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Letter to the editor in response to distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase, appearing in JPGN rep 2023 feb 28;4(2):E292 致编辑的信,回应《区分肥胖和丙氨酸氨基转移酶筛查阳性青少年的自身免疫性肝炎和脂肪性肝炎》,刊登于《JPGN Rep 2023 feb 28;4(2):E292》。
JPGN reports Pub Date : 2024-02-28 DOI: 10.1002/jpr3.12050
C. Mandato, Angelo Colucci, Pietro Vajro
{"title":"Letter to the editor in response to distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase, appearing in JPGN rep 2023 feb 28;4(2):E292","authors":"C. Mandato, Angelo Colucci, Pietro Vajro","doi":"10.1002/jpr3.12050","DOIUrl":"https://doi.org/10.1002/jpr3.12050","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"20 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resolution of metabolic dysfunction‐associated steatohepatitis with estradiol in a transgender female: A case report 变性女性服用雌二醇后,代谢功能障碍相关性脂肪性肝炎得到缓解:病例报告
JPGN reports Pub Date : 2024-02-26 DOI: 10.1002/jpr3.12054
Athreya Steiger, Nathan T. VanderVeen, Esther H. Kang, Amy K. Weimer
{"title":"Resolution of metabolic dysfunction‐associated steatohepatitis with estradiol in a transgender female: A case report","authors":"Athreya Steiger, Nathan T. VanderVeen, Esther H. Kang, Amy K. Weimer","doi":"10.1002/jpr3.12054","DOIUrl":"https://doi.org/10.1002/jpr3.12054","url":null,"abstract":"A 16‐year‐old trans female patient presented to our Gender Health Program for gender‐affirming care. Her intake evaluation revealed signs of hepatocellular injury and fibrosis concerning for metabolic dysfunction‐associated steatohepatitis (MASH) and she was referred to a Pediatric Hepatologist. Subsequent delays in initiating hormone therapy caused a decline in her mental health, and she began experiencing suicidal ideations. Gender‐affirming hormone therapy has been shown to significantly reduce depressive symptoms and suicidal ideations in transgender and gender diverse youth, and studies in animal models suggest improvement in hepatic steatosis in response to estrogen. A multidisciplinary meeting with Gender Health, Psychiatry, and Hepatology appropriately weighed the benefits of life‐saving hormone therapy and the possibility of an improvement in her comorbid liver condition with the risk of further liver damage from estrogen therapy. The teams and the patient agreed to start estradiol with subsequent resolution of laboratory and radiographic evidence of MASH.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"33 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140429462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor in response to: A case of pediatric alcohol‐associated hepatitis evaluated for liver transplant listing 致编辑的信一例小儿酒精相关性肝炎病例的肝移植列表评估
JPGN reports Pub Date : 2024-02-26 DOI: 10.1002/jpr3.12026
Amber Hildreth, J. Schwimmer
{"title":"Letter to the editor in response to: A case of pediatric alcohol‐associated hepatitis evaluated for liver transplant listing","authors":"Amber Hildreth, J. Schwimmer","doi":"10.1002/jpr3.12026","DOIUrl":"https://doi.org/10.1002/jpr3.12026","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"4 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140430635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food insecurity screening practices in a pediatric gastroenterology population 儿科肠胃病人群中的粮食不安全筛查做法
JPGN reports Pub Date : 2024-02-26 DOI: 10.1002/jpr3.12058
Ryan Morrow, Marisa G. Stahl, Ed Liu, Mary Shull, Monique M. Germone, Sadie Nagle, Isabel Griffith, Pooja Mehta
{"title":"Food insecurity screening practices in a pediatric gastroenterology population","authors":"Ryan Morrow, Marisa G. Stahl, Ed Liu, Mary Shull, Monique M. Germone, Sadie Nagle, Isabel Griffith, Pooja Mehta","doi":"10.1002/jpr3.12058","DOIUrl":"https://doi.org/10.1002/jpr3.12058","url":null,"abstract":"Food insecurity is a rising concern for US households and leads to adverse child health outcomes. Pediatric gastroenterology providers are uniquely equipped to help guide families experiencing this challenge given their specialized training in nutritional support and dietary therapy for disease management. Hence, this study