factors and further conducting psychosocial interventions earlier during the pregnancy period are crucial to prevent PPDs. For future research, we intend to incorporate additional risk factors, including blood biomarkers and facial expression indicators, to refine our risk model.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2438756"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some comments on \"Maternal hemoglobin A1c and left ventricular hypertrophy in infants of mothers with pregestational diabetes\".","authors":"Jeong Sook Kim, Soo-Jeong Lee","doi":"10.1080/14767058.2024.2434060","DOIUrl":"https://doi.org/10.1080/14767058.2024.2434060","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2434060"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second trimester cervical length screening, in a low-risk European population.","authors":"Francesca Ferrari, Beatrice Melis, Laura Basile, Enrica Perrone, Giuseppe Chiossi, Nicola Volpe, Carla Verrotti, Fabio Facchinetti","doi":"10.1080/14767058.2024.2436099","DOIUrl":"https://doi.org/10.1080/14767058.2024.2436099","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this work is to assess cervical length (CL) distribution in a low-risk population in order to evaluate the applicability of a possible universal CL screening in the second trimester, aimed at preventing preterm birth (PTB).</p><p><strong>Methods: </strong>In a multicentric, prospective cohort study, singleton pregnant women attending second trimester anatomy scan between 18 + 0 to 22 + 6 weeks of gestation were eligible. Teenage pregnancy and women with previous PTB were excluded. The recruitment occurred from February 2020 to December 2022. TVU CL was measured by expert sonographers, in 12 National Health Service (NHS) care clinics of Modena and Parma districts (Emilia-Romagna Region, Italy). Internal quality check of images was performed. Personal and obstetric history, as well as gestational age were collected. Primary outcomes were to define CL curves and the incidence of CL ≤25 mm in low-risk pregnant women Secondary outcomes were the incidences of PTB <37, <34, and <32 weeks.</p><p><strong>Results: </strong>Among 3226 screened women, mean and median CL were 40.8 and 40 mm, respectively. The 10th centile was equal to 33 mm while 25 mm represented the 2nd centile of the distribution. The incidence of CL ≤25 mm (short cervix) was 1.25%. Among those women, 7.5% were shorter than 150 cm, opposed to 2.1% in the normal CL group (<i>p</i> = .02); in addition there were more nullipara, women ≥ 40 and smokers (<i>p</i> = .03). Women with short cervix were at higher risk of PTB (23.6 vs 4.3%; RR: 4.6, 95%CI 2.49-8.48). At multivariate analysis, both CL ≤ 25 mm (RR: 5.51, 95%CI: 2.45-12.3) and stature ≤150 cm (RR: 2.54, 95%CI: 1.11-5.79) resulted independent predictors for PTB, once adjusted for other risk factors (fibroids, cervical surgery, obesity, low education, older age, smoking habit).</p><p><strong>Conclusion: </strong>Although our study confirmed that women with short cervix are more likely to deliver preterm, the low incidence of such risk factor means that most of the preterm births occurred among women with normal cervical length. Thus, in a low-risk Italian population, ineffectiveness of universal screening is forecast.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2436099"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent pregnancy loss: risk factors and predictive modeling approaches.","authors":"Xiaoyu Zhang, Jiawei Gao, Liuxin Yang, Xiaoling Feng, Xingxing Yuan","doi":"10.1080/14767058.2024.2440043","DOIUrl":"https://doi.org/10.1080/14767058.2024.2440043","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to identify and analyze the risk factors associated with recurrent pregnancy loss (RPL) and to evaluate the effectiveness of various predictive models in estimating the risk of RPL. The review also explores recent advancements in machine learning algorithms that can enhance the accuracy of these predictive models. The ultimate goal is to provide a comprehensive understanding of how these tools can aid in the personalized management of women experiencing RPL.</p><p><strong>Materials and methods: </strong>The review synthesizes current literature on RPL, focusing on various risk factors such as chromosomal abnormalities, autoimmune conditions, hormonal imbalances, and structural uterine anomalies. It also analyzes different predictive models for RPL risk assessment, including genetic screening tools, risk scoring systems that integrate multiple clinical parameters, and machine learning algorithms capable of processing complex datasets. The effectiveness and limitations of these models are critically evaluated to provide insights into their clinical application.</p><p><strong>Results: </strong>Key risk factors for RPL were identified, including chromosomal abnormalities (e.g. translocations and aneuploidies), autoimmune conditions (e.g. antiphospholipid syndrome), hormonal imbalances (e.g. thyroid dysfunction and luteal phase defects), and structural uterine anomalies (e.g. septate or fibroid-affected uteri). Predictive models such as genetic screening tools and risk scoring systems were shown to be effective in estimating RPL risk. Recent advancements in machine learning algorithms demonstrate potential for enhancing predictive accuracy by analyzing complex datasets, which may lead to improved personalized management strategies.