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Massive infected pancreatic necrosis in an 8‐year‐old: Endoscopic management 一名 8 岁儿童的大面积感染性胰腺坏死：内镜治疗
JPGN reports Pub Date : 2024-02-14 DOI: 10.1002/jpr3.12052
William F Abel, Varun Kesar, Reid D. Wasserman, Manoj Kumar, Vishal Patel, P. Yeaton, Vivek Kesar
{"title":"Massive infected pancreatic necrosis in an 8‐year‐old: Endoscopic management","authors":"William F Abel, Varun Kesar, Reid D. Wasserman, Manoj Kumar, Vishal Patel, P. Yeaton, Vivek Kesar","doi":"10.1002/jpr3.12052","DOIUrl":"https://doi.org/10.1002/jpr3.12052","url":null,"abstract":"Pancreatitis is a condition much more commonly found in adults, but when diagnosed in the pediatric population, is often due to medications, congenital pathology, and critical illness. This patient had previously undergone treatment with 6‐mercaptopurine and presented with pancreatitis that eventually worsened to a walled‐off necrotic collection with paracolic extensions reaching the pelvis. Given clinical worsening with development of shock, procedural options for source control were weighed with gastroenterology, pediatric surgery, and interventional radiology, before pancreatic necrosectomy was determined to be the treatment of choice, given the adjacency of the collection to the stomach. A total of three separate endoscopic pancreatic necrosectomy procedures were performed and the patient s clinical status improved greatly, with vast improvement later seen on outpatient imaging. This successful treatment course argues for the efficacy of pancreatic necrosectomy even in very large walled off collections, and most importantly, lead to a positive outcome in this young patient.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"185 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139839426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herbal and dietary supplement induced liver injury leading to hepatitis‐associated severe aplastic anemia: A case report 草药和膳食补充剂诱发肝损伤，导致肝炎相关性重型再生障碍性贫血：病例报告
JPGN reports Pub Date : 2024-02-12 DOI: 10.1002/jpr3.12041
R. Mercedes, S. Harpavat, Paula M. Hertel, Ghadir Sasa, Susan Kirk, Kalyani Patel, K. Mysore
{"title":"Herbal and dietary supplement induced liver injury leading to hepatitis‐associated severe aplastic anemia: A case report","authors":"R. Mercedes, S. Harpavat, Paula M. Hertel, Ghadir Sasa, Susan Kirk, Kalyani Patel, K. Mysore","doi":"10.1002/jpr3.12041","DOIUrl":"https://doi.org/10.1002/jpr3.12041","url":null,"abstract":"Herbal and dietary supplements (HDS) are a common etiology of drug induced liver injury and, specifically, Herbalife® supplements have been implicated. Hepatitis associated aplastic anemia (HAAA) is a rare and potentially fatal complication after acute hepatitis characterized by pancytopenia. While there have been rare cases of HDS leading to HAAA, no cases of Herbalife® induced liver injury leading to HAAA have been reported from this specific HDS. We report a unique case of severe aplastic anemia developing after sub‐fulminant liver failure associated with chronic HDS use. This case illustrates the importance of warning the public about HDS as their use continues to increase. It is not only important to recognize HDS as etiology, but also for healthcare providers to carefully monitor these patients after resolution of liver injury for the development of HAAA.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"151 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is it “all in the bag?” Multidisciplinary perspectives on ostomy surgery in pediatric IBD across the ImproveCareNow network 都是 "囊中物 "吗？ImproveCareNow 网络中关于小儿 IBD 造口手术的多学科观点
JPGN reports Pub Date : 2024-02-12 DOI: 10.1002/jpr3.12044
J. David, Jennifer L. Dotson, Laura Mackner
{"title":"Is it “all in the bag?” Multidisciplinary perspectives on ostomy surgery in pediatric IBD across the ImproveCareNow network","authors":"J. David, Jennifer L. Dotson, Laura Mackner","doi":"10.1002/jpr3.12044","DOIUrl":"https://doi.org/10.1002/jpr3.12044","url":null,"abstract":"Pediatric inflammatory bowel disease (IBD) is a chronic illness with various treatments, including ostomy surgery. Ostomy‐related medical decision‐making (MDM) is complex for multidisciplinary healthcare professionals (HCPs). This study sought to understand national multidisciplinary HCPs' perceptions about pediatric IBD ostomy surgery in the United States.This cross‐sectional REDCap survey recruited HCPs in pediatric IBD HCP roles from the ImproveCareNow (ICN) Learning Health System. The survey gathered data on, (1) demographics, (2) participants' perspectives on patients/families' ostomy perceptions, (3) participants' own perspectives on ostomies, and (4) participants' perspectives on multidisciplinary collaboration in ostomy surgery.Participants (n = 69, across n = 30 American ICN sites) were 84% White, 62% female, and 54% gastroenterologists. In reflecting on patients/families' perceptions, participants endorsed most (86%) view ostomies as a “failure,” various psychosocial concerns (e.g., 97% endorsed body image