aimed to evaluate food insecurity screening practices from the perspectives of patient caregivers and healthcare providers in a tertiary pediatric gastroenterology practice. A survey was administered to 1279 caregivers and 121 providers. Of the 248 completed caregiver responses, 10%−15% reported being asked about food insecurity. Among the 36 healthcare provider responses, 53% expressed comfort in conducting food insecurity screening but only 14% routinely screened. The most cited barrier to screening was the lack of readily available patient resources. Further research is imperative to address these screening barriers and assess the impact of food insecurity screening and interventions on pediatric gastrointestinal health outcomes.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140430335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collagenous gastritis with elevated fecal calprotectin in a pediatric patient 一名儿科患者的胶原性胃炎伴粪便钙黏蛋白升高
JPGN reports Pub Date : 2024-02-22 DOI: 10.1002/jpr3.12055
Natalie Rodriguez, Soma Kumar, Jun Mo, Phillipp Hartmann
{"title":"Collagenous gastritis with elevated fecal calprotectin in a pediatric patient","authors":"Natalie Rodriguez, Soma Kumar, Jun Mo, Phillipp Hartmann","doi":"10.1002/jpr3.12055","DOIUrl":"https://doi.org/10.1002/jpr3.12055","url":null,"abstract":"Collagenous gastritis is a rare and chronic inflammatory condition of undetermined etiology characterized histologically by thickened subepithelial collagen bands and increased intraepithelial lymphocytes. Here, we present a collagenous gastritis case in a 16‐year‐old female with chronic abdominal pain, persistently elevated fecal calprotectin (507 and 796 mcg/g), and resolved iron deficiency anemia. The patient's history, laboratory tests, endoscopy, and magnetic resonance imaging ruled out common causes of elevated fecal calprotectin, including Helicobacter pylori and gastrointestinal infections, medications, celiac disease, and inflammatory bowel disease, as well as less common causes such as collagenous colitis. Esophagogastroduodenoscopy revealed significant antral nodularity. Gastric biopsies showed thickened subepithelial collagen band and surface epithelium damage with increased intraepithelial lymphocytes. The ileocolonoscopy was normal. This is among the first reported cases of collagenous gastritis with elevated fecal calprotectin levels that could solely be attributed to this condition.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"15 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celiac crisis, transient hypertransaminasemia and positive smooth muscle antibodies (SMA): A celiac disease case report 乳糜泻危象、一过性高转氨酶血症和平滑肌抗体 (SMA) 阳性:乳糜泻病例报告
JPGN reports Pub Date : 2024-02-22 DOI: 10.1002/jpr3.12056
Federica Rodofile, Paola Melli, A. Di Siena, Paola Cogo
{"title":"Celiac crisis, transient hypertransaminasemia and positive smooth muscle antibodies (SMA): A celiac disease case report","authors":"Federica Rodofile, Paola Melli, A. Di Siena, Paola Cogo","doi":"10.1002/jpr3.12056","DOIUrl":"https://doi.org/10.1002/jpr3.12056","url":null,"abstract":"Celiac crisis (CC) is a rare complication of celiac disease (CD), usually observed in younger children with unrecognized CD or poor compliance with a gluten‐free diet (GFD). We present a case of celiac crisis in a 3‐year‐old girl who was recently diagnosed with celiac disease. She was referred to our clinic with anasarca, tetany, and severe malnutrition, with hypokalemia, hypocalcemia, hypomagnesemia, and hypoalbuminemia. During hospitalization, she presented hypertransaminasemia with positive anti‐actin smooth muscle antibodies (SMA). Abdominal ultrasound and liver biopsy were normal, excluding autoimmune hepatitis. Liver involvement is a common CD extraintestinal manifestation and cryptogenic form is the most common. SMA positivity could be associated with a systemic immune cross reaction. Our patient normalized liver values after 2 months of GFD.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventions to alleviate anxiety and pain during venipuncture in children with chronic gastrointestinal and/or liver disease: A single‐center prospective observational study 减轻患有慢性胃肠道疾病和/或肝病的儿童在静脉穿刺过程中的焦虑和疼痛的干预措施:单中心前瞻性观察研究
