Journal of Rheumatology最新文献

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Predictors of Secukinumab Treatment Response and Continuation in Axial Spondyloarthritis: Results From the EuroSpA Research Collaboration Network. 轴性脊柱关节炎患者对塞库单抗治疗反应和继续治疗的预测因素:欧洲脊柱关节炎研究合作网络的研究结果。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-15 DOI: 10.3899/jrheum.2024-0920
Marion Pons, Stylianos Georgiadis, Merete Lund Hetland, Zohra Faizy Ahmadzay, Simon Rasmussen, Sara N Christiansen, Daniela Di Giuseppe, Johan K Wallman, Karel Pavelka, Jakub Závada, Catalin Codreanu, Bente Glintborg, Anne G Loft, Helena Santos, Maria H Lourenço, Michael J Nissen, Adrian Ciurea, Laura Kuusalo, Vappu Rantalaiho, Brigitte Michelsen, Pawel Mielnik, Katja P Pirkmajer, Ziga Rotar, Bjorn Gudbjornsson, Olafur Palsson, Irene van der Horst-Bruinsma, Marleen van de Sande, Isabel Castrejón, Gary J Macfarlane, Karin Laas, Mikkel Østergaard, Lykke M Ørnbjerg
{"title":"Predictors of Secukinumab Treatment Response and Continuation in Axial Spondyloarthritis: Results From the EuroSpA Research Collaboration Network.","authors":"Marion Pons, Stylianos Georgiadis, Merete Lund Hetland, Zohra Faizy Ahmadzay, Simon Rasmussen, Sara N Christiansen, Daniela Di Giuseppe, Johan K Wallman, Karel Pavelka, Jakub Závada, Catalin Codreanu, Bente Glintborg, Anne G Loft, Helena Santos, Maria H Lourenço, Michael J Nissen, Adrian Ciurea, Laura Kuusalo, Vappu Rantalaiho, Brigitte Michelsen, Pawel Mielnik, Katja P Pirkmajer, Ziga Rotar, Bjorn Gudbjornsson, Olafur Palsson, Irene van der Horst-Bruinsma, Marleen van de Sande, Isabel Castrejón, Gary J Macfarlane, Karin Laas, Mikkel Østergaard, Lykke M Ørnbjerg","doi":"10.3899/jrheum.2024-0920","DOIUrl":"10.3899/jrheum.2024-0920","url":null,"abstract":"<p><strong>Objective: </strong>In patients with axial spondyloarthritis (axSpA) initiating secukinumab (SEC), we aimed to identify baseline (treatment start) predictors of achieving low disease activity (LDA) after 6 months, as measured by the Axial Spondyloarthritis Disease Activity Score using C-reactive protein (ASDAS-CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), as well as treatment continuation after 12 months.</p><p><strong>Methods: </strong>From 11 European registries, patients with axSpA who initiated SEC treatment in routine care, with available data on 6-month ASDAS-CRP and BASDAI assessments were included. Logistic regression analyses on multiply imputed baseline data were performed; potential baseline predictors included demographic, diagnosis, lifestyle, clinical, and patient-reported variables.</p><p><strong>Results: </strong>In a pooled cohort of 1174 patients with axSpA, 5 of 19 potential assessed variables were mutually predictive for achieving LDA by ASDAS-CRP and BASDAI: higher physician global assessment score, noncurrent smoking, lack of prior exposure to biologic/targeted synthetic disease-modifying antirheumatic drugs, and lower Health Assessment Questionnaire scores and BASDAI scores. Moreover, radiographic axSpA and CRP ≤ 10 mg/L were associated with achieving ASDAS-CRP LDA, and HLA-B27 positivity and history of psoriasis with achieving BASDAI LDA, whereas earlier time of secukinumab initiation (2015-2017) was associated with treatment continuation.</p><p><strong>Conclusion: </strong>In this European real-world study of patients with axSpA initiating SEC, predictors of achieving LDA by ASDAS-CRP and BASDAI at 6 months and remaining on treatment at 12 months included both clinical, patient-reported, and lifestyle factors, underscoring the complex mechanisms of real-world drug effectiveness.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of EULAR/ACR Classification Criteria for Polymyalgia Rheumatica in a Series of Patients With Acute Parvovirus B19 Infection. EULAR/ACR分级标准在一系列急性细小病毒B19感染患者风湿多肌痛中的应用
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-15 DOI: 10.3899/jrheum.2024-1024
Bernardo D'Onofrio, Carlo Selmi
