The association between iron supplementation during pregnancy and the risk of childhood leukemia: a meta-analysis of case-control studies.

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Maternal-Fetal & Neonatal Medicine Pub Date : 2025-12-01 Epub Date: 2025-03-05 DOI:10.1080/14767058.2025.2474268

Mahsa Dabir, Pedram Pam, Mehrdad Jamali, Fakhredin Saba, Zohreh Ghoreishi

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引用次数: 0

Abstract

Objectives: Acute leukemia (AL) presents significant health challenges, particularly in children, and iron plays a critical role in cellular processes that could influence cancer development. The study was motivated by the need to clarify the potential role of iron supplementation during pregnancy in influencing the risk of developing childhood leukemia.

Materials and methods: This meta-analysis adhered to PRISMA guidelines and systematically searched PubMed, Scopus, and Web of Science databases up to April 2024 for relevant observational studies. Inclusion criteria focused on case-control studies assessing the relationship between iron supplementation during pregnancy and leukemia risk, reporting odds ratios (ORs) with 95% confidence intervals (CIs). Data extraction and quality assessment were performed independently by two researchers using the Newcastle-Ottawa Scale (NOS). Statistical analysis involved calculating overall relative risk (RR) using a random-effects model and assessing heterogeneity through Cochran's Q test and the I² statistic. Publication bias was evaluated using Egger's and Begg's tests.

Results: The study analyzed data from 9 studies with 12 data sets involving a total of 4281 participants (2327 cases and 1954 controls). The findings indicated no significant association between iron supplementation during pregnancy and the overall risk of childhood leukemia (OR:1.01; 95% CI: 0.84-1.21, I2 = 63.2%). Also, no relationship was found between receiving iron supplements during pregnancy and the risk of AML (OR:1.01; 95% CI: 0.84-1.21, I2 = 56.6%) and ALL (OR:1.00; 95% CI: 0.81-1.24, I2 = 67.3%).

Conclusion: This study found no significant association between iron supplementation during pregnancy and AL risk among case-control studies. Further research is needed to explore the potential influence of genetic and environmental factors on this relationship.

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怀孕期间补充铁与儿童白血病风险之间的关系：病例对照研究的荟萃分析。

目的：急性白血病（AL）提出了重大的健康挑战，特别是在儿童中，铁在可能影响癌症发展的细胞过程中起着关键作用。这项研究的动机是需要澄清怀孕期间补充铁在影响儿童白血病风险方面的潜在作用。材料和方法：本荟萃分析遵循PRISMA指南，系统检索PubMed、Scopus和Web of Science数据库，检索到2024年4月的相关观察性研究。纳入标准侧重于评估妊娠期间补铁与白血病风险之间关系的病例对照研究，报告95%置信区间（ci）的优势比（ORs）。数据提取和质量评估由两名研究人员使用纽卡斯尔-渥太华量表（NOS）独立进行。统计分析包括使用随机效应模型计算总体相对风险（RR），并通过Cochran’s Q检验和I2统计量评估异质性。使用Egger’s和Begg’s检验评估发表偏倚。结果：本研究分析了9项研究的数据，涉及12个数据集，共涉及4281名参与者（2327例病例和1954例对照）。研究结果显示，孕期补铁与儿童白血病总体风险之间无显著关联(OR:1.01；95% ci: 0.84-1.21, i2 = 63.2%)。此外，在怀孕期间接受铁补充剂与AML风险之间没有关系(OR:1.01；95% CI: 0.84-1.21, I2 = 56.6%)和ALL (OR:1.00；95% ci: 0.81-1.24, i2 = 67.3%)。结论：在病例对照研究中，本研究发现孕期补铁与AL风险之间无显著关联。需要进一步研究遗传和环境因素对这种关系的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Maternal-Fetal & Neonatal Medicine 医学-妇产科学

CiteScore

4.40

自引率

0.00%

发文量

217

审稿时长

2-3 weeks

期刊介绍： The official journal of The European Association of Perinatal Medicine, The Federation of Asia and Oceania Perinatal Societies and The International Society of Perinatal Obstetricians. The journal publishes a wide range of peer-reviewed research on the obstetric, medical, genetic, mental health and surgical complications of pregnancy and their effects on the mother, fetus and neonate. Research on audit, evaluation and clinical care in maternal-fetal and perinatal medicine is also featured.