Journal of Rheumatology最新文献

{"title":"Safety and Efficacy of Golimumab Administered Intravenously in Adults with Ankylosing Spondylitis: Results through Week 28 of the GO-ALIVE Study.","authors":"Atul Deodhar, John D Reveille, Diane D Harrison, Lilianne Kim, Kim Hung Lo, Jocelyn H Leu, Elizabeth C Hsia","doi":"10.3899/jrheum.170487.C2","DOIUrl":"https://doi.org/10.3899/jrheum.170487.C2","url":null,"abstract":"<p><p>J Rheumatol 2018; doi: 10.3899/jrheum.170487 Recently, the sponsor became aware of data errors related to Bath Ankylosing Spondylitis Metrology Index (BASMI) and the University of California San Francisco (UCSF) Enthesitis Index that occurred during the study. The ensuing tabular and in-text corrections are provided hereinafter.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine-Induced Acute Generalized Exanthematous Pustulosis.","authors":"Hanlin Yin, Zhangyi Zhao, Wanyi Lin, Liangjing Lu","doi":"10.3899/jrheum.2025-0572","DOIUrl":"10.3899/jrheum.2025-0572","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"467-468"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Rheumatoid Arthritis-Associated Interstitial Lung Disease: Current Evidence and Next Steps Needed for Routine Clinical Use.","authors":"Lauren A O'Keeffe, Liya Sisay Getachew, Suchita P Nety, Alene A Saavedra, Natalie A Davis, Kevin T Mueller, Grace Qian, Gregory C McDermott, Jeffrey A Sparks","doi":"10.3899/jrheum.2025-0797","DOIUrl":"10.3899/jrheum.2025-0797","url":null,"abstract":"<p><p>Interstitial lung disease (ILD), characterized by pulmonary fibrosis and/or inflammation, is a common and severe extraarticular manifestation of rheumatoid arthritis (RA). RA-ILD is associated with reduced quality of life and increased mortality. Among people with RA, up to 15% develop clinically significant ILD, and even more have subclinical disease (radiologic abnormalities without symptoms). The most common RA-ILD patterns on chest high-resolution computed tomography (CT) imaging are usual interstitial pneumonia (UIP; the prototypic fibrotic subtype) and nonspecific interstitial pneumonia (the subtype characterized by inflammation). In this narrative review, we detail the current state of evidence for RA-ILD screening and the next steps needed to justify screening in some subgroups. Some current or former smokers with RA may currently qualify for lung cancer screening with low-dose CT imaging, which may also detect ILD. The 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) guideline for screening and monitoring of ILD conditionally recommended screening people with RA with an ILD risk factor (ie, male sex, older age, smoking, RA-related autoantibody elevation, obesity, and high RA disease activity). Several genetic and blood biomarkers are associated with RA-ILD. The <i>MUC5B</i> promoter variant is the strongest genetic risk factor for RA-ILD, specifically the UIP subtype. Proposed screening strategies show promise for accurately detecting RA-ILD; however, there has been less research on other consequences of screening for RA-ILD, including cost, anxiety, radiation exposure, incidental findings, and downstream clinical follow-up. Clinical trials are needed to identify an intervention that alters the natural history for those found to have subclinical RA-ILD on screening.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"362-375"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Harama et al reply.","authors":"Kimie Harama, Takao Sugiyama, Chisaki Ito, Toyohiko Sugimoto, Soichiro Kubota, Ryosuke Ito, Yoshiaki Kobayashi, Shunichiro Hanai, Daiki Nakagomi","doi":"10.3899/jrheum.2025-1067","DOIUrl":"10.3899/jrheum.2025-1067","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"474"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact Profiles in Psoriatic Arthritis: An Exploratory Latent Class Analysis of the Assessment of SpondyloArthritis International Society Health Index.","authors":"Rubén Queiro, Isla Morante","doi":"10.3899/jrheum.2025-0756","DOIUrl":"10.3899/jrheum.2025-0756","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to identify and characterize distinct subgroups of patients with psoriatic arthritis (PsA) based on their responses to the Assessment of SpondyloArthritis international Society Health Index (ASAS HI), using latent class analysis (LCA).</p><p><strong>Methods: </strong>We performed an exploratory LCA on 17 dichotomous ASAS HI items in a cohort of patients with PsA (n = 90). Model adequacy was evaluated by log-likelihood, Akaike information criterion (AIC), Bayesian information criterion (BIC), entropy, and average posterior probabilities (AvePP). Clinical measures (Psoriatic Arthritis Impact of Disease [PsAID], Disease Activity Index for Psoriatic Arthritis [DAPSA], tender/swollen joint counts, treatment) were compared across classes. Sensitivity analyses with 3 to 4 classes assessed robustness.