Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Meta-analysis of the efficacy of different blue light therapy methods for neonatal jaundice.","authors":"Ruoya Wu, Lingling Wen","doi":"10.1080/14767058.2024.2430649","DOIUrl":"https://doi.org/10.1080/14767058.2024.2430649","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and evaluate the efficacy of different blue light therapy methods and provide evidence-based recommendations for their selection in clinical practice.</p><p><strong>Methods: </strong>Clinical randomized controlled trials (RCTs) evaluating the efficacy of various blue light therapy methods for neonatal jaundice were retrieved from both domestic and international databases. The search period covered the inception of each database until November 2023. After screening, the quality of the included studies was assessed using the Cochrane Risk of Bias tool. Literature management was conducted with NoteExpress 3.2, while data collection and extraction were performed using Excel 2003. Statistical analysis was carried out using RevMan 5.4.1. Heterogeneity was assessed using the <i>Q</i> test (<i>p</i> value), and the OR value of the combined effect was calculated using either a fixed-effects or random effects model, depending on the presence of heterogeneity. A forest plot was generated to visualize the results. Sensitivity analysis was performed by excluding the largest-weighted study, and the potential for bias in outcome indicators was assessed using a funnel plot.</p><p><strong>Results: </strong>A total of 652 articles were retrieved, with 16 clinical RCTs meeting the inclusion criteria. The meta-analysis results indicated that, compared to continuous blue light therapy in the control group, intermittent blue light therapy achieved a higher total effective rate (OR = 1.82, 95%CI (1.25-2.64), <i>p</i> = .002), significantly lower serum bilirubin levels post-treatment (OR = -14.59, 95%CI (-26.11 to -3.08), <i>p</i> = .01), and a shorter time to jaundice resolution (OR = -2.35, 95%CI (-3.83 to -0.87), <i>p</i> = .002). Additionally, the incidence of adverse reactions was lower in the intermittent therapy group compared to the control group (OR = 0.27, 95%CI (0.19-0.36), <i>p</i> < .00001). Sensitivity analysis confirmed that the combined effect size was stable and reliable (OR (95%CI) = -16.23 (-28.67 to -3.79), <i>p</i> = .01). The funnel plot suggested potential publication bias.</p><p><strong>Conclusions: </strong>Intermittent blue light therapy is effective and demonstrates significant clinical benefits, making it a valuable treatment option for neonatal jaundice in clinical practice.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2430649"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor with regard to the article \"increasing body mass index is associated with intensive care unit admission and severe maternal morbidity\".","authors":"Qiuming Chen, Chenlin Pei, Jingrui Huang","doi":"10.1080/14767058.2025.2470413","DOIUrl":"https://doi.org/10.1080/14767058.2025.2470413","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2470413"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between iron supplementation during pregnancy and the risk of childhood leukemia: a meta-analysis of case-control studies.","authors":"Mahsa Dabir, Pedram Pam, Mehrdad Jamali, Fakhredin Saba, Zohreh Ghoreishi","doi":"10.1080/14767058.2025.2474268","DOIUrl":"10.1080/14767058.2025.2474268","url":null,"abstract":"<p><strong>Objectives: </strong>Acute leukemia (AL) presents significant health challenges, particularly in children, and iron plays a critical role in cellular processes that could influence cancer development. The study was motivated by the need to clarify the potential role of iron supplementation during pregnancy in influencing the risk of developing childhood leukemia.</p><p><strong>Materials and methods: </strong>This meta-analysis adhered to PRISMA guidelines and systematically searched PubMed, Scopus, and Web of Science databases up to April 2024 for relevant observational studies. Inclusion criteria focused on case-control studies assessing the relationship between iron supplementation during pregnancy and leukemia risk, reporting odds ratios (ORs) with 95% confidence intervals (CIs). Data extraction and quality assessment were performed independently by two researchers using the Newcastle-Ottawa Scale (NOS). Statistical analysis involved calculating overall relative risk (RR) using a random-effects model and assessing heterogeneity through Cochran's Q test and the I² statistic. Publication bias was evaluated using Egger's and Begg's tests.</p><p><strong>Results: </strong>The study analyzed data from 9 studies with 12 data sets involving a total of 4281 participants (2327 cases and 1954 controls). The findings indicated no significant association between iron supplementation during pregnancy and the overall risk of childhood leukemia (OR:1.01; 95% CI: 0.84-1.21, I2 = 63.2%). Also, no relationship was found between receiving iron supplements during pregnancy and the risk of AML (OR:1.01; 95% CI: 0.84-1.21, I2 = 56.6%) and ALL (OR:1.00; 95% CI: 0.81-1.24, I2 = 67.3%).