Luminescence最新文献

{"title":"Development and Validation of a Green Spectrofluorimetric Method for Nateglinide Quantification: Utilizing AR87 as a Probe With Box–Behnken Optimization and Quantum Mechanical Calculations","authors":"Ali Alqahtani,&nbsp;Taha Alqahtani,&nbsp;Adil Alshehri,&nbsp;Ahmed A. Almrasy","doi":"10.1002/bio.70076","DOIUrl":"https://doi.org/10.1002/bio.70076","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, a sensitive and selective spectrofluorimetric method was developed for the determination of the antidiabetic drug nateglinide based on its reaction with the xanthene dye acid red 87 (AR87). A fluorescence quenching process was observed for the AR87 at 545 nm upon the addition of nateglinide, which was exploited for the quantitative analysis. The reaction mechanism was investigated using quantum mechanical calculations suggesting a transfer between the electron-rich AR87 and the electron-deficient nateglinide. Additionally, the stoichiometry of the interaction was determined through Job's method revealing a 1:1 nateglinide–AR87 complex formation. The experimental parameters were optimized using a Box–Behnken design of experiments, including pH, reagent concentration, and buffer volume. The optimized method was validated according to ICH guidelines, demonstrating excellent linearity in the range of 0.1–3.0 μg/mL, with a detection limit of 0.0320 μg/mL and a quantitation limit of 0.0961 μg/mL. Furthermore, the greenness and blueness of the method were assessed using the AGREE and BAGI indices, indicating an environmentally friendly procedure. The developed method was successfully applied for the determination of nateglinide in pharmaceutical dosage forms and spiked human plasma samples posing a promising analytical tool for clinical and quality control applications.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Novel Synchronous Spectrofluorimetric Method Coupled With Chemometric Modelling for Ultrasensitive Analysis of Tenofovir and Dolutegravir With Implication for Pharmacokinetic Studies","authors":"Reem M. Alnemari,&nbsp;Saleh I. Alaqel,&nbsp;Maram H. Abduljabbar,&nbsp;Atiah H. Almalki,&nbsp;Ahmed Serag","doi":"10.1002/bio.70080","DOIUrl":"https://doi.org/10.1002/bio.70080","url":null,"abstract":"<div>\u0000 \u0000 <p>This study introduces a novel synchronous spectrofluorimetry coupled with chemometric tools for the determination of tenofovir and dolutegravir antiretroviral drugs. Utilizing partial least squares regression (PLS) fine-tuned by genetic algorithm as variable selection tool, the developed models demonstrate greater sensitivity, cost-effectiveness, and reduced environmental impact compared to traditional HPLC methods. The model's validation was further confirmed using external validation in addition to QC samples as per ICH M10 guidelines, which yielded high accuracy ranged between 94.78% and 102.48% for tenofovir and 94.56% and 103.31% for dolutegravir, respectively. Additionally, the %CV values for within-run precision were below 4%, while those for between-run precision stayed under 6%, for tenofovir and dolutegravir, respectively. Hence, the developed models were adeptly applied to pharmacokinetic studies in a rat model, revealing slight changes in the tenofovir and dolutegravir plasma concentration profiles and half-lives when administered in combination, highlighting possible drug interactions. Greenness analysis of this spectrofluorimetric approach using the AGREE tool further substantiates its advantages over conventional chromatographic techniques. Hence, this simple, rapid, and environmentally friendly analytical methodology presents a promising alternative for therapeutic drug monitoring and pharmacokinetic studies of tenofovir and dolutegravir antiretroviral drugs.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Electrochemiluminescence Biosensor for Detection of Methyl Parathion With a Novel Probe Ru-MIL-100 via the Acetylcholinesterase Inhibition Coupled With the Reaction Between HAc and Triethylamine","authors":"Xuhui Zhang,&nbsp;Yafei Chen,&nbsp;Jun Ling,&nbsp;Jianping Li","doi":"10.1002/bio.70073","DOIUrl":"https://doi.org/10.1002/bio.70073","url":null,"abstract":"<div>\u0000 \u0000 <p>It is of great significance to develop sensors for trace pesticide residues detection in food. Herein, an electrochemiluminescence (ECL) sensor with high sensitivity for the detection of methyl parathion (MP) was constructed by combining of the acetylcholinesterase (AChE) enzyme-inhibited reaction with tris-2,2′-bipyridyl ruthenium