Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Effects of different physical exercise types on health outcomes of individuals with hypertensive disorders of pregnancy: a prospective randomized controlled clinical study.","authors":"Cong Chen, Jinguo Zhai, Shuiwang Hu, Xuantian Liu, Xinzhi Tu, Bin Li, Kui Huang, Fu-Ying Tian, Haiyin Liu, Ruowang Hu, Jingjing Guo","doi":"10.1080/14767058.2024.2421278","DOIUrl":"https://doi.org/10.1080/14767058.2024.2421278","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impacts of different types of physical exercise on health outcomes of individuals with hypertensive disorders of pregnancy (HDPs).</p><p><strong>Methods: </strong>Forty individuals with HDPs admitted to a tertiary hospital providing maternal and pediatric care between July 2023 and March 2024 were enrolled in this prospective randomized controlled clinical study and completed a ≥4-week intervention. Data were collected before the intervention and before delivery. Participants were assigned randomly to control (no exercise intervention), aerobic exercise (AE), resistance training (RT), and AE + RT groups. All participants downloaded a mobile health-education app for gestational hypertension developed by our research group. Exercise videos in the app guided participants' performance of different types of exercise. General information; physical activity and sleep quality data; morning blood pressure, lipid profiles, and urinary micro-albumin/creatinine ratios; serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and advanced oxidation protein product (AOPP) concentrations; and pregnancy outcome data were collected and compared among groups.</p><p><strong>Results: </strong>After the intervention, the physical activity status, sleep quality, morning blood pressure, lipid profiles, urinary micro-albumin/creatinine ratios, and pregnancy outcomes differed significantly among all groups comparing with control (all <i>p</i> < .05). In the three exercise groups, the serum sFlt-1, PlGF, and AOPPs levels improved significantly (all <i>p</i> < .05). All differences were most pronounced in the AE + RT group.</p><p><strong>Limitations: </strong>The study period was relatively short. The further long-term follow-up research is needed. A larger sample size study is also needed.</p><p><strong>Conclusions: </strong>The study results suggest that AE + RT interventions are beneficial for individuals with HDPs in clinical settings, and could be implemented with careful consideration of individuals' specific conditions.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal posture and cognitive-behavioral interventions on labor outcomes in primigravidas with abnormal fetal head position: a randomized controlled clinical trial.","authors":"Xiaofeng Wan, Jinguo Zhai, Xiaoqin Lu, Xiuhong Wang, Hamza Saidi Lilenga, Mei Luo, Xiaochun Wang, Xueyan Wang, Yanli Zhou","doi":"10.1080/14767058.2024.2422448","DOIUrl":"https://doi.org/10.1080/14767058.2024.2422448","url":null,"abstract":"<p><strong>Objective: </strong>Fetal head malposition can result in neonatal and maternal complications. Fetal head malposition occurs frequently in labor. Appropriate and timely managements are required. Maternal posture and cognitive-behavioral interventions could improve labor outcomes in primigravidas with fetal head malposition.</p><p><strong>Methods: </strong>A randomized controlled clinical trial was performed between January and December 2022 (Chinese Clinical Trial Registry, ChiCTR2100049359). Eligible primigravidas were randomly assigned into four groups. Group A received traditional perinatal care. Group B, C, and D received posture management, posture management with music therapy, and posture management with video education, respectively, in addition to traditional perinatal care. The maternal postures referred to place pregnant women in certain positions (lateral, lateral-prone, hands and knees, open knee-chest) to change the anatomical structure of pelvis, thus, to facilitate the fetal downward movement and birth. Maternal and neonatal outcomes were recorded and compared.