Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Effectiveness of the Triple P Procedure and its modifications on reducing the blood loss and peripartum hysterectomy rates in women with Placenta Accreta Spectrum (PAS): a review of published literature.","authors":"Ilenia Mappa, Silvia Espuelas Malon, Francesco D'Antonio, Edwin Chandraharan","doi":"10.1080/14767058.2025.2452920","DOIUrl":"10.1080/14767058.2025.2452920","url":null,"abstract":"<p><strong>Background: </strong>Placenta Accreta Spectrum (PAS) disorders has been reported to be associated with a maternal mortality rate of 7-10%, worldwide, and many women who survive, experience life changing morbidity. Triple P procedure (<b>p</b>- perioperative placental localization and incision on the myometrium above the upper border of the placenta; <b>p</b>- pelvic devascularisation; and <b>p</b>-placental non-separation and myometrial excision) was developed in 2010 as a novel conservative alternative to peripartum hysterectomy to avoid severe maternal morbidity and mortality). There have been several modifications to the original Triple P Procedure to achieve \"pelvic devascularisation\" based on locally available resources.</p><p><strong>Objective: </strong>To determine the effectiveness of the Triple P Procedure and its modifications on reducing the blood loss and the rate of peripartum hysterectomy in women who were diagnosed to have placental accreta spectrum (PAS) by reviewing the published literature.</p><p><strong>Materials and methods: </strong>PubMed, Embase and Google Scholar Search searches were made using \"Triple P\" and \"Modified Triple P.\" Papers selected were assessed independently for content, data extraction and analysis. The following parameters were included for the analysis: total number of cases, total EBL, need for blood transfusion, injury to adjacent pelvic organs (urinary bladder, ureter, bowel), need for embolization, admission to intensive care unit (ICU), post-operative in-patient hospital stay, peripartum Hysterectomy, for \"Modified\" Triple P Procedure, the nature of the modification.Study characteristics were extracted using a predesigned data extraction table.</p><p><strong>Results: </strong>The literature search identified 6 articles on the Triple P Procedure and 8 articles on the modified Triple P Procedure which were deemed eligible for analysis and comparison, based on the inclusion criteria. 75 patients had the Triple P procedure with an estimated mean blood loss of 2.31 L and a blood transfusion rate of 52%. The bladder injury rate was only 1.3%. None of the patients had a peripartum hysterectomy. Overall, 654 patients had the Modified Triple P procedure with an estimated mean blood loss of 1.4 L and a blood transfusion rate of 64.5%. The mean hospital stay was 3.86 days and 6.1% had a peripartum hysterectomy.</p><p><strong>Conclusion: </strong>The Triple P Procedure and the Modified Triple P procedure are associated with lower estimated blood loss as compared to the reported rates with a peripartum hysterectomy. The Triple P Procedure was associated with lower rates of inadvertent injuries to the bladder and ureters as compared to the Modified Triple P Procedure and reported rates with peripartum hysterectomy. Both the Triple P and the Modified Triple P Procedure are associated with very low rates of peripartum hysterectomy (0% and 6.1%, respectively).</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2452920"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world use of a vacuum-induced hemorrhage-control device in births <34 weeks gestational age.","authors":"Kara M Rood, Angela Bianco, Joseph R Biggio, Marcela C Smid, Hyagriv N Simhan, James Li, Candice Yong, Patricia I Carney, Damien J Croft, Dena Goffman","doi":"10.1080/14767058.2025.2451658","DOIUrl":"10.1080/14767058.2025.2451658","url":null,"abstract":"<p><strong>Introduction: </strong>The Jada System^® is an FDA-cleared vacuum-induced hemorrhage-control device for the control and treatment of abnormal postpartum uterine bleeding or hemorrhage when conservative management is warranted. The instructions for use for Jada contain a warning stating that the safety and effectiveness of the Jada System in delivery at a gestational age less than 34 weeks or, if multiples, uterus judged less than 34 weeks size, have not been established. While the primary analysis of the RUBY registry, an 800 subject post-approval RWE study of the usage of Jada, included 50 individuals who had preterm births less than 34 weeks gestational age (wGA), the safety and outcomes were not evaluated specifically for less than 28 wGA and 28 to less than 34 wGA subgroups.