Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"The fetal cerebral Doppler in the last weeks of pregnancy can select very small fetuses unlikely to present intrapartum compromise.","authors":"José Morales-Roselló, Alicia Martínez-Varea, Blanca Novillo-Del Álamo, Asma Khalil","doi":"10.1080/14767058.2025.2456989","DOIUrl":"https://doi.org/10.1080/14767058.2025.2456989","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether, in late pregnancy, the cerebral Doppler can identify very small fetuses that are less likely to experience intrapartum compromise (IC).</p><p><strong>Material and methods: </strong>This was a retrospective study of 282 singleton pregnancies that underwent an ultrasound scan at 32 + 0- 40 + 6 weeks and were delivered after induction, or spontaneous onset of labor. Very small fetuses were defined as fetuses with estimated weight less than the 3rd centile. IC was diagnosed in case of abnormal intrapartum fetal heart rate or intrapartum fetal scalp pH < 7.20, requiring urgent cesarean section, neonatal pH below 7.10 and Apgar score at 5 min <7. The ability of the cerebral Doppler, middle cerebral artery pulsatility index, and cerebroplacental ratio, expressed in multiples of the median (MCA PI MoM and CPR MoM), to rule out the risk of IC was evaluated alone and combined with other sonographic and clinical parameters by means of logistic regression and ROC curve analyses.</p><p><strong>Results: </strong>The only significant parameters determining IC were parity, MCA PI, and CPR MoM. [AUC 0.62 (95% CI 0.54-0.71, <i>p</i> = 0.012), 0.62 (95% CI 0.53-0.71, <i>p</i> = 0.008), 0.60 (95% CI 0.51-0.69, <i>p</i> = 0.020), respectively], while the best prediction was obtained combining parity with MCA PI or CPR [AUC 0.68 (95% CI 0.60-0.76), 0.67 (95% CI 0.60-0.75), <i>p</i> < 0.0001 for both]. Moreover, 90% of IC cases had MCA PI and CPR values below 1.1 MoM, while 100% had MCA and CPR values below 1.5 and 1.3 MoM. Finally, the negative predictive value was 82% for any combination of parameters that included either the MCA MoM or CPR MoM.</p><p><strong>Conclusion: </strong>The cerebral Doppler can select a group of very small fetuses that are less likely to experience IC. These fetuses might be to some extent constitutionally small and might be candidates for a more conservative and individualized management.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2456989"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between salivary nitrate levels and perinatal anxiety and postpartum depression.","authors":"Yafan Lin, Xiangming Che, Tianzuo Li","doi":"10.1080/14767058.2025.2463402","DOIUrl":"https://doi.org/10.1080/14767058.2025.2463402","url":null,"abstract":"<p><strong>Background: </strong>Postpartum depression (PPD) is a common psychological condition affecting 10-20% of postpartum women, characterized by emotional instability, anxiety, and, in severe cases, hallucinations or suicidal ideation. Growing evidence suggests a link between oxidative stress and depression, with nitrite-a key metabolite of nitric oxide (NO)-emerging as a potential biomarker. This study explores the association between salivary nitrite levels, perinatal anxiety, and PPD, aiming to identify predictive factors for early intervention.</p><p><strong>Methods: </strong>A prospective clinical study was conducted involving 220 naturally delivered women. Saliva samples were collected at three time points: before labor analgesia, one hour post-analgesia, and on the discharge day. PPD was assessed using the Edinburgh Postnatal Depression Scale (EPDS) at 28 and 42 days postpartum. Logistic regression was applied to analyze the relationship between salivary nitrite levels and PPD risk (EPDS ≥ 9). Anxiety, information needs, and fear were evaluated as additional predictors.</p><p><strong>Results: </strong>Of 220 participants, 194 completed the study. The incidence of PPD was 10.82% at 28 days and 15.98% at 42 days postpartum. Higher pre-analgesia salivary nitrite levels were significantly associated with increased PPD risk at 28 days (OR = 1.017, <i>p</i> < 0.05) and 42 days (OR = 1.008, <i>p</i> < 0.05), with a stronger effect at 28 days. Preoperative anxiety was a strong predictor at 28 days (OR = 1.76, <i>p</i> = 0.019), while preoperative information needs were significant at 42 days (OR = 1.22, <i>p</i> = 0.043). Salivary nitrite levels significantly decreased after labor analgesia and remained low at discharge.