</p><p><strong>Conclusion: </strong>This study found no significant association between iron supplementation during pregnancy and AL risk among case-control studies. Further research is needed to explore the potential influence of genetic and environmental factors on this relationship.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2474268"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the clinical value of serum MMP-9 and VEGF expression levels in the prenatal diagnosis of patients with aggressive placenta previa.","authors":"Pei Zhang","doi":"10.1080/14767058.2025.2470414","DOIUrl":"10.1080/14767058.2025.2470414","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic efficacy and detection value of matrix metalloproteinase-9 (MMP-9) and VEGF in menacing pernicious placenta previa (PPP).</p><p><strong>Method: </strong>Among all the cases of PPP, a critical condition within the Placenta Accreta Spectrum (PAS) caused by aberrant implantation of the placenta in the uterine wall, which were analyzed between April 2021 and March 2023, there were sixty-three cases. The control group consisted of those sixty-three women who had a normal placenta. Serum levels of MMP-9 and VEGF were measured and compared in both groups. The expression levels of MMP-9 and VEGF were analyzed along with ultrasound scores related to different degrees of placental implantation. Comparisons between groups were performed using <i>t</i>-tests and one-way ANOVA. The diagnostic efficacy of each of the indicators was determined using receiver operating characteristic (ROC) curves by calculating the area under the curve (AUC) and Youden's index.</p><p><strong>Results: </strong>MMP-9, VEGF expression, and ultrasound scores of pregnant women in the PPP group were significantly higher than those in the control group (<i>p</i> < 0.05). Logistic regression analysis demonstrated that MMP-9, VEGF, and ultrasound scores were significantly associated with PPP (<i>p</i> < 0.05). ROC curves indicated that serum MMP-9, VEGF, and ultrasound scores predicted the AUC of 0.802, 0.817, and 0.983 for PPP, respectively. The Youden's index values were 0.492, 0.540, and 0.826, respectively.</p><p><strong>Conclusion: </strong>MMP-9, VEGF, and ultrasound scores help predict placental implantation in PPP, which, in turn, provides significant support for clinical understanding.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2470414"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of vaginal combined with abdominal color Doppler ultrasonography for ovarian cyst torsion.","authors":"Meina Zhang, Na Yang, Feng Dong, Shuang Zhao","doi":"10.1080/14767058.2025.2491455","DOIUrl":"https://doi.org/10.1080/14767058.2025.2491455","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic accuracy of combined vaginal and abdominal color Doppler ultrasonography for ovarian cyst torsion.</p><p><strong>Methods: </strong>In a cross-sectional diagnostic study from January 2019 to October 2023, 86 patients suspected of ovarian cyst torsion were assessed using vaginal and abdominal ultrasonography. Pathological findings were the gold standard. Diagnostic performances were analyzed using ROC curves.</p><p><strong>Results: </strong>Vaginal ultrasonography had a sensitivity of 76%, specificity of 61%, and AUC of 0.686. Abdominal ultrasonography showed a sensitivity of 72%, specificity of 50%, and AUC of 0.610. Combined use resulted in improved sensitivity (84%), specificity (72.2%), and the highest AUC (0.781). The combined method significantly outperformed abdominal ultrasonography in accuracy and AUC.</p><p><strong>Conclusion: </strong>Vaginal ultrasonography alone is more accurate than abdominal ultrasonography for diagnosing ovarian cyst torsion. The combination of both methods enhances diagnostic precision, offering significant benefits for early diagnosis and treatment planning.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2491455"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Letter to the editor: \"Diagnostic capacity and interobserver variability in FIGO, ACOG, NICE and Chandraharan cardiotocographic guidelines to predict neonatal acidemia\" The authors should reconsider their conclusions.","authors":"Luis Mariano Esteban, Ricardo Savirón-Cornudella","doi":"10.1080/14767058.2025.2501699","DOIUrl":"https://doi.org/10.1080/14767058.2025.2501699","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2501699"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial imbalances linked to early pregnancy loss: a comparative analysis of vaginal microbiota.","authors":"Lijie Wang, Ying Chen, Qi Wang, Fang Wang","doi":"10.1080/14767058.2025.2496787","DOIUrl":"https://doi.org/10.1080/14767058.2025.2496787","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the role and related functions of vaginal microbiota in early pregnancy loss.