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Excessive sodium supplementation but not fluid load is correlated with overall morbidity in extremely low birth weight infants 过量补充钠与极低出生体重儿的总体发病率相关,但与液体负荷无关
JPGN reports Pub Date : 2024-01-07 DOI: 10.1002/jpr3.12036
Konrad Becker, Hera Becker, Teresa Riedl‐Seifert, Markus Waitz, Andreas Jenke
{"title":"Excessive sodium supplementation but not fluid load is correlated with overall morbidity in extremely low birth weight infants","authors":"Konrad Becker, Hera Becker, Teresa Riedl‐Seifert, Markus Waitz, Andreas Jenke","doi":"10.1002/jpr3.12036","DOIUrl":"https://doi.org/10.1002/jpr3.12036","url":null,"abstract":"Sodium homeostasis in extremely low birth weight (ELBW) infants is critical. While a lack of sodium delays growth, excessive supplementation increases morbidity.We performed a single‐center retrospective study on sodium and fluid management during the first 2 weeks of live including all ELBW infants born between June 1, 2017 and May 31, 2019.Forty‐seven patients (median GA 26 + 6 weeks, median BW 845 g) were included. Mean sodium intake was above the ESPGHAN recommendation, 4.58 mmol/kg/day during the first 2 days and 1.99 mmol/kg/day during the following period. Incidence of PDA, IVH, and ROP was directly associated with sodium intake (OR 1.6, 1.3, and 1.4, respectively), but not with fluid supplementation. No association to BPD was found. The most important source for inadvertent sodium intake were 0.9% saline given by arterial lines. Sodium supplementation did not correlate directly with serum sodium levels, but a linear regression model combining sodium intake and fluid supplementation was able to predict serum sodium changes 24–48 h in advance (correlation coefficient of 0.294, p < 0.05).Sodium application substantially exceeded ESPGHAN recommendations in ELBW infants. An excess in sodium was associated with an overall increased morbidity, justifying increased efforts to identify inadvertent sodium sources in these patients with the aim to decrease sodium excess.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"67 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complementary feeding in infants born preterm: Aspects needing improvement 早产儿的辅助喂养:需要改进的方面
JPGN reports Pub Date : 2024-01-04 DOI: 10.1002/jpr3.12032
M. Meneghelli, Silvia Toniazzo, Elena Priante, M. E. Cavicchiolo, Francesca De Terlizzi, Paola Gaio, Paolo Spinella, Giovanna Verlato
{"title":"Complementary feeding in infants born preterm: Aspects needing improvement","authors":"M. Meneghelli, Silvia Toniazzo, Elena Priante, M. E. Cavicchiolo, Francesca De Terlizzi, Paola Gaio, Paolo Spinella, Giovanna Verlato","doi":"10.1002/jpr3.12032","DOIUrl":"https://doi.org/10.1002/jpr3.12032","url":null,"abstract":"The aim of our study was to collect data on complementary feeding (CF) in preterm infants (PIs).We enrolled PI ≤ 34 weeks of gestational age discharged from the neonatal intensive care unit (NICU) of the University Hospital of Padova. At 12 months of corrected age (CA), CF was investigated with questionnaires to the parents and a 24‐h dietary recall. In a subgroup of newborns, we also evaluated bone status at a CA of 12 months using quantitative ultrasound.We studied 167 ex PI at 1 year of CA. CF was introduced in 67.1% of them between 5 and 8 months of chronological age, with fruit as the first food (81%, n = 136). Sweet drinks were consumed by 17.4% of our sample, and salt was added in 33.5% of cases. PIs, at 1 year CA, introduced extra energy compared to the theoretical requirement (121 ± 31 kcal/kg/day) and higher protein intake than recommended (39 ± 11 g/day), while the intake of both total lipids and carbohydrates was slightly lower. Vitamins and minerals were adequate, except vitamin D. Regarding bone status, we found a correlation between vitamin D intakes from the diet and bone parameters (metacarpus‐bone transmission time: r = 0.36, p = 0.01) at 1 year of CA.Our population of PIs started CF in agreement with current suggestions though with a notable heterogeneity and with some mistakes. Vitamin D intake was correlated with bone status at 1 year of CA.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"48 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of age, disease severity, and BMI on bone health and growth in children and young people with Crohn's disease 年龄、疾病严重程度和体重指数对克罗恩病儿童和青少年骨骼健康和生长的影响