</p><p><strong>Results: </strong>A total of 136 primigravidas were included, with 34, 35, 34, and 33 women in group A, B, C, and D, respectively. The incidences of cesarean section were lower in groups B, C, and D than that in group A (5.7%, 2.9%, and 3.0% versus 20.6%, <i>p</i> < 0.05). The fetal position correction rates at the time of full dilation of cervix were higher in groups B, C, and D than that in group A (66.7%, 63.6%, 68.8% versus 27.6%, <i>p</i> < 0.05). Primigravidas in groups B, C, and D had better experiences and a lower anxiety level than those in group A (<i>p</i> < 0.001). The four groups had no statistically significant differences in the total labor duration, operative vaginal delivery, umbilical artery blood pH, and neonatal Apgar scores.</p><p><strong>Conclusion: </strong>Fetal head malposition could happen in primigravidas. Maternal posture management and cognitive-behavioral interventions during labor could improve labor outcomes in primigravidas with fetal head malposition.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver agreement of intrapartum cardiotocography interpretation by midwives using current FIGO and physiology-based guidelines.","authors":"Serena Neri, Ruben Ramirez Zegarra, Marialuigia Dininno, Elvira Di Pasquo, Sara Tagliaferri, Tullio Ghi","doi":"10.1080/14767058.2024.2425758","DOIUrl":"https://doi.org/10.1080/14767058.2024.2425758","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the interobserver agreement among midwives for the interpretation of intrapartum CTG traces, using both the 2015 FIGO guidelines and the physiology-based guidelines.</p><p><strong>Material and methods: </strong>Retrospective, single-center, observational study conducted at the Maternity Hospital of the University of Parma, Italy, between November 2022 and July 2023. We selected 100 nonconsecutive intrapartum CTG traces from women undergoing operative delivery (cesarean or instrumental vaginal delivery). Participating midwives received the last 60 min of CTG recording prior to the decision for an operative delivery was made. Five midwives with different professional experience classified the CTG tracing according to the 2015 FIGO guidelines and the physiology-based guidelines at the time of the decision for the operative delivery. Each midwife was categorized as senior or junior if her clinical experience was equal or more or less than 5 years. All participating midwives were blinded to the demographic and clinical variables of each case, as well as to the labor and neonatal outcome. The main outcome of the study was the interobserver agreement among the 5 midwives with either guideline. The secondary outcome was the interobserver agreement based on clinical experience. The agreement between the observers was estimated through the Krippendorff's alpha statistics.</p><p><strong>Results: </strong>The interobserver agreement for the interpretation of intrapartum CTG traces according to the 2015 FIGO guideline was in the upper limit of the \"unacceptable\" classification, with a Krippendorff's alpha of 0.632 (95% CI, 0.545-0.723). The interobserver agreement of the physiology-based CTG guideline was classified as \"unacceptable\" with a Krippendorff's alpha of 0.359 (95% CI, 0.125-0.582). The interobserver agreement among senior midwives according to the 2015 FIGO guidelines was considered as \"tentative acceptable agreement\" with a Krippendorff's alpha of 0.724 (95% CI, 0.636-0.805). Among junior midwives, the interobserver agreement according to the latter guideline was classified as \"unacceptable\" with a Krippendorff's alpha of 0.569 (95% CI, 0.359-0.751). Using the physiology-based guideline, the interobserver agreement of the senior midwives - Krippendorff's alpha 0.493 (95% CI, 0.320-0.623) - and \"junior\" midwives - Krippendorff's alpha 0.359 (95% CI, 0.100-0.581) - were considered both \"unacceptable\".</p><p><strong>Conclusions: </strong>Our study showed that intrapartum CTG interpretation is characterized by an overall unacceptable level of interobserver agreement among midwives, with the 2015 FIGO guidelines showing better agreement compared to physiology-based guidelines. The interpretation of intrapartum CTG by \"senior\" midwives using the 2015 FIGO guidelines showed the highest, interobserver agreement, indicating a \"tentative acceptable agreement\".