Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Statement of Retraction: Comparison of intravenous ferrous sucrose and oral ferrous sulphate in treatment of postpartum iron deficiency anemia.","authors":"","doi":"10.1080/14767058.2025.2521872","DOIUrl":"https://doi.org/10.1080/14767058.2025.2521872","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2521872"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal ultrasound for the diagnosis of the cerebellar abnormalities: a meta-analysis.","authors":"Zhen Sun, Yanqiu Chen, Qichen Su","doi":"10.1080/14767058.2025.2453997","DOIUrl":"10.1080/14767058.2025.2453997","url":null,"abstract":"<p><strong>Objective: </strong>Fetal cerebellar abnormalities are associated with neurodevelopmental disorders and structural brain malformations. Accurate and early diagnosis is crucial for prenatal counseling and planning postnatal interventions. While prenatal ultrasound is a key tool for detecting fetal brain abnormalities, variations in diagnostic accuracy across studies necessitate a systematic evaluation of its effectiveness in diagnosing cerebellar abnormalities.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across major databases to identify relevant studies on prenatal ultrasound for diagnosing cerebellar anomalies. Inclusion criteria included studies with clear diagnostic outcomes, diverse patient populations, and standardized ultrasound protocols. Meta-analytic techniques were employed to assess overall diagnostic accuracy, sensitivity, specificity, and heterogeneity using Meta Disk. The quality of the included studies was evaluated using the QUADAS-2 tool.</p><p><strong>Results: </strong>The meta-analysis included fifteen studies involving 1,902 fetuses with suspected cerebellar abnormalities. The pooled sensitivity and specificity of prenatal ultrasound were 0.83 (95% CI: 0.80-0.86) and 0.97 (95% CI: 0.96-0.98), respectively. The positive likelihood ratio was 7.96 (95% CI: 3.23-19.64), the negative likelihood ratio was 0.18 (95% CI: 0.09-0.36), and the odds ratio was 46.76 (95% CI: 14.06-155.53). The combined area under the curve (AUC) reached 0.93, indicating robust diagnostic performance. Heterogeneity was observed, influenced by factors such as gestational age at screening, operator expertise, and ultrasound equipment quality.</p><p><strong>Conclusions: </strong>Prenatal ultrasound is a reliable tool for detecting cerebellar abnormalities with high sensitivity and specificity. However, variability in diagnostic performance suggests the need for standardized protocols and advanced imaging techniques to enhance accuracy. Future research should focus on integrating multiple imaging modalities to optimize prenatal screening outcomes.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2453997"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor: spontaneous conversion of fetal heart block to sinus rhythm post-externalized pacemaker placement in an undiagnosed mother with lupus antibodies.","authors":"Murad Gezer","doi":"10.1080/14767058.2025.2512440","DOIUrl":"https://doi.org/10.1080/14767058.2025.2512440","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2512440"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidance for the management of fetal growth restriction: an expert review.","authors":"Cecilia Villalaín, Ignacio Herraiz, Ranjit Akolekar, Francesc Figueras, Fatima Crispi, Giuseppe Rizzo, Ilenia Mappa, Manel Mendoza, Teresa Del Moral, Tamara Stampalija, Tullio Ghi, Alberto Galindo","doi":"10.1080/14767058.2025.2526111","DOIUrl":"10.1080/14767058.2025.2526111","url":null,"abstract":"<p><strong>Background: </strong>Fetal growth restriction (FGR) is associated to increased perinatal morbidity and mortality. Prenatal identification and subsequent intervention can improve outcomes. Our aim was to provide recommendations of the management of FGR reaching all possible scenarios (high-income and low-middle-income countries, referral as well as referring centers) but not to stablish a universal standard of care.</p><p><strong>Methods: </strong>an organizational committee assigned a panel of experts' different topics regarding clinical practice management of FGR. Evidence was prioritized according to the GRADE classification system, with the highest levels of evidence given the greatest weight and organized in practical approach. Although most diagnostic, screening and management options are described, our aim is not to recommend all but to highlight the evidence for each one and give our recommendations for their use understanding that not all settings will have every option available.</p><p><strong>Results: </strong>We provide a practical approach to allow optimization of timing and mode of delivery in order to avoid unnecessary or excessive interventions and improve perinatal outcomes.</p><p><strong>Conclusion: </strong>This document aims to provide guidance for the clinical management of pregnancies with suspected FGR.