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Research Progress on TRPA1 in Diseases. TRPA1在疾病中的研究进展
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-04-11 DOI: 10.1007/s00232-023-00277-x
Jiajing Li, Hongfei Zhang, Qian Du, Junyu Gu, Jiangbo Wu, Qi Liu, Zhuo Li, Ting Zhang, Jingyu Xu, Rui Xie
{"title":"Research Progress on TRPA1 in Diseases.","authors":"Jiajing Li, Hongfei Zhang, Qian Du, Junyu Gu, Jiangbo Wu, Qi Liu, Zhuo Li, Ting Zhang, Jingyu Xu, Rui Xie","doi":"10.1007/s00232-023-00277-x","DOIUrl":"10.1007/s00232-023-00277-x","url":null,"abstract":"<p><p>For a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the physiological functions mediated by ion channels have subtle links with the occurrence of various diseases. Our group has been engaged in the study of ion channels. In recent years, the report rate of TRPA1, the only member of the TRPA subfamily in the newly described TRP channel, has been very high. TRPA1 channels are not only abundantly expressed in peptidergic nociceptors but are also found in many nonneuronal cell types and tissues, and through the regulation of Ca<sup>2+</sup> influx, various neuropeptides and signaling pathways are involved in the regulation of nerves, respiration, circulation, and various diseases and inflammation throughout the body. In this review, we mainly summarize the effects of TRPA1 on various systems in the body, which not only allows us to have a more systematic and comprehensive understanding of TRPA1 but also facilitates more in-depth research on it in the future.</p>","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"301-316"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9274594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity. 疏水性氨基酸侧链在CFTR氯化物通道孔的窄选择性过滤器中的导电性和选择性作用。
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-10-12 DOI: 10.1007/s00232-023-00294-w
Paul Linsdell
{"title":"Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.","authors":"Paul Linsdell","doi":"10.1007/s00232-023-00294-w","DOIUrl":"10.1007/s00232-023-00294-w","url":null,"abstract":"<p><p>Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Structural analysis of CFTR has identified a narrow, hydrophobic region close to the extracellular end of the open channel pore that may function as a selectivity filter. The present study combines comprehensive mutagenesis of hydrophobic amino-acid side-chains within the selectivity filter with functional evaluation of channel Cl<sup>-</sup> conductance and anion selectivity. Among these hydrophobic amino-acids, one (F337) appears to play a dominant role in determining both conductance and selectivity. Anion selectivity appears to depend on both side-chain size and hydrophobicity at this position. In contrast, conductance is disrupted by all F337 mutations, suggesting that unique interactions between permeating Cl<sup>-</sup> ions and the native phenylalanine side-chain are important for conductance. Surprisingly, a positively charged lysine side-chain can be substituted for several hydrophobic residues within the selectivity filter (including F337) with only minor changes in pore function, arguing against a crucial role for overall hydrophobicity. These results suggest that localized interactions between permeating anions and amino-acid side-chains within the selectivity filter may be more important in determining pore functional properties than are global features such as overall hydrophobicity.</p>","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"433-442"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forces and Flows at Cell Surfaces. 细胞表面的力和流。
IF 2.3 4区 生物学
Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-09-29 DOI: 10.1007/s00232-023-00293-x
Aurelia R Honerkamp-Smith
{"title":"Forces and Flows at Cell Surfaces.","authors":"Aurelia R Honerkamp-Smith","doi":"10.1007/s00232-023-00293-x","DOIUrl":"10.1007/s00232-023-00293-x","url":null,"abstract":"","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"331-340"},"PeriodicalIF":2.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10947748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins. 多肽柔韧性和疏水力矩是评价抗肽肽临床潜力的决定因素。
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-04-25 DOI: 10.1007/s00232-023-00286-w
Daniel Balleza
{"title":"Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins.","authors":"Daniel Balleza","doi":"10.1007/s00232-023-00286-w","DOIUrl":"10.1007/s00232-023-00286-w","url":null,"abstract":"<p><p>Using a flexibility prediction algorithm and in silico structural modeling, we have calculated the intrinsic flexibility of several magainin derivatives. In the case of magainin-2 (Mag-2) and magainin H2 (MAG-H2) we have found that MAG-2 is more flexible than its hydrophobic analog, Mag-H2. This affects the degree of bending of both peptides, with a kink around two central residues (R10, R11), whereas, in Mag-H2, W10 stiffens the peptide. Moreover, this increases the hydrophobic moment of Mag-H2, which could explain its propensity to form pores in POPC model membranes, which exhibit near-to-zero spontaneous curvatures. Likewise, the protective effect described in DOPC membranes for this peptide regarding its facilitation in pore formation would be related to the propensity of this lipid to form membranes with negative spontaneous curvature. The flexibility of another magainin analog (MSI-78) is even greater than that of Mag-2. This facilitates the peptide to present a kind of hinge around the central F12 as well as a C-terminal end prone to be disordered. Such characteristics are key to understanding the broad-spectrum antimicrobial actions exhibited by this peptide. These data reinforce the hypothesis on the determinant role of spontaneous membrane curvature, intrinsic peptide flexibility, and specific hydrophobic moment in assessing the bioactivity of membrane-active antimicrobial peptides.</p>","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"317-330"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9337467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Benzyl Alcohol on the Voltage-Current Characteristics of Tethered Lipid Bilayers. 苯甲醇对脂质双层膜电压-电流特性的影响。
