Journal of Maternal-Fetal & Neonatal Medicine最新文献

{"title":"Statement of Retraction: Omega-3 fatty acids plus vitamin for women with gestational diabetes or prediabetes: a meta-analysis of randomized controlled studies.","authors":"","doi":"10.1080/14767058.2025.2501451","DOIUrl":"https://doi.org/10.1080/14767058.2025.2501451","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2501451"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress hyperglycemia ratio: a novel predictor of left ventricular dysfunction in peripartum cardiomyopathy.","authors":"Jiajia Zhu, Wenxian Liu, Liying Chen, Baoli Liu","doi":"10.1080/14767058.2025.2464181","DOIUrl":"10.1080/14767058.2025.2464181","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the predictive value of the stress hyperglycemia ratio (SHR) for left ventricular (LV) systolic dysfunction in patients with peripartum cardiomyopathy (PPCM).</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 78 consecutive PPCM patients from January 2007 to March 2023. Their clinical, laboratory, and auxiliary examination data were collected. The estimated average glucose (eAG) was calculated using the formula: eAG = [1.59 × hemoglobin A1c (%) -%2.59]. The SHR was determined by the formula: SHR = (blood glucose at admission)/eAG. The primary outcome measured was the recovery of LV systolic function. A receiver operating characteristic (ROC) curve was used to evaluate the SHR. Logistic regression analysis was performed to identify risk factors for LV systolic dysfunction in PPCM patients.</p><p><strong>Results: </strong>The mean random blood glucose level in the PPCM patients was 6.38 mmol/L, with an SHR of 1.16. Among these patients, 37 (47.4%) exhibited persistent LV systolic dysfunction during follow-up. The SHR was significantly higher in the non-recovery group than in the recovery group (1.45 vs. 0.91, <i>p</i> < .001). An SHR cutoff of 1.079 predicted persistent LV systolic dysfunction with a sensitivity of 81.1% and a specificity of 90.2%, yielding a Youden index of 0.713. Logistic regression identified an SHR ≥ 1.079, a left ventricular end-diastolic diameter (LVEDD) > 55 mm, and digoxin usage as risk factors for LV systolic dysfunction.</p><p><strong>Conclusions: </strong>PPCM patients with an SHR of 1.079 or higher should receive increased scrutiny for persistent LV systolic dysfunction.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2464181"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential predictive utility of preoperative cervical length for preterm birth among various indications for cervical cerclage: a retrospective cohort study.","authors":"Nary Long, Yilin Fu, Zizhuo Wang, Ling Feng, Teng Ji","doi":"10.1080/14767058.2025.2479751","DOIUrl":"10.1080/14767058.2025.2479751","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the predictive utility of preoperative cervical length (CL) for preterm birth (PTB) in cervical cerclage with different surgical indications.</p><p><strong>Methods: </strong>This study included data from 289 pregnant women who underwent transvaginal cervical cerclage at the Wuhan Tongji Hospital (Hubei, China) between 2015 and 2024. Participants were divided into three groups according to surgical indication(s) for cerclage: history indicated (<i>n</i> = 173); ultrasound indicated (<i>n</i> = 89); and examination indicated (<i>n</i> = 27).</p><p><strong>Results: </strong>The area under the receiver operating characteristic curve (AUC) revealed that preoperative CL for PTB was greater for ultrasound-indicated cerclage (AUC 0.6613, cutoff 13.5 mm) than that for history-indicated cerclage (AUC 0.5675, optimal cutoff 30.5 mm). In history-indicated cerclage, there were no difference in the rate of PTBs between preoperative CL > 30.5 mm and ≤ 30.5 mm, nor in the rate of postoperative CL ≤ 15 mm during the fourth week. In the ultrasound-indicated group, compared with preoperative CL > 13.5 mm, women with a CL ≤ 13.5 mm exhibited a higher rate of PTB (82.1% versus 48.0%; <i>p</i> < .001), and a higher rate of postoperative CL ≤ 15 mm in the fourth week (71.4% versus 37.5%; <i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>The correlation between preoperative CL and PTB varied depending on the indication(s) for cerclage, and changes in postoperative CL contributed to varying predictive utility.