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study was a case-control study with a comparison group (reference group). We recruited 178 women, including 73 who had experienced at least one early clinical pregnancy loss and 105 patients with one live birth and no history of pregnancy loss. Data on demographics, disease history, menstrual and reproductive history was collected. The case group patients were sampled immediately upon presenting with pregnancy loss at their first visit. The reference group patients underwent samples when they chose to participate voluntarily. All vaginal discharge was performed DNA Preparation and Metagenomics Sequencing. DNA extraction was performed using the phenol/trichloromethane method and the DNA fragments were then size-selected to 300-700 bp using magnetic beads. The selected fragments were repaired and ligated with indexed adaptors. The captured DNA was amplified again by PCR and circularized to create a single-stranded circular (ssCir) library. The ssCir library was subsequently amplified through rolling circle amplification (RCA) to produce DNA nanoballs (DNBs). The DNBs were then loaded onto a flow cell and sequenced using the DNBSEQ Platform. Nonparametric tests, including Kruskal-Wallis and Wilcoxon tests, were employed. Relative abundance between groups was compared, and differential species selection was performed using the LEfSe software with linear discriminant analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;1. PCoA analysis based on Bray-Curtis distances at the species level revealed a difference between the groups (&lt;i&gt;p&lt;/i&gt; = 0.011). At the genus level, α-diversity, assessed using the Shannon, Simpson, and Inverse Simpson indices, indicated higher bacterial richness and diversity in the control group (Shannon: mean 0.554 vs. 0.383, &lt;i&gt;p&lt;/i&gt; = 0.0044; Simpson: mean 0.254 vs. 0.179, &lt;i&gt;p&lt;/i&gt; = 0.0043; Inverse Simpson: mean 1.636 vs. 1.414, &lt;i&gt;p&lt;/i&gt; = 0.0043); At the genus level, 107 microbial genera were identified, 18 of which displayed statistically significant differences. At the species level, 23 microbial species showed significant differences between the two groups. 2. We analyzed the differences in the most abundant phyla, genera, and species, with a particular focus on the top 20 most abundant genera and species. Firmicutes and Proteobacteria were significantly more prevalent among patients with pregnancy loss (PL). Among the top 20 most abundant genera, Streptococcus and Porphyromonas were significantly more abundant in patients with PL, whereas Bifidobacterium was significantly more prevalent in the reference group. Among the 20 most abundant species, Lactobacillus crispatus was significantly more prevalent in patients with PL, whereas common in the control group. 3. Principal Coordinates Analysis (PCoA) of Bray-Curtis distances, highlight their distinct clustering patterns, suggesting a","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2496787"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous conversion of fetal heart block to sinus rhythm post externalized pacemaker placement in an undiagnosed mother with lupus antibodies.","authors":"Joseph Repicky, Jyoti Gur, Steven Fishberger, Craig Byrum, Lauren Tague","doi":"10.1080/14767058.2024.2428390","DOIUrl":"10.1080/14767058.2024.2428390","url":null,"abstract":"<p><p>The incidence for congenital heart block is estimated as high as 1 in 15,000 live births. Up to 90% of cases of congenital heart block, in which there is no anatomical abnormalities, are attributed to maternal systemic lupus erythematous or Sjögren's disease. 50% of these mothers are asymptomatic at time of diagnosis. The post-natal cardiac manifestations have been felt to be irreversible. In this article we present, to our knowledge, the first case of spontaneous conversion of immune mediate 3^rd degree heart block to sinus rhythm postnatally.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2428390"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between a history of induced abortion for nonmedical reasons and maternal and neonatal perinatal outcomes: a retrospective cohort study.","authors":"Siqi Zhang, Chunxia Lu, Qing Zhao, Yuxin Xiang, Weichong He, Yong Qu, Yujiao Zhang, Wenbin Dong, Xiaoping Lei","doi":"10.1080/14767058.2025.2466207","DOIUrl":"10.1080/14767058.2025.2466207","url":null,"abstract":"<p><strong>Introduction: </strong>Following the implementation of the universal two-child policy in China, many multiparous women who had a history of induced abortion gave birth again. However, there is a lack of studies exploring the associations between induced abortion for nonmedical reasons and maternal and neonatal perinatal complications.</p><p><strong>Methods: </strong>In this retrospective cohort study, the participants were multiparous women who gave birth to singleton babies at or after 28 weeks of gestation between 1 December 2015, and 1 December 2020. The exposure factor was a maternal history of induced abortion for nonmedical reasons. Logistic regression models were used to adjust for potential confounding factors, and adjusted odds ratios (<i>ORs</i>) and 95% confidence intervals (<i>CIs</i>) were calculated for maternal and neonatal perinatal outcomes. The dose-effect relationships between the number of induced abortions for nonmedical reasons and adverse outcomes were tested by the Cochran-Armitage trend test (<i>p</i> for trend). Stratified analyses were conducted to test the robustness of the results in subgroups with different maternal ages or interpregnancy intervals.