{"title":"Application of EULAR/ACR Classification Criteria for Polymyalgia Rheumatica in a Series of Patients With Acute Parvovirus B19 Infection.","authors":"Bernardo D'Onofrio, Carlo Selmi","doi":"10.3899/jrheum.2024-1024","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1024","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversity in Axial Spondyloarthritis Drug Trials: Enrollment by Sex, Race, Ethnicity, and Geographic Region. 轴型脊椎关节炎药物试验的多样性:按性别、种族、民族和地理区域入组。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-15 DOI: 10.3899/jrheum.2024-1013
Mathieu Choufani, Wissam Ghusn, Maureen Dubreuil, Joerg Ermann
{"title":"Diversity in Axial Spondyloarthritis Drug Trials: Enrollment by Sex, Race, Ethnicity, and Geographic Region.","authors":"Mathieu Choufani, Wissam Ghusn, Maureen Dubreuil, Joerg Ermann","doi":"10.3899/jrheum.2024-1013","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1013","url":null,"abstract":"<p><strong>Objective: </strong>To examine demographic and geographic diversity in axial spondyloarthritis (axSpA) drug trials.</p><p><strong>Methods: </strong>We performed a descriptive epidemiological study using ClinicalTrials.gov data. We included completed phase II-IV drug trials in adults with axSpA, conducted between 2000 and 2023, with results posted on ClinicalTrials.gov. We extracted and analyzed data on sex, race, ethnicity, trial characteristics and trial locations.</p><p><strong>Results: </strong>59 trials with 16,162 participants were analyzed. Females constituted 30% of participants overall: 25% in AS/r-axSpA trials, 34% in axSpA trials, and 48% in nr-axSpA trials. 31 trials (53%) reported race, and 12 (20%) reported both race and ethnicity. Race reporting increased from 9% of trials (2000-2010) to 53% (2011-2015) and 100% (2016-2020). Among 10,037 participants with race data, 82% were White, 15% Asian, 2% American Indian/Alaska Native, 1% Black, and 0.02% Native Hawaiian/Pacific Islander. Asian representation increased from 4% (2011-2015) to 19% (2016-2020), American Indian/Alaska Native from 1% to 3%, while Black representation remained consistently low at 1%. Among 3,577 patients with ethnicity data, 14% of participants were Hispanic/Latino, increasing from 1% (2011-2015) to 14% (2016-2020). 51 trials with location data enrolled participants from 53 countries. Sub-Saharan Africa (0%) and South/Central Asia (2%) had the lowest geographic representation of enrollment sites.</p><p><strong>Conclusion: </strong>The enrollment of women in axSpA drug trials largely reflects disease demographics. Race and ethnicity reporting has improved over time. While participation of Asian, American Indian/Alaska Native and Hispanic/Latino patients has increased, Black and Native Hawaiian/Pacific Islander representation has remained low. Future efforts should prioritize inclusivity and participation in underrepresented regions globally.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Age on Active and Structural Magnetic Resonance Imaging Lesions in Sacroiliac Joints of Healthy Individuals and Patients With Nonspecific Back Pain. 年龄对健康个体和非特异性背痛患者骶髂关节活动性和结构性MRI病变的影响
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-15 DOI: 10.3899/jrheum.2024-0563
Ulrich Weber, Sengül Seven, Susanne J Pedersen, Mikkel Østergaard, Pedro M Machado, Stephanie Wichuk, Xenofon Baraliakos, Robert G W Lambert, Walter P Maksymowych
{"title":"Effect of Age on Active and Structural Magnetic Resonance Imaging Lesions in Sacroiliac Joints of Healthy Individuals and Patients With Nonspecific Back Pain.","authors":"Ulrich Weber, Sengül Seven, Susanne J Pedersen, Mikkel Østergaard, Pedro M Machado, Stephanie Wichuk, Xenofon Baraliakos, Robert G W Lambert, Walter P Maksymowych","doi":"10.3899/jrheum.2024-0563","DOIUrl":"10.3899/jrheum.2024-0563","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effect of increasing age on the frequency of inflammatory and structural magnetic resonance imaging (MRI) lesions in the sacroiliac joints (SIJ) in 3 independent cohorts of healthy individuals and patients with nonspecific back pain (NSBP).