</p><p><strong>Conclusion: </strong>This study is the first to demonstrate a significant association between salivary nitrite levels and the occurrence of postpartum depression (PPD), with this association being particularly pronounced at 28 days postpartum. Perinatal anxiety and information needs were also identified as important predictors of PPD. This research provides a new perspective for the early screening and intervention of PPD and points the way for future studies to further explore its mechanisms and predictive factors.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2463402"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeat fetoscopic laser surgery for postlaser twin anemia polycythemia sequence and recurrent twin-to-twin transfusion syndrome: matched outcomes in a single-center cohort‡.","authors":"Abby Birk, Ahmet Baschat, Jena Miller, Camille Shantz, Jessamine Jin, Mackenzie Simon-Collins, Sarah Olson, Kristin Voegtline, Denise Wolfson, Michelle Kush, Mara Rosner","doi":"10.1080/14767058.2025.2463424","DOIUrl":"https://doi.org/10.1080/14767058.2025.2463424","url":null,"abstract":"<p><strong>Background: </strong>Fetoscopic laser surgery aims to treat Twin-to-Twin Transfusion Syndrome with a single procedure. In rare cases, missed or recanalized anastomoses lead to recurrent disease, either postlaser Twin Anemia Polycythemia Sequence (TAPS) or recurrent Twin-to-Twin Transfusion Syndrome (TTTS). Repeat laser surgery is one possible treatment.</p><p><strong>Objectives: </strong>To describe our diagnostic and treatment criteria for recurrent disease along with technical strategies to perform repeat laser. We explore the clinical implications of repeat laser surgery by comparing characteristics and outcomes to patients matched for TTTS disease severity that was successfully treated by a single laser surgery.</p><p><strong>Study design: </strong>We performed a single-center, matched-case, retrospective analysis. Patients who underwent repeat laser surgery for disease recurrence are described in detail and were matched in a ratio of 1:3 to patients whose TTTS was treated with a single fetoscopic laser surgery. Patients were matched for disease stage, co-existing fetal growth restriction, and gestational age (GA) epoch at first laser (<18, 18-23.9, and ≥24). Gestational age at delivery was the primary outcome measure. Demographics, pregnancy characteristics, procedure details, complications, obstetric, and twin survival outcomes were compared. Continuous data were analyzed using Student's t or Wilcoxon Rank-Sum test and categorical data were analyzed using Chi squared or Fisher's exact test.</p><p><strong>Results: </strong>Sixteen (4.8%) of 334 patients met our criteria for recurrent disease after Solomon laser for TTTS: 12 had postlaser TAPS, three had recurrent TTTS, and two had both postlaser TAPS and recurrent TTTS. Repeat laser was performed in 11 (69%) patients. Techniques for repeat laser included carbon dioxide insufflation (2/11), amnioexchange (2/11), contralateral trochar entry (8/11), intentional septostomy (4/11), and entry into the opposite sac (2/11). There was no difference in median gestational age at delivery (31 vs 32.5 weeks, <i>p</i> = 0.228), double birth survival (72.7% vs 87.9%, <i>p</i> = 0.34), or overall perinatal survival (86% vs 91%, <i>p</i> = 0.89) between patients who underwent repeat laser and matched controls.</p><p><strong>Conclusions: </strong>We suggest a standardized approach to diagnosis of postlaser TAPS and recurrent TTTS and technical considerations for performing repeat laser. In patients eligible for repeat laser surgery, it is possible to achieve acceptable outcomes that are comparable to outcomes after single laser in patients matched for TTTS disease severity. These findings should be corroborated in a larger multicenter study, but may be useful to help patient counseling and management when repeat laser surgery is considered for recurrent disease.