</p><p><strong>Methods: </strong>We conducted a descriptive subgroup analysis of the real-world RUBY registry to assess the safety and effectiveness of Jada for postpartum hemorrhage management in preterm births less than 34 weeks (less than 28 wGA and 28 to less than 34 wGA). Of the 50 individuals treated, 24 had vaginal births and 26 had cesarean births.</p><p><strong>Results: </strong>Treatment success rates were 85.7% at less than 28 wGA (81.8% vaginal [9/11], 100% cesarean [3/3]) and 88.9% at 28 to less than 34 wGA (100% vaginal [13/13], 82.6% cesarean [19/23]). No maternal deaths, uterine perforations, device expulsions, or serious adverse device effects (ADEs) were reported in either subgroup. Two nonserious ADEs were reported in 1 individual (endometritis and bacterial vaginosis); 2 individuals required hysterectomy (1 vaginal, 1 cesarean).</p><p><strong>Conclusion: </strong>Results for the less than 28 wGA and 28 to less than 34 wGA subgroups were consistent with the overall less than 34 wGA subgroup, which was previously shown to be consistent with births ≥34 wGA; however, continued attention to uterine size is warranted before device placement in births less than 34 wGA.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov; NCT04995887.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2451658"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics in patients with unexplained recurrent spontaneous abortion and the impact on immune, coagulation, and inflammatory profiles.","authors":"Xi Wen, Xiaoying Yan, Yu Xiao, Jingyi Wang, Shan Jiang, Tong Liu, Liane Zhou","doi":"10.1080/14767058.2025.2477069","DOIUrl":"10.1080/14767058.2025.2477069","url":null,"abstract":"<p><strong>Objective: </strong>Unexplained Recurrent Spontaneous Abortion (RSA) impacts the physical and psychological well-being of women of reproductive age. This study aimed to reveal the potential mechanisms behind unexplained RSA from the perspective of glucose and lipid metabolic profiles before conception and their relationship with immune, coagulation, and inflammatory markers.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 100 patients with unexplained recurrent spontaneous abortion at our gynecology department from June 2022 to June 2023. According to whether abnormal glucose and lipid metabolism exist, patients were grouped into normal group and abnormal group. The study compared the glucose and lipid metabolic characteristics, immune status, coagulation, and inflammatory parameters between two groups.</p><p><strong>Results: </strong>The Abnormal Group exhibited higher fasting blood glucose, 2-hour oral glucose tolerance test, homeostatic model assessment of insulin resistance, total cholesterol, and LDL cholesterol, along with lower levels of HDL cholesterol. Additionally, alterations in immune profile parameters, including lower levels of CD4+ T cells, CD8+ T cells, B cells, NK cells, and elevated IL-6, were observed in the Abnormal Group. Regarding coagulation and inflammatory profile parameters, the Abnormal Group demonstrated prolonged prothrombin time, activated partial thromboplastin time, elevated fibrinogen and D-dimer levels, and increased platelet count, along with elevated C-reactive protein, TNF-α, and IL-1β levels. Correlation analysis revealed significant associations between the pre-pregnancy metabolic characteristics and immune, coagulation, and inflammatory profile parameters.</p><p><strong>Conclusion: </strong>Abnormal glucose and lipid metabolism may lead to or exacerbate unexplained RSA in some patients, and therapeutic interventions targeting glucose and lipid metabolism hold promise for improving pregnancy outcomes in this population.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2477069"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of a glycosylated fibronectin test (Lumella^TM) for assessment of impending preeclampsia.","authors":"Gian Carlo Di Renzo, Maurizio Arduini, Jose Luis Bartha, Alizee Froeliger, Jan Stener Jorgensen, Marian Kacerovsky, Pawel Stanirowski, Miroslaw Wielgos, Lina Gao, Michael G Gravett","doi":"10.1080/14767058.2025.2474674","DOIUrl":"10.1080/14767058.2025.2474674","url":null,"abstract":"<p><strong>Objective: </strong>Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality and morbidity, yet difficulties remain in the diagnosis of preeclampsia based on clinical parameters alone. The objective was to assess the performance of a hand-held point-of-care (POC) immunoassay in a clinical environment for glycosylated fibronectin (GlyFn) for the prediction of preeclampsia within 4 weeks of sampling.