</p><p><strong>Methods: </strong>We assessed MRI SIJ lesions in 3 cohorts (A, B, and C) of healthy individuals (cohort A, n = 79; cohort B, n = 78) and patients with NSBP (cohort A, n = 87; cohort C, n = 46) aged ≤ 45 years referred with back pain suspicious of axial spondyloarthritis (axSpA). MRI lesions were recorded on consecutive slices in SIJ quadrants or halves through the cartilaginous SIJ. Lesions were ascertained by 2-7 central readers according to standardized lesion definitions. Lesions recorded concordantly by the majority of readers were analyzed according to age categories (18-29, 30-39, and 40-50 yrs) and previously reported data-driven MRI cutoffs indicative of inflammatory or structural lesions typical of axSpA.</p><p><strong>Results: </strong>Only 3.8% (in both cohort A and cohort B) of healthy individuals and 5.7% (cohort A) and 4.3% (cohort C) of patients with NSBP had erosion in ≥ 1 SIJ quadrant, and progressive increases of erosion with age categories were not evident. None of the healthy individuals and 2.3% and 4.3% of cohort A and cohort C, respectively, of the patients with NSBP showed erosion in ≥ 3 SIJ quadrants, the cutoff indicative of axSpA; not a single individual met this cutoff in the highest age category. Fat metaplasia was slightly increased with age among healthy individuals and patients with NSBP in cohort A, but not in cohorts B or C.</p><p><strong>Conclusion: </strong>SIJ MRI data from healthy individuals and NSBP controls did not indicate progressive increases in structural lesions with increasing age categories when standardized definitions for axSpA lesions were adopted. MRI cutoffs for structural lesions denoting axSpA discriminated equally well between axSpA and NSBP across all age categories.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Parvovirus B19-Induced Atlantoaxial Arthritis. 细小病毒b19致寰枢关节关节炎1例。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-15 DOI: 10.3899/jrheum.2024-1293
Cristina Valero-Martínez
{"title":"A Rare Case of Parvovirus B19-Induced Atlantoaxial Arthritis.","authors":"Cristina Valero-Martínez","doi":"10.3899/jrheum.2024-1293","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1293","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing Giant Cell Arteritis With Tocilizumab: Relapses and Adverse Events. 托珠单抗治疗巨细胞动脉炎:复发和不良事件。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-01 DOI: 10.3899/jrheum.2024-1204
Miguel Ángel González-Gay, Santos Castañeda, Iván Ferraz-Amaro
{"title":"Managing Giant Cell Arteritis With Tocilizumab: Relapses and Adverse Events.","authors":"Miguel Ángel González-Gay, Santos Castañeda, Iván Ferraz-Amaro","doi":"10.3899/jrheum.2024-1204","DOIUrl":"10.3899/jrheum.2024-1204","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"206-209"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Trial. 审判
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-01 DOI: 10.3899/jrheum.2024-1052
Victor S Sloan, Lois Wingerson, Christopher Adams
{"title":"The Trial.","authors":"Victor S Sloan, Lois Wingerson, Christopher Adams","doi":"10.3899/jrheum.2024-1052","DOIUrl":"10.3899/jrheum.2024-1052","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"290-291"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unacceptable Work State in Rheumatoid Arthritis: Establishment of Thresholds for Presenteeism and Clinical Measurement Instruments. 类风湿性关节炎患者不可接受的工作状态:确定旷工阈值和临床测量工具。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-01 DOI: 10.3899/jrheum.2024-0833
Dafne Capelusnik, Sofia Ramiro, Elena Nikiphorou, Walter P Maksymowych, Marina Nighat Magrey, Helena Marzo-Ortega, Annelies Boonen
