JPGN reportsPub Date : 2025-05-20eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70033
Abebe Habtamu, Tenagne Million
{"title":"Nutritional assessment of children admitted at Tikur Anbessa Specialized Hospital, School of Medicine, College of Health Sciences.","authors":"Abebe Habtamu, Tenagne Million","doi":"10.1002/jpr3.70033","DOIUrl":"10.1002/jpr3.70033","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the nutritional status of children aged 1 month to 14 years during admission and discharge at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A prospective descriptive study design was employed, utilizing structured and nonstructured questionnaires to collect data. A total of 400 children, aged 1 month to 14 years, were included in the study. Anthropometric measurements were conducted to determine their nutritional status. Parents were interviewed to gather information on socio-demographic characteristics, clinical history, and feeding patterns of the children. Descriptive analysis was performed using SPSS software version 23.0. Chi-square tests were utilized to identify differences, while odds ratios (ORs) were employed to assess and quantify associations between categorical outcomes. ORs were reported with 95% confidence intervals (CIs). A <i>p</i>-value less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The study included 400 children, consisting of 245 (61.3%) males and 155 (38.8%) females. During admission, the assessment of nutritional status revealed that 301 (75.3%) of the children were classified as normal, 99 (24.7%) undernourished. On discharge 228 (57.0%) normal, 172 (43.0%) undernourished. Gender was found to be significantly associated with undernutrition during admission. Females were 2.376 times more likely to be exposed to undernutrition compared to males, with a 95% CI for the OR ranging from 1.497 to 3.773.</p><p><strong>Conclusion: </strong>The prevalence of undernutrition was significantly higher on discharge than during admission. Therefore, providing high-quality nursing care is crucial for children admitted to the hospital.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"248-254"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-05-20eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70034
Antonia F Ovale, Cassandra Charles, Janet Rosenbaum, Priscila Villalba-Davila, Shagun Sharma, Saema Khandakar, Thomas Wallach
{"title":"Severe acute respiratory syndrome coronavirus 2 transaminase elevation likely of non-hepatic origin, with protection from older age and vaccination.","authors":"Antonia F Ovale, Cassandra Charles, Janet Rosenbaum, Priscila Villalba-Davila, Shagun Sharma, Saema Khandakar, Thomas Wallach","doi":"10.1002/jpr3.70034","DOIUrl":"10.1002/jpr3.70034","url":null,"abstract":"<p><p>Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has known liver tropism. Multiple reports and studies demonstrated liver injury early in the pandemic. This retrospective cross-sectional comparison evaluates predictors of transaminase elevation during acute SARS-CoV2 infection, with particular interest in evaluating whether vaccination is associated with transaminase elevations. We extracted electronic medical record data for pediatric SARS-CoV2 patients presenting at safety net hospitals in Brooklyn, NY, between March 2020 and March 2022 with a coincident comprehensive metabolic panel, without multisystem inflammatory syndrome in children, prior liver disease and sickle cell disease (<i>n</i> = 133): 79.2% Black and 87% non-Hispanic. Transaminase elevation was more common among younger patients and patients requiring hospitalization or intensive care unit care. Vaccination was associated with lower quantitative levels of transaminase elevation but not the binary indicator for elevated transaminases. In aggregate, our results suggest transaminase elevation is a function of SARS-CoV2 disease severity.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"255-261"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-05-20eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70035
Razan Alkhouri, Craig Wong, Allyson Richards, David Martin, Joshua Hanson, Rasha Elmaoued, Rajmohan Dharmaraj, Ioannis Kalampokis