</p><p><strong>Methods: </strong>Multinational European prospective observational pilot study of predominantly high-risk patients in the second half of pregnancy to assess a point-of-care immunoassay for GlyFn in predicting preeclampsia within 4 weeks of sampling. GlyFn was measured using a second generation hand held POC immunoassay. Results were considered normal for GlyFn concentrations of < 350 µg/mL, positive for GlyFn concentrations of 351-600 µg/mL, and high-positive for GlyFn concentrations > 600 µg/mL.</p><p><strong>Results: </strong>Preeclampsia developed in 16 (19%) of 84 subjects and was associated with a shorter gestational age at delivery 35.3 weeks vs. 37.3 weeks for non-preeclamptics, <i>n</i> = 82; <i>p</i> = 0.001), a higher risk of fetal growth restriction (FGR; 31.2% vs. 10.3% for non-preeclamptics, <i>p</i> = 0.046), and an increased risk of preterm birth < 37 weeks gestation (83.3% vs. 33.3% for non-preeclamptics, (<i>n</i> = 78; <i>p</i> = 0.003). GlyFn positive or high positive was seen in 13/16 (81%) and in 35/68 (51.5%), yielding a sensitivity of 81%, a specificity of 49%, a positive predictive value of 27%, and a negative predictive value of 92%. GlyFn positive or high positive was also associated with preterm birth < 37 weeks in singleton pregnancy non-preeclamptic patients. Preterm birth occurred in 4.8% of those with normal GlyFn, in 26.7% with positive GlyFn, and in 50% of those with high GlyFn in singleton gestations without preeclampsia (<i>p</i> = 0.008).</p><p><strong>Conclusion: </strong>The ability to use this test in a POC format provides a method for practitioners to quickly determine risk for preeclampsia in their pregnant patients and offers an affordable alternative, as a single analyte to other diagnostic or screening tests that require laboratory-based testing or ultrasound equipment. Independent of preeclampsia, an elevated GlyFn was also correlated with preterm delivery and requires further study.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2474674"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis and prenatal diagnosis of 15q11-q13 microduplication syndrome.","authors":"Yijing Ma, Ru Yang, Xin Yan, Xumei Song, Fushou Zhan","doi":"10.1080/14767058.2025.2505752","DOIUrl":"10.1080/14767058.2025.2505752","url":null,"abstract":"<p><strong>Objective: </strong>15q11-q13 microduplication syndrome, a genetic disorder caused by duplications in the 15q11-q13 region, has been associated with autism spectrum disorder (ASD); however, research on chromosome 15 microduplications is scarce. We explored the copy number variant (CNV) characteristics of 15q11-q13 microduplication syndrome, pathogenic mechanisms of ASD-related causative genes in this region, and factors affecting ASD development.</p><p><strong>Methods: </strong>We performed laboratory investigations and data collection on seven cases of 15q11-q13 microduplications, comprising 5 prenatal and 2 postnatal cases, detected using chromosomal microarray analysis (CMA), comparing their CNV characteristics and clinical presentations.</p><p><strong>Results: </strong>Chromosomal karyotyping was not performed in one case, while the results for the others were normal. CMA revealed one case each of a microduplication at 15q11.2q13.3, 15q11.2, 15q13.2q13.3, 15q13.3, and three at 15q11.2q13.1, varying in size from 444 kb to 9.6 Mb. Of the seven confirmed cases, postnatal facial anomalies were present in two male patients (cases 5 and 6), with one exhibiting intellectual disability, speech delay, ASD features, and hypotonia. No significant abnormalities could be observed in the five female patients. Concerning the five prenatal cases, four exhibited an ultrasound testing suggestive of abnormality, one displayed no abnormality on the ultrasound, although the mother of the fetus had a history of adverse pregnancy outcomes. Finally, only case 5 displayed facial deformities after birth. The remaining four fetuses did not retain any abnormality during postnatal follow-up.\"</p><p><strong>Conclusion: </strong>The 15q11-q13 region may be associated with an increased ASD risk, and its clinical phenotype may be related to sex. Our study presents detailed clinical features and molecular genetic data, providing important insights into the link between 15q duplications and ASD and diagnosing and treating the syndrome.