Ru(bpy)₃²⁺-triethylamine (TEA) system for the first time. A new ECL probe of MIL-100 loaded with Ru(bpy)₃²⁺(Ru-MIL-100) was synthesized, and then Ru-MIL-100 and AChE were immobilized on the electrode with Nafion. Triethylamine was used as a coreactant to form a Ru-MIL-100–TEA luminescence system. The hydrolysis of iodinated acetylthiocholine by AChE to generate acetic acid that consumes TEA, leading to the quenching of ECL of the Ru-MIL-100–TEA system. But MP can inhibit the activity of AChE, which leads to the decrease of the generated acetic acid and the enhancement of ECL. With the increase of the MP concentration, the ECL intensity increases. Due to the high catalytic activity of the AChE and the excellent ECL luminescence performance of the Ru-MIL-100 probe, the sensor is highly sensitive. The detection concentration range of MP was 1.0 × 10⁻¹²–1.0 × 10⁻⁹ mol/L, and the detection limit was 2.07 × 10⁻¹³ mol/L. The biosensor was applied to the determination of MP in vegetable samples.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Variability of Bioluminescence and Abundance of the Dinoflagellate Noctiluca scintillans in the Arabian Sea","authors":"Sergey A. Piontkovski,&nbsp;Hajir M. Al-Lawati,&nbsp;Khalid A. Al-Hashmi,&nbsp;Alexandr V. Melnik","doi":"10.1002/bio.70057","DOIUrl":"10.1002/bio.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>Bioluminescence is a functional property used by many marine organisms for multilateral communications. In the Arabian Sea, the dinoflagellate <i>Noctiluca scintillans</i> (Macartney) Kofoid and Swezy, 1921, contributes gradually to the bioluminescent potential (BP) of the phytoplankton community. Experiments, field sampling, and remote sensing were employed, to estimate the seasonal variation of the BP and the abundance of cells in the northwestern Arabian Sea. An experimental setup for BP measurements integrated a “Chelsea Instruments” GlowTracka sensor, which required ~5 <i>N. scintillans</i> cells to obtain a statistically robust signal. Plankton were sampled with 200-μm mesh size nets, in the upper mixed layer. Also, <i>N. scintillans</i> cells were counted in Niskin bottle samples collected from the deep chlorophyll maximum. The remotely sensed chlorophyll-<i>a</i> concentration was analyzed, for the period from 2000 to 2022. A positive linear relationship between the abundance of <i>N. scintillans</i> cells in experiments and their BP was elucidated. Peaks of BP in experiments fit the Northeast and Southwest Monsoon periods and so did the <i>N. scintillans</i> abundance peaks in situ. These findings showed that BP may serve as an indicator of <i>N. scintillans</i> abundance and biomass in the northwestern Arabian Sea.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luminescent Carbon Dots From Biomass Waste for the Sensitive Determination of Ascorbic Acid in Tablet Dosage Forms","authors":"Nehal Mohamed,&nbsp;Mahmoud Hamed,&nbsp;Fotouh R. Mansour,&nbsp;Walaa Zarad,&nbsp;Samy Emara,&nbsp;Ahmed Shawky","doi":"10.1002/bio.70072","DOIUrl":"10.1002/bio.70072","url":null,"abstract":"<div>\u0000 \u0000 <p>Affordable and eco-friendly green spectrofluorometric (FL) methods can enhance the safety and cost-effectiveness of quality assurance and control in ascorbic acid (ASA) formulations. However, most current techniques for ASA analysis have faced challenges like complexity, delayed response times, low throughput, time-consuming procedures, and requirements for expensive equipment and hazardous chemicals for analyte modification. The study is aimed at producing natural carbon quantum dots (NACQDs) from pumpkin seed peels (PSPs), a natural waste material, using a rapid microwave-assisted method. A variety of techniques, including transmission electron microscopy, scanning electron microscopy, energy-dispersive x-ray spectroscopy, and Fourier-transform infrared spectroscopy, were employed to characterize the PSP-based NACQDs. The NACQDs were used as probes for FL analysis of ASA, where the addition of ASA caused fluorescence quenching of the NACQDs. The developed method demonstrated good linearity (<i>r</i> = 0.996), sensitivity, accuracy (percentage recovery ranging from 99.36% to 100.35%), and precision (%RSD less than 0.21%) in the quantification of ASA in the range of 0.3–15 μg/mL. The method's LOD and LOQ values were 0.1 and 0.3 μg/mL, respectively. The successful analysis of ASA in tablet formulations demonstrated the practicality of the proposed method. Greenness assessment tools highlighted its superior eco-friendliness compared to reference techniques.