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2479751"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric and neonatal outcomes of extremely obese pregnant women after late preterm gestation.","authors":"Harshitha Kallubhavi Choodinatha, Hyun Joon Im, Jin Lee, Min Jung Lee, Bo Young Choi, Hyeon Ji Kim, Jee Yoon Park","doi":"10.1080/14767058.2025.2470416","DOIUrl":"10.1080/14767058.2025.2470416","url":null,"abstract":"<p><strong>Objective: </strong>To determine the obstetric and neonatal outcomes of pregnant women with extreme obesity at birth after late preterm gestation.</p><p><strong>Methods: </strong>This was a retrospective study on extremely obese pregnant women with body mass index (BMI) ≥ 40.0 kg/m² (obesity stage III according to the BMI classification of the World Health Organization) who had delivered at Seoul National University Bundang Hospital between September 2003 and February 2023. Fetal death in utero and preterm births before 34 weeks of gestation were excluded. Obstetric and neonatal outcomes were reviewed.</p><p><strong>Results: </strong>A total of 94 extremely obese pregnant women were included and the median value of BMI at delivery was 42.4 kg/m². When analyzed according to the obesity II category of pre-pregnancy BMI, the rate of chronic hypertension was higher in the alleged extreme obese women than those with lower pre-pregnancy BMI (34% vs. 10%, <i>p</i> = 0.012). However, preterm labor with tocolytics was higher in the group with lower BMI than 35.0 kg/m² (26% vs. 5%, <i>p</i> = 0.007). The proportion of adverse neonatal outcomes such as neonatal intensive care unit admission, the use of respiratory support (including positive pressure ventilation, continuous positive airway pressure, and mechanical ventilator), and jaundice were higher in the group with pre-pregnancy BMI < 35.0 kg/m² than that with BMI ≥ 35.0 kg/m² group (all <i>p</i>-value < 0.05). The use of neonatal respiratory support increased as the category of pre-pregnancy BMI was lower and as the degree of weight gain during pregnancy was higher.</p><p><strong>Conclusions: </strong>In extremely obese women (stage III) at delivery in late preterm gestation, the obstetric outcomes such as use of tocolytics for preterm labor and adverse neonatal respiratory outcomes seemed to be higher for the women who were not that much obese before pregnancy than those who were already extremely obese. Therefore, weight gain during pregnancy needs to be closely monitored for pregnant women especially when obese.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2470416"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic and clinical outcomes of cesarean deliveries with skin closure using 2-octyl cyanoacrylate plus polymer mesh tape versus conventional smooth sutures plus waterproof wound dressings.","authors":"Stephen S Johnston, Najmuddin Gunja, Aakash Jha, Jörg Tomaszewski, Walter Danker","doi":"10.1080/14767058.2025.2463390","DOIUrl":"10.1080/14767058.2025.2463390","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Cesarean delivery is the most common major operating room procedure performed in the United States. Wound closure after cesarean delivery includes suturing for uterine closure and to close the fascial-and sometimes subcutaneous-tissue layer followed by skin closure. Optimal skin closure is critical as it affects the risk of both cesarean wound infection and dehiscence. To our knowledge, however, no clinical or real-world studies comparing 2OPMT with conventional sutures for skin closure following cesarean delivery have been published to date. We sought to compare the economic and clinical outcomes of cesarean deliveries with skin closure using 2-octyl cyanoacrylate plus polymer mesh tape (2OPMT) versus conventional smooth sutures plus waterproof wound dressings (CS-WWD).