JPGN reports Pub Date : 2024-02-15 DOI: 10.1002/jpr3.12053
Albert Fuchs, Berrit L Cordes, Rolf van Dick, Gianna Ebers, Antonia Kaluza, Christiane Konietzny, Ulrich Baumann
{"title":"Interventions to alleviate anxiety and pain during venipuncture in children with chronic gastrointestinal and/or liver disease: A single‐center prospective observational study","authors":"Albert Fuchs, Berrit L Cordes, Rolf van Dick, Gianna Ebers, Antonia Kaluza, Christiane Konietzny, Ulrich Baumann","doi":"10.1002/jpr3.12053","DOIUrl":"https://doi.org/10.1002/jpr3.12053","url":null,"abstract":"The goal of this longitudinal study was to reduce anxiety and pain in children with chronic conditions from the gastrointestinal tract during venipuncture. These children undergo regular venipuncture as part of their medical management and the procedure is often accompanied with anxiety and pain. In addition, children as well as their parents and health care professionals (HCPs) often suffer “compassionate pain” because of emotional interference.In a realistic clinical setting, different psychological and medical interventions were examined: (1) Psychoeducational brochures and (2) four different medical‐technical interventions during venipuncture. In a large hospital in Germany, 169 children, their parents, and HCPs were asked to rate anxiety and pain during venipuncture before and after the intervention.Children showed a clear preference for some of the medical‐technical interventions. Using Linear Mixed Models anxiety and pain rated by the children themselves showed no significant reduction. However, parents and HCPs reported a significant reduction. Age, gender, and status of liver transplantation were associated with a reduction in anxiety and pain in most of the analyses.Both psychoeducational brochures and medical‐technical interventions had a positive impact on anxiety and pain. However, effectivity for the medical–technical interventions was lower than in previous studies utilizing individual interventions. Reasons for this difference as well as possibilities to improve the intervention are discussed. In addition, this study provides practical day‐to‐day information about the implementation of interventions for the work in pediatric units such as when and how to provide psychoeducational materials.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"13 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive infected pancreatic necrosis in an 8‐year‐old: Endoscopic management 一名 8 岁儿童的大面积感染性胰腺坏死:内镜治疗
JPGN reports Pub Date : 2024-02-14 DOI: 10.1002/jpr3.12052
William F Abel, Varun Kesar, Reid D. Wasserman, Manoj Kumar, Vishal Patel, P. Yeaton, Vivek Kesar
{"title":"Massive infected pancreatic necrosis in an 8‐year‐old: Endoscopic management","authors":"William F Abel, Varun Kesar, Reid D. Wasserman, Manoj Kumar, Vishal Patel, P. Yeaton, Vivek Kesar","doi":"10.1002/jpr3.12052","DOIUrl":"https://doi.org/10.1002/jpr3.12052","url":null,"abstract":"Pancreatitis is a condition much more commonly found in adults, but when diagnosed in the pediatric population, is often due to medications, congenital pathology, and critical illness. This patient had previously undergone treatment with 6‐mercaptopurine and presented with pancreatitis that eventually worsened to a walled‐off necrotic collection with paracolic extensions reaching the pelvis. Given clinical worsening with development of shock, procedural options for source control were weighed with gastroenterology, pediatric surgery, and interventional radiology, before pancreatic necrosectomy was determined to be the treatment of choice, given the adjacency of the collection to the stomach. A total of three separate endoscopic pancreatic necrosectomy procedures were performed and the patient s clinical status improved greatly, with vast improvement later seen on outpatient imaging. This successful treatment course argues for the efficacy of pancreatic necrosectomy even in very large walled off collections, and most importantly, lead to a positive outcome in this young patient.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139779656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status seizures as a secondary effect from the “squash drinking syndrome” in an infant 婴儿 "喝壁球综合征 "继发的状态发作