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2505752"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational diabetes mellitus and adverse pregnancy outcomes increased on pandemic lockdown: a retrospective analysis.","authors":"Niankun Chen, Shaole Shi, Shanshan Zhao, Lixia Shen, Lingyi Kong, Zanxiong Liang, Shiqin Cai, Haitian Chen, Dongyu Wang, Zilian Wang","doi":"10.1080/14767058.2025.2460180","DOIUrl":"https://doi.org/10.1080/14767058.2025.2460180","url":null,"abstract":"<p><strong>Objectives: </strong>Adverse social contexts, such as lockdowns and disasters during pregnancy, can significantly impact maternal and neonatal outcomes. However, the specific effects on different populations remain unclear. This study aimed to investigate the variations in pregnancy outcomes resulting from the pandemic lockdown and to identify distinct populations in need of targeted intervention.</p><p><strong>Methods: </strong>Women who delivered at our institution spanning from 2017 to 2019 (pre-pandemic) and from 2020 to 2022 (during the pandemic lockdown) were included in this study. A comparison was conducted on maternal and neonatal outcomes across a total of 19,382 singleton pregnancies, with a specific focus on those affected by gestational diabetes mellitus (GDM).</p><p><strong>Results: </strong>As a total of 19,382 singleton pregnant women were included, this study found a significant increase in the incidence rates of GDM with an odds ratio of 1.194 (95%CI: 1.109-1.286, <i>p</i> < .001). Additionally, following the pandemic lockdown, there was an increase in rates of premature birth, premature rupture of membranes, and intrahepatic cholestasis of pregnancy. Further analysis of the GDM cohort revealed a notable rise in the risk of Group B Streptococcus infection and neonatal small for gestational age (SGA). Specifically, GDM patients with a body mass index (BMI) less than 18.5 kg/m² exhibited an increased risk of fetal growth restriction and SGA.</p><p><strong>Conclusions: </strong>The pandemic lockdown adversely affected pregnancy outcomes. Therefore, targeted screening and clinical management for specific populations should be prioritized.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2460180"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of lung ultrasound scores-directed pulmonary surfactant treatment in preterm infants with respiratory distress syndrome: a randomized controlled pilot study.","authors":"Yufan Wu, Honghui Su","doi":"10.1080/14767058.2025.2498558","DOIUrl":"10.1080/14767058.2025.2498558","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary surfactant therapy is critical for preterm infants with respiratory distress syndrome (RDS). Lung ultrasound (LUS) offers a noninvasive, radiation-free alternative for assessing RDS severity and guiding surfactant therapy.</p><p><strong>Methods: </strong>Eighty-two preterm infants with RDS were randomized to receive surfactant based on either LUS scores or a conventional clinical-radiological assessment, comparing the duration of mechanical ventilation, supplemental oxygen need, NICU stay, incidence of bronchopulmonary dysplasia (BPD), and mortality.</p><p><strong>Results: </strong>No significant differences were found between the groups in terms of mechanical ventilation duration (average 4.1 vs. 4.3 days), supplemental oxygen need (average 5.7 vs. 6.1 days), or NICU stay (average 15.4 vs. 15.9 days). The incidence of BPD was 4.9% in both groups, and there were no deaths reported.</p><p><strong>Conclusions: </strong>LUS-directed surfactant treatment did not show significant difference compared to the traditional methods, suggesting its potential as a noninvasive alternative for RDS management in preterm infants.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2498558"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of fetal outcomes in dichorionic diamniotic twins with hypertensive disorders during pregnancy by the fetal middle cerebral artery and umbilical artery doppler.","authors":"Ling-Ling Liu, Hai-Hua Xu, Xin Lin","doi":"10.1080/14767058.2025.2508273","DOIUrl":"https://doi.org/10.1080/14767058.2025.2508273","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive disorders of pregnancy (HDP) is associated with the poor prognosis of dichorionic diamniotic (DCDA) twins. The prediction value of middle cerebral artery (MCA) and umbilical artery (UA) Doppler indices requires exploration.