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2463424"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the relationship between serum vitamin A, C, E, D, and B12 levels and preeclampsia.","authors":"Wenjiao Yang, Zhenhua Hu, Weirong Gu","doi":"10.1080/14767058.2025.2466222","DOIUrl":"https://doi.org/10.1080/14767058.2025.2466222","url":null,"abstract":"<p><strong>Objective: </strong>Micronutrients play an important role in maintaining physiological functions while preventing complications associated with pregnancy. The main aim of this study was to evaluate the possible associations between vitamins A, C, D, E, B12, and preeclampsia using a retrospective analytical approach.</p><p><strong>Methods: </strong>This retrospective study enrolled pregnant women who attended routine antenatal checkups between January 2021 and January 2023 at the Obstetrics and Gynecology Hospital of Fudan University. One thousand pregnant women aged 18-50 years whose serum vitamin assessments were conducted during 12-20 weeks of gestation were enrolled. Inclusion criteria: women with preeclampsia, singleton pregnancies, and no previous history of hypertension or preeclampsia. Exclusion criteria: metabolic disorders, multiple pregnancies, and other specified exclusions. Approval of the hospital's ethics committee; all participants gave written informed consent. Demographic data analyzed include age, BMI, and gestational age, showing no significant differences in age span between groups (<i>p</i> > .05).</p><p><strong>Results: </strong>In the preeclampsia group, the serum level of vitamin A stands at 1.08 ± 0.29 μmol/L, which is lower than the control group of 1.13 ± 0.31 μmol/L (<i>p</i> < .05). Mean serum levels of vitamin C in preeclampsia are 51.81 ± 13.15 μmol/L, which was lower than in the control group, where it was 59.67 ± 16.40 μmol/L (<i>p</i> < .05). The mean serum vitamin B12 level in preeclampsia is 158.28 ± 46.77 pmol/L, lower than the 165.61 ± 40.99 pmol in the control group (<i>p</i> < .05). The two groups had no significant difference in serum vitamin E and vitamin D levels (<i>p</i> > .05).</p><p><strong>Conclusion: </strong>Serum vitamins A, C, and B12 at 12 to 20 weeks of pregnancy might be important predisposing factors for preeclampsia. They can be used as indicators of preeclampsia severity and offer clinical detection even before the patient presents with symptoms.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2466222"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accordance between weight-based and calculated blood loss for obstetric hemorrhage: a pre-study to a randomized controlled trial.","authors":"Linnea Skogvard, Gita Strindfors, Margit Endler","doi":"10.1080/14767058.2025.2469258","DOIUrl":"https://doi.org/10.1080/14767058.2025.2469258","url":null,"abstract":"<p><strong>Objective: </strong>Postpartum hemorrhage (PPH) is the leading cause of maternal death. Identifying excessive bleeding is crucial, but there is no gold standard for its measurement. We aimed to assess accordance between two formulas for calculated blood loss (CBL) and weight-based blood loss (WBBL) to determine if CBL has a place in either the clinical or research obstetric context.</p><p><strong>Method: </strong>This was a pre-posttest study nested in a pilot study. Women ≥ 18years and ≥ 36 gestational weeks with uncomplicated pregnancies and planned vaginal birth were included at a tertiary hospital in Stockholm, Sweden from December 2022 to February 2023. Hematocrit (Erythrocyte Volume Fraction, EVF) and hemoglobin (Hb) were taken at admission and 24 h postpartum. Blood loss was calculated in three ways: weighing blood collected in drapes and blood-soaked material; Gross's formula based on pre-postpartum EVF; and pre-postpartum Hb difference, assuming a 10 mg/L difference equivalent to 500 ml. We compared median blood loss between these methods using Related-samples Wilcoxon Signed-Rank Test, correlations using Spearman's Rho, and prediction of PPH (≥500 ml) using McNemar's test.