Conducting a High-Quality Systematic Review.

IF 3.6 2区 医学 Q2 RHEUMATOLOGY
Nadine Shehata, Rohan D'Souza
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引用次数: 0

Abstract

Systematic reviews (SRs) are a structured means of knowledge synthesis used by a variety of healthcare practitioners to aid in medical decision making. The SR, if conducted rigorously, is considered to be at the top of the hierarchy for research studies. In addition to synthesizing evidence, SRs identify research priorities, address questions that may not be answerable by individual studies, and identify gaps to be addressed in future primary research. There are several steps that need to be taken when developing SRs to provide the best available evidence-the most essential being the assessment of risk of bias (ROB). Several ROB tools have been developed for use according to study design. Increasingly used is the assessment of certainty of evidence using approaches such as those developed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group. Whereas ROB is assessed for individual studies, the certainty of evidence is assessed for each critical or important outcome across studies. Analysis can be quantitative (metaanalysis) or qualitative (narrative), with the former intended to develop estimates of the effect measure (ie, the statistic that compares collated data), with confidence limits around that estimate. This review will focus on the steps required to develop SRs, from registration of the review protocol to the conduct, analysis, and reporting, with a focus on the assessment of ROB and certainty of evidence to ensure the development of a methodological and rigorous process.

撰写系统综述。
系统评价是一种结构化的知识综合手段,被各种卫生保健从业者用来帮助医疗决策。如果进行严格的系统评价,则被认为是研究的最高层次。除了综合证据外,系统评价还确定了研究重点;解决个别研究无法回答的问题;并确定在未来的初级研究中需要解决的差距。在其发展过程中需要遵循几个步骤,以提供最佳的现有证据,最重要的是评估偏倚风险。根据研究设计,已经开发了几种偏倚风险工具。此外,越来越多地使用诸如建议、评估、发展和评估分级(GRADE)工作组开发的方法来评估证据的确定性。虽然对单个研究的偏倚风险进行了评估,但对所有研究的每个关键或重要结果的证据确定性进行了评估。分析可以是定量分析(元分析)或定性分析(叙述),前者旨在对效果度量(比较整理数据的统计数据)进行估计,并对该估计进行置信度限制。本综述将侧重于制定系统评价的步骤,包括审查方案的注册、分析和报告,重点是评估偏倚风险和证据的确定性,以确保制定严谨的方法过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Rheumatology
Journal of Rheumatology 医学-风湿病学
CiteScore
6.50
自引率
5.10%
发文量
285
审稿时长
1 months
期刊介绍: The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
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