</p><p><strong>Results: </strong>A 6-class solution was retained, ordered from class 0 (lowest impact) to class 5 (highest impact). Mean ASAS HI ranged from 1.2 in class 0 to 11.6 in class 5, with parallel increases in PsAID and DAPSA. Conditional probabilities revealed distinct profiles: class 0 had minimal impairment, classes 1-2 showed predominantly physical function limitations of mild to moderate severity, class 3 combined physical and emotional function burden, class 4 was characterized by dominant participation and social impact, and class 5 displayed severe multidimensional impairment. All classes had AvePP > 0.86. Sensitivity analyses with <i>K</i> = 3 and <i>K</i> = 4 reproduced the same gradient of impact but provided less granular separation.</p><p><strong>Conclusion: </strong>LCA of the ASAS HI identified 6 clinically meaningful health impact profiles in PsA. These findings support the use of the ASAS HI as a multidimensional tool capable of capturing diverse patient experiences and may help inform individualized management strategies in PsA.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"395-399"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Current Landscape of Health Disparities Research Among Youth With Juvenile Idiopathic Arthritis.","authors":"Jennifer M P Woo, Rebecca Hetrick","doi":"10.3899/jrheum.2025-1312","DOIUrl":"10.3899/jrheum.2025-1312","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"358-361"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12866947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota as a Biomarker and Target in Biologic Therapy for Autoimmune and Immune-Mediated Arthritis: A Systematic Review.","authors":"Madhumitha Rondla, Mohamed Sayed Zaazouee, Arya Akhila Perumangote Vasudevan, Karthik Mathialagan, Rewanth Katamreddy","doi":"10.3899/jrheum.2025-0915","DOIUrl":"10.3899/jrheum.2025-0915","url":null,"abstract":"<p><strong>Objective: </strong>Gut microbiota dysbiosis has been implicated in the pathogenesis of autoimmune and immune-mediated arthritis. Biologics may influence gut microbiota composition; however, it is uncertain whether biologics act directly on microbial communities or indirectly through disease modulation and restoration of immune homeostasis. This systematic review explores how biologic therapies modulate gut microbiota in autoimmune arthritis and their potential as biomarkers for treatment response and disease activity.</p><p><strong>Methods: </strong>We searched PubMed, Scopus, Cochrane Library, and Web of Science for studies assessing gut microbiota changes induced by any biologic therapy in immune-mediated or autoimmune arthritis. The outcomes included changes in microbiota and the potential for microbiota as predictive biomarkers for treatment response and disease activity.</p><p><strong>Results: </strong>A total of 12 studies were included. Biologic agents, predominantly tumor necrosis factor inhibitors and interleukin 17 inhibitors, significantly altered gut microbiota composition and diversity, with most studies showing increased α-diversity and normalization of β-diversity post therapy; however, these effects were not uniformly consistent. Treatment restored beneficial short-chain fatty acid-producing taxa, including <i>Faecalibacterium prausnitzii</i>, <i>Megamonas</i>, <i>Lachnoclostridium</i>, and <i>Blautia</i>, while reducing inflammatory genera such as Escherichia-Shigella and Klebsiella. Certain taxa, notably Lachnospiraceae and Megamonas, correlated with clinical improvement and reduced disease activity.</p><p><strong>Conclusion: </strong>Biologic therapy modulates gut microbiota composition in autoimmune and immune-mediated arthritis, promoting a shift toward eubiosis. Specific microbial taxa, including <i>Lachnospiraceae</i>, <i>Blautia</i>, and <i>F. prausnitzii</i>, show potential as noninvasive biomarkers for treatment response and disease activity. These findings guide further longitudinal and interventional studies to validate microbial signatures and their clinical applicability.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Living Treatment Recommendations for the Management of Axial Spondyloarthritis: Update #1.","authors":"Nicolas Richard, Jordi Pardo Pardo, Reza Mirza, Sibel Z Aydin, Louis Bessette, Dianne Mosher, Tristan Boyd, Jon Chan, Lihi Eder, Laura Passalent, Elie Karam, Bindu Nair, Glen S Hazlewood, Shirley M L Tse, Dax G Rumsey, Michel Zummer, Nigil Haroon, Robert Inman, Dafna D Gladman, Sherry Rohekar","doi":"10.3899/jrheum.2026-0227","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0227","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Joerns et al reply.","authors":"Elena K Joerns, Andrea Lopez-Ruiz, Ryan J Lennon, Cynthia S Crowson, Roslin Jose George, Vanessa L Kronzer, John M Davis, Elena Myasoedova","doi":"10.3899/jrheum.2026-0122","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0122","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Unasked Question: Musculoskeletal Symptoms in Sexual Activity.","authors":"Ismael Gutierrez-Jimenez, Manuel Hernandez-Hernandez, Aldo Barajas-Ochoa, José Alvarez-Nemegyei, Paloma Gradilla-Magaña, Mariana Nuñez-Martinez, Cesar Ramos-Remus","doi":"10.3899/jrheum.2025-1271","DOIUrl":"10.3899/jrheum.2025-1271","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"463-465"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}