</p><p><strong>Results: </strong>Out of 51 women included in the pilot, 37 and 36 had data for each CBL method respectively. Median blood loss was 350 ml for WBBL, 649 ml for Gross's formula (<i>p</i> = 0.008) and 750 ml for pre-postpartum Hb difference (<i>p</i> < 0.001). For the diagnosis PPH, WBBL and Gross's formula were concordant in 61% of cases (<i>p</i> = 0.002), compared to 43% for WBBL and pre-postpartum Hb difference (<i>p</i> = 0.001). There was a moderate positive correlation between WBBL and both CBL methods (<i>p</i> = 0.001). Excluding women who received intravenous fluids did not improve agreement between WBBL and CBL methods.</p><p><strong>Discussion: </strong>Both CBL methods significantly differ from, and overestimate bleeding compared to WBBL. There is a correlation between WBBL and CBL, but the estimates differ to the extent that CBL methods do not seem relevant for clinical obstetric practice or research.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2469258"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of obesity on first-trimester pregnancy dating using ultrasound: a retrospective cohort study.","authors":"Brianna Désiré, Jennifer Peck, Blake Porter, Sabrina Wyatt, Osariemen Omoregie, Rodney K Edwards","doi":"10.1080/14767058.2025.2466060","DOIUrl":"https://doi.org/10.1080/14767058.2025.2466060","url":null,"abstract":"<p><strong>Objectives: </strong>Obese women are known to have alterations in their menstrual cycles leading to ovulatory dysfunction. The purpose of this study is to evaluate the relationship between body mass index (BMI) and early pregnancy ultrasound dating and determine the frequency of redating.</p><p><strong>Methods: </strong>We performed a retrospective cohort study of women who underwent a first trimester dating ultrasound at The University of Oklahoma Health Sciences Center from January 2019 to June 2020. The estimated date of delivery (EDD) calculated from the ultrasound was compared to the EDD calculated from the LMP. A discrepancy of greater than 5 days prior to 9 weeks or greater than 7 days between 9 and 13 weeks prompted redating of the pregnancy.</p><p><strong>Results: </strong>2639 women met inclusion criteria, with BMI ≥ 30 kg/m² present in 39% of participants. Obese women had higher rates of pregnancy redating compared to non-obese women-adjusted risk ratio [aRR] 1.23 (95% confidence interval [CI] 1.07-1.41, <i>p</i> = 0.003). Class III obese women were more likely than any other BMI class to have their pregnancies redated by ultrasound-aRR 1.46 (95% CI 1.18-1.80, <i>p</i> < 0.001). Analyses adjusted for age, race, and parity showed that for each unit increase in BMI over 30 kg/m², women had a 2% increased risk of being redated (<i>p</i> < 0.001). Mean EDD by ultrasound minus mean EDD by LMP was -0.98, -2.70, -2.43, and -3.35 (<i>p</i> < 0.001) for non-obese, class I, class II, and class III obese women, respectively. 22% of non-obese women were redated compared to 27.3% of obese women (<i>p</i> = 0.002) and 31.2% of class III obese women (<i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>Obese women have higher rates of pregnancy redating compared to normal weight women, with class III obese women having the highest rates of all groups studied. Accurate pregnancy dating is important to decrease unnecessary interventions due to false diagnoses of fetal growth restriction or macrosomia.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2466060"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and microbiological outcomes of maternal bacteremia: the role of intrapartum antibiotic use, insights from an 11-Year cohort study.","authors":"Raneen Abu Shqara, Omer Saporta, Daniel Glickman, Lior Lowenstein, Maya Frank Wolf","doi":"10.1080/14767058.2025.2466216","DOIUrl":"https://doi.org/10.1080/14767058.2025.2466216","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Maternal sepsis remains a leading cause of maternal mortality worldwide. However, it is unclear whether obstetrical, neonatal, and microbiological outcomes associated with maternal bacteremia differ based on the timing of bacteremia presentation. This study aimed to evaluate maternal, neonatal, and microbiological characteristics of bacteremia in pregnancy, with a specific focus on the association between