</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between placental growth factor and small for gestational age infants: a matched case-control study.","authors":"Yimin Zhang, Shuming Shao, Qi Xu, Jiong Qin, Zheng Liu, Xiaorui Zhang","doi":"10.1080/14767058.2024.2428387","DOIUrl":"https://doi.org/10.1080/14767058.2024.2428387","url":null,"abstract":"<p><strong>Background: </strong>At present, research has not found easily accessible, accurate, and safe clinical biomarkers that can effectively predict the occurrence of infants born small for gestational age (SGA). The aim of this study is to explore the predictive role of maternal placental growth factor (PIGF) levels on the occurrence of SGA infants.</p><p><strong>Method: </strong>We conducted a matched case-control study on 226 SGA infants and 226 non-SGA infants born in the Department of Obstetrics, Peking University People's Hospital, from January 2021 to December 2022, with regular monitoring of maternal serum PIGF levels in second trimester during pregnancy. Apply multiple logistic regression analysis and receiver operating characteristic (ROC) curve analysis to determine whether PIGF is an independent influencing factor for the occurrence of SGA in infants, and evaluate whether PIGF can predict the occurrence of SGA in infants.</p><p><strong>Results: </strong>Multiple logistic regression analysis found that multipara (HR = 0.484, 95% CI = 0.250-0.937, <i>p</i> = 0.031), maternal pre-pregnancy underweight (HR = 4.710, 95% CI = 1.881-11.792, <i>p</i> = 0.001), pre-eclampsia(HR = 2.291, 95% CI = 1.068-4.913, <i>p</i> = 0.033), low levels of PIGF (HR = 26.417, 95% CI = 12.850-54.311, <i>p</i> < 0.001) and oligohydramnios (HR = 4.764, 95% CI = 1.845-12.301, <i>p</i> = 0.001) were independent factors affecting the occurrence of infants born SGA. In addition, ROC curve analysis showed that the area under the curve (AUC) predicted by PIGF level and four other influencing factors for the occurrence of SGA infants were 0.834 and 0.723, respectively. In addition, the combination of PIGF and four other independent influencing factors improved the predictive value (AUC 0.902) for the birth of SGA infants, with enhanced sensitivity and specificity.</p><p><strong>Conclusion: </strong>Low levels of PIGF in second trimester during pregnancy are an independent risk factor for SGA infants. Compared with other indicators, PIGF levels PIGF in second trimester are a better predictor of SGA in infants.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between maternal Continuous Glucose Monitoring \"time in range\" and fetal abdominal circumference in pregnant women with Type 1 Diabetes.","authors":"Liesel Woon, Tessa Glyn, Alexandra Gorelik, Rani Haj Yahya, Sarah A Price","doi":"10.1080/14767058.2024.2428391","DOIUrl":"https://doi.org/10.1080/14767058.2024.2428391","url":null,"abstract":"<p><strong>Background: </strong>To explore the relationship between maternal glycaemic control and fetal abdominal circumference in pregnancies complicated by T1D.</p><p><strong>Methods: </strong>This is a retrospective cohort study of 81 pregnant women with T1D using CGM. Inclusion criteria were T1D, CGM use, ≥2 in-house ultrasounds, and the birth of a live singleton neonate between 1st December 2019 and 1st December 2022. Linear regression analysis was used to assess the cross-sectional relationships between estimated fetal abdominal circumference (AC) on ultrasound and time in range (TIR) at matched time-points in the third trimester of pregnancy. Linear regression analysis was also used to examine whether first trimester TIR and HbA1c predicts third trimester fetal AC.