Journal of Rheumatology最新文献

{"title":"Gut Microbiota as a Biomarker and Target in Biologic Therapy for Autoimmune and Immune-Mediated Arthritis: A Systematic Review.","authors":"Madhumitha Rondla, Mohamed Sayed Zaazouee, Arya Akhila Perumangote Vasudevan, Karthik Mathialagan, Rewanth Katamreddy","doi":"10.3899/jrheum.2025-0915","DOIUrl":"10.3899/jrheum.2025-0915","url":null,"abstract":"<p><strong>Objective: </strong>Gut microbiota dysbiosis has been implicated in the pathogenesis of autoimmune and immune-mediated arthritis. Biologics may influence gut microbiota composition; however, it is uncertain whether biologics act directly on microbial communities or indirectly through disease modulation and restoration of immune homeostasis. This systematic review explores how biologic therapies modulate gut microbiota in autoimmune arthritis and their potential as biomarkers for treatment response and disease activity.</p><p><strong>Methods: </strong>We searched PubMed, Scopus, Cochrane Library, and Web of Science for studies assessing gut microbiota changes induced by any biologic therapy in immune-mediated or autoimmune arthritis. The outcomes included changes in microbiota and the potential for microbiota as predictive biomarkers for treatment response and disease activity.</p><p><strong>Results: </strong>A total of 12 studies were included. Biologic agents, predominantly tumor necrosis factor inhibitors and interleukin 17 inhibitors, significantly altered gut microbiota composition and diversity, with most studies showing increased α-diversity and normalization of β-diversity post therapy; however, these effects were not uniformly consistent. Treatment restored beneficial short-chain fatty acid-producing taxa, including <i>Faecalibacterium prausnitzii</i>, <i>Megamonas</i>, <i>Lachnoclostridium</i>, and <i>Blautia</i>, while reducing inflammatory genera such as <i>Escherichia</i>-<i>Shigella</i> and <i>Klebsiella</i>. Certain taxa, notably <i>Lachnospiraceae</i> and <i>Megamonas</i>, correlated with clinical improvement and reduced disease activity.</p><p><strong>Conclusion: </strong>Biologic therapy modulates gut microbiota composition in autoimmune and immune-mediated arthritis, promoting a shift toward eubiosis. Specific microbial taxa, including <i>Lachnospiraceae</i>, <i>Blautia</i>, and <i>F. prausnitzii</i>, show potential as noninvasive biomarkers for treatment response and disease activity. These findings guide further longitudinal and interventional studies to validate microbial signatures and their clinical applicability.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"739-751"},"PeriodicalIF":3.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Novel and Legacy Health Assessment Questionnaire Scoring Methods: A Scleroderma Patient-centered Intervention Network Cohort Study.","authors":"Yining Lu, Daphna Harel, Klint Kanopka, Marie-Eve Carrier, Linda Kwakkenbos, Susan J Bartlett, Catherine Fortuné, Amy Gietzen, Geneviève Guillot, Amanda Lawrie-Jones, Vanessa L Malcarne, Maureen D Mayes, Michelle Richard, Maureen Sauvé, James Stempel, Luc Mouthon, Andrea Benedetti, Brett D Thombs","doi":"10.3899/jrheum.2025-1069","DOIUrl":"10.3899/jrheum.2025-1069","url":null,"abstract":"<p><strong>Objective: </strong>To compare 5 Health Assessment Questionnaire (HAQ) scoring methods to measure functional disability among people with systemic sclerosis (SSc).</p><p><strong>Methods: </strong>Scleroderma Patient-centered Intervention Network (SPIN) Cohort participants completed the HAQ (20 items, 8 domains) at enrollment. We calculated (1) HAQ-Disability Index (HAQ-DI) scores, which sum the highest item score for each domain and account for the use of aids, devices, or assistance; (2) HAQ-Alternative Disability Index (HAQ-ADI) scores, which are calculated similarly but do not account for aids, devices, or assistance; and (3) modified HAQ (mHAQ) scores, which are based on 1 administered item from each domain, as well as a simple summed score of all 20 items. We then compared these scores and those generated from an item response tree (IRTree) on convergent validity with physical function, pain interference, and hand function using Pearson correlations.</p><p><strong>Results: </strong>IRTree-based scores were highly correlated (<i>r</i> 0.90-0.95) with other scoring procedures and showed moderate-to-strong correlations with all external measures (<i>r</i> 0.68-0.80). There was no evidence of a difference between IRTree-based and HAQ-DI correlations with external measures. IRTree-based scores performed better than HAQ-ADI, mHAQ, and summed scores for physical function and pain interference but worse for hand function.