Luminescence最新文献_第8页

Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic-Induced Toxicity in the HCT-116 Cell Model: A Luminesce-Based Study 在HCT-116细胞模型中探讨香薷和豆蔻对砷毒性的细胞保护作用：基于发光的研究

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-05 DOI: 10.1002/bio.70119

Vinod Kumar Nelson, Selva Kumar Radha Krishnan, Ayed A. Dera, Syed Parween Ali, M Yasmin Begum, Gowri Sankara Rao Burle, Punna Rao Suryadevara, Geetha Birudala

{"title":"Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic-Induced Toxicity in the HCT-116 Cell Model: A Luminesce-Based Study","authors":"Vinod Kumar Nelson, Selva Kumar Radha Krishnan, Ayed A. Dera, Syed Parween Ali, M Yasmin Begum, Gowri Sankara Rao Burle, Punna Rao Suryadevara, Geetha Birudala","doi":"10.1002/bio.70119","DOIUrl":"https://doi.org/10.1002/bio.70119","url":null,"abstract":"<div>\u0000 \u0000 <p>Arsenic is a highly menacing environmental pollutant that substantially affects the quality of life, even in traces. It develops various diseases through increasing intracellular ROS that interacts with vital organs. Chelation therapy is currently recommended for arsenic toxicity. However, these treatment options are not specific and only target symptoms. Besides, they also show toxic effects and irreversibly damage crucial organs. Hence, there is an urgent need for a potential and safer therapeutic strategy that can prevent arsenic toxicity. Therefore, in this study, we have investigated SA and EC individually and in combination against arsenic toxicity in HCT-116 cells. The results obtained from various experiments revealed that both plant materials comparably inhibited arsenic-induced cellular damage by increasing the antioxidant function. Conversely, combining both plants showed even better cytoprotection against arsenic toxicity. The FT-IR and HPLC analysis of the active fractions revealed the presence of polyphenol compounds (ferulic acid and gallic acid) responsible for the pharmacological effect. This finding is unique because no cytoprotective impact has been reported yet on this combination.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Label-Free Spectrofluorometric Method for Simultaneous Estimation of Methocarbamol and Aspirin in Biological and Pharmaceutical Matrices: Whiteness and Greenness Evaluation 同时测定生物和药物基质中甲氨基酚和阿司匹林的无标记荧光光谱法：白度和绿度评价

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-05 DOI: 10.1002/bio.70139

Heba Abd El-Aziz, Abdallah M. Zeid

{"title":"Label-Free Spectrofluorometric Method for Simultaneous Estimation of Methocarbamol and Aspirin in Biological and Pharmaceutical Matrices: Whiteness and Greenness Evaluation","authors":"Heba Abd El-Aziz, Abdallah M. Zeid","doi":"10.1002/bio.70139","DOIUrl":"https://doi.org/10.1002/bio.70139","url":null,"abstract":"<div>\u0000 \u0000 <p>A combination of methocarbamol and aspirin is commonly used for the treatment of acute musculoskeletal pain, such as low back and neck pain. Simultaneous analysis of these analytes in dosage forms and biofluids using rapid, sensitive, and selective methods would be highly beneficial. Herein, we report the first direct, label-free spectrofluorometric method for simultaneously quantifying methocarbamol (MET) and aspirin (ASP) in coformulated tablets and spiked human urine. The method utilizes excitation at 274 nm with independent emission detection at 300 nm for MET and 402 nm for ASP, using methanol as the diluting solvent. The assay was rectilinear over ranges of 0.10–0.80 μg/mL for MET and 0.05–0.50 μg/mL for ASP with detection limits of 14.9 and 10.6 ng/mL for MET and ASP, respectively. The method was validated in compliance with ICH regulations. The approach was applied efficiently to assay both analytes in their tablets and spiked human urine with high % recoveries (98%–103%) and low RSD (1.7%–3.3%). In addition, the sustainability and practicality of the developed method were assessed using the RGB-12 whiteness algorithm, indicating the whiteness of the developed method. The method's greenness was also confirmed using three greenness metrics that showed excellent eco-friendliness of the developed method.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of CaYSi2Al2O2N5:Eu2+ CaYSi2Al2O2N5:Eu2+ 的合成与表征