{"title":"Eosinophilic mesenteric vasculitis presenting as inflammatory bowel disease.","authors":"Razan Alkhouri, Craig Wong, Allyson Richards, David Martin, Joshua Hanson, Rasha Elmaoued, Rajmohan Dharmaraj, Ioannis Kalampokis","doi":"10.1002/jpr3.70035","DOIUrl":"10.1002/jpr3.70035","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD), including Crohn's Disease (CD) and ulcerative colitis, is a chronic inflammatory condition affecting the gastrointestinal tract. Treatment for IBD depends on disease severity and can include medical and surgical management. Advances in treatment and the availability of biologics have significantly reduced the need for surgical interventions. Eosinophilic mesenteric vasculitis (EMV) is a rare form of intestinal vasculitis that can mimic IBD. Diagnosis of EMV is challenging as it requires full-thickness biopsies. It can be mistaken for CD due to its response to steroids, which are a first-line therapy for EMV; however, EMV typically does not respond to other IBD-specific therapies. We present the case of a 15-year-old girl with a history of autoimmune hemolytic anemia who initially appeared to have CD but was diagnosed with EMV following a lack of clinical remission and persistence of the colonic stricture despite biologic therapy, which ultimately led to bowel obstruction symptoms requiring surgical resection.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"316-319"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-05-13eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70028
Minna M Wieck, Sujit K Jha
{"title":"Duodenal duplication cyst causing partial obstruction in a neonate.","authors":"Minna M Wieck, Sujit K Jha","doi":"10.1002/jpr3.70028","DOIUrl":"10.1002/jpr3.70028","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"322-324"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-05-12eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70027
Saskia Vande Velde, Stephanie Van Biervliet, Ann J M Van Gils, Pauline De Bruyne, Ruth De Bruyne, Lucas Matthyssens, Dirk Van de Putte, Katrien Van Renterghem
{"title":"Laparoscopic-assisted 'pull-introducer technique' for gastrostomy tube placement in small infants: A single-centre experience.","authors":"Saskia Vande Velde, Stephanie Van Biervliet, Ann J M Van Gils, Pauline De Bruyne, Ruth De Bruyne, Lucas Matthyssens, Dirk Van de Putte, Katrien Van Renterghem","doi":"10.1002/jpr3.70027","DOIUrl":"10.1002/jpr3.70027","url":null,"abstract":"<p><p>Kirberg et al. described in 2016 a one-step gastrostomy tube placement, the 'pull-introducer' technique, designed for small-for-gestational-age neonates, combining two endoscopic techniques. Nine infants (weight 3.4-8.1 kg) in our centre required a gastrostomy placement (two infants) or a combined gastrostomy placement and Nissen fundoplication (seven infants). A single-stage balloon gastrostomy was preferred in all cases because of a significant anaesthetic risk. The pull-introducer method was chosen because the commercially available one-step balloon gastrostomy gastropexy devices were considered too large. There were no immediate or long-term complications (except local infection). All nine infants were discharged from the hospital as planned. After 6 months, the balloon gastrostomy tube was replaced with a balloon button or balloon gastrostomy tube.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"262-265"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-04-17eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70022
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak
{"title":"Genital Crohn's disease in pediatrics and genetic associations.","authors":"Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak","doi":"10.1002/jpr3.70022","DOIUrl":"10.1002/jpr3.70022","url":null,"abstract":"<p><p>Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co-occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote timely management. A retrospective review of four patients diagnosed with MCD was conducted at Phoenix Children's and Children's Hospital Colorado. Patients presented with painful and painless penoscrotal swelling with and without erythema. Scrotal histopathology revealed granulomatous inflammation, and genetic testing identified pathogenic variants in NOD2, COL7A1, and Chek2, as well as additional variants of uncertain significance. Treatments included antibiotics, steroids, biologics, and methotrexate with mixed responses. Further research and clinical trials are needed to better understand the pathogenesis and develop best practices.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"266-273"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-04-14eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70021