concerns), and most (81%) have moderate to significant stigma about ostomies. In reflecting on their own perceptions, nearly half (44%) endorsed some to moderate stigma about ostomies and felt ostomy discussions were difficult when families had negative perceptions (88%). Over half (54%) endorsed currently having multidisciplinary care for pediatric IBD surgery. Most (70%) endorsed variability in the amount and/or quality of multidisciplinary collaboration.MDM related to pediatric IBD ostomy surgery presents nuanced clinical complexities for HCPs. This work underscores interest in multidisciplinary care, notable ostomy‐related psychosocial needs, and ostomy‐related stigma. Future work should develop systematic approaches to multidisciplinary pediatric IBD ostomy care, bolster psychosocial support, and evaluate how systematic care may impact psychosocial, and healthcare utilization outcomes.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"69 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to letter to the editor in response to: Distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase 回复致编辑的信：区分肥胖和丙氨酸氨基转移酶筛查阳性青少年的自身免疫性肝炎和脂肪性肝炎
JPGN reports Pub Date : 2024-02-12 DOI: 10.1002/jpr3.12049
Amber Hildreth, J. Schwimmer
{"title":"Reply to letter to the editor in response to: Distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase","authors":"Amber Hildreth, J. Schwimmer","doi":"10.1002/jpr3.12049","DOIUrl":"https://doi.org/10.1002/jpr3.12049","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"55 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is it “all in the bag?” Multidisciplinary perspectives on ostomy surgery in pediatric IBD across the ImproveCareNow network 都是 "囊中物 "吗？ImproveCareNow 网络中关于小儿 IBD 造口手术的多学科观点
JPGN reports Pub Date : 2024-02-12 DOI: 10.1002/jpr3.12044
J. David, Jennifer L. Dotson, Laura Mackner
{"title":"Is it “all in the bag?” Multidisciplinary perspectives on ostomy surgery in pediatric IBD across the ImproveCareNow network","authors":"J. David, Jennifer L. Dotson, Laura Mackner","doi":"10.1002/jpr3.12044","DOIUrl":"https://doi.org/10.1002/jpr3.12044","url":null,"abstract":"Pediatric inflammatory bowel disease (IBD) is a chronic illness with various treatments, including ostomy surgery. Ostomy‐related medical decision‐making (MDM) is complex for multidisciplinary healthcare professionals (HCPs). This study sought to understand national multidisciplinary HCPs' perceptions about pediatric IBD ostomy surgery in the United States.This cross‐sectional REDCap survey recruited HCPs in pediatric IBD HCP roles from the ImproveCareNow (ICN) Learning Health System. The survey gathered data on, (1) demographics, (2) participants' perspectives on patients/families' ostomy perceptions, (3) participants' own perspectives on ostomies, and (4) participants' perspectives on multidisciplinary collaboration in ostomy surgery.Participants (n = 69, across n = 30 American ICN sites) were 84% White, 62% female, and 54% gastroenterologists. In reflecting on patients/families' perceptions, participants endorsed most (86%) view ostomies as a “failure,” various psychosocial concerns (e.g., 97% endorsed body image concerns), and most (81%) have moderate to significant stigma about ostomies. In reflecting on their own perceptions, nearly half (44%) endorsed some to moderate stigma about ostomies and felt ostomy discussions were difficult when families had negative perceptions (88%). Over half (54%) endorsed currently having multidisciplinary care for pediatric IBD surgery. Most (70%) endorsed variability in the amount and/or quality of multidisciplinary collaboration.MDM related to pediatric IBD ostomy surgery presents nuanced clinical complexities for HCPs. This work underscores interest in multidisciplinary care, notable ostomy‐related psychosocial needs, and ostomy‐related stigma. Future work should develop systematic approaches to multidisciplinary pediatric IBD ostomy care, bolster psychosocial support, and evaluate how systematic care may impact psychosocial, and healthcare utilization outcomes.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"23 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to letter to the editor in response to: Distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase 回复致编辑的信：区分肥胖和丙氨酸氨基转移酶筛查阳性青少年的自身免疫性肝炎和脂肪性肝炎
JPGN reports Pub Date : 2024-02-12 DOI: 10.1002/jpr3.12049
Amber Hildreth, J. Schwimmer
{"title":"Reply to letter to the editor in response to: Distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase","authors":"Amber Hildreth, J. Schwimmer","doi":"10.1002/jpr3.12049","DOIUrl":"https://doi.org/10.1002/jpr3.12049","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cause or effect? Undetectable vitamin D in a patient with Crohn's disease 原因还是影响？一名克罗恩病患者体内检测不到维生素 D
JPGN reports Pub Date : 2024-02-08 DOI: 10.1002/jpr3.12045
Julia Esswein, Maggie Vickers, Michael Kleinman, John Whitworth, Mark Corkins, S. Riley Pace