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70140

S. A. Fartode, Anoop P. Fartode, Tushar R. Shelke, S. J. Dhoble

引用次数: 0

Trio-Colored Appraisal of Microwave-Assisted Synthesis of Carbon Quantum Dots as a Fluorescence Turn Off Nanoprobe for Analyzing Ledipasvir in Tablets and Rat Feces: Study of Silymarin Impact on Excretion Recovery 微波辅助合成碳量子点荧光关闭纳米探针用于分析雷地帕韦片剂和大鼠粪便中的三色评价：水飞蓟素对排泄恢复的影响研究

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70138

Aya R. Ahmed, Haydi S. Elbordiny, Mai M. Elnaggar, Mahmoud A. Ragab, Tarek S. Belal, Sara I. Aboras

{"title":"Trio-Colored Appraisal of Microwave-Assisted Synthesis of Carbon Quantum Dots as a Fluorescence Turn Off Nanoprobe for Analyzing Ledipasvir in Tablets and Rat Feces: Study of Silymarin Impact on Excretion Recovery","authors":"Aya R. Ahmed, Haydi S. Elbordiny, Mai M. Elnaggar, Mahmoud A. Ragab, Tarek S. Belal, Sara I. Aboras","doi":"10.1002/bio.70138","DOIUrl":"https://doi.org/10.1002/bio.70138","url":null,"abstract":"<div>\u0000 \u0000 <p>The current work offers a rigorous way for the microwave-assisted synthesis of N and S doped carbon quantum dots (QDs). The latter are deemed highly sensitive and selective fluorescence sensors that were widely investigated in pharmaceutical analysis. Quenching of luminescence of the prepared QDs in lab fabricated sensor at λ emission = 418 nm after excitation at 370 nm was implemented to quantify the anti-HCV drug Ledipasvir (LDP). LDP showed a linear response within the dynamic range of 1–40 μM. The calculated LDP detection and quantification limits were 313.06 and 948.67 nM, respectively. Besides the analysis of LDP in bulk and commercial dosage form, the scope of application extended to evaluate the effect of the nutraceutical silymarin (liver support) on the excretion of LDP in rat feces. The compliance with the green and white analytical chemistry fundamentals is comprehensively investigated and compared with selected versatile reported procedures. Numerous prevalent metrics, namely, analytical eco-scale, AGREE, RGB12, RGB fast, BAGI, and complex GAPI, were employed. Our developed fluorometric procedure demonstrated great sensitivity, selectivity, and functionality that outperformed other sophisticated platforms. Thus, the utility of the depicted procedure in pharmaceutical analysis and studying pharmacokinetics aspects is profoundly proven.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A Dual-Channel Fluorescent Probe for Detection of Biothiols in Green and Further Differentiation of Cys/Hcy in Near-Infrared Regions 绿色生物硫醇双通道荧光探针检测及近红外区域Cys/Hcy的进一步分化

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70142

Yuyuan Sun, Hui Wang, Xulong He, Fan Liu, Yu Yuan, Xiaodong Jia, Gang Chen, Shuwei Zhang

引用次数: 0

Biogenic Fabrication of Iron Oxide Nanoparticles Using Tinospora cordifolia Leaf Extract: A Green Approach for Enhanced Antioxidant Activity and Bio Adsorption, Reusability, Toxicity Analysis of Methylene Blue Dye 利用堇叶Tinospora cordifolia叶提取物制备氧化铁纳米颗粒：一种增强抗氧化活性和亚甲基蓝染料生物吸附、可重复利用、毒性分析的绿色途径

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70133

Janani Ravi, Subash Chandra Bose Ragunathan, Santhiya Mani, R. Mythili, Saurav Dixit, Palvannan Thayumanavan