</p><p><strong>Results: </strong>There were 3985 multiparous women with a history of induced abortion for nonmedical reasons and 1823 multiparous women without such a history. Compared to women without such a history, women with a history of induced abortion for nonmedical reasons had increased risks of cesarean section (adjusted <i>OR</i>, 1.44; 95% <i>CI</i>: 1.23 - 1.69), placenta-related complications (adjusted <i>OR</i>, 2.14; 95% <i>CI</i>: 1.68 - 2.72), uterine-related complications (adjusted <i>OR</i>, 1.24; 95% <i>CI</i>: 0.97 - 1.59), HDP (adjusted <i>OR</i>, 1.49; 95% <i>CI</i>: 1.16 - 1.93), and preterm birth (adjusted <i>OR</i>, 1.24; 95% <i>CI</i>: 1.05 - 1.48) in subsequent pregnancy. In addition, there were dose-effect relationships between the number of induced abortions and the number of cesarean sections (<i>P</i>_trend <.001), placenta-related complications (<i>P</i> _trend <.001), uterine-related complications (<i>P</i>_trend =.016), HDP (<i>P</i>_trend =.0003), and preterm birth (<i>P</i> _trend =.0006). Similar trends were observed in most subgroups with different maternal ages or interpregnancy intervals.</p><p><strong>Conclusions: </strong>A history of induced abortion for nonmedical reasons was associated with increased risks of maternal and neonatal perinatal complications. Furthermore, dose-effect relationships were observed for these associations.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2466207"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for emergency department visits and readmissions for postpartum hypertension.","authors":"Jenny Y Mei, Sabrina Alexander, Hector E Muñoz, Aisling Murphy","doi":"10.1080/14767058.2025.2451662","DOIUrl":"10.1080/14767058.2025.2451662","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Postpartum hypertension accounts for 15 to 20% of postpartum Emergency Department (ED) visits and readmissions in the United States. Postpartum readmission is a quality metric and target of quality improvement as it indicates poor control of hypertension and can portend increased morbidity. We aim to evaluate risk factors for postpartum ED visits and readmissions for hypertension.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a retrospective cohort study of all birthing patients with peripartum hypertension at a single tertiary care center over a 5-year period (2017-2022). Inclusion criteria were age 18 years or above, existing diagnosis of chronic hypertension or hypertensive disease of pregnancy diagnosed during the intrapartum or postpartum course, and both delivery and ED visit or readmission at the study institution. Maternal baseline and intrapartum characteristics were chart abstracted. Primary outcome was ED visit or readmission (EDR) for postpartum hypertension. Patients who had EDR within 42 days of delivery were compared to those who underwent routine outpatient surveillance. For all analyses, &lt;i&gt;p&lt;/i&gt; values were two-way, and the level of statistical significance was set at &lt;i&gt;p&lt;/i&gt; &lt; 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 16,162 patients who gave birth during the study period, 2403 (14.9%) patients met the definition of peripartum hypertension. 218 (9.1%) presented to the ED or were readmitted for hypertension. Risk factors for EDR were as follows: maternal age ≥40 years (22.9% vs 15.3%, &lt;i&gt;p&lt;/i&gt; = 0.003), prenatal aspirin use (6.9% vs 3.9%, &lt;i&gt;p&lt;/i&gt; = 0.039), cesarean delivery (42.7% vs 35.8%, &lt;i&gt;p&lt;/i&gt; = 0.044), chronic hypertension (37.2% vs 31.6%, &lt;i&gt;p&lt;/i&gt; = 0.029), preeclampsia with severe features (32.6% vs 15.6%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), postpartum hemorrhage (22.9% vs 12.0%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), and intrapartum need for intravenous anti-hypertensives (23.9% vs 3.3%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Factors at discharge that increased risk of EDR included prescription of anti-hypertensives at discharge (27.5% vs 8.6%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and having &gt;50% elevated blood pressures within the 24 h prior to discharge (16.5% vs 11.9%, &lt;i&gt;p&lt;/i&gt; = 0.046). In a multivariable logistic regression controlling for prenatal aspirin use, mode of delivery, postpartum hemorrhage, and chorioamnionitis, a higher risk of EDR remained for maternal age ≥40 years (aOR, 1.56; 95% confidence interval (CI), 1.11-2.20; &lt;i&gt;p&lt;/i&gt; = 0.011), PO anti-hypertensives at discharge (aOR, 4.05; 95% CI, 2.86-5.73; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), preeclampsia with severe features (aOR, 2.50; 95% CI, 1.83-3.42; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), and history of IV anti-hypertensive exposure (aOR, 9.30; 95% CI, 6.20-13.95; &lt;i&gt;p&lt;/i&gt; &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Maternal age of 40 years and above, chronic hypertension, preeclampsia with severe features, prescription of anti-hypertensives on discharge, and elevated blood pressures leading up to discharge are associated with postpa","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2451662"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}