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2526111"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What trans-vaginal ultrasound parameters are better correlated with a shorter labor induction to vaginal delivery interval? A prospective observational cohort study.","authors":"Serena Xodo, Maria De Martino, Giovanni Baccarini, Elisa Rizzante, Valentina Zanin, Stefania Liviero, Lisa Celante, Marta Angelini, Lorenza Driul","doi":"10.1080/14767058.2025.2522997","DOIUrl":"10.1080/14767058.2025.2522997","url":null,"abstract":"<p><strong>Objective: </strong>During the induction of labor (IOL) planning, it is important to provide patients with information regarding how long the induction process might take. This study aimed to determine which ultrasonographic cervical parameters are independently associated with a shorter IOL-to-vaginal delivery (VD) interval.</p><p><strong>Methods: </strong>This was a prospective observational cohort study. For enrollment purposes, women with single pregnancy, fetus in cephalic presentation, age between 18 and 45 years and good Italian proficiency were included. Women with a history of uterine surgery, in active labor, and cases of fetal growth abnormalities were excluded. The enrolled women underwent a transvaginal ultrasound within 7 days from the scheduled labor induction in order to measure the following parameters: the cervical length (CL), the utero-cervical angle (UCA), the cervical sliding sign (CSS) and the cervical consistency index (CCI). Before starting the labor induction process, patients were also digitally evaluated, acquiring the Bishop score (BS). The method of IOL was determined based on the BS. Ultrasound assessments and Bishop score evaluations were performed independently and in a blinded manner to reduce bias. Statistical analyses were performed using STATA 18.0.</p><p><strong>Results: </strong>Between June 2023 and November 2024, 400 women were nonconsecutively enrolled in the study. Of these, 83 experienced spontaneous labor before the scheduled labor induction, resulting in 317 women who underwent IOL. The median IOL-to-VD interval was 1264 min (IQR 694-1940). Univariable regression analysis demonstrated significant associations between the IOL-to-VD interval and CL (β = 29.15; 95% CI 16.16, 42.23; <i>p</i> < 0.001), CCI (β = 12.60; 95% CI 3.93, 21.24; <i>p</i> = 0.004), and BS (β = -211.15; 95% CI -271.59, -150.71; <i>p</i> < 0.001). Multivariable analysis confirmed independent associations with CL (β = 13.89; 95% CI 0.35,27.44; <i>p</i> = 0.044) and BS (β = -183.96; -249.66, -118.27; <i>p</i> < 0.001). When stratified by parity, univariable regression in parous women showed significant associations between the IOL-to-VD interval and CL (β = 37.44; 95% CI 20.17, 54.72; <i>p</i> < 0.001), CSS (β = -582; 95% CI -1014.05, 151.20; <i>p</i> = 0.009), CCI (β = 15.43; 95% CI 1.75, 29.11; <i>p</i> = 0.027), and BS (β = -227.96; -315.57, -140.35; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>In summary, among the evaluated parameters, CL consistently showed the strongest and most independent association with a shorter IOL-to-VD interval across analyses, supporting its role as the most reliable predictor. Future research should explore multivariable prediction models incorporating various ultrasonographic cervical parameters to enhance the predictive accuracy of transvaginal ultrasound.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2522997"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of hypertensive disorders of pregnancy on fetal myocardial remodelling and cardiac function assessed by two-dimensional speckle tracking imaging.","authors":"Yanhong Zhang, Lisi Zhang, Congxin Sun, Guihong Chen, Wei Zhao, Na Li, Jing Ma, Jianli Xue, Pin Wang, Wei Xiang, Shuping Ge, Yanju Wang","doi":"10.1080/14767058.2025.2531146","DOIUrl":"https://doi.org/10.1080/14767058.2025.2531146","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To assess the effects of hypertensive disorders of pregnancy on fetal myocardial remodeling and cardiac function applying two-dimensional speckle tracking techniques.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This is a case-control study with a 1:1 ratio, including fetuses with normal development and those exposed to hypertensive disorders of pregnancy. A total of 108 fetuses were included in the study, comprising 54 in the case group and 54 in the control group. A series of parameters, including ventricular size, spherical index, ejection fraction, myocardial strain, fractional change in ventricular area, and short axis shortening rate, were measured using Fetal HQ software with two-dimensional speckle tracking imaging. Statistical methods were employed to compare the case and control groups, with the aim of assessing the impact of hypertensive disorders of pregnancy on fetal myocardial remodeling and cardiac function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;(1) The end-diastolic longitudinal diameter and area of the right ventricle in the HDP group were statistically significantly smaller than those in the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). However, no statistically significant differences were observed in the longitudinal and transverse diameters and areas of the four-chambered heart, as well as