{"title":"Biogenic Fabrication of Iron Oxide Nanoparticles Using Tinospora cordifolia Leaf Extract: A Green Approach for Enhanced Antioxidant Activity and Bio Adsorption, Reusability, Toxicity Analysis of Methylene Blue Dye","authors":"Janani Ravi, Subash Chandra Bose Ragunathan, Santhiya Mani, R. Mythili, Saurav Dixit, Palvannan Thayumanavan","doi":"10.1002/bio.70133","DOIUrl":"https://doi.org/10.1002/bio.70133","url":null,"abstract":"<div>\u0000 \u0000 <p>Phyto-synthesized iron oxide nanoparticles (Fe<sub>3</sub>O<sub>4</sub>-NPs) using <i>Tinospora cordifolia</i> (TC) leaf aqueous extract were investigated for their potential in adsorbing methylene blue dye (MB). TC-Fe<sub>3</sub>O<sub>4</sub>-NPs (<i>T. cordifolia</i>-synthesized iron oxide nanoparticles) were characterized using UV–Vis spectroscopy, FT-IR, XRD, and FESEM-EDAX. An absorption peak at 228 nm confirmed the synthesis, while FT-IR identified functional groups. XRD analysis verified the crystalline nature with prominent hkl planes at (220), (311), (400), (422), and (440). FESEM revealed a mean surface volume diameter of 82.21 nm. Adsorption studies showed optimal conditions with 10 ppm dye, 1 mg of adsorbent, 60 min of contact time, and pH 7. Under these conditions, the nanoparticles achieved a maximum adsorption efficiency of 88 ± 2.42% and a qmax of 104.49 mg g<sup>−1</sup>, fitting the Langmuir isotherm model. Additionally, TC-Fe<sub>3</sub>O<sub>4</sub>-NPs exhibited antioxidant activity with IC<sub>50</sub> values of 77.56 ± 4.69 μg/mL and 28.67 ± 2.59 μg/mL in the DPPH and ABTS assays, respectively. The adsorbed dye was efficiently desorbed, enabling reusability for up to 5 cycles. Additionally, TC-Fe<sub>3</sub>O<sub>4</sub>-NPs demonstrated antioxidant activity, reducing dye-induced toxicity in <i>Allium cepa</i> roots and non-pathogenic bacteria, contributing to healthier root growth and enhanced bacterial viability. These findings highlight TC-Fe<sub>3</sub>O<sub>4</sub>-NPs as efficient, reusable adsorbents with potential environmental applications.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical-Quality-by-Design Fluoroprobes for Quantitation of Entecavir and Penciclovir in Spiked Human Plasma and Content Uniformity Testing: Insights of DNA Mismatching, Three-Colors Assessment and Sustainability Profiling 用于加标人血浆中恩替卡韦和喷昔洛韦定量的分析质量设计荧光探针和含量均匀性测试：DNA不匹配，三色评估和可持续性分析的见解

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70128

Sarah S. Saleh, Ahmed Samir, Omnia A. El-Naem

{"title":"Analytical-Quality-by-Design Fluoroprobes for Quantitation of Entecavir and Penciclovir in Spiked Human Plasma and Content Uniformity Testing: Insights of DNA Mismatching, Three-Colors Assessment and Sustainability Profiling","authors":"Sarah S. Saleh, Ahmed Samir, Omnia A. El-Naem","doi":"10.1002/bio.70128","DOIUrl":"https://doi.org/10.1002/bio.70128","url":null,"abstract":"<div>\u0000 \u0000 <p>Entecavir and penciclovir are nucleoside-analog antiviral drugs structurally related to guanine that act by inhibiting the active viral replication process. Through this study, the quantitation of both drugs was carried out using two fluorescent probes, referred to as fluoroprobes. The first type was prepared by the addition of surfactants such as Tween 80 and sodium dodecyl sulfate (micelle-enhanced fluoroprobes), while the second type includes the formation of a tertiary complex of drug-terbium-DNA (Tb-DNA fluoroprobes). The preparation of the fluoroprobes was optimized using analytical quality by design (AQbD) via I-optimal design. A positive effect of the selected antiviral drugs on DNA mismatching was observed. The analytical procedures were validated according to ICH guidelines with a linearity range of 2.0–40.0 μM and 25.0–300.0 nM for micelle-enhanced and Tb-DNA fluoroprobes, respectively. The analytical procedures were evaluated in compliance with the three-color (GBW) assessments: greenness (using AGREE and ComplexGAPI metrics), blueness (using the BAGI tool), and whiteness (using the RGB algorithm). The sustainability profiles were established using the efficient-valid-green (EVG) framework. Both types of fluoroprobes were successfully applied to quantify entecavir and penciclovir in content uniformity testing and spiked human plasma as a simpler and cheaper alternative to hyphenated analytical techniques.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correction to “Hydrogen Peroxide Fluorescent Probe Monitored Butyric Acid Inhibition of Ferroptosis Process” 对“过氧化氢荧光探针监测丁酸抑制铁下垂过程”的修正

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-02 DOI: 10.1002/bio.70144

引用次数: 0

Sensitive Assessment of Ketotifen Levels in Tablets and Plasma Using a Photoinduced Electron Transfer (PET) Inhibition Spectrofluorimetric Approach 利用光诱导电子转移（PET）抑制光谱荧光法灵敏评估片和血浆中酮替芬水平