</p><p><strong>Conclusions: </strong>The integration of risk factors and predictive modeling offers a promising approach to improving outcomes for women affected by RPL. A comprehensive understanding of these factors and models can aid clinicians and researchers in refining risk assessment and developing targeted interventions. The review underscores the need for further research into specific pathways involved in RPL and the potential of novel treatments aimed at mitigating risk.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2440043"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Increasing body mass index is associated with intensive care unit admission and severe maternal morbidity\".","authors":"Nicholas Baranco, Sameer Khan, Pamela Parker, Dimitrios S Mastrogiannis","doi":"10.1080/14767058.2024.2431098","DOIUrl":"https://doi.org/10.1080/14767058.2024.2431098","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the relationship between increased body mass index (BMI) with severe maternal morbidity (SMM).</p><p><strong>Study design: </strong>We obtained data for a retrospective cohort of singleton live births using an electronic birth certificate database from 2010 to 2022 in Central New York. Institutional review board exemption was obtained. Pre-pregnancy BMI was assessed as a continuous variable and a categorical variable with groups of BMI <18.5 kg/m², 30-39.9 kg/m², 40-49.9 kg/m², and ≥50 kg/m² compared to patients with BMI 18.5-29.9 kg/m². Primary outcomes were maternal intensive care unit (ICU) admission and composite SMM defined as ICU admission, unplanned hysterectomy, reoperation, eclampsia, and blood transfusion. Secondary outcomes were the individual SMM components, 5-minute APGAR score <7, and neonatal intensive care unit (NICU) admission. ANOVA and χ² were used to compare continuous and categorical variables respectively, and logistic regression was used to obtain adjusted odds ratios for primary and secondary outcomes.</p><p><strong>Results: </strong>There were 223,837 patients with singleton live births with mean BMI 27.86 kg/m². 54,385 (24.3%) had BMI 30-39.9 kg/m², 13,299 (5.9%) had BMI 40-49.9 kg/m², and 1,958 (0.87%) had BMI ≥50 kg/m². 3,203 (1.4%) patients experienced SMM, and 423 (0.2%) patients were admitted to ICU. For each 1-point increase in BMI the adjusted odds ratio (aOR) of SMM increased by 0.8% (aOR 1.008, 95% CI 1.002-1.013) and ICU admission increased by 2.0% (aOR 1.02, 95% CI 1.005-1.034). Odds of ICU admission for those with BMI 40-49.9 kg/m² increased by 69% (aOR 1.69, 95% CI 1.16-2.47); BMI ≥50 kg/m² increased by 300% (aOR 3.01, 95% CI 1.53-5.91), but those with BMI 30-39.9 kg/m² did not have significantly higher odds of ICU admission (aOR 1.09, 95% CI 0.84-1.42).</p><p><strong>Conclusion: </strong>Increasing BMI was significantly associated with increased SMM and maternal ICU admission.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2431098"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive efficacy of machine-learning algorithms on intrahepatic cholestasis of pregnancy based on clinical and laboratory indicators.","authors":"Jianhu He, Xiaojun Zhu, Xuan Yang, Hui Wang","doi":"10.1080/14767058.2024.2413854","DOIUrl":"https://doi.org/10.1080/14767058.2024.2413854","url":null,"abstract":"<p><strong>Objectives: </strong>Intrahepatic cholestasis of pregnancy (ICP), a condition exclusive to pregnancy, necessitates prompt identification and intervention to improve the perinatal outcomes. This study aims to develop suitable machine-learning models for predicting ICP based on clinical and laboratory indicators.</p><p><strong>Methods: </strong>This study retrospectively analyzed data from 1092 pregnant women, with 537 diagnosed with ICP and 555 healthy cases as a control. Two study schemes were devised. For scheme 1, 62 indicators from the first period of gestation were utilized to establish predictive models. For scheme 2, 62 indicators from at least two periods of gestation were utilized to establish predictive models. Under each scheme, three different machine-learning models were developed based on the Arya Privacy Computing Platform, encompassing Support Vector Machine (SVM), Deep Neural Network (DNN), and Xgboost for Scheme 1, and Recurrent Neural Network (RNN), Long Short-Term Memory Network (LSTM), and Gated Recurrent Unit (GRU) for Scheme 2. The predictive efficacy of each model on ICP was evaluated and compared.</p><p><strong>Results: </strong>Under Scheme 1, the cohort comprised 1092 pregnant women (537 with ICP, 555 healthy). The SVM model exhibited a sensitivity, specificity, and accuracy of 85.5%, 47.50%, and 67.90%, respectively, while DNN showed 65.70%, 92.70%, and 79.40%, respectively, and Xgboost achieved 65.60%, 81.90%, and 73.40%, respectively. In Scheme 2, 899 pregnant women were analyzed (466 with ICP, 433 healthy). RNN demonstrated a sensitivity, specificity, and accuracy of 97.60%, 82.10%, and 90.50%, respectively; LSTM presented 90.70%, 81.70%, and 86.60%, respectively; and GRU achieved 89.90%, 83.80%, and 89.40%, respectively.</p><p><strong>Conclusion: </strong>DNN and RNN are the two most suitable models to predict ICP in a convenient and available way. It provides flexible choice for medical staff and helps them optimize the therapeutic strategies to meet different clinical setting and improve the clinical prognosis of ICP.