JPGN reports Pub Date : 2024-01-04 DOI: 10.1002/jpr3.12037
R. Kherati, Archana Bansal, J. Oleksiewicz, A. Kadir, Natasha Burgess, Sabrina Barr, Sandhia Naik, Nick Crof, Marco Gasparetto
{"title":"The impact of age, disease severity, and BMI on bone health and growth in children and young people with Crohn's disease","authors":"R. Kherati, Archana Bansal, J. Oleksiewicz, A. Kadir, Natasha Burgess, Sabrina Barr, Sandhia Naik, Nick Crof, Marco Gasparetto","doi":"10.1002/jpr3.12037","DOIUrl":"https://doi.org/10.1002/jpr3.12037","url":null,"abstract":"The objective of this study was to explore the correlation between paediatric Crohn's disease (CD) characteristics, bone health and growth parameters at diagnosis and follow‐up.Retrospective data was collected for 47 children aged 4–16 who were newly diagnosed with CD between January 2018 and December 2019. Mean follow‐up time was 2.5 years.Eleven (24%) children had growth delay at diagnosis, which persisted in 4 (44%) of 9 recorded children at follow‐up. Of the 35 children tested, 20 (57%) had inadequate Vitamin D levels (<50 mmol/L) at diagnosis. Thirty‐seven (79%) children had a dual‐energy X‐ray absorptiometry scan at diagnosis, with 20 of them having at least 1 low Z‐score. Children with poorer bone mineral density and bone mineral concentration Z‐scores for age had a younger age at diagnosis (p = .042 and p = .021), more severe disease (p = .04 and p = .029) and a lower BMI (p < .001) at diagnosis. Children diagnosed with CD ≥11 years had a lower‐than‐expected height velocity (p < .0001 and p < .001). Multivariate regression analysis demonstrated an older age of diagnosis was a significant predictor of a lower height velocity at follow‐up.Disease severity and age of diagnosis are important CD‐related factors that influence bone health and growth. Vitamin D is an accessible component that if optimised can improve all three factors. Monitoring and optimising each aspect systematically has the potential to enable children to achieve their bone health and growth potentials.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"86 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139386070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appendiceal mucinous neoplasm in adolescence: Diagnosis, management, and surveillance. 青春期阑尾粘液瘤:诊断、管理和监控。
JPGN reports Pub Date : 2023-12-27 eCollection Date: 2024-02-01 DOI: 10.1002/jpr3.12017
Andrew Farrar, Paola Blanco, Abigail Fabbrini, Lindsey Armstrong, Jonathan Metts, Hector Monforte, Sara Karjoo, Paul Danielson, Michael Wilsey
{"title":"Appendiceal mucinous neoplasm in adolescence: Diagnosis, management, and surveillance.","authors":"Andrew Farrar, Paola Blanco, Abigail Fabbrini, Lindsey Armstrong, Jonathan Metts, Hector Monforte, Sara Karjoo, Paul Danielson, Michael Wilsey","doi":"10.1002/jpr3.12017","DOIUrl":"10.1002/jpr3.12017","url":null,"abstract":"<p><p>This case report describes a 17-year-old patient with a low-grade appendiceal mucinous neoplasm. The patient presented with non-bloody diarrhea, abdominal pain, and weight loss. A colonoscopy revealed a cecal polypoid mass that required laparoscopic surgery. The residual appendix was dilated with myxoglobulosis and histopathology confirmed the diagnosis of a low-grade appendiceal mucinous neoplasm staged pT3Nx. The potential risk of pseudomyxoma peritonei is a serious complication of these tumors. Surveillance plans include computed tomography abdomen and pelvis, and tumor markers every 6 months for the next 2 years. This case highlights the importance of considering appendiceal malignancy in patients with abdominal pain and weight loss, despite the rarity of the disease. It also emphasizes the need for careful monitoring due to the possible complications associated with these tumors. Treatment and prognosis for appendiceal neoplasms depend on the histopathologic characteristics, tumor-nodes-metastasis stage, tumor grade, and presence of peritoneal disease.