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Managing Giant Cell Arteritis With Tocilizumab: Relapses and Adverse Events.
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-1204
Miguel Ángel González-Gay, Santos Castañeda, Iván Ferraz-Amaro
{"title":"Managing Giant Cell Arteritis With Tocilizumab: Relapses and Adverse Events.","authors":"Miguel Ángel González-Gay, Santos Castañeda, Iván Ferraz-Amaro","doi":"10.3899/jrheum.2024-1204","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1204","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Trial. 审判
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-1052
Victor S Sloan, Lois Wingerson, Christopher Adams
{"title":"The Trial.","authors":"Victor S Sloan, Lois Wingerson, Christopher Adams","doi":"10.3899/jrheum.2024-1052","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1052","url":null,"abstract":"<p><p>Mrs. Ellis (a pseudonym) is a 57-year-old woman with a 10-year history of rheumatoid arthritis (RA) and a previous episode of transverse myelitis with residual pain and weakness.After the patient's insufficient response to methotrexate (MTX) and upon realizing that tumor necrosis factor inhibitors are relatively contraindicated in demyelinating disease, I wrote a prescription for abatacept (ABA), which could conceivably help both her RA and her transverse myelitis.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Sensitivity Cardiac Troponin T as a Marker to Improve Cardiovascular Disease Risk Assessment Among Patients With Rheumatoid Arthritis.
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0723
Gang Wang, Zhichun Liu
{"title":"High-Sensitivity Cardiac Troponin T as a Marker to Improve Cardiovascular Disease Risk Assessment Among Patients With Rheumatoid Arthritis.","authors":"Gang Wang, Zhichun Liu","doi":"10.3899/jrheum.2024-0723","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0723","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheumatoid Arthritis Treatment Has Changed Dramatically Over the Past 3 Decades, but Has the Disease Itself Changed? 类风湿性关节炎的治疗方法在过去三十年间发生了巨大变化，但疾病本身是否也发生了变化？
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-1160
Carol A Hitchon, Hani S El-Gabalawy
{"title":"Rheumatoid Arthritis Treatment Has Changed Dramatically Over the Past 3 Decades, but Has the Disease Itself Changed?","authors":"Carol A Hitchon, Hani S El-Gabalawy","doi":"10.3899/jrheum.2024-1160","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1160","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
We Would Like You to Get on Board. 我们希望您加入我们。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0870
Soumya Chatterjee
{"title":"We Would Like You to Get on Board.","authors":"Soumya Chatterjee","doi":"10.3899/jrheum.2024-0870","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0870","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge About Human Papillomavirus Among Patients With Immune-Mediated Inflammatory Diseases. 免疫相关炎症性疾病患者对人类乳头瘤病毒的了解。
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0959
Tiphaine Goulenok, Arthur Mageau, Chrystelle François, Claire Dossier, Eric Hachulla, Thomas Papo, Karim Sacré
{"title":"Knowledge About Human Papillomavirus Among Patients With Immune-Mediated Inflammatory Diseases.","authors":"Tiphaine Goulenok, Arthur Mageau, Chrystelle François, Claire Dossier, Eric Hachulla, Thomas Papo, Karim Sacré","doi":"10.3899/jrheum.2024-0959","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0959","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Gout Care in a Canadian Academic Medical Center Through a Multidisciplinary Nurse-Led Protocol.
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0707
Thomas Audet, Marie-Aude Picard-Turcot, Julie Robindaine, Nathalie Carrier, Pierre Dagenais
{"title":"Improving Gout Care in a Canadian Academic Medical Center Through a Multidisciplinary Nurse-Led Protocol.","authors":"Thomas Audet, Marie-Aude Picard-Turcot, Julie Robindaine, Nathalie Carrier, Pierre Dagenais","doi":"10.3899/jrheum.2024-0707","DOIUrl":"10.3899/jrheum.2024-0707","url":null,"abstract":"<p><strong>Objective: </strong>Following Health Canada's knowledge translation framework, we report the results of a clinical audit from 2012 to 2015 followed by a multidisciplinary, nurse-led gout care protocol with a treat-to-target (T2T) strategy implemented in April 2018.</p><p><strong>Methods: </strong>A clinical audit with chart reviewing was completed for adults with gout and urate-lowering therapy (ULT) indication at the Centre Hospitalier Universitaire de Sherbrooke. A nurse-led treatment algorithm using allopurinol was then developed. Titration of ULT by a nurse every 4 weeks was done until serum uric acid (SUA) target. In the postprotocol implementation, adults with gout and ULT indication were retrospectively recruited through a billing agency until December 2020. The main outcome was SUA target achievement at 6 months.</p><p><strong>Results: </strong>Of 50 patients identified in the audit, 31% reached SUA target at 6 months and 16% were lost to follow-up. A 74-patient postprotocol implementation cohort was recruited, with 43 in the protocol group and 31 under usual care. Most prevalent ULT indication was ≥ 2 gout attacks per year (n = 52) at 70%. Target SUA was reached in 65% (n = 28) in the protocol group at 6 months compared to 19% (n = 6) in the usual care group (<i>P</i> < 0.001). Failing to titrate medication in the usual care group was the leading cause for nonachievement of SUA target at 6 months. Five percent of patients were lost to follow-up, all in the usual care group.</p><p><strong>Conclusion: </strong>A multidisciplinary, nurse-led protocol with a T2T strategy implemented after a clinical audit significantly improved gout care. Such protocol could be replicated elsewhere in Canada.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective Use of Apremilast in Refractory Arthritis Associated With Cystic Fibrosis.