intrapartum antibiotic use and bacteremia caused by ampicillin-resistant &lt;i&gt;Enterobacteriaceae&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort study was conducted, including all women who delivered at Galilee Medical Center, a tertiary university-affiliated hospital, over an 11-year period (2012-2023). The maternal bacteremia rate, the primary outcome, was analyzed. The study included pregnant women from 24 weeks of gestation to 7 days postpartum, with bacteremia confirmed by positive blood cultures. The distribution of pathogens in blood cultures was compared according to timing of presentation (antepartum, intrapartum, or postpartum), and between women with preterm and term bacteremia. Maternal bactermia-related admission to the intensive care unit were characterized. Additionally, the impact of intrapartum antibiotic use on bacterial resistance profiles was assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;During the study period, 46,103 women gave birth, of whom 104 (2.2 per 1,000 deliveries) had confirmed maternal bacteremia from 24 weeks of gestation to 7 days postpartum. Over the 11-year period, the incidence of bacteremia decreased from 0.4% to 0.15%, with Enterobacteriaceae bacteremia consistently more frequent than Group B streptococcal (GBS) bacteremia. Antepartum bacteremia (21%) was primarily caused by pyelonephritis (82%), intrapartum bacteremia (45%) by chorioamnionitis (98%), and postpartum bacteremia (34%) by endometritis (94%). Overall, Enterobacteriaceae was the most commonly isolated pathogen (55%), followed by GBS (19%). The rate of Enterobacteriaceae-isolated bacteremia was significantly higher in preterm deliveries compared to term deliveries (68% vs. 47%, &lt;i&gt;p&lt;/i&gt; = 0.039), while the rate of GBS-isolated bacteremia was significantly lower in preterm deliveries (0% vs. 30%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Neonatal early onset sepsis occurred more frequently in preterm deliveries (16% vs. 2%, &lt;i&gt;p&lt;/i&gt; = 0.027), with all preterm cases caused by ampicillin-resistant &lt;i&gt;Escherichia coli&lt;/i&gt;. Among women with postpartum bactermia, the use of intrapartum ampicillin significantly increased the incidence of ampicillin-resistant Enterobacteriaceae bacteremia (92% vs. 52%, &lt;i&gt;p&lt;/i&gt; = 0.023).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Maternal bacteremia, predominantly caused by Enterobacteriaceae, poses a serious risk to both mothers and newborns. The study highlights the association between intrapartum ampicillin use and ampicillin-resistant Enterobacteriaceae bacteremia in both mothers and the neonates, emphasizing","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2466216"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of pre-/early pregnancy high blood pressure and pregnancy outcomes: a systemic review and meta-analysis.","authors":"Ming Jin, Xiaowen Liu, Xiaojing Liu, Yaxian Wu, Yali Zhang, Le Zhang, Zhiwen Li, Rongwei Ye, Nan Li","doi":"10.1080/14767058.2023.2296366","DOIUrl":"10.1080/14767058.2023.2296366","url":null,"abstract":"<p><strong>Background: </strong>Maternal high blood pressure (BP) was associated with adverse pregnancy outcomes. This study aimed to synthesize evidence on the association between high BP prior to or in early pregnancy with maternal and fetal complications.</p><p><strong>Methods: </strong>We searched the cohort studies assessing the effect of high BP in the Medline, Embase, Web of Science and China National Knowledge Internet databases. A random-effects model was used to estimate the pooled odds ratios (ORs) with 95% confidence intervals (CIs). The protocol was registered in PROSPERRO (CRD 42023414945).</p><p><strong>Results: </strong>23 eligible studies were identified. High BP prior to or in early pregnancy was associated with higher odds of hypertensive disorders of pregnancy (OR 2.90, 95% CI 1.91-3.89), gestational hypertension (2.56, 2.01-3.12), preeclampsia (3.20, 2.66-3.74), gestational diabetes mellitus (1.71, 1.36-2.06), preterm birth (1.66, 1.39-1.93), stillbirth (2.01, 1.45-2.58) and neonatal intensive care unit admission (1.22, 1.08-1.37). Subgroup analyses indicated that pre-hypertension could significantly increase the odds of these outcomes except for stillbirth, though the odds were lower than hypertension.