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we in the GI tract? Trachealization of the esophagus in a 10-year-old boy without eosinophilic esophagitis. 我们在消化道吗?一名无嗜酸性粒细胞食管炎的 10 岁男孩的食管气管切开术。
JPGN reports Pub Date : 2023-12-27 eCollection Date: 2024-02-01 DOI: 10.1002/jpr3.12019
Geoffrey Daves, Aakash Goyal, Shannon Kelley
{"title":"Are we in the GI tract? Trachealization of the esophagus in a 10-year-old boy without eosinophilic esophagitis.","authors":"Geoffrey Daves, Aakash Goyal, Shannon Kelley","doi":"10.1002/jpr3.12019","DOIUrl":"10.1002/jpr3.12019","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 1","pages":"93-94"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JPGN Reports: 2024 and beyond. JPGN 报告:2024 年及以后。
JPGN reports Pub Date : 2023-12-27 eCollection Date: 2024-02-01 DOI: 10.1002/jpr3.12030
Dominique Belli, Sandeep K Gupta, Renata Auricchio
{"title":"<i>JPGN Reports</i>: 2024 and beyond.","authors":"Dominique Belli, Sandeep K Gupta, Renata Auricchio","doi":"10.1002/jpr3.12030","DOIUrl":"https://doi.org/10.1002/jpr3.12030","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic extravasation of total parenteral nutrition following umbilical venous catheter insertion: A rare complication 脐静脉导管插入后全肠外营养的肝外渗:罕见的并发症
JPGN reports Pub Date : 2023-12-21 DOI: 10.1002/jpr3.12031
T. Berger, Ayelet Gavri, Stuart Jesin, Tzipi Strauss, Batia Weiss
{"title":"Hepatic extravasation of total parenteral nutrition following umbilical venous catheter insertion: A rare complication","authors":"T. Berger, Ayelet Gavri, Stuart Jesin, Tzipi Strauss, Batia Weiss","doi":"10.1002/jpr3.12031","DOIUrl":"https://doi.org/10.1002/jpr3.12031","url":null,"abstract":"Umbilical venous catheters are commonly inserted in critically ill newborns and can lead to severe complications when misplaced. We report a preterm female with a prenatal diagnosis of duodenal atresia who presented 2 days after the surgical repair with abdominal distension, hemodynamic instability, elevated liver enzymes with severe cholestatic jaundice, and a hepatic collection on abdominal sonography. An urgent explorative laparotomy demonstrated a large amount of white, milky‐appearing fluid in the abdominal cavity. Together with the sonographic findings, this led to the diagnosis of hepatic total parenteral nutrition extravasation. Upon removal of the umbilical venous catheter line, the infant's clinical state rapidly improved; however, cholestasis continued for months, with a very slow resolution. During follow‐up, the liver enzymes normalized, and a complete resolution of the liver collection was observed, without drainage.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"14 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study 食道闭锁儿童的胃排空和肌电活动测试:试点研究
JPGN reports Pub Date : 2023-12-20 DOI: 10.1002/jpr3.12021
Carlijn Mussies, Gilles Duvoisin, Angela Le, S. Birro, Sarah Hulbert, Taher I. Omari, M. A. Benninga, M. V. van Wijk, U. Krishnan