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Eco-Friendly Spectrofluorometric Estimation of Itraconazole and Ibuprofen in Pharmaceutical and Biological Matrices","authors":"Engy Attaa Bakr,&nbsp;Abdallah M. Zeid,&nbsp;Shereen M. Shalan,&nbsp;Yasser El-Shabrawy","doi":"10.1002/bio.70071","DOIUrl":"10.1002/bio.70071","url":null,"abstract":"<div>\u0000 \u0000 <p>A rapid, facile, and green spectrofluorometric method was developed for the concurrent precise estimation of itraconazole and ibuprofen. The developed method involved the use of Tween-80 micelle as a green sample matrix for the efficient assay of the analytes of interest. Besides the greenness of Tween-80, it significantly enhanced the native fluorescence of itraconazole by about 450%. The spectrofluorometric measurements of studied analytes were conducted in a 1% Tween-80 micellar medium at 370 nm for itraconazole and 288 nm for ibuprofen, following an excitation at 260 nm for both drugs. The fluorescent intensity–concentration relationships for both drugs were linear within the concentration ranges of 30–400 ng mL⁻¹ for itraconazole and 300–5000 ng mL⁻¹ for ibuprofen, showing high correlation coefficient values. The method exhibited high precision, with quantitation limits of 13.3 ng mL⁻¹ for itraconazole and 260.6 ng mL⁻¹ for ibuprofen. Successful application to commercial tablet formulations demonstrated the method's accuracy and sensitivity. Validation per ICH guidelines confirmed its effectiveness for quantifying the drugs in spiked human plasma, achieving high recovery rates. Furthermore, an evaluation of the method's environmental impact using GAPI and analytical Eco-Scale metrics confirmed its eco-friendliness.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataluminescence Sensor Based on Halloysite Nanotubes/MgO Nanocomposite for Rapid Detection of Ether","authors":"Yilu Liu,&nbsp;Zhaoxia Shi,&nbsp;Yintang Zhang,&nbsp;Zhaohui Li,&nbsp;Maotian Xu","doi":"10.1002/bio.70069","DOIUrl":"10.1002/bio.70069","url":null,"abstract":"<div>\u0000 \u0000 <p>MgO surface makes it easy to introduce a certain amount of oxygen vacancy and can enhance catalytic reaction activity. Besides, as a silicoaluminate mineral material, halloysite nanotube (HNT) has a unique tubular structure. In this paper, the HNTs@MgO composite was successfully synthesized based on natural clay material HNTs as a carrier, and the CTL sensor based on HNTs@MgO was successfully developed for the rapid determination of ether in air. The HNTs@MgO material was characterized by a series of means such as SEM, XPS, and XRD, which clearly confirmed that MgO successfully combined with HNTs. And the sensor showed good sensitivity and selectivity, with a good linear relationship between CTL intensity and ether concentration in the range of 0.5–190.0 mg/L (<i>R</i>² = 0.9942), and the limit of detection (LOD) was 0.18 mg/L (<i>S/N</i> = 3). The RSD values of the results of 11 consecutive measurements by the same sensor and 7 days of consecutive measurements were 1.96% (<i>n</i> = 11) and 3.42% (<i>n</i> = 7), showing good repeatability and reproducibility. At last, the CTL sensor was used to detect air samples, the recoveries ranged from 91.6% to 109.6%. Thus, it was concluded that HNTs@MgO composite is a cost-effective and promising material with potential application in atmospheric detection.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"39 12","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive “On-Off” Fluorescent Sensor From N-Doped Carbon Dots for Fe3+ Detection and Anticounterfeiting Applications","authors":"Zherui Wan,&nbsp;Xiaoxu Cui,&nbsp;Zhonghao Li,&nbsp;Haorui Zhong,&nbsp;Yilei Liu,&nbsp;Yesheng Liang,&nbsp;Zhiyong Zhang,&nbsp;Guang Yang","doi":"10.1002/bio.70058","DOIUrl":"10.1002/bio.70058","url":null,"abstract":"<div>\u0000 \u0000 <p>Herein, a kind of N-doped fluorescent carbon dots (N-CDs) were prepared by using melamine and carboxymethyl cellulose (CMC) as precursors through a straightforward hydrothermal method. The designed sensor displayed a uniform nanoscale distribution, excellent hydrophilicity, and strong fluorescence emission with a fluorescence quantum yield of 37.98%. Moreover, the N-CDs could be utilized for Fe³⁺ detection by the fluorescence “On–Off” transition via the mechanism of internal filtration effect (IFE) and static quenching process. Two good linear relationships within the concentrations of Fe³⁺ from 10 to 100μM and 100 to 500 μM could be obtained, which indicated that the “On–Off” fluorescent sensor could quantitative analysis of Fe³⁺ and the calculated detection limit (LOD) was 0.510 μM (3σ/slope). Additionally, the N-CDs could be used for the detection of Fe³⁺ in the solid phase based on the fluorescence “On–Off” strategy, which is promising for anticounterfeiting application.