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a retrospective, observational study using a database derived from hospital electronic health records and billing data from over 1,000 U.S. hospitals (PINC AI&lt;sup&gt;™&lt;/sup&gt; Healthcare Database). Eligible patients were aged 18-49 who underwent cesarean delivery between 1 October 2015 and 30 June 2022. From records of medical supplies used during deliveries, we identified deliveries for which skin closure was performed using either 2OPMT or CS-WWD. Outcomes included: post-surgical length of stay (LOS), total hospital costs for the cesarean delivery stay, 30-day readmissions of various acuity to the same hospital in which the cesarean delivery occurred, and two 30-day clinical/wound complication outcomes (occurrence during the initial cesarean delivery stay or within 30 days thereafter), which included: (a) a composite endpoint of cesarean wound surgical site infection and/or dehiscence; and (b) a composite endpoint of cesarean wound surgical site infection and/or dehiscence, puerperal infection, endometritis, urinary tract infection, hematoma of the skin, cellulitis, and/or other unspecified skin infection. We compared outcomes between the groups after stable balance weighting the CS-WWD group to mimic the 2OPMT group on numerous patient, provider, and hospital characteristics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After weighting, the CSWWD (&lt;i&gt;N&lt;/i&gt; = 13,551) and 2OPMT (&lt;i&gt;N&lt;/i&gt; = 16,068) groups were well-balanced on all characteristics (standardized mean differences for balancing covariates &lt;|0.10|). Compared with the CS-WWD group, the 2OPMT group had statistically significant shorter mean post-surgical LOS (1.56 days for 2OPMT vs. 1.73 days for CS-WWD, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), lower mean hospital costs for the cesarean delivery stay ($9,499 vs. $10,362, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), lower incidence proportions of 30-day inpatient readmission (1.43% vs. 1.83%, &lt;i&gt;p&lt;/i&gt; = 0.009), 30-day emergency room visits (5.22% vs. 6.18%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), 30-day composite of inpatient readmission/emergency room visits (6.47% vs. 7.70%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), 30-day visits of other kinds, such as outpatient (5.32% vs. 9.50%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), 30-da","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2463390"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term indomethacin stabilizes the short cervix.","authors":"Karl Seif, Paola Abi Habib, Bilge Cetinkaya Demir, Sifa Turan, Colleen Driscoll, Christopher Harman, Ozhan Turan","doi":"10.1080/14767058.2025.2508274","DOIUrl":"https://doi.org/10.1080/14767058.2025.2508274","url":null,"abstract":"<p><strong>Objective: </strong>Short cervical length (CL) is a known predictor of preterm delivery (PTD). We aimed to study the progression of CL as gestational age (GA) advances in patients with short cervix treated under our long-term Indomethacin therapy (LIT) protocol, and to document the effect of LIT on the cervix.</p><p><strong>Methods: </strong>Retrospective cohort study conducted in a single medical center from 2010 to 2020. Patients with singleton pregnancies and 2^nd trimester CL ≤25 mm received LIT per our clinical protocol which included weekly CL and ultrasound (US) surveillance of amniotic fluid and Doppler indices. We compared initial cervical length (CLI) once LIT was started to final cervical length (CLF) once LIT was stopped, and cervical stabilization was defined as CLF-CLI ≥ 0. A longitudinal analysis of CL as GA progressed was performed using a multivariable linear mixed-effects regression model. A subgroup analysis was performed on patients whose total serial CL surveillance period lasted at least 3 weeks, and GA at delivery was analyzed based on cervical stabilization in this initial 3-week period. Statistical analyses were performed using Stata 16.</p><p><strong>Results: </strong>135 patients with short CL treated under our LIT protocol were included. 90 (67%) had CLF-CLI ≥ 0. Based on the regression model, the rate of CL change with time was 0.04 mm/day. This did not change when progesterone (both vaginal and intramuscular) use was added as an interaction term. 105 (78%) delivered >32 weeks, and 68 (50%) delivered at full term. There was no difference in the rate of delivery >28 weeks between those with CLI ≤10mm and those with CLI between 11 and 25 mm (78% v 90%, <i>p</i> > 0.05). 112 patients (83%) had at least 3 weeks of US surveillance. Of those, 76 (68%) had CLF-CLI ≥ 0 and 107 (95.5%) delivered at >28 weeks. The PPV of CLF-CLI ≥ 0 to predict delivery >28 weeks was 95%.