</p><p><strong>Objective: </strong>To investigate the significance of the fetal MCA and UA doppler indices in DCDA fetal outcomes and depict hemodynamic alterations.</p><p><strong>Methods: </strong>DCDA twin pregnancies were classified into the normotensive control group (<i>n</i> = 177) and the HDP group [<i>n</i> = 189, with 60 gestational hypertensions (GH) and 129 preeclampsia/eclampsia (PE/EC)]. Maternal and fetal outcomes were compared, the fetal MCA and UA doppler indices were analyzed, including pulsatility index (PI), resistance index (RI), the ratio of peak systolic blood flow velocity to end-diastolic blood flow velocity (S/D), and the mean velocities (Vm), and the cerebroplacental ratio (CPR) was computed for further study. The receiver operating characteristic curve was used to predict and evaluate small for gestational age (SGA) neonates in HDP twin pregnancies.</p><p><strong>Results: </strong>Significant differences were shown between the HDP group and the normotensive control group in terms of maternal age, gestational weight gain, blood pressure, post 20-week urinary protein, the use of maternal medication utilization (magnesium sulfate, labetalol, dexamethasone), inter-twin growth discordance, and SGA (<i>p < 0.05</i>). In DCDA twins, the fetal MCA doppler indices (PI, RI and S/D) increased initially and then declined, UA indices (PI, RI and S/D) were declining, and both the Vm of MCA and UA were going up. In late DCDA twin pregnancies with GH, UA Doppler moderately predicted SGA neonates; in those with PE/EC, CPR did the same values (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>In DCDA pregnancies complicated by hypertensive disorders, SGA twins exhibit distinct doppler deterioration patterns. Implementing customized monitoring strategies based on the fetal MCA and UA indices can effectively predict adverse conditions, enable timely interventions, and ensure fetal health.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2508273"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of doubling rate of hCG in predicting early pregnancy loss: a retrospective analysis.","authors":"Xiaoping Wang, Fangxiang Mu, Qiliang Jian, Fang Wang","doi":"10.1080/14767058.2025.2508902","DOIUrl":"https://doi.org/10.1080/14767058.2025.2508902","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore whether the human chorionic gonadotropin (hCG) doubling rate every 48 h (HDR) predicts early pregnancy outcomes in women with pregnancy loss.</p><p><strong>Methods: </strong>The early clinical pregnancy outcomes in 257 women with a history of pregnancy loss were analyzed in this retrospective study. The optimal cutoff value of HDR was determined by the receiver operating characteristic (ROC) curve and the Youden index. The primary outcome was pregnancy loss occurring before 12 weeks of gestation.</p><p><strong>Results: </strong>A total of 257 patients were enrolled in this study. According to the pregnancy outcome at 12 weeks of gestation, the patients were divided into ongoing pregnancy (<i>N</i> = 198) and early pregnancy loss (EPL) groups (<i>N</i> = 59). In the total study population, the HDRs in ongoing pregnancy group were significantly higher than those in EPL group at specific intervals of hCG levels: 150-400 mIU/ml, 400-800 mIU/ml, and 3200-6400 mIU/ml. The corresponding thresholds were 1.855, 2.219, and 1.730, respectively (<i>p</i> < 0.05). A similar result was observed among patients with recurrent pregnancy loss (RPL) across the intervals of 400-800 mIU/ml, 800-1600 mIU/ml, 3200-6400 mIU/ml, and 20000-30000 mIU/ml, with corresponding thresholds of 2.219, 1.812, 1.730, and 1.450, respectively.</p><p><strong>Conclusions: </strong>HDR may serve as an evaluative tool for predicting the risk of EPL in women with pregnancy loss. Differences in the intervals showing predictive value between women with and without RPL imply that individualized interpretation of HDR may be warranted in these subgroups. However, given the limited sample size, especially within the EPL group, these findings should be interpreted with caution.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2508902"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of retraction: Different routes and forms of uterotonics for treatment of retained placenta: a randomized clinical trial.","authors":"","doi":"10.1080/14767058.2025.2509344","DOIUrl":"https://doi.org/10.1080/14767058.2025.2509344","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2509344"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}