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70134

Islam M. Mostafa, Abobakr A. Mohamed, Yaser Alahmadi, Ahmed K. B. Aljohani, Raed Alghamdi, Mahmoud A. Omar

{"title":"Sensitive Assessment of Ketotifen Levels in Tablets and Plasma Using a Photoinduced Electron Transfer (PET) Inhibition Spectrofluorimetric Approach","authors":"Islam M. Mostafa, Abobakr A. Mohamed, Yaser Alahmadi, Ahmed K. B. Aljohani, Raed Alghamdi, Mahmoud A. Omar","doi":"10.1002/bio.70134","DOIUrl":"https://doi.org/10.1002/bio.70134","url":null,"abstract":"<div>\u0000 \u0000 <p>Ketotifen (KTF) is a type of asthma medication that is taken along with other antiasthma medications and may reduce the frequency, severity, and duration of asthma symptoms or attacks in children. This research introduces a novel spectrofluorimetric method for detecting KTF in its tablets and human blood plasma samples (spiked with KTF). The detection mechanism is based on a photoinduced electron transfer (PET) inhibition spectrofluorimetric approach for the sensitive detection of KTF different samples. By protonating KTF with 2.0 M acetic acid, the PET process is effectively inhibited, leading to a significant enhancement in the fluorescence intensity of KTF at 392 nm. This method detects KTF at values from 50 to 500 ng mL<sup>−1</sup>. The technique offers excellent detection and quantification limits of 13.41 and 40.65 ng mL<sup>−1</sup>, respectively. The range of the obtained percentage recoveries of KTF for spiked plasma samples was found to be 98.40% ± 1.30%–99.82% ± 1.20%, demonstrating the method's precision and reliability in diverse biological matrices. Also, the approach successfully evaluated KTF content uniformity in tablets without interference.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of 5,5′-Bi(1,10-Phenanthroline)-Based PVC Membrane Potentiometric Sensor for Silver Determination 5,5′-双（1,10-菲罗啉）基PVC膜电位传感器的研制

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70136

Derya Güngördü Solğun, Nurcan Kaya, Gülşah Saydan Kanberoğlu, Mehmet Salih Ağirtaş

{"title":"Development of 5,5′-Bi(1,10-Phenanthroline)-Based PVC Membrane Potentiometric Sensor for Silver Determination","authors":"Derya Güngördü Solğun, Nurcan Kaya, Gülşah Saydan Kanberoğlu, Mehmet Salih Ağirtaş","doi":"10.1002/bio.70136","DOIUrl":"https://doi.org/10.1002/bio.70136","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, the selectivity of the 5.5′-bi(1,10-phenanthroline) Compound (<b>1</b>) against Ag<sup>+</sup> ions as a chemical sensor was investigated by both absorption and potentiometric methods. First, a 1 × 10<sup>−5</sup> M solution of Compound (<b>1</b>) in acetonitrile was prepared. For the selectivity test, 1 × 10<sup>−2</sup> M solutions of metal ions in acetonitrile were prepared. UV–visible absorption measurements were performed by adding metal ions to a 5.5′-bi(1,10-phenanthroline) compound at certain concentrations. Among the studied metal ions, it was found to be selective only against silver ions. In addition, solid-state contact polyvinylchloride (PVC) membrane electrodes prepared using 5.5′-bi(1,10-phenanthroline) as an ionophore were found to be selective against Ag<sup>+</sup> ions among other ions. The optimum membrane composition of the measurement was determined as 3% 5.5′-bi(1,10-phenanthroline) + 32% PVC + 64% o-nitrophenyl octyl ether (o-NPOE) + 1% potassium tetrakis(4-chlorophenyl) borate (KTpClPB). The potentiometric properties of the silver selective electrode were determined as linear working range 1.0 × 10<sup>−7</sup>–1.0 × 10<sup>−3</sup> M, detection limit 1.0 × 10<sup>−7</sup> M, pH working range 3.23–9.08, and response time 3 s. Absorption and potentiometric methods confirm the selectivity towards silver ions. The IRC analysis of the silver-containing complex, performed using the DFT/B3LYP method with the LanL2DZ basis set, reveals an activation energy of approximately 0.002 Eh, with the transition state energy at −1.433173 Eh.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0