JPGN reports最新文献

{"title":"Case report of a gastric bezoar causing anterograde gastroduodenal intussusception requiring surgical intervention in a 15-year-old female.","authors":"Olga Ostrovetsky, Abanoub Nakhla, Christopher Prien, Rachael Sundland, Srilakshmi Atthota, Kyle Glithero, Daniel Hechtman, Graciela Wetzler, Lynn Model","doi":"10.1002/jpr3.70199","DOIUrl":"10.1002/jpr3.70199","url":null,"abstract":"<p><p>Gastroduodenal bezoars are masses of indigestible material that accumulate within the stomach and may lead to obstruction. We present a young female who presented with abdominal pain, nausea, and vomiting, and was found to have a large gastric bezoar extending into the duodenum, resulting in gastroduodenal intussusception. Endoscopic removal was unsuccessful due to the size of the mass, which consisted predominantly of hair. The patient underwent surgical removal, with resolution of symptoms and uneventful recovery. This case highlights an uncommon cause of gastroduodenal intussusception and emphasizes the importance of recognizing bezoars as a potential lead point in patients with obstructive symptoms. Prompt diagnosis and intervention are essential, particularly when endoscopic management is not feasible.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary and alternative medicine use by patients in pediatric gastroenterology clinics.","authors":"Joshua D Prozialeck, Lauren M Potthoff, Bridget Whitehead, John E Fortunato","doi":"10.1002/jpr3.70207","DOIUrl":"10.1002/jpr3.70207","url":null,"abstract":"<p><strong>Objectives: </strong>Use of complementary and alternative medicine (CAM) therapies among children seen in pediatric gastroenterology (GI) clinics is high. Multiple CAM therapies are effective as primary and adjuvant therapies for GI disorders and symptoms. Our study aimed to define the historical use of CAM and interest in CAM therapies in a specialized integrative medicine (IM) clinic among patients within an academic pediatric GI practice in the United States.</p><p><strong>Methods: </strong>We conducted a survey of pediatric patients in outpatient GI clinics. Collected information included patient and caregiver demographics, GI symptoms, GI diagnoses, historical CAM use, interest in learning more about CAM therapies, and interest in an IM clinic. Associations between CAM use or interest and patient or caregiver demographics were tested using chi-square.</p><p><strong>Results: </strong>A total of 392 pediatric patients participated (47.2% female). The most common symptoms were abdominal pain (43.4%), constipation (34.7%), and reflux (25.8%). The most common GI disorders were eosinophilic esophagitis (11%), either irritable bowel syndrome or functional abdominal pain (4.3%), and inflammatory bowel disease (3.8%). Prior CAM use was reported by 35.7%. Respondents were most interested in learning more about supplements (36.7%), probiotics (30.6%), and yoga (18.9%). Approximately 86% of patients expressed interest in an IM clinic.</p><p><strong>Conclusions: </strong>CAM use in our study is high. A large majority of respondents are interested in a clinic for complementary care. Our study highlights the support for ongoing education for physicians and patients, deeper investigation into CAM use for pediatric GI patients, and the creation of integrative clinical programs.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectal foreign body removal: Shot glass extracted with magill forceps.","authors":"Hyung-Gyo Cho, John Fortunato","doi":"10.1002/jpr3.70211","DOIUrl":"10.1002/jpr3.70211","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Wolfram Syndrome-2, a cause of severe gastrointestinal bleeding: A case series and a literature review\".","authors":"","doi":"10.1002/jpr3.70193","DOIUrl":"10.1002/jpr3.70193","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/PG9.0000000000000339.].</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"482"},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid sarcoma presenting as an isolated pancreatic mass in a 3-year-old child.","authors":"Jappmann Kaur Monga, Cara L Mack, Michelle Saad, Dylan Applin, Maisam Abu-El-Haija, David Vitale, Zachary Graff, Gila Ginzburg","doi":"10.1002/jpr3.70192","DOIUrl":"10.1002/jpr3.70192","url":null,"abstract":"<p><p>Myeloid sarcoma (MS) is an extramedullary tumor of myeloid precursor cells, frequently associated with acute myeloid leukemia (AML), and rarely occurring in isolation. We present a child with obstructive jaundice secondary to a pancreatic head mass. Initial imaging was consistent with pancreatic hematoma; however, continued symptoms led to endoscopic ultrasound (EUS)-guided biopsies that raised concern for autoimmune pancreatitis. Further histological and cytogenetic analysis confirmed pancreatic MS associated with a RUNX1::RUNX1T1 fusion. Bone marrow evaluation was negative by conventional diagnostic methods; however, reverse transcriptase with qualitative real-time polymerase chain reaction (RT-qPCR) detected RUNX1::RUNX1T1 transcripts. Chemotherapy achieved both radiologic resolution and disappearance of RUNX1::RUNX1T1 transcripts within the bone marrow. This represents one of the first reported cases of isolated pancreatic MS in a child, without progression to AML. Our case highlights the diagnostic challenges of pancreatic masses, the underutilization of EUS-guided biopsy in pediatrics, and the use of RT-qPCR for both diagnosis and disease resolution.