the longitudinal diameter and area of the left ventricle, when comparing the two groups (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). (2) In terms of fetal cardiac morphology, the right ventricular segments 2-7 SI in the HDP group were observed to be smaller than those in the control group, with a statistically significant difference (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Conversely, the differences between the two groups in right ventricular segment 1, right ventricular segments 8-24 SI, left ventricular segments 24 SI and four-chambered cardiac GSI were not statistically significant (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). (3) In terms of fetal ventricular systolic function, the HDP group exhibited lower left ventricular ejection fraction and cardiac output, right ventricular GLS, left and right ventricular FAC, left ventricular FS in segments 10-24, and right ventricular FS in segments 11-16 than the control group. These differences were statistically significant (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Furthermore, the left ventricular GLS, GCS, and right ventricular free wall St, left ventricular segments 1-9, and right ventricular segments 1-10 and 4-chamber GSI were observed to be lower than those of the control group. The GLS, GCS, and free wall St of the right ventricle, as well as the GLS, GCS, and free wall St of the left ventricle (segments 1-9) and the right ventricle (segments 1-10 and 12-24) were also evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Hypertensive disorders of pregnancy (HDP) have been demonstrated to affect fetal myocardial remodeling and contractile function, with a more pronounced impact observed on the right ventricle compared to the left ventricle. Two-dimensional speckle tracking technology offers ","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2531146"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-HDL/HDL cholesterol ratio (NHHR) as a novel predictor of gestational diabetes mellitus: a NHANES-based cross-sectional study.","authors":"Fangfang Shan, Mengmeng Ye, Haochan Wu, Hui Zhou, Zhaoxia Zhong, Yibo Wu","doi":"10.1080/14767058.2025.2516261","DOIUrl":"10.1080/14767058.2025.2516261","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between the non-HDL/HDL cholesterol ratio (NHHR) and gestational diabetes mellitus (GDM) risk, and assess NHHR's predictive utility as a novel biomarker in U.S. pregnant women.</p><p><strong>Patients and methods: </strong>A cross-sectional analysis of 1590 pregnant women from NHANES (1999-2018) was conducted. GDM was defined as fasting glucose ≥5.1 mmol/L. NHHR was calculated as (total cholesterol - HDL-C)/HDL-C. Multivariable logistic regression, restricted cubic spline (RCS) models, and ROC analysis were used to evaluate associations, threshold effects, and diagnostic accuracy, incorporating NHANES sampling weights.</p><p><strong>Results: </strong>The highest NHHR quartile was associated with 4.48-fold higher odds of GDM (95% CI: 2.72-7.39, <i>p</i> < 0.001) after full adjustment. A nonlinear dose-response relationship with a threshold at NHHR = 2.267 was identified; above this threshold, GDM odds rose sharply (OR = 2.6, 95% CI: 2.0-3.3). Subgroup analyses confirmed consistency across age, ethnicity, and BMI (<i>p</i> for interaction > 0.05). NHHR demonstrated limited standalone diagnostic accuracy (AUC = 0.549, 95% CI: 0.510-0.587).</p><p><strong>Conclusion: </strong>While NHHR demonstrates limited standalone diagnostic accuracy (AUC = 0.549), its specificity for metabolic dysregulation suggests potential as a complementary biomarker in multi-parameter models.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2516261"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal membrane oxygenation in pregnancy and the post-partum period: a systematic review and meta-analysis.","authors":"Sijie Lu, Yantao Zhang, Shilin Wei, Jian Li, Mingming Li, Junjie Ying, Dezhi Mu, Yujun Shi, Yongnan Li, Xiangyang Wu","doi":"10.1080/14767058.2025.2457002","DOIUrl":"10.1080/14767058.2025.2457002","url":null,"abstract":"<p><strong>Objective: </strong>There is an increase in the application data of Extracorporeal Membrane Oxygenation (ECMO) in perinatal women, particularly since the outbreak of coronavirus disease 2019. Therefore, we reviewed publications on the use of ECMO in pregnant and postpartum women and analyzed the maternal and fetal outcomes, updated the progress of ECMO in perinatal women.</p><p><strong>Methods: </strong>We conducted a systematic literature search across PubMed, EMBASE, Cochrane Library, and the International Clinical Trials Registry (ICTRP), yielding 30 eligible clinical studies that investigated the application of ECMO during pregnancy. A comprehensive data extraction process was implemented to retrieve information from these selected studies. A single rate analysis on material survival, material harmonic compilations, and fetus survival were performed by R software.