{"title":"Unacceptable Work State in Rheumatoid Arthritis: Establishment of Thresholds for Presenteeism and Clinical Measurement Instruments.","authors":"Dafne Capelusnik, Sofia Ramiro, Elena Nikiphorou, Walter P Maksymowych, Marina Nighat Magrey, Helena Marzo-Ortega, Annelies Boonen","doi":"10.3899/jrheum.2024-0833","DOIUrl":"10.3899/jrheum.2024-0833","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to identify threshold values of presenteeism measurement instruments that reflect unacceptable work state in employed patients with rheumatoid arthritis (RA) and whether those thresholds can predict future adverse work outcomes (AWOs). Additionally, we assessed the performance of presenteeism thresholds previously established in axial spondyloarthritis (axSpA) among patients with RA for the same instruments.</p><p><strong>Methods: </strong>Data from the multinational Patient-Reported Outcomes in Employment Study in Rheumatoid Arthritis (RA-PROSE) study were used. Thresholds to determine when patients consider themselves in an \"unacceptable work state\" were calculated at baseline for 4 instruments assessing presenteeism and for the patient global assessment of RA-related pain. Different approaches derived from the receiver-operating characteristic methodology were used. Accuracy of thresholds to predict AWO throughout 12 months was assessed and previously developed presenteeism thresholds for axSpA were also tested.</p><p><strong>Results: </strong>A total of 104 employed patients were included: 15% of the patients considered themselves in an unacceptable work state, of which 7 (7%) had at least 1 AWO over 12 months. Thresholds of all instruments specifically developed in RA showed good performance vs the external criterion (area under the curve [AUC] > 0.75), except for the Quantity and Quality (QQ) method (AUC 0.62). The available axSpA thresholds were more accurate by reducing overestimation. The final optimal thresholds were Work Productivity and Activity Impairment Questionnaire (WPAI)-presenteeism ≥ 40, QQ method < 97, Workplace Activity Limitations Scale ≥ 0.75, 25-item Work Limitations Questionnaire with modified physical demands scale ≥ 29, and pain intensity ≥ 4. For AWO over 12 months, pain and WPAI performed best in predicting AWO.</p><p><strong>Conclusion: </strong>The final thresholds to assess unacceptable presenteeism for axSpA were also chosen as most accurate for use in RA. In addition, accurate thresholds of pain reflecting unacceptable work state are available.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Myocarditis in Patients With Still Disease: Clinical Findings From the Multicenter International AIDA Network Still Disease Registry. 评估斯蒂尔病患者的心肌炎;多中心国际 AIDA 网络斯蒂尔病登记处的临床发现。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-01 DOI: 10.3899/jrheum.2024-0683
Piero Ruscitti, Ilenia Di Cola, Antonio Vitale, Valeria Caggiano, Pierpaolo Palumbo, Ernesto Di Cesare, Jiram Torres-Ruiz, Guillermo Arturo Guaracha-Basañez, Eduardo Martín-Nares, Francesco Ciccia, Daniela Iacono, Flavia Riccio, Maria Cristina Maggio, Samar Tharwat, Soad Hashad, Donato Rigante, Augusta Ortolan, Henrique A Mayrink Giardini, Isabele Parente de Brito Antonelli, Rafael Alves Cordeiro, Roberto Giacomelli, Luca Navarini, Onorina Berardicurti, Alessandro Conforti, Daniela Opris-Belinski, Jurgen Sota, Carla Gaggiano, Giuseppe Lopalco, Fiorenzo Iannone, Francesco La Torre, Violetta Mastrorilli, Marcello Govoni, Francesca Ruffilli, Giacomo Emmi, Edoardo Biancalana, Petros P Sfikakis, Maria Tektonidou, José Hernández-Rodríguez, Verónica Gómez-Caverzaschi, Özgül Soysal Gündüz, Giovanni Conti, Serena Patroniti, Antonio Gidaro, Arianna Bartoli, Alma Nunzia Olivieri, M Francesca Gicchino, Antonio Luca Brucato, Lorenzo Dagna, Alessandro Tomelleri, Corrado Campochiaro, Amato De Paulis, Ilaria Mormile, Francesca Della Casa, Haner Direskeneli, Fatma Alibaz-Oner, Anastasios Karamanakos, Aikaterini Dimouli, Gaafar Ragab, Ayman Abdelmonem Ahmed Mahmoud, Abdurrahman Tufan, Hamit Kucuk, Riza Kardas, Ezgi D Batu, Seza Ozen, Ewa Wiesik-Szewczyk, Andrea Hinojosa-Azaola, Alberto Balistreri, Claudia Fabiani, Bruno Frediani, Luca Cantarini