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and calcium supplementation in children with eosinophilic esophagitis on a dairy-free elimination diet: A single-center review.","authors":"Madyson Derouin, Robert Becker, Caitlin Jacobs, Ankur Chugh, Rose Lee","doi":"10.1002/jpr3.70191","DOIUrl":"10.1002/jpr3.70191","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raising the bar: Utilizing quality improvement tools to increase compliance with clinical care guidelines in inflammatory bowel disease patients.","authors":"Amir Jazayeri, Emi Suzuki, Laura Bauman, Brent Polk, Jeannie S Huang","doi":"10.1002/jpr3.70189","DOIUrl":"10.1002/jpr3.70189","url":null,"abstract":"<p><p>Patients admitted for inflammatory bowel disease (IBD) are often managed by rotating teams of care providers during their hospital stay. This can lead to potential variability in the care they receive. Our team developed a scoring system of six key high-quality care components called the standardized IBD care index (SICI) to standardize care management. A multi-phase implementation was conducted to improve adherence to SICI components. At baseline, compliance with the SICI score was approximately 45%, with a goal of 75% post implementation. After implementation, we were able to exceed our goal of 75% compliance with sustained success for the entirety of the study period. This project demonstrates that standardizing care practices can reduce physician-dependent variability and have measurable improvements in the quality of care provided for IBD patients.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safe and effective use of tofacitinib and ustekinumab combination therapy in infantile onset inflammatory bowel disease.","authors":"Smridhi Mahajan, Christian Wysocki, Bhaskar Gurram","doi":"10.1002/jpr3.70190","DOIUrl":"10.1002/jpr3.70190","url":null,"abstract":"<p><p>Infantile-onset inflammatory bowel disease (IOIBD) is a rare and severe subset of very-early-onset IBD, often associated with immune dysregulation and poor response to conventional therapies. Data regarding the use of Janus kinase inhibitors (JAKI) in this population is limited. We conducted a retrospective chart review of four patients treated with tofacitinib in combination with ustekinumab after failing multiple agents at a tertiary referral center. All four patients demonstrated clinical, laboratory, and endoscopic remission. No adverse events were observed. Genetic evaluation did not reveal monogenic causes in any of these patients. These findings suggest that JAKI may represent a safe and effective therapeutic option for carefully selected patients with difficult-to-treat IOIBD, either as a bridge to or in combination with ustekinumab. Larger prospective studies are warranted to better define the role of JAKI in this challenging patient population.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cystic fibrosis transmembrane conductance regulator modulator therapies on liver stiffness and liver enzymes: An observational perspective single-center cohort study.","authors":"Laura Giugliano, Elisabetta Augustoni, Antonio Pizzol, Anna Opramolla, Cristina Chiadò, Anna Zagaria, Irene Esposito, Giulia Roberto, Alice Ponte, Andrea Evangelista, Paola Quarello, Michele Pinon, Pier Luigi Calvo","doi":"10.1002/jpr3.70186","DOIUrl":"10.1002/jpr3.70186","url":null,"abstract":"<p><strong>Objectives: </strong>The efficacy of cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>)-modulator therapies in preventing or ameliorating cystic fibrosis liver disease (CFLD) by correcting <i>CFTR</i> in cholangiocytes is not well-documented. This study aimed to assess liver function during CFTR-modulators.</p><p><strong>Methods: </strong>Patients eligible to start Elexacaftor/Tezacaftor/Ivacaftor (July 2021-December 2022), followed-up at the Piedmont Cystic Fibrosis reference <i>Centre of the Città della Salute e della Scienza, Turin</i>, <i>Italy</i>, were enrolled through a prospective single-center cohort study and evaluated using hematological exams and liver stiffness measurement (LSM) before treatment and at 1, 3, 6, and 12 months thereafter. The treated group was compared to a group of untreated people with cystic fibrosis (pwCF), evaluated at baseline and after 12 months.</p><p><strong>Results: </strong>Sixty-nine treated pwCF, mean age 16.0 years, 51% males, were compared to 130 non-treated pwCF, mean age 12.14 years, 49% males. Treated pwCF were classified by LSM as normal (<5 kPa) (<i>N</i> = 44, 64%), mild liver fibrosis (5-7 kPa) (<i>N</i> = 16, 23%), or moderate-severe fibrosis (>7 kPa) (<i>N</i> = 9, 13%). A significant trend in LSM reduction was observed at Month 12 in the subgroups with LSM 5-7 kPa and LSM > 7 kPa (-1.05, <i>p</i> = 0.016 and -1.57, <i>p</i> = 0.022, respectively). PwCF without fibrosis at baseline and non-treated pwCF showed no LSM change over time. Liver enzyme levels increased at Month 12, trend mirrored in non-treated pwCF for AST level, remaining within normal ranges.</p><p><strong>Conclusions: </strong>During treatment, a significant LSM reduction was observed in pwCF with liver fibrosis at baseline, especially after Month 1. This rapid improvement could be multifactorial and may suggest a potential early response without significant liver toxicity.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of secondary esophageal motility by Endoluminal Functional Lumen Imaging Probe (EndoFLIP) in young patients with pediatric feeding disorder with and without persistent dysphagia.","authors":"Gurleen Kaur Kahlon, Sara Koroli, Ricardo Medina-Centeno, Dana I Williams","doi":"10.1002/jpr3.70175","DOIUrl":"10.1002/jpr3.70175","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"422-427"},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}