JPGN reports最新文献

Meckel's diverticulum: A challenging diagnosis. 梅克尔憩室：一个具有挑战性的诊断。

JPGN reports Pub Date : 2024-10-20 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12140

Kathryn Kaihlanen, Claudia Phen, Anita Sengupta, Diana Diesen, Neil J Fernandes, Isabel Rojas

{"title":"Meckel's diverticulum: A challenging diagnosis.","authors":"Kathryn Kaihlanen, Claudia Phen, Anita Sengupta, Diana Diesen, Neil J Fernandes, Isabel Rojas","doi":"10.1002/jpr3.12140","DOIUrl":"10.1002/jpr3.12140","url":null,"abstract":"Objectives: This single-center, cross-sectional study aims to elucidate the clinical presentation, diagnostic evaluation, and outcomes in a subset of pediatric patients with atypical and/or challenging presentations of Meckel's diverticulum.Methods: We conducted a single-center cross-sectional study on children diagnosed with Meckel's diverticulum at Children's Health in Dallas, Texas between 2010 and 2022. We identified 11 patients aged 0-17-years-old with confirmed Meckel's diverticulum who presented with atypical symptoms and/or a challenging diagnostic course. Patient demographics, symptoms at presentation, diagnostic workup, time to diagnosis, management, and outcomes were collected. Descriptive statistics were utilized.Results: Eleven patients (n = 8, 73% male) were included in the study with an average age of 10.5 years (range: 1-17 years). The mean time interval from initial presentation of symptoms to diagnosis was 8 months (range: 0-33 months). Barriers to diagnosis of Meckel's diverticulum identified in our study included atypical presentations, negative or nonconfirmatory Meckel scan results, negative surgical findings, and competing differential diagnoses.Conclusion: Meckel's diverticulum is a challenging diagnosis and should be considered even if initial evaluation is negative as certain patients exhibit atypical presentations that necessitate surgical intervention for diagnosis.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"423-432"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of gastric ultrasound in pediatric Menetrier's disease: Report of two cases. 胃超声在小儿美涅耳病中的作用：附2例报告。

JPGN reports Pub Date : 2024-10-20 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12143

Francesco Pellegrino, Anna Opramolla, Antonio Pizzol, Caterina Rigazio, Laura Giugliano, Michele Pinon, Pier Luigi Calvo

引用次数: 0

Identifying parentally perceived barriers for children with celiac disease to participate in elementary school meal programs. 确定父母认为患有乳糜泻的儿童参加小学膳食计划的障碍。

JPGN reports Pub Date : 2024-10-20 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12141

Nan Du, Elsa R Treffeisen, Vanessa Weisbrod, Frances Kelley, Jocelyn Silvester

引用次数: 0

A novel variant BCL11B mutation in a pediatric patient with difficult-to-treat eosinophilic esophagitis. 难治性嗜酸性食管炎患儿的新变异BCL11B突变

JPGN reports Pub Date : 2024-10-20 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12139

Nikita Lalchandani Day, Lauren P Carlson, Matthew A Buendia, Girish Hiremath

{"title":"A novel variant BCL11B mutation in a pediatric patient with difficult-to-treat eosinophilic esophagitis.","authors":"Nikita Lalchandani Day, Lauren P Carlson, Matthew A Buendia, Girish Hiremath","doi":"10.1002/jpr3.12139","DOIUrl":"10.1002/jpr3.12139","url":null,"abstract":"Eosinophilic esophagitis (EoE) is an immunoinflammatory disease of the esophagus attributable to a complex interaction between genetic and environmental factors. While several genetic risk variants have been linked with EoE, we report a novel association between B-cell lymphoma/leukemia 11B genetic mutation in a child with dysmorphic facies, developmental delays, atopic comorbidities, and difficult-to-treat EoE. After a prolonged course of EoE and multiple esophagogastroduodenoscopies with biopsies, this patient achieved clinical and histologic remission on a combination of swallowed topical steroids and high-dose proton pump inhibitor (PPI) therapy. However, her EoE relapsed when we attempted to wean her off PPI, and it was finally controlled after adding PPI back to her regimen. This report underscores the importance of genetic testing in patients with unusual clinical features and difficult-to-treat EoE. Relevant to real-world clinical practice, this case also raises the question of the treatment goals in children with EoE and underlying genetic mutation(s).","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"525-527"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding difficulties, food intake, and growth in children with esophageal atresia. 食道闭锁患儿的喂养困难、食物摄入和生长发育。

JPGN reports Pub Date : 2024-10-17 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12136

Kjersti Birketvedt, Audun Mikkelsen, Ragnhild Hanssen, Helle Schiørbeck, Hanneke IJsselstijn, Christine Henriksen, Ragnhild Emblem

