Tradition versus Innovation: Conventional Radiography and Ultrasound in Calcium Pyrophosphate Deposition Identification - Instructions for Use.

Abstract

Objective: Conventional radiography (CR) and ultrasound (US) are interchangeably used for identification of calcium pyrophosphate deposition (CPPD). The aim of this study was to assess whether combining US and CR offers greater accuracy over either modality alone for the identification of CPPD.

Methods: Consecutive patients scheduled for knee replacement surgery for osteoarthritis were enrolled. Before surgery, patients underwent CR and US of the knee. Menisci and hyaline cartilage were collected and analysed using polarised light microscopy to confirm the presence of CPPD (gold standard). CR and US were assessed for absence/presence of CPPD by expert radiologists and sonographers. Diagnostic performance statistics were calculated. Poisson models with robust variance estimators were used to determine the likelihood of identifying CPPD.

Results: 51 patients (63% female, mean age 74 years ± 8 SD) were enrolled. US demonstrated higher overall accuracy than CR for CPPD identification (0.78 vs 0.73). Sequential use of both modalities provided an advantage when only one knee site was positive in one of the two techniques; however, when two or three sites were positive, no additional advantage was observed. When US was negative, subsequent CR did not improve CPPD detection, but in cases of a negative CR, a positive US increased the likelihood of CPPD by 4.21 times, while a negative US increased the likelihood of absence of CPPD by 76%.

Conclusion: US was more accurate than CR for identification of CPPD. Only in few specific cases, performing both exams could be an added value for CPPD identification.