静脉注射Golimumab治疗儿童多关节病程特发性关节炎:开放标签III期研究的长期延伸

IF 3.4 2区 医学 Q2 RHEUMATOLOGY
Hermine I Brunner, César Pacheco-Tena, Ingrid Louw, Gabriel Vega-Cornejo, Ekaterina Alexeeva, Simone Appenzeller, Vyacheslav Chasnyk, Thomas Griffin, Carmen Navarrete Suarez, Sheila Knupp-Oliveira, Andrew Zeft, Yonatan Butbul Aviel, Deirdre De Ranieri, Beth S Gottlieb, Deborah M Levy, C Egla Rabinovich, Clóvis Artur Silva, Yury Spivakovsky, Yosef Uziel, Sarah Ringold, Xie L Xu, Jocelyn H Leu, Edwin Lam, Yuhua Wang, Daniel J Lovell, Alberto Martini, Nicolino Ruperto
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引用次数: 0

摘要

风湿病杂志[J];doi: 10.3899 / jrheum。在这篇文章最初发表后,研究小组意识到在长期扩展研究中发生了额外的非严重不良事件(ae)。此处提供了“任何AE”和“感染”的最新数字,以及相应的比率(每100患者年暴露)。“Any AE”的数量及其相应的比率(括号内)从965(207.5)更新为969(208.4)。“感染”人数及其相应的比率(括号内)已从426例(91.6例)更新为428例(92.0例)。这两项事件的订正数字和比率载于订正后的下表。此外,结果部分“安全结果”下的以下两句话分别修改为“任何AE”和“感染”的校正率每100人年(这些句子中的其他比率不变)。第一句修改为“到第252周,每100患者-年暴露的ae、严重ae (SAEs)和导致停药的ae的发生率分别为208.4、7.7和6.5(表)。”第二句修改后的句子是“每100名患者年的感染率和严重感染率分别为92.0和3.9。”这些变化是轻微的,不影响数据的解释或关于戈利姆单抗治疗多关节病程青少年特发性关节炎安全性的结论。提交此勘误表是为了确保科学的准确性和透明度。作者为这些错误道歉。此更正适用于2024年8月15日第一次发布和印刷版。在线版本现已更正。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intravenous Golimumab in Children With Polyarticular-Course Juvenile Idiopathic Arthritis: Long-Term Extension of an Open-Label Phase III Study.
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来源期刊
Journal of Rheumatology
Journal of Rheumatology 医学-风湿病学
CiteScore
6.50
自引率
5.10%
发文量
285
审稿时长
1 months
期刊介绍: The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
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