{"title":"Feeding difficulties, food intake, and growth in children with esophageal atresia.","authors":"Kjersti Birketvedt, Audun Mikkelsen, Ragnhild Hanssen, Helle Schiørbeck, Hanneke IJsselstijn, Christine Henriksen, Ragnhild Emblem","doi":"10.1002/jpr3.12136","DOIUrl":"10.1002/jpr3.12136","url":null,"abstract":"Objectives: Challenges regarding feeding difficulties and nutrition in children with esophageal atresia (EA) have been sparsely studied. The aim of this study was to explore parent-reported feeding difficulties in children with EA by applying Montreal Children's Hospital-Feeding Scale (MCH-FS), and to further explore associations between feeding difficulties and clinical factors, growth and nutritional intake.Methods: Parents of EA children born between 2012 and 2017 were invited. Clinical data were collected from medical records. In a prospective cohort-study parent-reported feeding difficulties (by MCH-FS) were reported at two assessments, and at the second assessment, dietary data were collected by using the 24-h food-recall method.Results: Out of 55 eligible participants, we evaluated 53 children at median age of 1.6 years (Q1:Q3 1.0:2.9) (first assessment) and 38 at median age of 4.2 years (Q1:Q3 1.0:2.9) (second assessment). Feeding difficulties were reported by 34% and 31% of the parents, respectively, but no particular profile of concerns could be identified. Children's energy intake and weight-for-age were correlated with feeding difficulties (MCH-FS total score) (p < 0.02).Conclusion: Parent-reported feeding difficulties were identified in one-third of children with EA and related to low energy intake and low weight-for-age, but not to clinical factors. This implies that feeding difficulties must be screened for during follow-up in all EA children and may facilitate early detection of challenges and intervention if needed.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"462-469"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrahepatic biliary atresia and normal-range serum gamma-glutamyltranspeptidase activity: A case report. 肝外胆道闭锁与血清γ -谷氨酰转肽酶活性正常1例。

JPGN reports Pub Date : 2024-10-17 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12131

Benno Kohlmaier, Heidelis Tichy, Jasmin Blatterer, Holger Till, Axel Schlagenhauf, A S Knisely

引用次数: 0

Scar revision for persistent pain and activity limitation after exploratory laparotomy in infancy: A case series. 瘢痕修复术治疗婴儿剖腹探查术后持续疼痛和活动受限：一个病例系列。

JPGN reports Pub Date : 2024-10-15 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12137

Shruthi Srinivas, Katherine C Bergus, Ethan A Mezoff, Peter C Minneci

引用次数: 0

Myointimal hyperplasia of the mesenteric veins mimicking inflammatory bowel disease in a 13-year-old patient. 一例13岁患者的肠系膜静脉肌内膜增生与炎症性肠病相似。

JPGN reports Pub Date : 2024-10-07 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12130

Dua Abuquteish, Rose Chami, Govind B Chavhan, Thomas Walters, Iram Siddiqui

引用次数: 0

Change from originator infliximab to biosimilar does not affect 1-year outcome in children with inflammatory bowel disease. 从原药英夫利昔单抗改为生物仿制药不影响炎症性肠病儿童1年预后。

JPGN reports Pub Date : 2024-09-27 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12134

Viven Solomon, Sydney Kuzoian, Genesis Michel, Michael Brimacombe, Jeffrey S Hyams

{"title":"Change from originator infliximab to biosimilar does not affect 1-year outcome in children with inflammatory bowel disease.","authors":"Viven Solomon, Sydney Kuzoian, Genesis Michel, Michael Brimacombe, Jeffrey S Hyams","doi":"10.1002/jpr3.12134","DOIUrl":"10.1002/jpr3.12134","url":null,"abstract":"Objectives: Payer mandates have resulted in children with inflammatory bowel disease (IBD) switching from originator Remicade® (O-Rem) to an infliximab biosimilar (B-IFX). Patients and families are fearful of switching because disease has been well controlled on O-Rem. Real-world data documenting clinical outcomes after such switches in pediatric patients are limited. The aim of this project was to examine 1 year of follow-up in a large adolescent/young adult IBD cohort who changed from O-Rem to B-IFX.Methods: We identified patients with IBD at Connecticut Children's receiving O-Rem for at least 1 year, who were either in clinical remission or had low disease activity, and who were subsequently switched to B-IFX. An age, gender, IBD-subtype, and duration since diagnosis cohort that continued on O-Rem was then matched to the switch cohort and served as a comparator group (1: switch vs. 2: no-switch). B-IFX was Inflectra® in all cases.Results: Two hundred and seventy-nine patients (mean age 18.7 years, Crohn's disease = 243, ulcerative colitis = 36) were studied (switch, n = 93, no-switch, n = 186). Mean time since diagnosis was >6 years in both groups, and mean duration of anti-tumor necrosis factor use was >5 years. There were no significant changes in hemoglobin, albumin, C-reactive protein, erythrocyte sedimentation rate, or disease activity in either group over 1 year. Dosing modifications as well as the frequency of low-level antibodies to infliximab were similar in both groups over the study period.Conclusion: Switching from O-Rem to B-IFX has no impact on clinical or laboratory parameters over the subsequent year. Clinicians can reliably reassure patients and families that switching is safe.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"442-446"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic diagnosis of asymptomatic appendicitis in a pediatric patient. 小儿无症状阑尾炎的内镜诊断。

JPGN reports Pub Date : 2024-09-27 eCollection Date: 2024-11-01 DOI: 10.1002/jpr3.12135

Mojdeh Mostafavi, Aubrey J Katz

引用次数: 0