JPGN reportsPub Date : 2023-12-20DOI: 10.1002/jpr3.12023
Ulrich Baumann, J. Bronsky, Jernej Dolinšek, M. Fewtrell, Giuseppe Indolfi, Sanja Kolaček
{"title":"Impact of new legislation on the availability of pediatrics medical devices in the European Union with an emphasis on paediatric gastroenterology, hepatology and nutrition","authors":"Ulrich Baumann, J. Bronsky, Jernej Dolinšek, M. Fewtrell, Giuseppe Indolfi, Sanja Kolaček","doi":"10.1002/jpr3.12023","DOIUrl":"https://doi.org/10.1002/jpr3.12023","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"102 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138958725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2023-12-20DOI: 10.1002/jpr3.12025
Y. Smadi, Jessina Thomas, Khaled Bittar, Hannah Norton, Joel A. Friedlander, Jeffrey Bornstein
{"title":"Office‐based sedation‐free transnasal esophagogastroduodenoscopy with biopsies using single‐use gastroscopes: A pediatric single‐center experience","authors":"Y. Smadi, Jessina Thomas, Khaled Bittar, Hannah Norton, Joel A. Friedlander, Jeffrey Bornstein","doi":"10.1002/jpr3.12025","DOIUrl":"https://doi.org/10.1002/jpr3.12025","url":null,"abstract":"Unsedated transnasal endoscopy (TNE) as transnasal esophagoscopy (TN‐Eso) has emerged as a promising alternative to esophagogastroduodenoscopy (EGD) under sedation to assess eosinophilic esophagitis (EoE). We report our center's experience using single‐use gastroscopes to perform sedation‐free transnasal EGD (TN‐EGD) with biopsies in an office‐based setting.A retrospective review was performed on patients with eosinophilic esophagitis who underwent office‐based sedation‐free TNE with topical analgesia and virtual reality (VR) procedural dissociation and distraction. A sterile, single‐use, ultra‐slim 3.5 mm outer diameter, 110 cm long gastroscope with 2 mm working channel (EvoEndo) was used to perform TNE with biopsies/brushings. Data including demographics, procedure success rate, total visit time, biopsy adequacy, procedure time, procedural preference, and complications were collected.Office‐based TNE was completed in 8 patients (six males, age range 11–20 years). The endoscope was advanced by an experienced transoral endoscopist successfully through the nares into stomach (transnasal esophagogastroscopy [TN‐EG]) in all subjects (100%) and into the duodenum (TN‐EGD) in seven subjects (87.5%). Biopsies were obtained from esophagus in all cases and from the stomach/duodenum in five cases. Histological assessment, esophageal brushing, disaccharidase enzyme analysis, or duodenal aspirate analysis were performed as indicated. EoE reevaluation was the primary indication to perform endoscopy in all patients. Visual and histologic findings were all adequate for assessment. There were no significant adverse events.Office‐based TN‐EGD with VR procedural distraction and dissociation using single‐use gastroscopes was effective to monitor EoE, gastritis, and duodenitis in a pediatric practice.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"118 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2023-11-27eCollection Date: 2023-11-01DOI: 10.1097/PG9.0000000000000388
Mojdeh Mostafavi, Annie Abraham, James Mueller, Wael Sayej
{"title":"Concurrent, New-Onset Autoimmune Hepatitis, Celiac Disease, and Hashimoto's Thyroiditis Following COVID-19: A Case Report.","authors":"Mojdeh Mostafavi, Annie Abraham, James Mueller, Wael Sayej","doi":"10.1097/PG9.0000000000000388","DOIUrl":"10.1097/PG9.0000000000000388","url":null,"abstract":"<p><p>Here we describe a 13-year-old adolescent female diagnosed with concurrent autoimmune disorders including Grave disease, Celiac disease, and autoimmune hepatitis within 3 months after infection with severe acute respiratory syndrome coronavirus 2. The patient initially presented to her pediatrician with complaints of epistaxis, cessation of menses, palpitations, and weight loss. Initial evaluation showed evidence of hyperthyroidism, elevated liver enzymes, and abnormal Celiac disease serologies. Additional testing including laboratory tests, liver biopsy, and an upper endoscopy with biopsies confirmed the diagnosis of Grave disease, Celiac disease, and type 1 autoimmune hepatitis. This case highlights the importance of recognizing the risk of autoimmune disorders associated with the novel coronavirus disease 2019.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"4 4","pages":"e388"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2023-11-27eCollection Date: 2023-11-01DOI: 10.1097/PG9.0000000000000382
Madison Riddell, Chris Novak, Sarah Dinn, Gary Galante