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"39 12","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Synthesis of Silver Nanoparticles for Nanosensor-Based Mercury Detection","authors":"M. Vanaja,&nbsp;K. Paulkumar,&nbsp;M. Sivakavinesan,&nbsp;G. Annadurai,&nbsp;Abdurahman Hajinur Hirad,&nbsp;Abdullah A. Alarfaj,&nbsp;A. M. Murugan","doi":"10.1002/bio.70063","DOIUrl":"10.1002/bio.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>The production of nanoparticles via green methods is a developing study domain due to potential environmental applications. The green synthesis method is very easy, less toxic and eco-friendly when compared to the chemical synthesis method. This study addresses the silver nanoparticle synthesis utilizing the <i>Acorus calamus</i> leaf extract, which was then employed for environmental applications. The synthesized silver nanoparticles had been verified by UV–vis spectrophotometer, while XRD (X-Ray Diffraction) demonstrated their crystalline structure. The morphology characters of the silver nanoparticles were observed by TEM (transmission electron microscope) as well as SAED (selected area electron diffraction) pattern. The produced silver nanoparticles have been used in selective detection of mercury ions, which is an easy, eco-friendly, less time consuming process. Utilizing an EDAX (energy dispersive X-ray analysis) along with SEM (scanning electron microscope), it was determined that mercury ions had been attached to the surface of silver nanoparticles. FTIR (Fourier transform infrared spectroscopy) had been utilized to characterize the functional groups that exist in the silver nanoparticles that were involved in mercury detection.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"39 12","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a Simple Quinoline-Based Chromo-Fluorogenic Receptor for Highly Specific Quantification of Copper (II) Ions: Environmental and Bioimaging Applications","authors":"Murugavel Durgaparameshwari,&nbsp;Karuppaiyan Kaviya,&nbsp;D. S. Prabakaran,&nbsp;Madhappan Santhamoorthy,&nbsp;Ramar Rajamanikandan,&nbsp;Mysoon M. Al-Ansari,&nbsp;Kailasam Saravana Mani","doi":"10.1002/bio.70068","DOIUrl":"10.1002/bio.70068","url":null,"abstract":"<div>\u0000 \u0000 <p>Many industries use copper metal ions (Cu²⁺ ions), and their salts are utilized as supplemental materials in both agriculture and medicine. Identifying and monitoring these Cu²⁺ ions in biological and environmental specimens is crucial due to their association with several health issues. In this investigation, we have designed a simple quinoline-based receptor (<i>E</i>)-3-(((2,4-di-tert-butyl-5-hydroxyphenyl)imino)methyl)-6-methoxyquinolin-2(1H)-one (<b>QAP</b>) containing imine functional groups to inspect its capability to identify metal ions in a semi-aqueous medium. The photophysical characteristics and structural confirmation of the receptor <b>QAP</b> were investigated using various spectroscopic techniques. Among various metal ions, the receptor <b>QAP</b> displayed an intense color shift from slightly yellow to strong yellow in the existence of Cu²⁺ ions, as visualized by the nude eye. Furthermore, the fluorescence spectral maximum wavelength at 485 nm and the strong cyan fluorescence color were quenched upon introducing Cu²⁺ ions. The alteration in the spectral and colorimetric features of QAP with Cu²⁺ ions is due to coordination complex formation. The present sensor shows the linear range from 3 to 69 μM, subsequent in a computed limit of detection as 3.16 nM, which is much lower than that of the maximum threshold of Cu²⁺ ions in drinking water set by WHO. Therefore, the receptor can respond to Cu²⁺ ions sensing in two ways: by changing color and by quenching fluorescence. The binding mode of the Cu²⁺ ions to the functional groups of the receptor <b>QAP</b> is a 1:1 stoichiometry, according to ESI-mass, Job's plot analysis, and density functional theory (DFT) computations. The practical utility of the fluorescent receptor <b>QAP</b> was applied for Cu²⁺ ions determination in environmental samples (drinking, tap, and dam water) and cancer cells (HeLa cells).</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"39 12","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}