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-09-20 DOI: 10.1007/s00232-023-00291-z
Hadeel Alobeedallah, Bruce Cornell, Mohammed Ghazal, Hans Coster
{"title":"The Effect of Benzyl Alcohol on the Voltage-Current Characteristics of Tethered Lipid Bilayers.","authors":"Hadeel Alobeedallah, Bruce Cornell, Mohammed Ghazal, Hans Coster","doi":"10.1007/s00232-023-00291-z","DOIUrl":"10.1007/s00232-023-00291-z","url":null,"abstract":"<p><p>In this study a lipid bilayer membrane model was used in which the bilayer is tethered to a solid substrate with molecular tethers. Voltage-current (V-I) measurements of the tethered bilayer membranes (tBLM) and tBLM with benzyl alcohol (BZA) incorporated in their structures, were measured using triangular voltage ramps of 0-500 mV. The temperature dependence of the conductance deduced from the V-I measurements are described. An evaluation of the activation energies for electrical conductance showed that BZA decreased the activation/ Born energies for ionic conduction of tethered lipid membranes. It is concluded that BZA increased the average pore radius of the tBLM.</p>","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"423-431"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Forces and Flows at Cell Surfaces. 更正：细胞表面的力和流。
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-12-01 DOI: 10.1007/s00232-023-00297-7
Aurelia R Honerkamp-Smith
{"title":"Correction to: Forces and Flows at Cell Surfaces.","authors":"Aurelia R Honerkamp-Smith","doi":"10.1007/s00232-023-00297-7","DOIUrl":"10.1007/s00232-023-00297-7","url":null,"abstract":"","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":" ","pages":"341"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Adhesion between Polyphenylene Sulfide Fabric and Polytetrafluoroethylene Film for Thermally Stable Air Filtration Membrane 热稳定空气过滤膜中增强聚苯硫醚织物与聚四氟乙烯膜的粘附性
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-08-30 DOI: 10.14579/membrane_journal.2023.33.4.201
Jin Uk Kim, Hye Jeong Son, Sang Hoon Kang, Chang Soo Lee
{"title":"Enhancing Adhesion between Polyphenylene Sulfide Fabric and Polytetrafluoroethylene Film for Thermally Stable Air Filtration Membrane","authors":"Jin Uk Kim, Hye Jeong Son, Sang Hoon Kang, Chang Soo Lee","doi":"10.14579/membrane_journal.2023.33.4.201","DOIUrl":"https://doi.org/10.14579/membrane_journal.2023.33.4.201","url":null,"abstract":"","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":"21 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87159438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Physical Fouling Tolerance of PES Filtration Membranes by Using Double-layer Casting Methods 采用双层铸造法提高PES过滤膜的抗物理污染能力
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-08-30 DOI: 10.14579/membrane_journal.2023.33.4.191
Chang-Hun Kim, Youngmin Yoo, In-Chul Kim, Seung-Eun Nam, Jung-Hyun Lee, Youngbin Baek, Young Hoon Cho
{"title":"Improving Physical Fouling Tolerance of PES Filtration Membranes by Using Double-layer Casting Methods","authors":"Chang-Hun Kim, Youngmin Yoo, In-Chul Kim, Seung-Eun Nam, Jung-Hyun Lee, Youngbin Baek, Young Hoon Cho","doi":"10.14579/membrane_journal.2023.33.4.191","DOIUrl":"https://doi.org/10.14579/membrane_journal.2023.33.4.191","url":null,"abstract":"","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":"18 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78457055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Development Based on 2D Composite Membrane for Pervaporation 基于二维复合膜的渗透汽化研究进展
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-08-30 DOI: 10.14579/membrane_journal.2023.33.4.158
Seungwoo Ha, R. Patel
{"title":"Recent Development Based on 2D Composite Membrane for Pervaporation","authors":"Seungwoo Ha, R. Patel","doi":"10.14579/membrane_journal.2023.33.4.158","DOIUrl":"https://doi.org/10.14579/membrane_journal.2023.33.4.158","url":null,"abstract":"","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":"40 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86309927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MXene Based Composite Membrane for Water Purification and Power Generation: A Review 水净化与发电用MXene基复合膜研究进展
IF 2.4 4区 生物学
Journal of Membrane Biology Pub Date : 2023-08-30 DOI: 10.14579/membrane_journal.2023.33.4.181
Seohyun Kim, R. Patel
{"title":"MXene Based Composite Membrane for Water Purification and Power Generation: A Review","authors":"Seohyun Kim, R. Patel","doi":"10.14579/membrane_journal.2023.33.4.181","DOIUrl":"https://doi.org/10.14579/membrane_journal.2023.33.4.181","url":null,"abstract":"","PeriodicalId":50129,"journal":{"name":"Journal of Membrane Biology","volume":"124 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87788118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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