{"title":"An Adolescent Female With Concurrent Presentation of Autoimmune Hepatitis and Secondary Syphilis.","authors":"Madison Riddell, Chris Novak, Sarah Dinn, Gary Galante","doi":"10.1097/PG9.0000000000000382","DOIUrl":"10.1097/PG9.0000000000000382","url":null,"abstract":"<p><p>We describe concurrent diagnoses of autoimmune hepatitis (AIH) and secondary syphilis in a 17-year-old adolescent with jaundice, with possible syphilitic hepatitis (SH) excluded after a thorough investigation. Our patient presented with a several-day history of malaise, progressive jaundice, and vomiting. She disclosed being sexually active and requested testing for sexually transmitted infections. Her subsequent investigations demonstrated acute hepatitis with a positive antinuclear antibody and elevated IgG. She also tested positive for syphilis with a reactive rapid plasma regain and treponema pallidum particle agglutination assay. We considered 2 etiologies for her elevated liver enzymes: syphilitic hepatitis and AIH. AIH was confirmed on liver biopsy, establishing the first reported pediatric case of concurrent AIH and secondary syphilis. Syphilis is hypothesized to be an infectious trigger for AIH.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"4 4","pages":"e382"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2023-11-27eCollection Date: 2023-11-01DOI: 10.1097/PG9.0000000000000383
Matthew D Swatski, Panamdeep Kaur, Rachel E Borlack, Shonnell McBain, Joshua Uffer, Osama Almadhoun
{"title":"A Case Series of New-Onset Ulcerative Colitis Following Recent Diagnosis of COVID-19.","authors":"Matthew D Swatski, Panamdeep Kaur, Rachel E Borlack, Shonnell McBain, Joshua Uffer, Osama Almadhoun","doi":"10.1097/PG9.0000000000000383","DOIUrl":"10.1097/PG9.0000000000000383","url":null,"abstract":"<p><p>There have been only 2 reported cases of new-onset ulcerative colitis in pediatrics following acute coronavirus disease 2019 (COVID-19). We are reporting a case series of 3 adolescent female patients, 2 of whom were vaccinated against COVID-19, who developed new-onset ulcerative colitis following a recent diagnosis of COVID-19 infections at a singular pediatric hospital. This case series should be an impetus to clinicians who have pediatric patients with persistent symptoms of hematochezia, diarrhea, and abdominal pain following acute COVID-19 infection to consider further workup for inflammatory bowel disease.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"4 4","pages":"e383"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2023-08-16eCollection Date: 2023-11-01DOI: 10.1097/PG9.0000000000000340
Claudio Tiberti, Margherita Bonamico, Raffaella Nenna, Laura Petrarca, Chiara Maria Trovato, Nicoletta Pietropaoli, Valeria Fassino, Fabio Midulla, Andrea Lenzi, Salvatore Oliva, Monica Montuori
{"title":"Investigating the Relationship Between COVID-19 and Celiac Disease. A Dual Research Approach.","authors":"Claudio Tiberti, Margherita Bonamico, Raffaella Nenna, Laura Petrarca, Chiara Maria Trovato, Nicoletta Pietropaoli, Valeria Fassino, Fabio Midulla, Andrea Lenzi, Salvatore Oliva, Monica Montuori","doi":"10.1097/PG9.0000000000000340","DOIUrl":"10.1097/PG9.0000000000000340","url":null,"abstract":"<p><strong>Background: </strong>Most evidence on the coronavirus disease 2019 (COVID-19) pandemic, has been obtained from web- or telephone-based surveys. In particular, few laboratory data, often incomplete, have been reported on the frequency of COVID-19-related serology at celiac disease (CD) diagnosis or on the effects of COVID-19 on the development of CD-specific autoimmunity.</p><p><strong>Objectives: </strong>The objective of this retrospective cross-sectional case/control study was to: (1) evaluate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in 78 children and adolescents at CD diagnosis (CD, 44 females, median age 7.4 years); (2) evaluate the frequency of IgA-anti-transglutaminase antibodies (IgA-tTGAbs) in 97 nonceliac patients (50 females, median age 9.0 years) who contracted SARS-CoV-2 infection during the pandemic (February-April 2021). As a control (CTRL) group, we analyzed 141 healthy subjects (79 females, median age 9.8 years) enrolled during the pandemic.</p><p><strong>Methods: </strong>SARS-CoV-2 IgM- and IgG-antibodies were detected by chemiluminescent microparticle immunoassays. IgA-tTGAbs were detected by a fluid-phase radioimmunoassay.</p><p><strong>Results: </strong>Six out of 78 (7.7%) CD patients tested positive for SARS-CoV-2Abs, with a frequency not significantly different from CTRL subjects (9.2%). None of the 97 nonceliac COVID-19 patients tested positive for IgA-tTG antibodies.</p><p><strong>Conclusion: </strong>These 2 distinct research approaches showed (1) similar frequencies of SARS-CoV-2 immunoreactivities in CD patients and CTRL subjects and, (2) no ability of SARS-CoV-2 to induce a CD-specific immune response, at least in the 3-4 months following SARS-CoV-2 infection.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"4 4","pages":"e340"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2022-12-02eCollection Date: 2023-02-01DOI: 10.1097/PG9.0000000000000249
Lea Oliveros, Michelle Rosario, Alexander Wilsey, Sara Karjoo, Michael Wilsey
{"title":"Gastric Outlet Obstruction Caused by a Foreign Body Ingestion.","authors":"Lea Oliveros, Michelle Rosario, Alexander Wilsey, Sara Karjoo, Michael Wilsey","doi":"10.1097/PG9.0000000000000249","DOIUrl":"10.1097/PG9.0000000000000249","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"4 1","pages":"e249"},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}