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0978
Angelo Nigro
{"title":"Effective Use of Apremilast in Refractory Arthritis Associated With Cystic Fibrosis.","authors":"Angelo Nigro","doi":"10.3899/jrheum.2024-0978","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0978","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Age on Rheumatic Immune-related Adverse Events: Experience from the Canadian Research Group of Rheumatology in Immuno-Oncology (CanRIO).
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0603
Jenny Li, Marie Hudson, Carrie Ye, Janet Roberts, Aurore Fifi-Mah, May Y Choi, Sabrina Hoa, C Thomas Appleton, Janet Pope, Nancy Maltez, Lourdes Gonzalez Arreola, Anthony Obrzut, Shahin Jamal
{"title":"Impact of Age on Rheumatic Immune-related Adverse Events: Experience from the Canadian Research Group of Rheumatology in Immuno-Oncology (CanRIO).","authors":"Jenny Li, Marie Hudson, Carrie Ye, Janet Roberts, Aurore Fifi-Mah, May Y Choi, Sabrina Hoa, C Thomas Appleton, Janet Pope, Nancy Maltez, Lourdes Gonzalez Arreola, Anthony Obrzut, Shahin Jamal","doi":"10.3899/jrheum.2024-0603","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0603","url":null,"abstract":"<p><strong>Objective: </strong>Immune checkpoint inhibitors (ICI) have revolutionized cancer outcomes but are limited by immunerelated adverse events (irAE), including rheumatic irAEs (Rh-irAE). Aging is associated with increased inflammation, referred to as \"inflamm-aging\". In this study, we explore the impact of age on severity, frequency, and treatment of Rh-irAEs.</p><p><strong>Methods: </strong>Adults with new Rh-irAEs after ICI exposure are followed prospectively across 10 Canadian sites as part of the CanRIO prospective cohort. In this study of patients seen between January 2020 and March 2023, we compare the severity of Rh-irAE and number of irAE between patients ≥65 years and <65 years and explore potential epidemiologic, treatment-related, and phenotypic differences between the older and younger patients.</p><p><strong>Results: </strong>A total of 139 patients with de novo Rh-irAEs were included, 58 in the \"younger\" (<65 years) and 81 in the \"older\" (≥65 years) group. There were no significant differences in severity of Rh-irAE (p=0.84) or number of irAEs (p=0.21), although there was a non-significant trend towards more older patients than younger patients with ≥3 irAEs (24% vs. 14%). Types of treatment for Rh-irAEs were similar between the groups. ICI continuation did not differ. Within the ICI-inflammatory arthritis (ICI-IA) subgroup, there was also no significant difference in the incidence of severe Rh-irAEs (p=0.51).</p><p><strong>Conclusion: </strong>Similar numbers of overall irAE and severity of Rh-irAE were observed between older vs. younger patients who developed Rh-irAE after treatment with ICI therapy, suggesting that \"inflamm-aging\" does not play a significant role in Rh-irAEs. Larger studies are needed to explore potential differences in patient phenotypes.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What's in a Name: The Value of Defining Core Competencies for Extended Role Practitioners in Arthritis Care.
IF 3.6 2区 医学
Journal of Rheumatology Pub Date : 2024-12-15 DOI: 10.3899/jrheum.2024-0995
Amanda Steiman, Katie Lundon, Laura Passalent, Leslie Soever, Deborah M Levy, Christopher Nielsen, Rachel Shupak
{"title":"What's in a Name: The Value of Defining Core Competencies for Extended Role Practitioners in Arthritis Care.","authors":"Amanda Steiman, Katie Lundon, Laura Passalent, Leslie Soever, Deborah M Levy, Christopher Nielsen, Rachel Shupak","doi":"10.3899/jrheum.2024-0995","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0995","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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