JPGN reports Pub Date : 2024-02-14 DOI: 10.1002/jpr3.12043
A. Rosell-Camps, Lucinda F. Bunce, Bernardí Barceló‐Martí, Artur Sharluyan‐Petrosyan
{"title":"Status seizures as a secondary effect from the “squash drinking syndrome” in an infant","authors":"A. Rosell-Camps, Lucinda F. Bunce, Bernardí Barceló‐Martí, Artur Sharluyan‐Petrosyan","doi":"10.1002/jpr3.12043","DOIUrl":"https://doi.org/10.1002/jpr3.12043","url":null,"abstract":"The “hypotonic drink syndrome” is characterized by loss of appetite, normal activity levels and, in some cases, intestinal disturbances in children with an intake of more than 30% of the recommended daily calories in the form of non‐dairy drinks. Diarrhea and growth retardation are possible complications due to the amount of nonnutritive calorie intake (“empty calories”) contained in this type of hypotonic beverages.We present the case of an 11‐month‐old boy who suffered a “Squash drinking syndrome” requiring admission to the pediatric intensive care unit because of a status seizure secondary to a severe hyponatremia (118 mmol/L) due to massive ingestion of hypotonic drinks, such as squash. The seizure did not subside until sodium levels reached 123 mmol/L with hypertonic saline (3%). Neurological, renal, digestive, endocrine and metabolic problems were all ruled out and normal sodium levels were maintained with dietary recommendations and a restriction of hypotonic fluid intake.To prevent these situations it is important to be aware of this entity and to know how to identify the possible complications that may appear after excessive ingestion of hypotonic drinks, as in the case of our patient, ranging from lack of appetite, growth failure and diarrhea, to a status seizure.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139779194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status seizures as a secondary effect from the “squash drinking syndrome” in an infant 婴儿 "喝壁球综合征 "继发的状态发作
JPGN reports Pub Date : 2024-02-14 DOI: 10.1002/jpr3.12043
A. Rosell-Camps, Lucinda F. Bunce, Bernardí Barceló‐Martí, Artur Sharluyan‐Petrosyan
{"title":"Status seizures as a secondary effect from the “squash drinking syndrome” in an infant","authors":"A. Rosell-Camps, Lucinda F. Bunce, Bernardí Barceló‐Martí, Artur Sharluyan‐Petrosyan","doi":"10.1002/jpr3.12043","DOIUrl":"https://doi.org/10.1002/jpr3.12043","url":null,"abstract":"The “hypotonic drink syndrome” is characterized by loss of appetite, normal activity levels and, in some cases, intestinal disturbances in children with an intake of more than 30% of the recommended daily calories in the form of non‐dairy drinks. Diarrhea and growth retardation are possible complications due to the amount of nonnutritive calorie intake (“empty calories”) contained in this type of hypotonic beverages.We present the case of an 11‐month‐old boy who suffered a “Squash drinking syndrome” requiring admission to the pediatric intensive care unit because of a status seizure secondary to a severe hyponatremia (118 mmol/L) due to massive ingestion of hypotonic drinks, such as squash. The seizure did not subside until sodium levels reached 123 mmol/L with hypertonic saline (3%). Neurological, renal, digestive, endocrine and metabolic problems were all ruled out and normal sodium levels were maintained with dietary recommendations and a restriction of hypotonic fluid intake.To prevent these situations it is important to be aware of this entity and to know how to identify the possible complications that may appear after excessive ingestion of hypotonic drinks, as in the case of our patient, ranging from lack of appetite, growth failure and diarrhea, to a status seizure.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"760 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139838995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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