JPGN reports最新文献

{"title":"A novel central line securement vest reduces line trauma and improves quality of life in patients with intestinal failure.","authors":"Ryan E St Pierre-Hetz, Kimberly S Ackerman, Angelica M Cercone, Jane Anne Yaworski, Clifton W Callaway, Jeffrey A Rudolph, Mioara D Manole","doi":"10.1002/jpr3.70165","DOIUrl":"10.1002/jpr3.70165","url":null,"abstract":"<p><strong>Objective: </strong>We sought to assess the impact of a novel central line securement vest on the rate of line complications (trauma, infections, and replacements), and measures of quality of life (QOL) in pediatric patients with intestinal failure.</p><p><strong>Methods: </strong>We enrolled patients at a single tertiary pediatric center. We randomized 23 intestinal failure patients to a vest (<i>n</i> = 12, vest group) or traditional securement methods (<i>n</i> = 11, control group). Eleven patients in the vest group and 10 patients in the control group completed the study. Rates of trauma, infections, and replacements were calculated for each participant 12 months prior to and 12 months following enrollment, or for as long as the line remained in place and the vest was used. QOL scores were collected throughout the study.</p><p><strong>Results: </strong>The vest group had lower rates of trauma during the period of vest use versus prior to its use. The rates of infections and replacements were similar during vest use and prior to use. The control group had similar rates of trauma, infections, and replacements before and during the study period. The QOL scores in domains of activity level, overall QOL, and self-perception were higher in the vest versus control group.</p><p><strong>Conclusions: </strong>In this pilot study, the use of a central line securement vest was associated with lower rates of line trauma. Several QOL domains showed better scores after the use of the vest in patients randomized to the vest versus the control group. Larger studies are warranted to assess the central line securement vest.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT04522778; https://clinicaltrials.gov/study/NCT04522778.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"416-421"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not all weight loss is psychiatric: Diagnostic bias in pediatric Crohn's disease.","authors":"Karolina Aleksandra Jamrozik, Martina Begucci, Vanessa Nadia Dargenio, Nathali Bergmann, Lea Charlotte Hellberg, Hannah Franziska Schumacher, Fernanda Cristofori, Ruggiero Francavilla","doi":"10.1002/jpr3.70187","DOIUrl":"10.1002/jpr3.70187","url":null,"abstract":"<p><p>Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that can often be misdiagnosed, particularly in the female population. This is especially true in the initial stages, which are frequently characterized by weight loss and, at times, dietary intake restriction. We present the case of a patient who experienced a misdiagnosis of anorexia nervosa (AN), leading to significant diagnostic delay (DD) of approximately 8 months and failure to initiate timely treatment. Greater awareness among clinicians and the early utilization of non-invasive markers, such as fecal calprotectin, could significantly aid in achieving an accurate diagnosis right from the disease's onset.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"439-441"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular facial myositis and sialadenitis presenting with new onset ulcerative colitis.","authors":"Nicole Du, Nicole Mendez, Anil Darbari","doi":"10.1002/jpr3.70173","DOIUrl":"10.1002/jpr3.70173","url":null,"abstract":"<p><p>Extra-intestinal manifestations of inflammatory bowel disease (IBD) can involve most organ systems, although the immunologic underpinnings are not well understood. Most patients who present with an extra-intestinal manifestation have a single site of extra-intestinal involvement; however, a small cohort presents with multiple different sites of involvement. Ocular and facial muscle and salivary gland involvements are rarely seen in IBD, especially in children with ulcerative colitis (UC). In this study, we describe a case of ocular facial myositis and sialadenitis in a child with new-onset UC.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"436-438"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of vertically acquired Hepatitis C in a child using direct-acting antiviral therapy administered via gastrojejunal tube: A case report.","authors":"Connie Chen, Leah Gibson, James Squires","doi":"10.1002/jpr3.70174","DOIUrl":"10.1002/jpr3.70174","url":null,"abstract":"<p><p>Hepatitis C virus (HCV) remains a significant global health burden, with vertical transmission being the primary route of infection in children. Direct-acting antivirals (DAAs) have transformed HCV treatment in pediatrics, but limited data exist on their administration in medically complex children who are dependent on enteral tubes. We report the case of a medically complex child with vertically acquired HCV who achieved sustained virologic response at 12 weeks (SVR12) following treatment with crushed sofosbuvir/velpatasvir (SOF/VEL) administered to a patient with a gastrojejunal tube. She was ineligible for oral therapy due to feeding difficulties but was granted insurance approval for off-label enteral administration. The patient completed a 12-week SOF/VEL regimen and achieved SVR12. This case supports the feasibility and effectiveness of enteral DAA administration using crushed SOF/VEL in children with complex medical needs. Further research and formal guidance are needed to optimize treatment strategies for pediatric patients with similar challenges.