{"title":"Evaluation of Myocarditis in Patients With Still Disease: Clinical Findings From the Multicenter International AIDA Network Still Disease Registry.","authors":"Piero Ruscitti, Ilenia Di Cola, Antonio Vitale, Valeria Caggiano, Pierpaolo Palumbo, Ernesto Di Cesare, Jiram Torres-Ruiz, Guillermo Arturo Guaracha-Basañez, Eduardo Martín-Nares, Francesco Ciccia, Daniela Iacono, Flavia Riccio, Maria Cristina Maggio, Samar Tharwat, Soad Hashad, Donato Rigante, Augusta Ortolan, Henrique A Mayrink Giardini, Isabele Parente de Brito Antonelli, Rafael Alves Cordeiro, Roberto Giacomelli, Luca Navarini, Onorina Berardicurti, Alessandro Conforti, Daniela Opris-Belinski, Jurgen Sota, Carla Gaggiano, Giuseppe Lopalco, Fiorenzo Iannone, Francesco La Torre, Violetta Mastrorilli, Marcello Govoni, Francesca Ruffilli, Giacomo Emmi, Edoardo Biancalana, Petros P Sfikakis, Maria Tektonidou, José Hernández-Rodríguez, Verónica Gómez-Caverzaschi, Özgül Soysal Gündüz, Giovanni Conti, Serena Patroniti, Antonio Gidaro, Arianna Bartoli, Alma Nunzia Olivieri, M Francesca Gicchino, Antonio Luca Brucato, Lorenzo Dagna, Alessandro Tomelleri, Corrado Campochiaro, Amato De Paulis, Ilaria Mormile, Francesca Della Casa, Haner Direskeneli, Fatma Alibaz-Oner, Anastasios Karamanakos, Aikaterini Dimouli, Gaafar Ragab, Ayman Abdelmonem Ahmed Mahmoud, Abdurrahman Tufan, Hamit Kucuk, Riza Kardas, Ezgi D Batu, Seza Ozen, Ewa Wiesik-Szewczyk, Andrea Hinojosa-Azaola, Alberto Balistreri, Claudia Fabiani, Bruno Frediani, Luca Cantarini","doi":"10.3899/jrheum.2024-0683","DOIUrl":"10.3899/jrheum.2024-0683","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to (1) evaluate the cardiac involvement, with a focus on myocarditis, in patients with Still disease included in the multicenter Autoinflammatory Disease Alliance (AIDA) Network Still disease registry; and (2) assess the predictive factors for myocarditis by deriving a clinical risk patient profile for this severe manifestation.</p><p><strong>Methods: </strong>A multicenter observational study was established, in which consecutive patients with Still disease in the AIDA Network Still disease registry were characterized by cardiac involvement. Cardiac involvement was defined according to the presence of pericarditis, tamponade, myocarditis, and/or aseptic endocarditis.</p><p><strong>Results: </strong>In total, 73 patients with Still disease and cardiac involvement were assessed (mean age 36.3 [SD 19.9] years; male sex, 42.5%), out of which 21.9% were children. The most common cardiac manifestation was pericarditis, occurring in 90.4% of patients; patients also presented with myocarditis (26%), and less frequently endocarditis (2.7%) and tamponade (1.4%). In comparing clinical features of patients with myocarditis to those without, significantly increased frequencies of skin rash and pleuritis, as well as higher systemic scores, were seen. Further, a higher mortality rate was shown in patients with myocarditis. In regression models, skin rash and the systemic score independently predicted the myocarditis.</p><p><strong>Conclusion: </strong>The characteristics of patients with Still disease and cardiac involvement were assessed in the AIDA Network. The most common feature was the pericarditis, but a more severe clinical picture was also reported in patients with myocarditis. The latter was associated with increased mortality rate and higher systemic score, identifying patients who should be carefully managed.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"226-233"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Sensitivity Cardiac Troponin T as a Marker to Improve Cardiovascular Disease Risk Assessment Among Patients With Rheumatoid Arthritis. 高敏感性心肌肌钙蛋白T作为类风湿关节炎患者心血管疾病风险评估的标志物
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2025-03-01 DOI: 10.3899/jrheum.2024-0723
Gang Wang, Zhichun Liu
{"title":"High-Sensitivity Cardiac Troponin T as a Marker to Improve Cardiovascular Disease Risk Assessment Among Patients With Rheumatoid Arthritis.","authors":"Gang Wang, Zhichun Liu","doi":"10.3899/jrheum.2024-0723","DOIUrl":"10.3899/jrheum.2024-0723","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"295"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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