</p><p><strong>Conclusion: </strong>While normally CL shortens progressively throughout pregnancy, patients with short CL managed with LIT had no further shortening. There is a need for a randomized controlled trial of LIT for prevention of PTD in patients with short CL.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2508274"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the value of transvaginal ultrasonography and MRI in the diagnosis of cesarean scar pregnancy: a meta-analysis.","authors":"Xiao Han, Boyang Zhang","doi":"10.1080/14767058.2024.2445661","DOIUrl":"https://doi.org/10.1080/14767058.2024.2445661","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic value of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) in cesarean scar pregnancy (CSP) by a method of meta-analysis.</p><p><strong>Methods: </strong>Studies on TVS and MRI for CSP were collected from PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang data, and Chinese Scientific Journal Database (VIP database) until April 1, 2024. Stata 15.0 software was used for data analysis. Mann-Whitney U-test was applied to compare the diagnostic efficiency of the TVS and MRI groups.</p><p><strong>Results: </strong>Nine articles with 713 subjects were involved in this review. The pooled sensitivity (0.96, 95%CI: 0.94-0.97), specificity (0.90, 95%CI: 0.84-0.94), and DOR (197.28, 95%CI: 99.71-390.31) in the MRI group were higher than those (Sensitivity = 0.83, 95%CI: 0.77-0.87; Specificity= 0.74, 95%CI: 0.63-0.83; DOR = 13.66, 95%CI: 7.84-23.79) in the TVS group. The positive likelihood ratio and negative likelihood ratio of the MRI group were 9.56 (95%CI: 8.82-15.72) and 0.05 (95%CI: 0.03-0.07), while those of the TVS group were 3.21 (95%CI:2.18-4.74) and 0.24 (95%CI: 0.18-0.31), respectively. In the MRI and TVS groups, the area under the curve (AUC) of the summary receiver operating characteristic was 0.9497 and 0.86, respectively. The results of Mann-Whitney U-tests of the two groups showed significant differences in the pooled sensitivity (Z= -3.311, <i>p</i> < 0.001), specificity (Z= -2.123, <i>p</i> = 0.034), and DOR (Z= -3.272, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Both MRI and TVS can effectively diagnose CSP. However, compared with TVS, MRI has better diagnostic accuracy for CSP, with higher sensitivity and specificity. Considering the good diagnostic accuracy of ultrasound, patients with ultrasound suspicion of CSP should be sent to a reference center where MRI can express its full diagnostic potential regarding depth, topography of invasion and myometral residue, which is useful for subsequent management.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2445661"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral vein thrombosis: management tactics with a focus on pregnancy, the use of hormone therapy and assisted reproductive technologies.","authors":"Svetlana Akinshina, Viktoria Bitsadze, Jamilya Khizroeva, Maria Tretyakova, Kristina Grigoreva, Nilufar Gashimova, Alexander Vorobev, Vladislav Zubenko, Nataliya Makatsariya, Lala Valikhanova, Daredzhan Kapanadze, Marina Zainulina, Alina Solopova, Tamara Mashkova, Fidan Yagubova, Valentina Tsibizova, Jean-Christophe Gris, Ismail Elalamy, Grigoris Gerotziafas, Alexander Makatsariya","doi":"10.1080/14767058.2024.2447349","DOIUrl":"https://doi.org/10.1080/14767058.2024.2447349","url":null,"abstract":"<p><p><b>Purpose:</b> Cerebral vein thrombosis is a rare, life-threatening condition that has now become more commonly diagnosed due to advancements in imaging techniques. Our purpose is to improve understanding of pathogenesis, diagnosis and pregnancy and IVF management in patients with a history of cerebral thrombosis.</p><p><p><b>Materials and methods:</b> We present an overview of the modern tactics of anticoagulant therapy for cerebral thrombosis with a focus on pregnancy, the use of hormone therapy, and assisted reproductive technologies.</p><p><p><b>Results:</b> The most common risk factors for cerebral vein thrombosis are pregnancy, the postpartum period, and the use of oral contraceptives, which explains the high incidence of this pathology in women. The development of cerebral thrombosis is a vivid example of the interaction and synergetic effects of persistent factors that cause an increased risk of thrombotic complications, which include thrombophilia and acquired risk factors. Despite the possible risks, pregnancy after previously suffered cerebral thrombosis is not contraindicated provided adequate anticoagulant therapy.