N Nedelkopoulou, S Sharma, M Khalid, C Hinchliffe
{"title":"Upadacitinib for difficult-to-treat paediatric Crohn's disease.","authors":"N Nedelkopoulou, S Sharma, M Khalid, C Hinchliffe","doi":"10.1002/jpr3.70021","DOIUrl":"10.1002/jpr3.70021","url":null,"abstract":"<p><p>Paediatric-onset inflammatory bowel disease (IBD) has an enormous impact on healthcare systems as it translates to a lifetime of healthcare. Since the approval of anti-tumour necrosis factor-alpha agents, it has become evident that in the long journey of paediatric IBD, there is an absolute need for more treatment options. Emerging evidence from the adult literature suggests that upadacitinib is effective and safe; however, paediatric data are scarce. We present two adolescents with highly refractory to treatment Crohn's disease. One of them had undergone subtotal colectomy. Both patients were treated effectively with upadacitinib.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"309-311"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-04-09eCollection Date: 2025-05-01DOI: 10.1002/jpr3.70016
Clemens Gardemann, Ulrike Och, Manfred Fobker, Thomas Kaiser, Judit Horvath, Beatrice Da Prada, Thorsten Marquardt
{"title":"DGAT-1 deficiency: Congenital diarrhea and dietary treatment.","authors":"Clemens Gardemann, Ulrike Och, Manfred Fobker, Thomas Kaiser, Judit Horvath, Beatrice Da Prada, Thorsten Marquardt","doi":"10.1002/jpr3.70016","DOIUrl":"10.1002/jpr3.70016","url":null,"abstract":"<p><p>DGAT-1 (Diacylglycerol Acyltransferase-1) deficiency is an autosomal recessive disorder which causes severe impairment in lipid absorption. We report a case of an infant suffering from persistent diarrhea starting at the age of four weeks. Further investigations identified DGAT-1 deficiency as underlying cause. A treatment plan was developed which included a very-low fat diet administered as infant formula, essential fatty acid supplementation, C8 medium chain triglycerides- and fat-soluble vitamin supplementations. The patient was put into full remission after administration of the treatment plan and weight curves normalized at the 50th percentile at the age of 24 months. Intermittent episodes of loose stools were due to an excessive intake of fructose via extensive fruit consumption. DGAT-1 deficiency is a rare genetic disease which leads to congenital diarrhea and is especially dangerous in infancy. Our treatment plan put the patient into full remission showing that C8 MCT oil should be preferred over treatment with C8/C10 mixtures.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 2","pages":"121-125"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPGN reportsPub Date : 2025-03-31eCollection Date: 2025-08-01DOI: 10.1002/jpr3.70012
Rui Wen, Jing Zhang, Pan Wang
{"title":"Myofibroblastic tumor (GIMT) in children: A case report.","authors":"Rui Wen, Jing Zhang, Pan Wang","doi":"10.1002/jpr3.70012","DOIUrl":"10.1002/jpr3.70012","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 3","pages":"320-321"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An indolent case of traumatic bowel injury as a superior mesenteric artery syndrome mimic.","authors":"Arvinth Shivaa Sethuraman, Ashley Giselle Fonseca, Jacobo Leopoldo Santolaya","doi":"10.1002/jpr3.70019","DOIUrl":"10.1002/jpr3.70019","url":null,"abstract":"<p><p>Traumatic bowel injury is an uncommon injury pattern that can have a delayed presentation after an initial trauma hospitalization and present to pediatricians with nonspecific symptoms. This syndrome is often missed and can mimic other common gastrointestinal conditions. Our case presents a previously healthy 16-year-old girl with recent trauma admission who re-presented to the hospital with a presumed superior mesenteric artery syndrome and had a mixed response to initial management. Given persistent symptoms despite standard care, subsequent management consisted of an exploratory laparotomy that led to findings of a strictured segment of the bowel that was resected and led to clinical recovery. These patients can initially present with normal imaging and have an evolving inflammatory-mediated process due to microvascular injury and abscess formation. These injuries should be included in the differential diagnosis of patients with nausea, vomiting, abdominal pain, weight loss, and fever in the setting of recent blunt abdominal trauma.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"6 2","pages":"181-183"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}