Association of Past Smoking Status With Gout in Māori People in Aotearoa New Zealand.

IF 3.6 2区医学 Q2 RHEUMATOLOGY

Journal of Rheumatology Pub Date : 2024-11-15 DOI:10.3899/jrheum.2024-0239

Niamh C Fanning, John F Pearson, Nicola Dalbeth, Huti Watson, Tony R Merriman, Lisa K Stamp

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Abstract

Objective: Evidence for an association of smoking with gout is conflicting. We assessed associations of current and past smoking with gout in an Aotearoa New Zealand (NZ) population.

Methods: Multivariable logistic regression analysis was performed on cross-sectional data from participants of NZ Māori (from 2 studies: Genetics of Gout in Aotearoa [GGA] study of 293 participants with gout and 431 without; and Ngāti Porou Hauora [NPH] study of 111 participants with gout and 42 without), Pacific people (257 participants with gout and 357 without), and European (694 participants with gout and 688 without) ancestry.

Results: Current smoking was not associated with gout in NZ Māori (GGA: adjusted odds ratio [aOR] 1.54, P = 0.13; NPH: aOR 3.02, P = 0.10), Pacific people (aOR 0.64, P = 0.21), or European (aOR 0.92, P = 0.80) cohorts. Ex-smoker status was associated with higher gout prevalence in Māori cohorts (GGA: aOR 1.71, P = 0.02; NPH: aOR 7.95, P < 0.001), but not in Pacific people (aOR 1.10, P = 0.69) or European (aOR 1.18, P = 0.22) cohorts. Associations were independent of age, sex, BMI, alcohol intake, kidney function, hypertension, diabetes, physical activity, sugary drink consumption, education, and employment. No association of smoker status with serum urate concentrations was observed in participants without gout.

Conclusion: Ex-smoker status was associated with higher gout prevalence in people of NZ Māori ancestry. No association of current smoking with gout was observed across ancestral groups, raising uncertainties about the relevance of an association specific to ex-smokers.

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新西兰奥特亚罗瓦毛利人既往吸烟状况与痛风的关系

目的：有关吸烟与痛风关系的证据并不一致。我们评估了新西兰奥特亚罗亚（Aotearoa New Zealand）人群中当前和过去吸烟与痛风的关系：我们对新西兰毛利人（来自两项研究）的横截面数据进行了多变量逻辑回归分析：结果：目前吸烟与痛风无关：在新西兰毛利人（GGA：调整赔率[aOR]1.54，P = 0.13；NPH：aOR 3.02，P = 0.10）、太平洋人（aOR 0.64，P = 0.21）或欧洲人（aOR 0.92，P = 0.80）队列中，当前吸烟与痛风无关。在毛利人队列中，戒烟者与痛风发病率较高有关（GGA：aOR 1.71，P = 0.02；NPH：aOR 7.95，P < 0.001），但在太平洋人（aOR 1.10，P = 0.69）或欧洲人（aOR 1.18，P = 0.22）队列中则无关。两者之间的关系与年龄、性别、体重指数、酒精摄入量、肾功能、高血压、糖尿病、体力活动、含糖饮料摄入量、教育程度和就业无关。在没有痛风的参与者中，没有观察到吸烟者身份与血清尿酸盐浓度的关系：结论：在新西兰毛利血统的人群中，曾经吸烟与痛风发病率较高有关。在所有祖先群体中均未观察到当前吸烟与痛风的相关性，这使人们对前吸烟者的相关性产生了不确定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Rheumatology 医学-风湿病学

CiteScore

6.50

自引率

5.10%

发文量

285

审稿时长

1 months

期刊介绍： The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.