</p><p><strong>Results: </strong>Of the 1460 women included, our primary outcome was maternal survival: 74.4% (95% confidence interval [CI]: 67.8%-81.1%). Among them, the survival rate of VV ECMO patients was 83.6% (95% confidence interval [CI]: 76.4%-90.8%); the survival rate of VA ECMO patients was 62.8% (95% confidence interval [CI]: 48.7%-76.8%). The secondary outcomes were maternal hemorrhagic complications: 34.8% (95% [CI]: 24.1%-45.5%), and fetal survival: 73.2% (95% [CI]: 62.0%-84.4%).</p><p><strong>Conclusions: </strong>Our analysis revealed that the outcomes of ECMO (both type) use in pregnant patients may be comparable or superior to those observed in non-pregnant cohorts. Moreover, patients treated with VV ECMO exhibited a significantly higher survival rate compared to those on VA ECMO.</p><p><strong>Details of registration: </strong>The protocol for this systematic review was registered on INPLASY (2022110036) in 11 November 2022.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2457002"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimester-specific thyroid function markers and gestational diabetes risk: evidence from a tertile-based cohort of euthyroid pregnancies.","authors":"Erkan Sağlam, Serenat Eris Yalçın, Mustafa Raşit Özler, Bekır Siddik Yılmaz, Nuray Nerez","doi":"10.1080/14767058.2025.2535467","DOIUrl":"https://doi.org/10.1080/14767058.2025.2535467","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and the fT3/fT4 ratio-measured during the first and second trimesters-are associated with the development of gestational diabetes mellitus (GDM) in euthyroid pregnant women. Their predictive value was evaluated using tertile-based logistic regression.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, 200 euthyroid pregnant women without thyroid disease or treatment history were included. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Thyroid parameters were measured in the first (9-14 weeks) and second (22-28 weeks) trimesters. Tertile-based univariate and multivariate logistic regression analyses were conducted, adjusting for maternal age, BMI, smoking, and family history of diabetes.</p><p><strong>Results: </strong>Women in the highest tertile (tertile 3) of first-trimester fT3 (>3.61 pg/mL) and fT3/fT4 ratio (>0.27) had a significantly increased risk of GDM (adjusted OR = 9.72 and 4.05, respectively; <i>p</i> < 0.001). Conversely, being in the highest tertile of TSH (tertile 3 > 2.34 µIU/mL) during both trimesters was associated with a significantly lower risk of GDM (OR = 0.32-0.04; <i>p</i> < 0.001). TSH levels increased, while fT3 and fT4 levels decreased significantly across trimesters (<i>p</i> < 0.001). GDM was associated with lower gestational age at delivery (<i>p</i> < 0.001), increased NICU admission (<i>p</i> = 0.041), and a modest positive correlation between first-trimester fT3/fT4 ratio and birth weight (<i>r</i> = 0.15; <i>p</i> = 0.034).</p><p><strong>Conclusion: </strong>Being in the highest tertiles of fT3 and fT3/fT4 ratio during the first trimester-despite remaining within the euthyroid range-was linked to elevated GDM risk. In contrast, the highest TSH tertiles in both trimesters were associated with a decreased risk. These findings suggest that even subtle thyroid hormone variations within normal limits may influence glucose metabolism and support the utility of early thyroid function evaluation for predicting gestational metabolic risk.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2535467"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of preterm premature rupture of membranes on neonatal outcomes in low-birth-weight infants: a retrospective study.","authors":"Xianyun Song, Yi Yao, Yunqian Chi, Zihan Zhang, Yunhe Wang, Zhengwei Bei, Xingying Zhang, Wei Hao","doi":"10.1080/14767058.2025.2548987","DOIUrl":"https://doi.org/10.1080/14767058.2025.2548987","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the effect of preterm premature rupture of membranes (PPROM) on neonatal outcomes in low-birth-weight infants.</p><p><strong>Methods: </strong>We included premature infants born in our hospital and divided them into PPROM group and non-PPROM group. Maternal and neonatal data were collected, and follow-up assessments were performed at 3, 6, and 9 months of corrected age.</p><p><strong>Results: </strong>The PPROM group had significantly lower birth weights, gestational ages, higher maternal infection rates, longer hospital stays, and higher complication rate (<i>p</i> < 0.001). PPROM, 5-minute Apgar score <7, and birth weight <1500 g was significant risk factors for complications (<i>p</i> < 0.001). Birth weight <1500 g, sepsis, premature encephalopathy, asphyxia and necrotizing enterocolitis (<i>p</i> < 0.01) were significant predictors of death. Infants with PPROM duration >7 days had the highest mortality rate and lower mental development index scores at 3 months (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>PPROM significantly impacts neonatal outcomes in low-birth-weight infants, leading to higher complication rates and longer hospital stays, which is associated with high risk of neonatal complication.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2548987"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}