</p><p><strong>Conclusion: </strong>IRTree-based scoring is a novel approach that incorporates information from all HAQ items and whether participants use aids, devices, or assistance. Its association with external measures, however, did not differ from the standard HAQ-DI. HAQ-DI scoring is easy to implement, and extensive comparative data are available, making it the preferred scoring method.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"773-781"},"PeriodicalIF":3.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Rheumatology Association Annual Scientific Meeting Halifax Convention Centre, Halifax, Nova Scotia, Canada, April 16-19, 2026.","authors":"","doi":"10.3899/jrheum.2026-0447","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0447","url":null,"abstract":"<p><p>The 80th Annual Meeting of the Canadian Rheumatology Association took place at the Halifax Convention Centre in Halifax, Nova Scotia, from April 16 to 19, 2026. The event featured a comprehensive program of original research presentations, symposia, awards, and lectures.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Hip Osteoarthritis as a Risk Factor for Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis.","authors":"Rebecca Fitzpatrick, Shadpour Demehri, Joseph Murray, Julie R Brahmer, Elena Ghotbi, Durrant Barasa, Clifton O Bingham, Ami A Shah, Laura C Cappelli","doi":"10.3899/jrheum.2025-0808.C1","DOIUrl":"10.3899/jrheum.2025-0808.C1","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"716"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor Analysis to Determine Subgroups of Gastrointestinal Symptoms in Systemic Sclerosis.","authors":"Laura Ross, Dylan Hansen, Susanna Proudman, Jennifer Walker, Wendy Stevens, Nava Ferdowsi, Joanne Sahhar, Gene-Siew Ngian, Diane Apostolopoulos, Lauren V Host, Mandana Nikpour, Chamara Basnayake, Elizabeth R Volkmann","doi":"10.3899/jrheum.2025-0982","DOIUrl":"10.3899/jrheum.2025-0982","url":null,"abstract":"<p><strong>Objective: </strong>Systemic sclerosis (SSc) gastrointestinal (GI) disease is heterogeneous in presentation, with individual symptoms lacking specificity for specific anatomical and functional abnormalities. We used factor analysis to investigate whether latent subgroups of SSc-GI symptoms can be detected.</p><p><strong>Methods: </strong>Using the University of California, Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal 2.0 (GIT 2.0) questionnaire data from 773 Australian Scleroderma Cohort Study participants, we performed a factor analysis of, firstly, GIT 2.0 domains scores, and then individual GIT 2.0 question responses to identify latent factors. A subsequent cluster analysis was performed to explore whether clinically definable SSc phenotypes were associated with specific GI symptoms.</p><p><strong>Results: </strong>SSc-GI symptoms were highly correlated. Factor analysis of individual GIT 2.0 question responses revealed 4 latent factors within the dataset that could be clinically described as upper GI tract symptoms, bloating, diarrhea and incontinence, and constipation. Cluster analysis revealed 2 patient clusters, distinguished by disease duration and severity of GI manifestations. Anticentromere antibodies and pulmonary arterial hypertension were more common in participants with severe GI disease.</p><p><strong>Conclusion: </strong>Despite the high correlation between GI manifestations, it is possible to detect subgroups of SSc-GI symptoms. Improved understanding of these subgroups of SSc-GI disease may advance the discovery of targeted interventions to improve the daily function and quality of life of those living with SSc.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"652-658"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Rheumatologist Perspectives of the Patient Self-Administered Inflammatory Arthritis Detection Tool: Implementation Considerations, Potential Barriers, and Opportunities.","authors":"Norma K Biln, Nick Bansback, Kam Shojania, Charlyn Black, Mark J Harrison","doi":"10.3899/jrheum.2025-0926","DOIUrl":"10.3899/jrheum.2025-0926","url":null,"abstract":"<p><strong>Objective: </strong>As part of a research program examining rheumatology referrals in British Columbia, the Patient Self-Administered Inflammatory Arthritis Detection (SAID) Study evaluated the SAID tool, which contains validated patient-completed questionnaires for identifying and prioritizing individuals with inflammatory arthritis, supporting its utility and feasibility. This article reports the perspectives of participating patients and rheumatologists regarding the SAID tool.</p><p><strong>Methods: </strong>A multimethods design was used to collect and analyze patient survey and rheumatologist interview data, with an emphasis on implementation considerations. Ninety-two patients who completed the questionnaires in the Patient SAID Study also provided feedback on their experience. Semistructured interviews were conducted with 3 rheumatologists. Quantitative and qualitative data were analyzed using Microsoft Excel and NVivo to identify usability, relevance, and barriers or enablers to implementing the tool in primary-to-specialist referral.