</p><p><strong>Results: </strong>At baseline, the mean ± standard deviation (SD) of the first trimester HbA1c was 7.0 ± 1.4% and mean ± SD total daily dose (TDD) insulin was 46.6 ± 21.0 units. The mean ± SD birthweight was 3367.0 ± 861.3 grams. There was no cross-sectional relationship between TIR and fetal AC at 28-, 32- or 36-week' gestation. The results of the regression analysis indicate a significant relationship between first trimester TIR (independent predictor) and fetal AC (dependent variable) at 32- and 36-weeks' gestation while controlling for maternal age, BMI, pump use, and TDD insulin (Adj<i>β=</i> -0.42, 95%CI -0.80 to -0.03 and Adj<i>β = -</i>0.57, 95%CI -1.02 to -0.12 at 32- and 36-weeks respectively). Although there was a significant relationship between first trimester HbA1c and fetal AC at 32-weeks' gestation (<i>β =</i> 3.81, 95%CI 0.29 to 7.33), the relationship was not significant after adjustment for confounders.</p><p><strong>Conclusions: </strong>There was no cross-sectional relationship between TIR and fetal AC in the third trimester of pregnancy but first trimester TIR did predict fetal AC in late pregnancy.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association between vitamin D and gestational diabetes mellitus: a two-sample Mendelian randomization study.","authors":"Pei Zhang, XiaoHong Hu, YanQi Jin","doi":"10.1080/14767058.2024.2427760","DOIUrl":"https://doi.org/10.1080/14767058.2024.2427760","url":null,"abstract":"<p><strong>Background: </strong>Previous articles on the relationship between vitamin D and gestational diabetes mellitus (GDM) were inconsistent. Their relationship has been observed primarily through observational studies, and the causality of this association has not been established.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization (MR) research was conducted to test the causal association between vitamin D and GDM, utilizing publically available statistics from genome-wide association studies (GWAS). This study obtained genetic variants from GWAS including vitamin D (<i>N</i> = 373,045,10,783,672 Single Nucleotide Polymorphisms SNPs), and GDM (5687 cases and 117,892 controls). The major technique was the inverse variance weighted approach (IVW), although there were other approaches as well, such as MR-Egger regression, weighted median, weighted mode, and simple mode. Additionally, we conducted sensitivity analyses to detect any potential diversity and horizontal pleiotropy.</p><p><strong>Results: </strong>The study suggested that there was no causal link between vitamin D and GDM (all methods <i>p</i> > 0.05). For heterogeneity, MR egger Q value was 113.7, <i>p</i> < 0.05; IVW Q value was 114.7, <i>p</i> < 0.05. Therefore, random- effects IVW approach was applied. Regarding pleiotropy, the MR Egger regression intercept was 0.0046, which was close to zero with a <i>p</i> value of 0.452, suggesting the absence of pleiotropy.</p><p><strong>Conclusions: </strong>We observed no assosiation between genetically predicted vitamin D and the risk of GDM, implying that insufficient vitamin D may do not confer an increased susceptibility to GDM.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor.","authors":"H Yüksel, E Zafer","doi":"10.1080/14767058.2024.2428399","DOIUrl":"https://doi.org/10.1080/14767058.2024.2428399","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of cervical excisional treatment is associated with changes in the cervical microbiota in women with preterm prelabor rupture of membranes.","authors":"Jana Matulova, Ivana Musilova, Rudolf Kukla, Radka Bolehovska, Klara Balcarova, Johanna Wiik, Verena Sengpiel, Pavel Bostik, Bo Jacobsson, Marian Kacerovsky","doi":"10.1080/14767058.2024.2425761","DOIUrl":"https://doi.org/10.1080/14767058.2024.2425761","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the differences in the cervical load and prevalence of <i>Lactobacillus crispatus</i> DNA, <i>Lactobacillus iners</i> DNA, <i>Gardnerella vaginalis</i> DNA<i>, Sneathia sanguinegens</i> DNA, and <i>Ureaplasma</i> species DNA between pregnant women with preterm prelabor rupture of membranes (PPROM) with and without a history of cervical excisional treatment. We also assessed the changes in the cervical load and prevalence of <i>L. crispatus</i> DNA, <i>L. iners</i> DNA, <i>G. vaginalis</i> DNA, <i>S. sanguinegens</i> DNA, and <i>U.</i> spp DNA. according to the cone length.</p><p><strong>Methods: </strong>This retrospective study included 132 women with singleton pregnancies complicated by PPROM. For all women, information about the cervical loads of bacterial DNA corresponding to <i>L. crispatus</i>, <i>L. iners</i>, <i>G. vaginalis</i>, <i>S. sanguinegens</i>, and <i>U.