{"title":"Cause or effect? Undetectable vitamin D in a patient with Crohn's disease","authors":"Julia Esswein, Maggie Vickers, Michael Kleinman, John Whitworth, Mark Corkins, S. Riley Pace","doi":"10.1002/jpr3.12045","DOIUrl":"https://doi.org/10.1002/jpr3.12045","url":null,"abstract":"Crohn's disease has been described as the “great mimicker” with a wide array of presentations. We describe a case of a teenager who presented with tetany and undetectable vitamin D as initial presentation of Crohn's disease. There are reports of adults in tetany due to electrolyte derangements in chronic gastrointestinal diseases secondary to malabsorption. However, the role of deficient vitamin D as it contributes to immune system dysfunction has only begun to be explored. Vitamin D is essential for calcium absorption, immune regulation, and gut epithelial barrier. This case report discusses vitamin D physiology and its potential mediation in the pathogenesis of inflammatory bowel disease.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"125 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139852816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cause or effect? Undetectable vitamin D in a patient with Crohn's disease 原因还是影响？一名克罗恩病患者体内检测不到维生素 D
JPGN reports Pub Date : 2024-02-08 DOI: 10.1002/jpr3.12045
Julia Esswein, Maggie Vickers, Michael Kleinman, John Whitworth, Mark Corkins, S. Riley Pace
{"title":"Cause or effect? Undetectable vitamin D in a patient with Crohn's disease","authors":"Julia Esswein, Maggie Vickers, Michael Kleinman, John Whitworth, Mark Corkins, S. Riley Pace","doi":"10.1002/jpr3.12045","DOIUrl":"https://doi.org/10.1002/jpr3.12045","url":null,"abstract":"Crohn's disease has been described as the “great mimicker” with a wide array of presentations. We describe a case of a teenager who presented with tetany and undetectable vitamin D as initial presentation of Crohn's disease. There are reports of adults in tetany due to electrolyte derangements in chronic gastrointestinal diseases secondary to malabsorption. However, the role of deficient vitamin D as it contributes to immune system dysfunction has only begun to be explored. Vitamin D is essential for calcium absorption, immune regulation, and gut epithelial barrier. This case report discusses vitamin D physiology and its potential mediation in the pathogenesis of inflammatory bowel disease.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139792903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein‐losing enteropathy secondary to collagenous colitis in a 2‐year‐old 一名 2 岁儿童继发于胶原性结肠炎的蛋白丢失性肠病
JPGN reports Pub Date : 2024-02-06 DOI: 10.1002/jpr3.12051
Hamza Hassan Khan, David N. Lewin, Carmine Suppa
{"title":"Protein‐losing enteropathy secondary to collagenous colitis in a 2‐year‐old","authors":"Hamza Hassan Khan, David N. Lewin, Carmine Suppa","doi":"10.1002/jpr3.12051","DOIUrl":"https://doi.org/10.1002/jpr3.12051","url":null,"abstract":"Protein‐losing enteropathy associated with collagenous colitis (CC) is a rare but described entity in the adult population. However, literature regarding this in the pediatric population is scarce. Here we describe a 2‐year‐old female who presented with fevers, accompanied by nonbloody, watery diarrhea, and decreased oral intake. Work‐up was significant for severe hypoalbuminemia at 1.5 grams per deciliter (g/dL), pancytopenia, and elevated fecal alpha‐1‐antitrypsin at 1.13 milligrams per grams (mg/g). Gastrointestinal mucosal evaluation was normal endoscopically; however, histology was consistent with CC. She responded to 12‐week treatment with budesonide with resolution of symptoms and laboratory values. At this point, she has not had a recurrence 1 year later.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"97 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139802157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein‐losing enteropathy secondary to collagenous colitis in a 2‐year‐old 一名 2 岁儿童继发于胶原性结肠炎的蛋白丢失性肠病
JPGN reports Pub Date : 2024-02-06 DOI: 10.1002/jpr3.12051
Hamza Hassan Khan, David N. Lewin, Carmine Suppa
{"title":"Protein‐losing enteropathy secondary to collagenous colitis in a 2‐year‐old","authors":"Hamza Hassan Khan, David N. Lewin, Carmine Suppa","doi":"10.1002/jpr3.12051","DOIUrl":"https://doi.org/10.1002/jpr3.12051","url":null,"abstract":"Protein‐losing enteropathy associated with collagenous colitis (CC) is a rare but described entity in the adult population. However, literature regarding this in the pediatric population is scarce. Here we describe a 2‐year‐old female who presented with fevers, accompanied by nonbloody, watery diarrhea, and decreased oral intake. Work‐up was significant for severe hypoalbuminemia at 1.5 grams per deciliter (g/dL), pancytopenia, and elevated fecal alpha‐1‐antitrypsin at 1.13 milligrams per grams (mg/g). Gastrointestinal mucosal evaluation was normal endoscopically; however, histology was consistent with CC. She responded to 12‐week treatment with budesonide with resolution of symptoms and laboratory values. At this point, she has not had a recurrence 1 year later.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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