{"title":"Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study","authors":"Carlijn Mussies, Gilles Duvoisin, Angela Le, S. Birro, Sarah Hulbert, Taher I. Omari, M. A. Benninga, M. V. van Wijk, U. Krishnan","doi":"10.1002/jpr3.12021","DOIUrl":"https://doi.org/10.1002/jpr3.12021","url":null,"abstract":"Abnormalities of gastric function in children with esophageal atresia (EA) could potentially contribute to gastrointestinal symptoms and reduced quality of life (QOL). Therefore, we aimed to determine the feasibility and clinical usefulness of gastric function testing in children with EA.The validated PedsQL Gastrointestinal Symptoms Questionnaire (PedsQL‐GI) was completed to assess gastrointestinal symptoms and symptom‐related QOL. Gastric emptying and gastric myoelectrical activity were studied using 13C‐gastric emptying octanoic acid breath test (13C‐GEBT) and surface electrogastrography (EGG). Correlations between 13C‐GEBT and EGG parameters and PedsQL‐GI scores were investigated.Fifteen patients (four males) were included (median age: 6 [3.0–8.5] years). Mean PedsQL‐GI scores as reported by the children were comparable to the healthy population. However, parents reported a diminished QOL. Gastric function tests (gastric emptying and/or surface EGG) showed abnormalities in 12 patients (80%). Patients with abnormal slow waves showed abnormal gastric emptying coefficient more often. There was no significant association between 13C‐GEBT nor EGG results and PedsQL‐GI scores.13C‐GEBT and EGG can be used to evaluate gastric function in patients with EA. Abnormal gastric function tests were present in 80% of our cohort. However, abnormal gastric function did not significantly correlate with reported gastrointestinal symptom‐related QOL.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"53 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138957188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of filiform polyposis from classical pseudopolyposis in a pediatric ulcerative colitis patient 一名小儿溃疡性结肠炎患者从典型假性息肉病演变为丝状息肉病
JPGN reports Pub Date : 2023-12-20 DOI: 10.1002/jpr3.12020
Victor Liaw, Jason Park, Bradley Barth, Jacobo Santolaya
{"title":"Evolution of filiform polyposis from classical pseudopolyposis in a pediatric ulcerative colitis patient","authors":"Victor Liaw, Jason Park, Bradley Barth, Jacobo Santolaya","doi":"10.1002/jpr3.12020","DOIUrl":"https://doi.org/10.1002/jpr3.12020","url":null,"abstract":"Filiform polyposis (FP) is a morphologic variant of pseudopolyposis associated with inflammatory conditions of the gastrointestinal tract, namely, inflammatory bowel disease. Pediatric cases are uncommon in the literature. Here, we present a pediatric patient with FP arising from ulcerative colitis (UC). He initially presented at 7 years of age for an acute UC flare and was found to have classical pseudopolyposis. A follow‐up colonoscopy at age 9 showed the evolution of classical pseudopolyposis to FP. The patient clinically improved with sulfasalazine monotherapy and remained in remission based on consistent pediatric ulcerative colitis activity index scores of zero and normal‐range inflammatory markers. Repeat surveillance colonoscopy at age 14 showed persistent and diffuse FP in the background of healthy colonic mucosa. This case documents the development of FP from classical pseudopolyps in the setting of an asymptomatic patient in clinical remission.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"84 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of new legislation on the availability of pediatrics medical devices in the European Union with an emphasis on paediatric gastroenterology, hepatology and nutrition 新立法对欧盟儿科医疗器械供应的影响,重点是儿科肠胃病学、肝病学和营养学
JPGN reports Pub Date : 2023-12-20 DOI: 10.1002/jpr3.12023
Ulrich Baumann, J. Bronsky, Jernej Dolinšek, M. Fewtrell, Giuseppe Indolfi, Sanja Kolaček
{"title":"Impact of new legislation on the availability of pediatrics medical devices in the European Union with an emphasis on paediatric gastroenterology, hepatology and nutrition","authors":"Ulrich Baumann, J. Bronsky, Jernej Dolinšek, M. Fewtrell, Giuseppe Indolfi, Sanja Kolaček","doi":"10.1002/jpr3.12023","DOIUrl":"https://doi.org/10.1002/jpr3.12023","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"102 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138958725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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