</i> spp., which was assessed using PCR, was available.</p><p><strong>Results: </strong>Women with a history of cervical excisional treatment had a higher cervical load of <i>L. iners</i> DNA (4.4 × 10⁶ copies DNA/mL vs. 3.5 × 10⁵ copies DNA/mL, <i>p</i> = .04) and a higher load and prevalence of <i>U</i>. spp. DNA (1.1 × 10⁵ copies DNA/mL vs. 9.6 × 10⁴ copies DNA/mL, <i>p</i> = .03; 2.7% vs. 0.5%, <i>p</i> = .04) than those without a history of cervical excisional treatment. In the subset of women with a history of cervical excisional treatment, those with a cone length 18 mm and more had a lower relative abundance of <i>L. crispatus</i> DNA (6% vs. 89%, <i>p</i> = .02), a higher load and relative abundance of <i>L. iners</i> DNA (1.1 × 10⁷ copies DNA/mL vs. 8.2 × 10⁵ copies DNA/mL, <i>p</i> = .04; 91% vs. 35%, <i>p</i> = .04), and higher loads of <i>G. vaginalis</i> DNA (7.6 × 10⁴ copies DNA/mL vs. 3.2 × 10² copies DNA/mL, <i>p</i> = .02) than those with cone length < 18 mm.</p><p><strong>Conclusions: </strong>A history of cervical excisional treatment was associated with alterations in the cervical microbiota composition in pregnant women with PPROM.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of subsequent IVF cycles among women with PCOS after the first unstimulated IVM treatment: a single-center matched retrospective case-control study.","authors":"Ya-Lan Xu, Wei Guo, Yong-Xiu Hao, Shuo Yang, Rong Li, Xiao-Ying Zheng, Jie Qiao","doi":"10.1080/14767058.2024.2425756","DOIUrl":"10.1080/14767058.2024.2425756","url":null,"abstract":"<p><strong>Objective: </strong><i>In-vitro</i> maturation (IVM) is an advanced technique and an alternative to conventional <i>in-vitro</i> fertilization (IVF). It is safe, effective, and cost-effective in patients with polycystic ovary syndrome (PCOS). However, no clinical guidelines state that IVM could work without compromised pregnancy outcomes in patients with PCOS. The purpose of this study was to identify whether previous unstimulated IVM improved the clinical outcomes of women with PCOS in the subsequent IVF cycle.</p><p><strong>Methods: </strong>In this matched retrospective case-control study, we compared the results of IVF treatment in two groups of women with PCOS between January 2008 and December 2017. The study group comprised 79 women who underwent a subsequent IVF treatment after IVM failure (IVM-IVF group). Considering the year, age, and BMI, a 1:3 matched control group of 237 women with PCOS who received their first IVF cycle was established (IVF group).</p><p><strong>Results: </strong>Compared with the IVF group, the IVM-IVF group had a significantly lower initial gonadotropin dose [112.5 IU (112.5-150 IU) <i>vs</i>. 150 IU (150-200 IU), <i>p</i> < 0.001] and total gonadotropin dose [1350 IU (1125-2162.5 IU) <i>vs</i>. 1875 IU (1425.00-2643.75 IU), <i>p</i> < 0.001]. The live birth rate, clinical pregnancy, and miscarriage rates were comparable between the IVM-IVF and IVF groups at 12 months [55.6% <i>vs</i>. 48.6%, (adjusted <i>p</i> = 0.923), 68.1% <i>vs</i>. 59% (adjusted <i>p</i> = 0.677), and 18.8% <i>vs</i>. 17.7% (adjusted <i>p</i> = 0.645), respectively] and the first transfer cycle [36.1% <i>vs</i>. 34.2% (adjusted <i>p</i> = 0.560), 55.6% <i>vs</i>. 41.9% (adjusted <i>p</i> = 0.177), and 35% <i>vs</i>. 18.3% (adjusted <i>p</i> = 0.396), respectively]. The occurrence of moderate/severe OHSS did not significantly differ between the groups [5.1% <i>vs</i>. 7.6% (adjusted <i>p</i> = 0.698)]. Notably, LH levels, the LH/FSH ratio, and androstenedione levels were significantly reduced in the IVM-IVF group after the IVM treatment.</p><p><strong>Conclusion: </strong>Alternatives to IVF are underappreciated in clinical practice and research because of the lack of evidence on the efficacy of IVM in certain populations. IVF treatment given during a follow-up visit after an unstimulated IVM can achieve pregnancy outcomes comparable to those of a first IVF cycle without adversely affecting the subsequent pregnancy outcome.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}