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"391-393"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transnasal endoscopy for eosinophilic esophagitis surveillance in adolescents with mild autism spectrum disorder: A single-center case series.","authors":"Natalee Sarintra, Robbie Pesek, Travis Ayers, Christina Tootle, Sulaiman S Bharwani, Alejandro Ramirez, Hamza Hassan Khan","doi":"10.1002/jpr3.70183","DOIUrl":"10.1002/jpr3.70183","url":null,"abstract":"<p><p>Children with autism spectrum disorder (ASD) often experience sensory sensitivities and procedural anxiety, which can complicate sedated esophagogastroduodenoscopy (EGD). Transnasal endoscopy (TNE) is a less invasive, unsedated alternative, but data on its use in this population are limited. We evaluated the safety, tolerability, and clinical utility of sedation-free TNE in adolescents with Level 1 ASD (mild autism) undergoing surveillance for eosinophilic esophagitis (EoE). In this retrospective case series, five adolescents (mean age 13.2 years; 80% male) underwent TNE between April 2024 and April 2025. We assessed procedural success, adverse events, biopsy adequacy, and behavioral strategies. All procedures were completed successfully without sedation or serious adverse events. Child Life Specialists (CLSs) supported 80% of cases, using behavioral aids, such as virtual reality (VR) goggles and desensitization tools. Mean procedure time was 10.75 ± 1.96 min. We concluded that TNE is a safe and feasible alternative to sedated EGD in carefully selected adolescents with mild ASD and warrants further study in larger cohorts.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"465-470"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ischemic polypectomy for small intestinal polyps in a 7-year-old girl with juvenile polyposis syndrome.","authors":"Shingo Kurasawa, Shun Watanabe, Satoshi Ukai, Ayako Furuya, Kato Sawako, Yoshiko Nakayama","doi":"10.1002/jpr3.70188","DOIUrl":"10.1002/jpr3.70188","url":null,"abstract":"<p><p>This is the first report of endoscopic ischemic polypectomy (EIP) for small intestinal polyps in a pediatric patient with juvenile polyposis syndrome (JPS). A 7-year-old girl underwent double-balloon enteroscopy, during which 17 pedunculated polyps were treated using the crossed-clip strangulation method without complications. Ten-month follow-up confirmed complete clip detachment, no residual lesions, and resolution of anemia and hypoalbuminemia, and growth was satisfied. EIP, avoiding electrocautery, may theoretically reduce the risk of bleeding and perforation and represents an alternative option for managing small intestinal, pedunculated, clearly benign polyps in children with JPS.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"471-473"},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful propranolol therapy for infantile hepatic hemangioma with cardiac failure.","authors":"Fadhel Al Ateeqi, Ala K Shaikhkhalil, Haitham Talo, Naeem Jagirdar, Mahdia Al-Haidar","doi":"10.1002/jpr3.70180","DOIUrl":"10.1002/jpr3.70180","url":null,"abstract":"<p><p>Infantile hepatic hemangioma (IHH) can cause severe complications such as high-output cardiac failure and growth faltering, requiring prompt diagnosis and intervention. In the absence of standardized treatment guidelines, propranolol has emerged as an effective and well-tolerated therapy. We report a female infant with multifocal IHH who presented with high-output cardiac failure, hepatomegaly, and growth faltering. She experienced rapid and sustained clinical as well as radiologic improvement with propranolol therapy. This case reinforces propranolol's role as a safe, effective first-line therapy for symptomatic IHH and underscores the importance of early multidisciplinary care.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"387-390"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut function among children treated for severe acute malnutrition: A cohort study in Uganda.","authors":"Betty Lanyero, Nicolette Nabukeera-Barungi, Ezekiel Mupere, Bikila S Megersa, Iris Weidema, Pingping Jiang, Maria Wiese, Musemma K Muhammed, Henrik Friis, Hanne Frøkiær, Dennis S Nielsen, Vibeke Brix Christensen, Benedikte Grenov","doi":"10.1002/jpr3.70182","DOIUrl":"10.1002/jpr3.70182","url":null,"abstract":"<p><strong>Objectives: </strong>Impaired gut function in children with severe acute malnutrition (SAM) is associated with morbidity. We aimed to assess changes in six biomarkers representing different domains of gut function among children with complicated SAM during nutritional rehabilitation, and to identify predictors of these changes.