</p><p><p><b>Conclusions:</b> The most common provoking factors for the development of cerebral thrombosis in women are pregnancy and the use of estrogen-containing drugs. The issue of thromboprophylaxis during pregnancy, when using ART methods and the possibility of using hormonal therapy after cerebral vein thrombosis requires further study.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2447349"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Diagnostic capacity and interobserver variability in FIGO, ACOG, NICE and Chandraharan cardiotocographic guidelines to predict neonatal acidemia\" The authors should reconsider their conclusions.","authors":"Olivier Morel, Roselene Karassane, Anne-Laure Fijean, Charline Bertholdt, Matthieu Dap","doi":"10.1080/14767058.2025.2477078","DOIUrl":"https://doi.org/10.1080/14767058.2025.2477078","url":null,"abstract":"","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2477078"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease in women with early-onset preeclampsia: a matched case-control study.","authors":"P Domínguez Del Olmo, I Herraiz, C Villalaín, B De la Parte, E Rodríguez-Sánchez, G Ruiz-Hurtado, L Fernández-Friera, E Morales, J L Ayala, J Solís, A Galindo","doi":"10.1080/14767058.2025.2459302","DOIUrl":"10.1080/14767058.2025.2459302","url":null,"abstract":"<p><strong>Objective: </strong>To compare the risk of cardiovascular disease and the occurrence of cardiovascular events in the mid-long term after delivery, between women with and without a history of early-onset preeclampsia.</p><p><strong>Methods: </strong>A prospective case-control study has been conducted in Hospital Universitario 12 de Octubre, Madrid. 50 women with early-onset preeclampsia (diagnosed < 34 + 0 weeks) who delivered between 2008 and 2017 and a matched group (by age, parity, pregestational body mass index and date of delivery) of 50 women with uncomplicated pregnancies were recruited. In them, a 1-day visit for cardiovascular assessment was performed 3-12 years after delivery, consisting of the completion of blood and urine tests including oxidative stress analysis, vascular ultrasound to assess subclinical atherosclerosis and 24-hour blood pressure monitoring. Furthermore, Framingham10 and Framingham30 scales of cardiovascular disease risk were applied. Univariate analysis was used for comparisons, and the Kaplan-Meier method was performed to estimate their survival time until the development of a cardiovascular disease event (chronic hypertension, renal disease, myocardial infarction, thromboembolism and cerebrovascular disease).</p><p><strong>Results: </strong>Patients were evaluated at a median of 7.5 years (interquartile range, 6.5-9) after delivery. Women with a history of early-onset preeclampsia vs controls showed significantly lower levels of hemoglobin (12.9 vs 13.7 g/dL), hematocrit (38.9 vs 40.8%), prothrombin activity (93.1 vs 99.8%), IgA (223.5 vs 279.9 mg/dL) and C3 factor (101.0 vs 110.5 mg/dL) and prolongated prothrombin time (12.4 vs 11.6 s). Early-onset preeclampsia cases showed worse blood pressure control, with higher percentages of over-limit systolic blood pressure (17.9 vs. 11.2%, <i>p</i> < 0.01) and diastolic blood pressure (28.1 vs. 18.7%, <i>p</i> < 0.01) readings in 24 h. There were no significant differences in the vascular ultrasound studies as well as in the estimated cardiovascular risk obtained with the Framingham scales. At the visit time, a cardiovascular event was present in 44% women with history of early-onset preeclampsia vs 10% in the control group (<i>p</i> < 0.01). The most common event was chronic hypertension, with a relative risk of 4.7 (95% confidence interval 1.7-13.0) for the early-onset preeclampsia group.</p><p><strong>Conclusions: </strong>Women with a history of early-onset preeclampsia, compared to their matched controls, showed a greater risk of cardiovascular disease mainly at the expense of a 4.7-fold risk of developing chronic hypertension, with a median follow-up of 7.5 years after delivery.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2459302"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}