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2413854"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal survival rate after expectant management of periviable preterm premature rupture of membranes at gestational age 15-23⁺⁶ weeks.","authors":"Phunyaporn Nipastpong, Vorapong Phupong","doi":"10.1080/14767058.2024.2434066","DOIUrl":"https://doi.org/10.1080/14767058.2024.2434066","url":null,"abstract":"<p><strong>Objective: </strong>To assess the neonatal survival rates, maternal complications, neonatal complications, and factors associated with survival rates following periviable premature rupture of membranes (PROM) between 15 and 23⁺⁶ weeks of gestation.</p><p><strong>Materials and methods: </strong>The retrospective study included patients with periviable PROM between 15 and 23⁺⁶ weeks of gestation from January 1, 2008, to December 31, 2022. Multivariate regression analysis was performed to identify factors influencing neonatal survival.</p><p><strong>Results: </strong>A total of 71 cases of periviable PROM between 15 and 23⁺⁶ weeks of gestation were included in the study, and the neonatal survival rate was found to be 26.8%. Maternal complications occurred in 59.2% of cases. Of the 19 surviving newborns, 89.5% experienced neonatal complications. Univariate analysis showed that gestational age at delivery, duration of latency and antenatal steroid administration were the factors significantly associated with increased survival rates after periviable PROM before 24 weeks of gestation.</p><p><strong>Conclusion: </strong>The survival rate of periviable PROM between 15 and 23⁺⁶ weeks of gestation was 26.8% with neonatal complications of 89.5%. This information may be useful for counseling pregnant women experiencing periviable PROM.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2434066"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proof of concept testing of a vascular closure device for use in fetal surgery.","authors":"Braxton Forde, Samuel Martin, Marc Oria, Jordan Kapke, Eyal Krispin, Jose L Peiro","doi":"10.1080/14767058.2024.2435468","DOIUrl":"https://doi.org/10.1080/14767058.2024.2435468","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Prior clinical findings have demonstrated that maternal laparotomy with trans-amniotic trans-uterine suturing of the fetoscopic port site during in utero myelomeningocele repair reduces the risk of membrane rupture. However, due to laparotomy-associated morbidity, we aimed to explore the feasibility of using a vascular closure device for percutaneous trans-amniotic trans-uterine suturing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This IRB and IACUC-exempt study utilized 2 strategies for proof-of-concept testing of using the Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; Device for suture placement; 1. Ultrasound guided application on a high fidelity maternal abdominal uterus model used for fetal procedures and 2. Placement under direct visualization with sheep undergoing cesarean delivery for other research purposes. In the high-fidelity uterus model, the Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device was used to place a transuterine/transamniotic stitch with accompanying video recording of the approach (https://go.screenpal.com/watch/cZfhoDVsYvW password: perclose). Regarding the second approach, at the time of a cesarean section, 12 French Checkflo&lt;sup&gt;®&lt;/sup&gt; cannulas were inserted into the sheep amniotic space &lt;i&gt;via&lt;/i&gt; different approaches: (1) Seldinger technique, (2) Seldinger technique insertion of Checkflo&lt;sup&gt;®&lt;/sup&gt; cannula and subsequent use of the Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device to suture the port site after check flow removal, (3) Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device utilized in what is described as a \"pre-close\" technique, where prior to cannula placement, trans-uterine trans-amniotic stitches are placed followed by the insertion of a 12 French Checkflo&lt;sup&gt;®&lt;/sup&gt; cannula over the same guidewire. Samples of the sutured uterine wall were sent to pathology and H&E staining was performed to assess uterine hole closure and amnion-to-uterus fixation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The high-fidelity model confirmed that the Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; Device was easily visualized by ultrasound and suture deployment was without complication. In the animal model, the Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; device effectively sutured the amnion to the uterus in both the pre- and post-close approach. The pre-close technique achieved better amnion-to-uterus approximation and more appropriate uterine hole closure. H&E staining revealed that without suturing, amnion separation from the chorion layer occurred, and the uterine hole persisted. The post-close technique showed partial connection between the amnion and chorion, but inadequate uterine hole closure with amnion shift into the defect. Optimal closure, with secure amnion-to-chorion fixation and uterine closure, was achieved through the pre-close technique.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The Abbott Perclose&lt;sup&gt;™&lt;/sup&gt; ProStyle&lt;sup&gt;™&lt;/sup&gt; Device seems to be a feasible device for use of uterin","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2435468"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}