</p><p><strong>Results: </strong>Most patients found the SAID tool easy to log into (85%) and complete (82%). Across diagnostic groups, most (76%) believed it could help their general practitioner assess symptoms but emphasized the need for more nuanced response options and space for elaboration. Rheumatologists viewed the tool as brief, useful, and potentially valuable for triage, especially if integrated at the referral stage. Key barriers included time constraints, false negatives, and lack of integration with electronic medical records. All rheumatologists supported optional implementation led by motivated patients, provided it complemented-not complicated-existing workflows.</p><p><strong>Conclusion: </strong>With targeted modifications and appropriate implementation mechanisms, the SAID tool has the potential to improve the quality of referrals, support triage decision making, and address current gaps in access to rheumatology care within evolving digital health systems.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"659-668"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Intravenous Golimumab in Adults with Ankylosing Spondylitis: Results through 1 Year of the GO-ALIVE Study.","authors":"John D Reveille, Atul Deodhar, Paul H Caldron, Anna Dudek, Diane D Harrison, Lilianne Kim, Kim Hung Lo, Jocelyn H Leu, Elizabeth C Hsia","doi":"10.3899/jrheum.180718.C1","DOIUrl":"10.3899/jrheum.180718.C1","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"715"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Versus Bilateral Ultrasound of the Hands in Patients With Clinically Suspect Arthralgia: What Is the Difference? A Longitudinal Study.","authors":"Anna M P Boeren, Edwin H G Oei, A Willemze, Pascal H P de Jong, Annette H M van der Helm-van Mil, Elise van Mulligen","doi":"10.3899/jrheum.2025-0373","DOIUrl":"10.3899/jrheum.2025-0373","url":null,"abstract":"<p><strong>Objective: </strong>In clinically suspect arthralgia (CSA), ultrasound (US) can be used to detect subclinical joint inflammation, which is a known predictor for progression to clinically apparent inflammatory arthritis (IA). Although most US protocols include both hands, a more efficient, unilateral US approach is also sufficient but has never been investigated. Therefore, we described US findings for 1 hand and both hands in patients with CSA and investigated if a US protocol that includes 1 hand is as predictive as a protocol with 2 hands.</p><p><strong>Methods: </strong>Two cohorts of patients with CSA underwent bilateral US. Subclinical synovitis and tenosynovitis (grayscale ≥ 2 and/or power Doppler ≥ 1) in 1 hand and both hands were described per hand and joint. Additionally, we analyzed the association between IA development and US positivity.</p><p><strong>Results: </strong>In total, 320 patients with CSA were studied. In cohort 1, 23% of patients had bilateral US-detected subclinical (teno)synovitis, 20% in the dominant hand only, and 10% in the nondominant hand only. In cohort 2, 10% had bilateral involvement, 12% in the dominant hand only, and 8% in the nondominant hand only. US of the dominant hand predicted IA development almost equally as US of both hands, with hazard ratios (HRs) of 2.8 (95% CI 1.3-6.0) for both hands and 2.6 (95% CI 1.3-5.3) for the dominant hand in cohort 1. In cohort 2, HRs were comparable.</p><p><strong>Conclusion: </strong>US-detected subclinical (teno)synovitis in patients with CSA is partly bilateral and partly unilateral. Predictive values for IA development are comparable. To reduce scanning time in clinical practice, clinicians could consider scanning 1 hand instead of both hands in patients with CSA.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"612-619"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Golimumab Administered Intravenously in Adults with Ankylosing Spondylitis: Results through Week 28 of the GO-ALIVE Study.","authors":"Atul Deodhar, John D Reveille, Diane D Harrison, Lilianne Kim, Kim Hung Lo, Jocelyn H Leu, Elizabeth C Hsia","doi":"10.3899/jrheum.170487.C2","DOIUrl":"10.3899/jrheum.170487.C2","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"714"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Opportunities for Reducing Diagnosis Delay of Rheumatoid Arthritis in a Low-Resourced Country.","authors":"Syed Mustafa Ali, Salman Khurshid Imami, Faiza Naeem, Muhammad Ahmed Saeed, Sumaira Farman, Nighat Mir Ahmad, Babur Salim, Muhammad Yasir Pervez, Shehzad Afzal, Sarmad Wahaj Siddiqui, Habib Ahmed, Helen Brooks, Maria Panagioti, Saira Elaine Anwer Khan, Sabine N van der Veer","doi":"10.3899/jrheum.2025-1364","DOIUrl":"10.3899/jrheum.2025-1364","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"697-699"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}