</p><p><strong>Methods: </strong>We followed 108 children aged 6-59 months with complicated SAM who participated in a probiotic trial (ISRCTN16454889). Plasma citrulline, a marker of enterocyte mass, fecal myeloperoxidase and neopterin, markers of intestinal inflammation and other gut function biomarkers were assessed at admission, discharge from inpatient therapeutic care (ITC), and after 8 weeks of outpatient therapeutic care (OTC). We assessed changes in these biomarkers and compared OTC values with 30 healthy community reference children.</p><p><strong>Results: </strong>During ITC, plasma citrulline increased from very low to near normal values (geometric mean: 5.69-21.4 µmol/L, <i>p</i> < 0.001). The number of days with diarrhea predicted a higher increase in plasma citrulline (<i>p</i> = 0.020) during ITC, while children with human immunodeficiency virus and diarrhea on admission had a lower change in plasma citrulline in OTC. Fecal myeloperoxidase decreased (geometric mean: 16,546-3781 ng/mL, <i>p</i> < 0.001), while fecal neopterin increased (582-923 nmol/L, <i>p</i> < 0.01) during ITC; both were higher than normal level cut-offs of 2000 ng/mL and 70 nmol/L. During OTC, no biomarker differences were observed between children with SAM and community reference children. Probiotics did not influence the changes in any biomarker.</p><p><strong>Conclusions: </strong>Inpatient treatment of children with complicated SAM may improve gut function; however, intestinal inflammation seems to persist even after 8 weeks in OTC. <b>Trial Registration:</b> www.isrctn.com: ISRCTN16454889.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"452-460"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional constipation in children and young adults with Prader-Willi syndrome.","authors":"Melinda J Pierce, Isabella Niu, Lusine Ambartsumyan, Parisa Salehi","doi":"10.1002/jpr3.70185","DOIUrl":"10.1002/jpr3.70185","url":null,"abstract":"<p><strong>Objectives: </strong>Prader-Willi Syndrome (PWS) is characterized by hyperphagia, endocrinopathies, and gastrointestinal abnormalities. Clinical concerns about constipation and fecal incontinence (FI) are common, but no studies to date have clear data on functional defecation disorders in children with PWS. This study aims to describe the prevalence of functional constipation (FC) in children with PWS seen at Seattle Children's Hospital between 2019 and 2023.</p><p><strong>Methods: </strong>Parental perception of stooling was collected with a survey designed to correlate with the Rome IV criteria for FC. A retrospective chart review, including survey answers, was done for 69 patients ages 1-21 years who completed the initial survey between 2019 and 2023. FC status was assigned according to responses. Results were collected in an online secure REDCap database, and statistical analysis was done in STATA statistical software.</p><p><strong>Results: </strong>Approximately 17% of the population reported symptoms consistent with FC. Those with FC trended older and had higher rates of laxative use. Growth hormone and levothyroxine use were similar between groups. Parents of patients with FC were more likely to identify their child had constipation, though half did not. Lastly, 35% of patients had FI after established toilet training, though it was not always associated with FC at the time of the visit.</p><p><strong>Conclusions: </strong>Rates of constipation in the pediatric PWS population are nearly 80% higher than in the general population, with high rates of FI. The accuracy of parental reports of constipation may be unreliable without reviewing symptoms. This study highlights the importance of parent and provider education and recognition of functional defecation disorders in children with PWS.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"410-415"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of Peutz-Jeghers syndrome in a child with Crohn's disease.","authors":"Hasala Rannulu, Eve May, Bethany Cunningham, Eric Cochran, Rachel Zdenek, Stefany H Garrity","doi":"10.1002/jpr3.70184","DOIUrl":"10.1002/jpr3.70184","url":null,"abstract":"<p><p>Peutz-Jeghers syndrome (PJS) is a rare genetic disorder characterized by hamartomatous polyps and mucocutaneous hyperpigmented freckles, whereas Crohn's disease (CD) is a condition characterized by chronic intestinal inflammation. Here, we present a rare case report of an 11-year-old male who presented with both CD and PJS. To our knowledge, this is only the fifth case report describing both of these diseases in the same patient. While CD is relatively common in industrialized countries, having CD in conjunction with PJS is exceedingly rare. This paucity of data describing the coexistence of the two conditions in the same patient has led to a general lack of guidance and screening recommendations in patients with both of these diseases. It is known that each disorder alone increases a patient's risk of malignancy; however, more data are needed to determine the appropriate cancer screening algorithm for patients with these dual diagnoses as well as management approaches.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" ","pages":"432-435"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}