</p><p><strong>Conclusions: </strong>High BP prior to or in early pregnancy was associated with adverse pregnancy outcomes and this association increased with hypertension severity. The findings emphasized an urgent need for heightened surveillance for maternal BP, especially pre-hypertensive status.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"37 1","pages":"2296366"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal congenital talipes equinovarus: genomic abnormalities and obstetric follow-up results.","authors":"Meiying Cai, Jiansong Lin, Yanting Que, Liangpu Xu, Na Lin, Hailong Huang","doi":"10.1080/14767058.2023.2299113","DOIUrl":"10.1080/14767058.2023.2299113","url":null,"abstract":"<p><strong>Objective: </strong>The etiology of congenital talipes equinovarus (CTEV) is unknown, and the relationship between chromosome microdeletion/microduplication and fetal CTEV is rarely reported. In this study, we retrospectively analyzed fetal CTEV to explore the relationship among the CTEV phenotype, chromosome microdeletion/microduplication, and obstetric outcomes.</p><p><strong>Methods: </strong>Chromosome karyotype analysis and single nucleotide polymorphism (SNP) array were performed for the 68 fetuses with CTEV.</p><p><strong>Results: </strong>An SNP array was performed for 68 fetuses with CTEV; pathogenic copy number variations (CNVs) were detected in eight cases (11.8%, 8/68). In addition to one case consistent with karyotype analysis, the SNP array revealed seven additional pathogenic CNVs, including three with 22q11.21 microdeletions, two with 17p12p11.2 microduplications, one with 15q11.2 microdeletions, and one with 7q11.23 microduplications. Of the seven cases carrying pathogenic CNVs, three were tested for family genetics; of these, one was <i>de novo</i>, and two were inherited from either the father or mother. In total, 68 fetuses with CTEV were initially identified, of which 66 cases successfully followed-up. Of these, 9 were terminated, 2 died in utero, and 55 were live births. In 9 cases, no clinical manifestations of CTEV were found at birth; the false-positive rate of prenatal ultrasound CTEVdiagnosis was thus 13.6% (9/66).</p><p><strong>Conclusion: </strong>CTEV was associated with chromosome microdeletion/microduplication, the most common of which was 22q11.21 microdeletion, followed by 17p12p11.2 microduplication. Thus, further genomic detection is recommended for fetuses with CTEV showing no abnormalities on conventional karyotype analysis.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"37 1","pages":"2299113"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrinogen as a potential diagnostic marker for prediction and evaluation of postpartum hemorrhage: a retrospective study.","authors":"Yanke Zou, Yixiao Jiang, Dawei Zhu, Ling Liu, Xiuhui Zheng, Xing Gu, Changxiao Huang, Li Li","doi":"10.1080/14767058.2023.2300418","DOIUrl":"10.1080/14767058.2023.2300418","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether prenatal fibrinogen (FIB) or other related factors could be utilized to evaluate the risk of postpartum hemorrhage (PPH).</p><p><strong>Methods: </strong>A retrospective study was conducted in a database from January 2015 to December 2019. A total of 128 patients were enrolled and evaluated with FIB, in which 55 patients were assigned to low FIB and 73 in normal FIB.</p><p><strong>Results: </strong>According to the volume of blood loss, the mean of the low FIB group (<4 g/L) was markedly higher than that of the normal FIB group (≥4 g/L). Prenatal FIB was negatively correlated with PPH volume. The receiver operating characteristic (ROC) curve results indicated that the value of prenatal FIB was 0.701 to predict refractory PPH.</p><p><strong>Conclusions: </strong>Prenatal FIB was significantly related to thrombin time (TT), which may be an independent factor to predict the coagulation state of prenatal pregnancy.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"37 1","pages":"2300418"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}